3 Persisting problems in tuberculosis

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

1993 • 2,410 citations

Disseminated tuberculosis in interferon gamma gene-disrupted mice.

1993 • 1,982 citations

Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice

1995 • 1,643 citations

Mechanism of a Reaction in Vitro Associated with Delayed-Type Hypersensitivity

1966 • 1,604 citations

A Prospective Study of the Risk of Tuberculosis among Intravenous Drug Users with Human Immunodeficiency Virus Infection

1989 • 1,587 citations

On the Antibacterial Action of Cultures of a Penicillium, with Special Reference to their Use in the Isolation of B. influenzæ

1929 • 1,540 citations

Quantifying the burden of disease: the technical basis for disability-adjusted life years.

1994 • 1,513 citations

Tuberculosis in Patients with Human Immunodeficiency Virus Infection

1999 • 1,483 citations

New use of BCG for recombinant vaccines

1991 • 1,463 citations

Tuberculosis: Commentary on a Reemergent Killer

1992 • 1,400 citations

inhA , a Gene Encoding a Target for Isoniazid and Ethionamide in Mycobacterium tuberculosis

1994 • 1,348 citations

Global epidemiology of tuberculosis. Morbidity and mortality of a worldwide epidemic

1995 • 1,315 citations

Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis

1993 • 1,307 citations

Lack of Acidification inMycobacteriumPhagosomes Produced by Exclusion of the Vesicular Proton-ATPase

1994 • 1,289 citations

The catalase—peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis

1992 • 1,287 citations

Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.

1966 • 1,274 citations

Plagues and Peoples

1976 • 1,225 citations

A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

1996 • 1,174 citations

Respiratory physiology: The essentials

1975 • 1,156 citations

An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence

1996 • 1,116 citations

Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg

1993 • 1,107 citations

Streptomycin, a Substance Exhibiting Antibiotic Activity Against Gram-Positive and Gram-Negative Bacteria.*

1944 • 1,046 citations

Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages.

1992 • 1,040 citations

Recognition of a lipid antigen by CD1-restricted αβ+ T cells

1994 • 976 citations

Natural and synthetic non-peptide antigens recognized by human γδ T cells

1995 • 974 citations

RESPONSE OF CULTURED MACROPHAGES TO MYCOBACTERIUM TUBERCULOSIS, WITH OBSERVATIONS ON FUSION OF LYSOSOMES WITH PHAGOSOMES

1971 • 973 citations

Tuberculosis: Pathogenesis, Protection and Control

1996 • 962 citations

The Emergence of Drug-Resistant Tuberculosis in New York City

1993 • 952 citations

Deactivation of macrophages by transforming growth factor-β

1988 • 876 citations

Interferon-γ –Receptor Deficiency in an Infant with Fatal Bacille Calmette–Guérin Infection

1996 • 869 citations

Host factors and the pathogenesis of HIV-induced disease

1996 • 857 citations

Tuberculosis in Patients with Human Immunodeficiency Virus Infection

1991 • 849 citations

Transmission of Tuberculosis in New York City -- An Analysis by DNA Fingerprinting and Conventional Epidemiologic Methods

1994 • 825 citations

Global Epidemiology of Tuberculosis

1995 • 782 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.

1992 • 771 citations

CD1-Restricted T Cell Recognition of Microbial Lipoglycan Antigens

1995 • 751 citations

How Many People Can the Earth Support?

1998 • 726 citations

Treatment of 171 Patients with Pulmonary Tuberculosis Resistant to Isoniazid and Rifampin

1993 • 724 citations

Treatment of Multidrug-Resistant Tuberculosis

1993 • 722 citations

Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus

1996 • 714 citations

The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major

1994 • 687 citations

Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited.

1995 • 680 citations

THE PATHOGENESIS OF TUBERCULOSIS

1952 • 672 citations

Resurgent Tuberculosis in New York City: Human Immunodeficiency Virus, Homelessness, and the Decline of Tuberculosis Control Programs

1991 • 670 citations

Tuberculosis in New York City — Turning the Tide

1995 • 659 citations

THE PROGNOSIS OF A POSITIVE TUBERCULIN REACTION IN CHILDHOOD AND ADOLESCENCE

1974 • 653 citations

Immunogenicity and protective efficacy of a tuberculosis DNA vaccine

1996 • 629 citations

Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors.

