Genetic susceptibility to leishmanial infections: studies in mice and man

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg

1993 • 1,107 citations

Jaks and Stats in signaling by the cytokine receptor superfamily

1995 • 902 citations

Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus.

1990 • 643 citations

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

1995 • 603 citations

Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF‐a and TNF‐0 by human mononuclear cells: a possible link to insulin‐dependent diabetes mellitus

1993 • 562 citations

Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis.

1995 • 459 citations

Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha.

1990 • 453 citations

Genetic regulation of resistance to intracellular pathogens

1982 • 382 citations

Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function

1991 • 286 citations

The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen.

1995 • 270 citations

Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness.

1996 • 263 citations

Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression.

1994 • 247 citations

Regulation of Leishmania populations within the host. II. genetic control of acute susceptibility of mice to Leishmania donovani infection.

1977 • 225 citations

Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse.

1979 • 222 citations

Resistance to Leishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages

1991 • 201 citations

Determination of the cytokine profile in American cutaneous leishmaniasis using the polymerase chain reaction

1993 • 197 citations

Influence of H–2 complex on acquired resistance to Leishmania donovani infection in mice

1980 • 179 citations

Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene.

1995 • 174 citations

Genetic control of natural resistance to Leishmania donovani

1974 • 160 citations

Natural resistance to Salmonella infection, delayed hypersensitivity and Ir genes in different strains of mice

1974 • 158 citations

A Tumour Necrosis Factor Beta Gene Polymorphism in Relation to Monokine Secretion and Insulin‐Dependent Diabetes Mellitus

1991 • 156 citations

Polymorphic MHC ancestral haplotypes affect the activity of tumour necrosis factor-alpha

1993 • 151 citations

Genomic Organization and Sequence of the Human NRAMP Gene: Identification and Mapping of a Promoter Region Polymorphism

1995 • 149 citations

Association between HLA‐DR2 and Production of Tumour Necrosis Factor α and Interleukin 1 by Mononuclear Cells Activated by Lipopolysaccharide

1988 • 144 citations

malvolio, the Drosophila homologue of mouse NRAMP-1 (Bcg), is expressed in macrophages and in the nervous system and is required for normal taste behaviour.

1995 • 140 citations

Role of inorganic nitrogen oxides and tumor necrosis factor alpha in killing Leishmania donovani amastigotes in gamma interferon-lipopolysaccharide-activated macrophages from Lshs and Lshr congenic mouse strains

1991 • 139 citations

Nramp Transfection Transfers Ity/Lsh/Bcg-Related Pleiotropic Effects on Macrophage Activation: Influence on Oxidative Burst and Nitric Oxide Pathways

1995 • 133 citations

Tumour necrosis factor (TNF-alpha) in leishmaniasis. II. TNF-alpha-induced macrophage leishmanicidal activity is mediated by nitric oxide from L-arginine.

1990 • 121 citations

Genetics of Resistance to Bacterial and Parasitic Infection

1988 • 121 citations

Tumor Necrosis Factor (Cachectin) in Human Visceral Leishmaniasis

1991 • 113 citations

Genetic regulation of leishmanial and mycobacterial infections: the Lsh / Ity / Bcg gene story continues

1994 • 97 citations

NH2-terminal sequence of macrophage-expressed natural resistance-associated macrophage protein (Nramp) encodes a proline/serine-rich putative Src homology 3-binding domain.

1994 • 93 citations

Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35.

1996 • 90 citations

The macrophage resistance gene Lsh/Ity/Bcg

1989 • 82 citations

Genetics of resistance to bacterial and parasitic infection

1989 • 78 citations

Immunologic responsiveness in American cutaneous leishmaniasis lesions.

1990 • 76 citations

Genetic regulation of macrophage priming/activation: the Lsh gene story

1991 • 74 citations

Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein.

1992 • 73 citations

Immunogenetics of human american Cutaneous Leishmaniasis

1991 • 66 citations

The Bcg Gene Story

1994 • 60 citations

GENETIC ANALYSIS OF LEISHMANIA MEXICANA INFECTION IN MICE: SINGLE GENE (Scl‐2) CONTROLLED PREDISPOSITION TO CUTANEOUS LESION DEVELOPMENT

1990 • 59 citations

MAPPING OF GENES CONTROLLING LEISHMANIA MAJOR INFECTION IN CXS RECOMBINANT INBRED MICE

1993 • 58 citations

Genetic and Physical Mapping of 2q35 in the Region of the NRAMP and IL8R Genes: Identification of a Polymorphic Repeat in Exon 2 of NRAMP

1994 • 57 citations

Serum levels of tumor necrosis factor in patients with American cutaneous leishmaniasis.

1993 • 57 citations

GENETIC CONTROL OF LEISHMANIA MAJOR INFECTION IN CONGENIC, RECOMBINANT INBRED AND F2 POPULATIONS OF MICE

1993 • 51 citations

Immunomodulation of murine visceral leishmaniasis by administration of monoclonal anti‐Ia antibodies: differential effects of anti‐I‐A vs. anti‐I‐E antibodies

1987 • 37 citations

Altered course of visceral leishmaniasis in mice expressing transgenic I‐E molecules

1992 • 35 citations

An H-11-linked gene has a parallel effect on Leishmania major and L. donovani infections in mice

1985 • 29 citations

Molecular mechanisms of natural resistance to mycobacterial infections.

1994 • 26 citations

Influence of macrophage resistance geneLsh/Ity/Bcg(candidateNramp) onToxoplasma gondiiinfection in mice

1994 • 25 citations

THE INDUCIBLE FORM OF NITRIC OXIDE SYNTHASE (NOS2) ISOLATED FROM MURINE MACROPHAGES MAPS NEAR THE NUDE MUTATION ON MOUSE CHROMOSOME 11

1994 • 11 citations