Interferon-gamma-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

1983 • 1,918 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

RESPONSE OF CULTURED MACROPHAGES TO MYCOBACTERIUM TUBERCULOSIS, WITH OBSERVATIONS ON FUSION OF LYSOSOMES WITH PHAGOSOMES

1971 • 973 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.

1990 • 690 citations

Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.

1990 • 573 citations

Phagocytosis of Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3.

1990 • 544 citations

Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. Reversal of the usual nonfusion pattern and observations on bacterial survival.

1975 • 528 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Iron transport in microbes, plants, and animals

1987 • 359 citations

Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.

1988 • 337 citations

Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates.

1989 • 320 citations

Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria

1985 • 315 citations

Mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis.

1987 • 310 citations

Activation of macrophages to inhibit proliferation of Mycobacterium tuberculosis: comparison of the effects of recombinant gamma-interferon on human monocytes and murine peritoneal macrophages.

1986 • 257 citations

The Role of Iron in Bacterial Infections, with Special Consideration of Host-Tubercle Bacillus Interaction

1973 • 233 citations

Killing of Mycobacterium microti by immunologically activated macrophages

1981 • 171 citations

Virulence and Resistance to Superoxide, Low pH and Hydrogen Peroxide among Strains of Mycobacterium tuberculosis

1978 • 165 citations

Attempts to characterize the mechanisms involved in mycobacterial growth inhibition by gamma-interferon-activated bone marrow macrophages

1988 • 110 citations

Superoxide Dismutase from Mycobacterium tuberculosis

1976 • 96 citations

Relative permissiveness of macrophages from black and white people for virulent tubercle bacilli

1990 • 84 citations

Cytokine modulation of mycobacterium tuberculosis growth in human macrophages

1990 • 67 citations

Cytokine regulation of the intracellular growth of Mycobacterium paratuberculosis in bovine monocytes

1988 • 65 citations

Oxidative and non-oxidative intracellular killing of Mycobacterium avium complex

1989 • 51 citations

Progress in the immunology of the mycobacterioses.

1987 • 45 citations

Virulence of Mycobacterium tuberculosis and Susceptibility to Peroxidative Killing Systems

1978 • 40 citations

The role of activated macrophages in protection and immunopathology in tuberculosis

1990 • 36 citations

Intracellular killing of mycobacteria

1990 • 23 citations

Killing intracellular mycobacteria in in vitro macrophage systems: What may be the role of known host microbicidal mechanisms?

1990 • 16 citations

Mycobacterium lepraemurium activates macrophages but fails to trigger release of superoxide anion.

1988 • 14 citations

Antimycobacterial functions in bone-marrow-derived macrophages

1990 • 10 citations

Murine T-cell clones against Entamoeba histolytica: in vivo and in vitro characterization.

1989 • 9 citations

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