1993 • 603 citations

Tuberculosis in developing countries: burden, intervention and cost.

1990 • 600 citations

The Effect of Directly Observed Therapy on the Rates of Drug Resistance and Relapse in Tuberculosis

1994 • 597 citations

The Making of the Atomic Bomb

1986 • 583 citations

CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigen

1992 • 577 citations

Accelerated course of human immunodeficiency virus infection after tuberculosis.

1995 • 546 citations

Phagocytosis of Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3.

1990 • 544 citations

Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. Reversal of the usual nonfusion pattern and observations on bacterial survival.

1975 • 528 citations

Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes.

1986 • 527 citations

Differential Effects of Cytolytic T Cell Subsets on Intracellular Infection

1997 • 526 citations

Vaccination against tuberculosis by DNA injection

1996 • 513 citations

Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin.

1994 • 512 citations

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

1990 • 507 citations

BCG and vole bacillus vaccines in the prevention of tuberculosis in adolescence and early adult life.

1977 • 505 citations

Effect of Mycobacterium tuberculosis on HIV replication. Role of immune activation.

1996 • 504 citations

Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis.

1996 • 502 citations

Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations

1994 • 479 citations

The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol

1997 • 457 citations

The intrinsic transmission dynamics of tuberculosis epidemics

1995 • 457 citations

Effect of isoniazid prophylaxis on incidence of active tuberculosis and progression of HIV infection

1993 • 443 citations

Tuberculosis in twins: a re-analysis of the Prophit survey.

1978 • 441 citations

Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis.

1995 • 438 citations

[Epidemiology of tuberculosis].

1971 • 433 citations

Identification of Mycobacterium tuberculosis DNA in a pre-Columbian Peruvian mummy.

1994 • 431 citations

Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins

1994 • 431 citations

Compensatory ahp C Gene Expression in Isoniazid-Resistant Mycobacterium tuberculosis

1996 • 422 citations

Crystal Structure and Function of the Isoniazid Target of Mycobacterium tuberculosis

1995 • 419 citations

Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis

1995 • 411 citations

Disease Extinction and Community Size: Modeling the Persistence of Measles

1997 • 411 citations

Tuberculosis: Pathogenesis, protection, and control

1995 • 409 citations

Racial Differences in Susceptibility to Infection byMycobacterium tuberculosis

1990 • 407 citations

The Cellular Transfer of Cutaneous Hypersensitivity to Tuberculin

1945 • 402 citations

"SPECIAL" CALLS IN GENERAL PRACTICE.

1963 • 394 citations

The White Plague: Tuberculosis, Man and Society

1954 • 388 citations

Cytokine production at the site of disease in human tuberculosis

1993 • 379 citations

Pathogenesis of tuberculosis: interaction of Mycobacterium tuberculosis with macrophages

1993 • 373 citations

Tuberculosis and HIV infection in sub-Saharan Africa

1992 • 358 citations

Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages.

1994 • 358 citations

Epidemiology of Tuberculosis in the United States, 1985 Through 1992

1994 • 357 citations

Molecular basis of streptomycin resistance in Mycobacterium tuberculosis: alterations of the ribosomal protein S12 gene and point mutations within a functional 16S ribosomal RNA pseudoknot

1993 • 354 citations

Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha.

1995 • 348 citations

Interferon-gamma-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates

1991 • 340 citations

How many people can the earth support?

1996 • 333 citations

Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase.

1996 • 329 citations

IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection.

1995 • 325 citations

Lysogeny and transformation in mycobacteria: stable expression of foreign genes.

