Vaccination against tuberculosis by DNA injection

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

1993 • 2,410 citations

Long-term persistence of plasmid DNA and foreign gone expression in mouse muscle

1992 • 743 citations

Systemic Gene Expression After Intravenous DNA Delivery into Adult Mice

1993 • 725 citations

Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis

1993 • 528 citations

Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin.

1994 • 512 citations

Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein.

1990 • 454 citations

Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein.

1994 • 453 citations

Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins

1994 • 431 citations

Vaccination with a Plasmid Vector Carrying the Rabies Virus Glycoprotein Gene Induces Protective Immunity against Rabies Virus

1994 • 393 citations

Cell Biology of Antigen Processing and Presentation to Major Histocompatibility Complex Class I Molecule-Restricted T Lymphocytes

1992 • 373 citations

Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA

1993 • 344 citations

Preclinical efficacy of a prototype DNA vaccine: Enhanced protection against antigenic drift in influenza virus

1995 • 325 citations

T Cells Against a Bacterial Heat Shock Protein Recognize Stressed Macrophages

1989 • 310 citations

Efficient mapping of protein antigenic determinants.

1986 • 292 citations

Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells

1987 • 287 citations

Direct Gene Transfer into Nonhuman Primate Myofibers In Vivo

1992 • 284 citations

A mycobacterial 65-kD heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic.

1990 • 188 citations

Mycobacteria‐reactive Lyt‐2⁺ T cell lines

1988 • 175 citations

MOLECULAR BIOLOGY OF THE MYCOBACTERIA

1989 • 145 citations

Genetic vaccination against leishmaniasis

1994 • 116 citations

A single mycobacterial protein (hsp 65) expressed by a transgenic antigen-presenting cell vaccinates mice against tuberculosis.

1994 • 105 citations

DNA vaccines: A novel approach to immunization

1995 • 92 citations

A ubiquitous mammalian expression vector, pHMG, based on a housekeeping gene promoter

1989 • 81 citations

Exact definition of species-specific and cross-reactive epitopes of the 65-kilodalton protein of Mycobacterium leprae using synthetic peptides.

1988 • 66 citations

Gene Transfer into Mammalian Somatic Cells in Vivo

1992 • 62 citations

Role of extracellular adenosine triphosphate in the cytotoxic T- lymphocyte-mediated lysis of antigen presenting cells

1995 • 58 citations

Characterization of T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing mycobacterial hsp65

1996 • 56 citations

Safety considerations for nucleic acid vaccines

1994 • 54 citations

A major immunogenic 36,000-molecular-weight antigen from Mycobacterium leprae contains an immunoreactive region of proline-rich repeats

1990 • 54 citations

Role of cytotoxic cells in the protective immunity against and immunopathology of intracellular infections

1995 • 41 citations

The role of CD8+ T cells in immunity to tuberculosis infection

1993 • 38 citations

Role of Th-1 lymphocytes in the development of protective immunity against Mycobacterium leprae. Analysis of lymphocyte function by polymerase chain reaction detection of cytokine messenger RNA.

1992 • 32 citations

Variation in selectivity of tumor cell cytolysis by murine macrophages, macrophage-like cell lines and NK cells

1982 • 31 citations

PEPMOTIF: a program for locating class I major histocompatibility complex restricted peptides in protein sequences

1995 • 2 citations