Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice

The Fas Death Factor

1995 • 4,070 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.

1992 • 771 citations

Purification and characterization of the Fas-ligand that induces apoptosis.

1994 • 521 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Perforin: structure and function

1995 • 361 citations

The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis.

1987 • 318 citations

The roles of perforin‐ and Fas‐dependent cytotoxicity in protection against cytopathic and noncytopathic viruses

1995 • 286 citations

T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens.

1992 • 256 citations

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

1992 • 243 citations

CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity

1994 • 229 citations

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.

1989 • 186 citations

H2O2 induces monocyte apoptosis and reduces viability of Mycobacterium avium-M. intracellulare within cultured human monocytes

1996 • 82 citations

Recognition and destruction of Bacillus Calmette-Guerin-infected human monocytes.

1993 • 52 citations

Lysis of human macrophages by cytolytic CD4+ T cells fails to affect survival of intracellularMycobacterium bovis-bacille Calmette-Guérin (BCG)

1995 • 22 citations

CD4⁺cytolytic T cells can destroy autologous and MHC-matched macrophages but fail to kill intracellularMycobacterium bovis-BCG

1995 • 8 citations