1988 • 321 citations

Characterization of the Catalase-Peroxidase Gene (katG) and inhA Locus in Isoniazid-Resistant and -Susceptible Strains of Mycobacterium tuberculosis by Automated DNA Sequencing: Restricted Array of Mutations Associated with Drug Resistance

1996 • 319 citations

Measles endemicity in insular populations: Critical community size and its evolutionary implication

1966 • 319 citations

Local production of tumor necrosis factor and IFN-gamma in tuberculous pleuritis.

1990 • 318 citations

Stationary phase-associated protein expression in Mycobacterium tuberculosis: function of the mycobacterial alpha-crystallin homolog

1996 • 316 citations

Characterization by automated DNA sequencing of mutations in the gene (rpoB) encoding the RNA polymerase beta subunit in rifampin-resistant Mycobacterium tuberculosis strains from New York City and Texas

1994 • 315 citations

Humoral and cell-mediated immune responses to live recombinant BCG–HIV vaccines

1991 • 315 citations

THE FATE OF MYCOBACTERIUM TUBERCULOSIS IN MOUSE TISSUES AS DETERMINED BY THE MICROBIAL ENUMERATION TECHNIQUE

1956 • 312 citations

Mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis.

1987 • 310 citations

Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens.

1994 • 309 citations

Nationwide Survey of Drug-Resistant Tuberculosis in the United States

1994 • 308 citations

The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection.

1995 • 308 citations

Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis

1994 • 303 citations

Prevention of phagosome-lysosome fusion in cultured macrophages by sulfatides of Mycobacterium tuberculosis.

1976 • 301 citations

The BCG Story: Lessons from the Past and Implications for the Future

1989 • 295 citations

RESPIRATORY PHYSIOLOGY-THE ESSENTIALS,

1995 • 292 citations

COLD PLATELET AGGLUTININS

1975 • 291 citations

T-cell cytokine responses in human infection with Mycobacterium tuberculosis

1995 • 291 citations

Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates

1991 • 281 citations

Characterization of rifampin-resistance in pathogenic mycobacteria

1994 • 278 citations

HIV-associated tuberculosis in developing countries: clinical features, diagnosis, and treatment.

1992 • 272 citations

Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: a molecular study

1994 • 269 citations

Protective immunity elicited by recombinant bacille Calmette-Guerin (BCG) expressing outer surface protein A (OspA) lipoprotein: a candidate Lyme disease vaccine.

1993 • 269 citations

The Private Science of Louis Pasteur

1996 • 269 citations

AERIAL DISSEMINATION OP PULMONARY TUBERCULOSIS: A TWO-YEAR STUDY OF CONTAGION IN A TUBERCULOSIS WARD1

1995 • 267 citations

BIOCHEMICAL DIFFERENTIATION OF MYCOBACTERIUM TUBERCULOSIS GROWN IN VIVO AND IN VITRO

1956 • 266 citations

Secular trends of tuberculosis in western Europe.

1993 • 265 citations

Enhanced production of TGF-beta by blood monocytes from patients with active tuberculosis and presence of TGF-beta in tuberculous granulomatous lung lesions.

1995 • 265 citations

The mycobacteria: a sourcebook

1985 • 262 citations

Blood-volume and tolerance to pentolinium in the treatment of hypertension.

1960 • 260 citations

Activation of macrophages to inhibit proliferation of Mycobacterium tuberculosis: comparison of the effects of recombinant gamma-interferon on human monocytes and murine peritoneal macrophages.

1986 • 257 citations

The Biology of the Mycobacteria

1982 • 251 citations

Streptomycin Resistance in Pulmonary Tuberculosis

1948 • 250 citations

Resistance to Tuberculosis

1964 • 249 citations

Die Aetiologie der Tuberkulose

1932 • 243 citations

Immunization with extracellular proteins of Mycobacterium tuberculosis induces cell-mediated immune responses and substantial protective immunity in a guinea pig model of pulmonary tuberculosis

1992 • 241 citations

Inhibition by 1,25(OH)2-vitamin D3 of the multiplication of virulent tubercle bacilli in cultured human macrophages

1987 • 239 citations

The BCG Experience: Implications for Future Vaccines against Tuberculosis

2014 • 227 citations

Directly Observed Treatment of Tuberculosis -- We Can't Afford Not to Try It

1993 • 226 citations

History of Tuberculosis

1998 • 224 citations

Infectious Diseases in Primitive Societies

1975 • 224 citations

Streptomycin resistance in mycobacteria

1994 • 222 citations

Effective immunization against cutaneous leishmaniasis with recombinant bacille Calmette-Guérin expressing the Leishmania surface proteinase gp63.

