The structure and evolution of the two nonallelic rat preproinsulin genes

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975 • 3,026 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

Improved Estimation of Secondary Structure in Ribonucleic Acids

1973 • 2,302 citations

Why genes in pieces?

1978 • 2,256 citations

The isolation of structural genes from libraries of eucaryotic DNA

1978 • 1,877 citations

Biochemical Evolution

1977 • 1,283 citations

Rat Insulin Genes: Construction of Plasmids Containing the Coding Sequences

1977 • 1,252 citations

An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA

1977 • 1,138 citations

Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning

1977 • 951 citations

Analysis of Endonuclease R· Eco RI Fragments of DNA from Lambdoid Bacteriophages and Other Viruses by Agarose-Gel Electrophoresis

1974 • 633 citations

Conservation of the primary structure at the 3′ end of 18S rRNA from eucaryotic cells

1978 • 427 citations

Organisation and sequences at the 5′ end of a cloned complete ovalbumin gene

1979 • 340 citations

The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cells

1978 • 324 citations

Species variation in the amino acid sequence of insulin

1966 • 322 citations

Transcription of structural and intervening sequences in the ovalbumin gene and identification of potential ovalbumin mRNA precursors

1978 • 255 citations

A precursor of globin messenger RNA

1976 • 254 citations

British Optical Astronomy

1972 • 204 citations

AUG is the only recognisable signal sequence in the 5′ non-coding regions of eukaryotic mRNA

1978 • 172 citations

Improved methods for the formation and stabilization of R-loops

1979 • 163 citations

Comparison of cloned rabbit and mouse β-globin genes showing strong evolutionary divergence of two homologous pairs of introns

1978 • 156 citations

Structural analysis of the fibroin gene at the 5′ end and its surrounding regions

1979 • 136 citations

Preparation of pancreatic mRNA: cell-free translation of an insulin-immunoreactive polypeptide.

1976 • 101 citations

Complete nucleotide sequence of the 5′ noncoding region of human α- and β-globin mRNA

1977 • 81 citations

Mutagenesis in vitro by DNA polymerase from an RNA tumour virus

1979 • 80 citations

Application of recombinant DNA technology to questions of developmental biology: A review

1979 • 65 citations

Eukaryotic gene regulation

2000 • 65 citations

Immunological and chemical characterization of bovine preproinsulin.

1977 • 60 citations

Preproinsulin, a new precursor in insulin biosynthesis

1977 • 25 citations

Inverted sequences in rat DNA

1977 • 11 citations

Variations in LD50/30 in a Strain of Rats Over 20 Years

1974 • 4 citations