v-Crk-induced cell transformation: changes in focal adhesion composition and signaling

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Paxillin: a new vinculin-binding protein present in focal adhesions.

1990 • 687 citations

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 • 653 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

α-Actinin: Immunofluorescent localization of a muscle structural protein in nonmuscle cells

1975 • 599 citations

Anchorage and growth regulation in normal and virus‐transformed cells

1968 • 547 citations

pp125^FAK-Dependent Tyrosine Phosphorylation of Paxillin Creates a High-Affinity Binding Site for Crk

1995 • 534 citations

A cytoskeletal structure with associated polyribosomes obtained from HeLa cells

1977 • 530 citations

Focal adhesion kinase and associated proteins

1994 • 525 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

The Molecular Architecture of Focal Adhesions

1995 • 479 citations

Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton.

1989 • 457 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas.

1995 • 423 citations

Cell to substratum contacts of chick fibroblasts and their relation to the microfilament system. a correlated interference-reflexion and high-voltage electron-microscope study

1978 • 409 citations

Cytoskeletal elements of chick embryo fibroblasts revealed by detergent extraction

1976 • 398 citations

c-Abl kinase regulates the protein binding activity of c-Crk.

1994 • 362 citations

Identification of Rap1 as a Target for the Crk SH3 Domain-Binding Guanine Nucleotide-Releasing Factor C3G

1995 • 359 citations

Signalling through SH2 and SH3 domains

1993 • 355 citations

Integrin-mediated Cell Adhesion Promotes Tyrosine Phosphorylation of p130Cas, a Src Homology 3-containing Molecule Having Multiple Src Homology 2-binding Motifs

1995 • 340 citations

SH3 domains direct cellular localization of signaling molecules

1993 • 339 citations

Adhesion plaques of Rous sarcoma virus-transformed cells contain the src gene product.

1980 • 334 citations

Adhesions of fibroblasts to substratum during contact inhibition observed by interference reflection microscopy

1975 • 324 citations

Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites.

1994 • 313 citations

Formation of cell-to-substrate contacts during fibroblast motility: An interference-reflexion study

1980 • 307 citations

Tyrosine Phosphorylation of p130Cas and Cortactin Accompanies Integrin-mediated Cell Adhesion to Extracellular Matrix

1995 • 289 citations

Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases

1995 • 288 citations

SH3 — an abundant protein domain in search of a function

1992 • 280 citations

Matrix/Integrin Interaction Activates the Mitogen-activated Protein Kinase, p44erk-1 and p42erk-2

1995 • 274 citations

Signal transduction through integrins: A central role for focal adhesion kinase?

1995 • 273 citations

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity [published erratum appears in J Cell Biol 1994 Mar;124(5):865]

1994 • 271 citations

Two species of human CRK cDNA encode proteins with distinct biological activities.

1992 • 269 citations

Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.

1993 • 257 citations

Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.

1994 • 253 citations

The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110.

1991 • 224 citations

Adhesion-induced tyrosine phosphorylation of the p130 SRC substrate

1995 • 223 citations

Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk

1994 • 211 citations

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

1990 • 209 citations

Isolation and chromosomal localization of CRKL, a human crk-like gene.

1993 • 203 citations

Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.

1990 • 191 citations

Talin: A cytoskeletal component concentrated in adhesion plaques and other sites of actin‐membrane interaction

1983 • 173 citations

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.

1992 • 168 citations

The product of the cellular crk gene consists primarily of SH2 and SH3 regions.

1992 • 147 citations

Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation

1990 • 128 citations

Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins.

1991 • 127 citations

G1/S control of anchorage-independent growth in the fibroblast cell cycle.

1991 • 120 citations

Tyrosine-phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyze Crk-phosphotyrosine-dependent interactions in vitro.

1992 • 120 citations

The epidermal growth factor receptor is associated with actin filaments

1992 • 101 citations

Cellular proteins binding to the first Src homology 3 (SH3) domain of the proto-oncogene product c-Crk indicate Crk-specific signaling pathways.

1995 • 100 citations

Ligand‐induced association of epidermal growth factor receptor to the cytoskeleton of A431 cells

1989 • 82 citations

Ornithine Decarboxylase- and ras-Induced Cell Transformations: Reversal by Protein Tyrosine Kinase Inhibitors and Role of pp130^CAS

1995 • 81 citations

Epitope Mapping of Monoclonal Antibodies to gag Protein p19 of Avian Sarcoma and Leukaemia Viruses

1987 • 78 citations

Identification and Characterization of a High-Affinity Interaction Between v-Crk and Tyrosine-Phosphorylated Paxillin in CT10-Transformed Fibroblasts

1993 • 71 citations

A cell cycle and mutational analysis of anchorage-independent growth: cell adhesion and TGF-beta 1 control G1/S transit specifically

1993 • 70 citations

Mitotic architecture of the cell: the filament networks of the nucleus and cytoplasm.

1983 • 60 citations

Detection of the v-abl gene product at cell-substratum contact sites in Abelson murine leukemia virus-transformed fibroblasts

1984 • 57 citations

Characterization, partial purification, and peptide sequencing of p130,the main phosphoprotein associated with v-Crk oncoprotein

1994 • 49 citations

Relationship between the organization of actin bundles and vinculin plaques

1986 • 8 citations