1993 • 218 citations

Interleukin 12 at the site of disease in tuberculosis.

1994 • 218 citations

Present aspects of bacterial resistance in tuberculosis.

1965 • 214 citations

Eleven Years of Community-Based Directly Observed Therapy for Tuberculosis

1995 • 213 citations

Cross-modulation by transforming growth factor beta in human tuberculosis: suppression of antigen-driven blastogenesis and interferon gamma production.

1996 • 212 citations

In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis

1995 • 211 citations

Tuberculosis and HIV Infection in Sub-Saharan Africa

1992 • 211 citations

Structure, function and biogenesis of the cell envelope of mycobacteria in relation to bacterial physiology, pathogenesis and drug resistance; some thoughts and possibilities arising from recent structural information

1991 • 207 citations

Twin Studies on the Significance of Genetic Factors in Tuberculosis1,2

1943 • 202 citations

Pathogenesis of Pulmonary Tuberculosis: an Interplay of Tissue-Damaging and Macrophage-Activating Immune Responses-Dual Mechanisms That Control Bacillary Multiplication

2014 • 201 citations

A stationary-phase stress-response sigma factor from Mycobacterium tuberculosis.

1996 • 197 citations

THE AGE SELECTION OF MORTALITY FROM TUBERCULOSIS IN SUCCESSIVE DECADES1

1995 • 196 citations

Cost effectiveness of chemotherapy for pulmonary tuberculosis in three sub-Saharan African countries

1991 • 195 citations

Sequestration From Immune CD4 ⁺ T Cells of Mycobacteria Growing in Human Macrophages

1993 • 194 citations

Manipulation and potentiation of antimycobacterial immunity using recombinant bacille Calmette-Guérin strains that secrete cytokines.

1996 • 189 citations

Assessment of BCG vaccination in India. Third Report. 1960.

2013 • 188 citations

Lipoarabinomannan from Mycobacterium tuberculosis induces the production of tumour necrosis factor from human and murine macrophages.

1989 • 185 citations

CD4+ alpha beta T cell and gamma delta T cell responses to Mycobacterium tuberculosis. Similarities and differences in Ag recognition, cytotoxic effector function, and cytokine production.

1995 • 184 citations

Delayed-type hypersensitivity, mycobacterial vaccines and protective immunity

1994 • 184 citations

Success rates for new drugs entering clinical testing in the United States

1995 • 183 citations

EVIDENCE FOR PERSISTENCE OF INFECTIOUS AGENTS IN ISOLATED HUMAN POPULATIONS1

1974 • 182 citations

Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative‐stress regulatory gene:implications for sensitivity to isoniazid

1995 • 181 citations

Absence of a prominent Th2 cytokine response in human tuberculosis

1996 • 181 citations

Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls

1994 • 180 citations

Cytotoxicity for lung epithelial cells is a virulence-associated phenotype of Mycobacterium tuberculosis

1995 • 178 citations

Pathogenesis of tuberculosis: pathway to apical localization

1994 • 178 citations

The protective immune response to Mycobacterium tuberculosis

1995 • 178 citations

Regional Differences in the Lung

1978 • 177 citations

Selective induction of transforming growth factor beta in human monocytes by lipoarabinomannan of Mycobacterium tuberculosis

1996 • 176 citations

History of Syphilis

1992 • 175 citations

Enhancement Of Intracellular Growth Of Mycobacterium Tuberculosis In Human Monocytes by Transforming Growth Factor- l

1994 • 172 citations

Systemic and mucosal immunity induced by BCG vector expressing outer-surface protein A of Borrelia burgdorferi

1994 • 171 citations

Genetic susceptibility to leishmanial infections: studies in mice and man

1996 • 170 citations

Living in the Shadow of Death: Tuberculosis and the Social Experience of Illness in American History.

1995 • 170 citations

Characteristics of protective immunity engendered by vaccination of mice with purified culture filtrate protein antigens of Mycobacterium tuberculosis.

1995 • 169 citations

Auxotrophic vaccines for tuberculosis

1996 • 168 citations

The private science of Louis Pasteur

1995 • 167 citations

Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis

1995 • 166 citations

THE WHITE PLAGUE, TUBERCULOSIS, MAN AND SOCIETY

1953 • 162 citations

Increase of tuberculous infection in the organs of B cell-deficient mice

1996 • 162 citations

Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis

1996 • 159 citations

The history of tuberculosis as a global epidemic

1993 • 159 citations

MICROBIAL PERSISTENCE

1966 • 159 citations

Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection.

1996 • 156 citations

HUMAN GENETICS

1984 • 155 citations

Allelic exchange in Mycobacterium tuberculosis with long linear recombination substrates

1996 • 152 citations

ahpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex

1996 • 148 citations

The forgotten plague: how the battle against tuberculosis was won--and lost

1993 • 145 citations

Killing ofMycobacterium tuberculosiswithin human monocytes: activation by cytokines and calcitriol

1991 • 144 citations

Recurrent Japanese encephalitis epidemics in West Bengal.

1980 • 142 citations

Peripheral V gamma 9/V delta 2 T cell deletion and anergy to nonpeptidic mycobacterial antigens in asymptomatic HIV-1-infected persons.

1996 • 141 citations

Genetics and Resistance to Tuberculosis

1992 • 139 citations

Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice

1997 • 138 citations

Patient Compliance: The Most Serious Remaining Problem in the Control of Tuberculosis in the United States

1979 • 136 citations

The sterilizing value of rifampicin and pyrazinamide in experimental short course chemotherapy

1978 • 136 citations

Characterization of the Mycobacterium tuberculosis phagosome

1996 • 135 citations

Synchronized replication of Mycobacterium tuberculosis

1977 • 134 citations

Human Mycobacterium tuberculosis-reactive CD4+ T-cell clones: heterogeneity in antigen recognition, cytokine production, and cytotoxicity for mononuclear phagocytes

1991 • 134 citations

Immune Mechanisms of Protection

2014 • 133 citations

Short-course chemotherapy for pulmonary tuberculosis.

1975 • 132 citations

Killing of Mycobacterium tuberculosis by Neutrophils: A Nonoxidative Process

1990 • 129 citations

The Influence of Adverse Conditions upon the Respiratory Metabolism and Growth of Human Tubercle Bacilli

1933 • 127 citations

Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages

1996 • 126 citations

Aerial dissemination of pulmonary tuberculosis.

1957 • 124 citations

BCG vaccination against tuberculosis in Chicago. A twenty-year study statistically analyzed.

1961 • 123 citations

Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex.

1995 • 122 citations

The Mycobacteria : a sourcebook

1984 • 120 citations

Stimulation of human peripheral blood mononuclear cells with live Mycobacterium bovis BCG activates cytolytic CD8⁺ T cells in vitro

1996 • 120 citations

BCG vaccination of Indian infants in Saskatchewan

1949 • 120 citations

Does the Risk of Tuberculosis Increase in Old Age?

1983 • 118 citations

Defective antigen presentation by Mycobacterium tuberculosis-infected monocytes

1994 • 117 citations

AERIAL DISSEMINATION OF PULMONARY TUBERCULOSIS A TWO-YEAR STUDY OF CONTAGION IN A TUBERCULOSIS WARD1

1959 • 116 citations

Regional differences in the lung.

1978 • 114 citations

Relationship Between Bacille Calmette-Guerin (BCG) Strains and the Efficacy of BCG Vaccine in the Prevention of Tuberculosis

1995 • 113 citations

Geographic Latitude and the Efficacy of Bacillus Calmette-Guerin Vaccine

1995 • 112 citations

Disruption of phagosomal membranes of normal alveolar macrophages by the H37Rv strain of Mycobacterium tuberculosis. A correlate of virulence.

1984 • 111 citations

Targeted replacement of the mycocerosic acid synthase gene in Mycobacterium bovis BCG produces a mutant that lacks mycosides.

1996 • 110 citations

Protective immune responses induced by secretion of a chimeric soluble protein from a recombinant Mycobacterium bovis bacillus Calmette-Guérin vector candidate vaccine for human immunodeficiency virus type 1 in small animals.

1995 • 108 citations

Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity

1996 • 107 citations

Evidence for a Th1-like bronchoalveolar T-cell subset and predominance of interferon-gamma gene activation in pulmonary tuberculosis.

1994 • 106 citations

A Twenty-Year Appraisal of BCG Vaccination in the Control of Tuberculosis

1958 • 105 citations

Studies on isoniazid and tubercle bacilli. II. The growth requirements, catalase activities, and pathogenic properties of isoniazid-resistant mutants.

1954 • 104 citations

Analysis of the host-parasite equilibrium in chronic murine tuberculosis by total and viable bacillary counts.

1961 • 102 citations

The immunity conferred by effective BCG and vole bacillus vaccines, in relation to individual variations in induced tuberculin sensitivity and to technical variations in the vaccines

1967 • 101 citations

The protective effect of BCG vaccination as indicated by autopsy studies

1979 • 100 citations

Metabolism ofMycobacterium tuberculosis

2014 • 100 citations

Evidence inconsistent with a role for the Bcg gene (Nramp1) in resistance of mice to infection with virulent Mycobacterium tuberculosis.

1996 • 99 citations

HUMAN IMMUNODEFICIENCY VIRUS INFECTION AND ROUTINE CHILDHOOD IMMUNISATION

1987 • 98 citations

[Epidemiology of tuberculosis].

1990 • 98 citations

The urease locus of Mycobacterium tuberculosis and its utilization for the demonstration of allelic exchange in Mycobacterium bovis bacillus Calmette-Guérin.

1995 • 95 citations

Lipids and Carbohydrates ofMycobacterium tuberculosis

2014 • 95 citations

Drug sensitivity and environmental adaptation of myocobacterial cell wall components

1996 • 94 citations

Apical Localization of Pulmonary Tuberculosis, Chronic Pulmonary Histoplasmosis, and Progressive Massive Fibrosis of the Lung

1983 • 91 citations

INFECTION OF MICE WITH MAMMALIAN TUBERCLE BACILLI GROWN IN TWEEN-ALBUMIN LIQUID MEDIUM

1947 • 89 citations

Evaluation of BCG vaccination among Puerto Rican children.

1974 • 88 citations

Tuberculosis disseminators. A study of the variability of aerial infectivity of tuberculous patients.

1960 • 88 citations

Expression of contact-dependent cytolytic activity by Mycobacterium tuberculosis and isolation of the genomic locus that encodes the activity

1993 • 87 citations

Specific lysis of mycobacterial antigen-bearing macrophages by class II MHC-restricted polyclonal T cell lines in healthy donors or patients with tuberculosis

1990 • 85 citations

BCG VACCINATION AGAINST TUBERCULOSIS IN CHICAGO

1961 • 84 citations

Relative permissiveness of macrophages from black and white people for virulent tubercle bacilli

1990 • 84 citations

B.C.G. and Vole Bacillus Vaccines in the Prevention of Tuberculosis in Adolescence and Early Adult Life

1963 • 82 citations

Biochemical and molecular analysis of phospholipase C and phospholipase D activity in mycobacteria

1996 • 81 citations

The Conquest of Tuberculosis

1964 • 81 citations

The arcana of tuberculosis; with a brief epidemiologic history of the disease in the U.S.A. III.

1958 • 79 citations

Recurrent cutaneous leishmaniasis: A role for persistent parasites?

1994 • 76 citations

Tuberculosis studies in Muscogee County, Georgia. Twenty-year evaluation of a community trial of BCG vaccination.

1976 • 76 citations

Control of Tuberculosis

1967 • 74 citations

Induction of transforming growth factor beta 1 by purified protein derivative of Mycobacterium tuberculosis

1995 • 74 citations

Increase of gamma/delta T cells in hospital workers who are in close contact with tuberculosis patients

1994 • 72 citations

THE TREATED PULMONARY LESION AND ITS TUBERCLE BACILLUS.*

1956 • 72 citations

Effect of mycobacteria on sensitivity to the cytotoxic effects of tumor necrosis factor

1991 • 71 citations

Functional gamma delta T-lymphocyte defect associated with human immunodeficiency virus infections.

1997 • 71 citations

Efficacy and applicability of mass B. C.G. vaccination in tuberculosis control.

1967 • 69 citations

Recombination in mycobacteria

1996 • 69 citations

When Did Mycobacterium tuberculosis Infection First Occur in The New World?: An Important Question with Public Health Implications

1995 • 68 citations

The great human diasporas

1995 • 68 citations

Factors in the Resistance of Guinea Pigs to Tuberculosis, with Especial Regard to Inbreeding and Heredity

1921 • 66 citations

Mechanisms of Pathogenesis in Tuberculosis

2014 • 66 citations

Functional γδ T-lymphocyte Defect Associated with Human Immunodeficiency Virus Infections

1997 • 64 citations

T-Cell Responses and Cytokines

2014 • 63 citations

Risk Factors for Transmission of Mycobacterium tuberculosis in a Primary School Outbreak: Lack of Racial Difference in Susceptibility to Infection

1994 • 62 citations

INFECTIOUSNESS OF AIR FROM A TUBERCULOSIS WARD

1962 • 61 citations

Isoniazid-Resistance and Catalase Activity of Tubercle Bacilli1

2019 • 61 citations

Die Aetiologie der Tuberkulose

1882 • 61 citations

Resistance to Tuberculosis: Experimental Studies in Native and Acquired Defensive Mechanisms

1965 • 61 citations

OBSERVATIONS ON THE PROTECTIVE EFFECT OF BCG VACCINATION IN A SOUTH INDIAN RURAL POPULATION.

1964 • 61 citations

Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control

1993 • 61 citations

SHORT-COURSE CHEMOTHERAPY IN PULMONARY TUBERCULOSIS

1976 • 61 citations

Pathogenesis of Tuberculosis in Human Immunodeficiency Virus-Infected People

2014 • 59 citations

Clinical tuberculosis

2012 • 59 citations

Famine Disease in German Concentration Camps. Complications and Sequels

1953 • 57 citations

THE PATHOGENESIS OF PULMONARY TUBERCULOSIS AMONG OLDER PERSONS.

1965 • 56 citations

The effect of Mycobacterium tuberculosis on the susceptibility of human cells to the stimulatory and toxic effects of tumour necrosis factor.

1992 • 55 citations

Cultivation of Mycobacterium tuberculosis for Research Purposes

2014 • 54 citations

Selective Expression Of Monocyte Chemotactic And Activating Factor/Monocyte Chemoattractant Protein 1 In Human Blood Monocytes By Mycobacterium Tuberculosis

1994 • 53 citations

The heat resistance of tubercle bacilli in the lungs of infected mice.

1961 • 50 citations

Use of Carbon Sources for Lipid Biosynthesis in Mycobacterium leprae: a Comparison with Other Pathogenic Mycobacteria

1988 • 50 citations

B.C.G. and Vole Bacillus Vaccines in the Prevention of Tuberculosis in Adolescents: First (Progress) Report to the Medical Research Council

1956 • 50 citations

THE CHEMOTHERAPY OF TUBERCULOSIS

1960 • 49 citations

The residual infectivity of the primary complex of tuberculosis.

1938 • 49 citations

Cost savings from alternative treatments for tuberculosis

1986 • 49 citations

The bactericidal activities of antituberculous drugs.

1956 • 48 citations

The age selection of mortality from tuberculosis in successive decades

1939 • 48 citations

Reduced Intracellular Growth of Mycobacteria in Human Macrophages Cultivated at Physiologic Oxygen Pressure

1992 • 47 citations

Evidence forIn VivoGeneration of Cytotoxic T Cells: PPD-stimulated Lymphocytes from Tuberculous Pleural Effusions Demonstrate Enhanced Cytotoxicity with Accelerated Kinetics of Induction

1992 • 47 citations

Prevention of tuberculous cavity formation by desensitization with tuberculin-active peptide.

1974 • 44 citations

The Erasmus Wilson Lectures ON ADENOMA AND ADENO-CARCINOMA OF THE RECTUM: Delivered before the Royal College of Surgeons of England

1903 • 44 citations

Mycobacteria‐reactive γδ T cells in HIV‐infected individuals: lack of Vγ9 cell responsiveness is due to deficiency of antigen‐specific CD4 T helper type 1 cells

1996 • 43 citations

Groups at risk : WHO report on the tuberculosis epidemic, 1996

1996 • 43 citations

Hypogammaglobulinaemia and Tuberculosis

1958 • 42 citations

Ultrastructure ofMycobacterium tuberculosis

2014 • 41 citations

Ethambutol-isoniazid versus PAS-isoniazid in original treatment of pulmonary tuberculosis.

1967 • 40 citations

Recurrent tuberculosis: why do patients develop disease again? A United States Public Health Service cooperative survey.

1988 • 40 citations

Cytokine gene expression by cultures of human lymphocytes with autologous Mycobacterium tuberculosis-infected monocytes

1994 • 40 citations

The Pathogenesis of Tuberculosis

1945 • 38 citations

Mycobacteriophages: Cornerstones of Mycobacterial Research

2014 • 38 citations

Efficient homologous recombination in fast-growing and slow-growing mycobacteria

1996 • 37 citations

Social networks of disease spread in the lower illinois valley: A simulation approach

1988 • 36 citations

Tuberculosis in Twins.

1963 • 36 citations

A species-specific nucleotide sequence of Mycobacterium tuberculosis encodes a protein that exhibits hemolytic activity when expressed in Escherichia coli

1995 • 34 citations

The Viability and Virulence of Old Cultures of Tubercle Bacilli. Studies on Twelve-Year Broth Cultures Maintained at Incubator Temperature.

1933 • 34 citations

The first clinical trial of streptomycin in human tuberculosis.

1955 • 33 citations

Some observations on the utility of simian pulmonary tuberculosis in defining the therapeutic potentialities of isoniazid.

1956 • 33 citations

In search of tuberculosis virulence genes

1996 • 32 citations

Studies on isoniazid and tubercle bacilli. I. The isolation of isoniazid-resistant mutants in vitro.

1954 • 31 citations

Relationship of the human immunodeficiency virus epidemic to pediatric tuberculosis and Bacillus Calmette-Guérin immunization

1992 • 31 citations

THE PERSISTENCE OF TUBERCULOUS INFECTIONS

1934 • 31 citations

The Relation of Oxygen Tension to Virulence of Tubercle Bacilli and to Acquired Resistance in Tuberculosis

1957 • 30 citations

THE CLINICOPATHOLOGIC SIGNIFICANCE OF THE DEMONSTRATION OF VIABLE TUBERCLE BACILLI IN RESECTED LESIONS

1955 • 30 citations

The Economic Impact of Tuberculosis in Hospitals in New York City: A Preliminary Analysis

1993 • 29 citations

The biology of the mycobacteria. Volume 1. Physiology, identification and classification.

1982 • 29 citations

Research issues involving HIV-associated tuberculosis in resource-poor countries

1996 • 29 citations

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Apical Localization of Pulmonary Tuberculosis

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Lecture ON KOCH'S TREATMENT OF TUBERCULOSIS.

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"PROFESSOR KOCH'S REMEDY FOR TUBERCULOSIS."

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Anatomical Characteristics of Tuberculosis in Jamaica.

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The Resistance of Tubercle Bacilli to Chemotherapeutic Agents1

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Anatomical Characteristics of Tuberculosis in Jamaica

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1937 • 1 citations

Deleted Work

1955 • 0 citations