E‐cadherin as a tumor (invasion) suppressor gene

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

Cell binding function of E-cadherin is regulated by the cytoplasmic domain.

1988 • 811 citations

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.

1994 • 772 citations

Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.

1990 • 753 citations

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.

1994 • 647 citations

Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.

1994 • 633 citations

A Homolog of the armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin

1991 • 632 citations

Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer.

1992 • 612 citations

Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization

1992 • 562 citations

E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis.

1991 • 536 citations

The 102 kd cadherin-associated protein: Similarity to vinculin and posttranscriptional regulation of expression

1991 • 501 citations

Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas.

1993 • 457 citations

E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration.

1993 • 434 citations

Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells.

1985 • 429 citations

Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma.

1993 • 398 citations

Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain

1992 • 394 citations

The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties.

1992 • 385 citations

The uvomorulin-anchorage protein alpha catenin is a vinculin homologue.

1991 • 364 citations

Desmosomes and hemidesmosomes

1993 • 310 citations

E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study.

1993 • 297 citations

E-cadherin gene mutations in human gastric carcinomacell lines.

1994 • 288 citations

Single amino acid substitutions in one Ca2+ binding site of uvomorulin abolish the adhesive function

1990 • 286 citations

Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin.

1992 • 280 citations

Mutations of the E–cadherin gene in human gynecologic cancers

1994 • 280 citations

Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein.

1989 • 223 citations

Tumor dedifferentiation: An important step in tumor invasion

1985 • 181 citations

Submembranous junctional plaque proteins include potential tumor suppressor molecules.

1993 • 179 citations

Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas.

1994 • 140 citations

E-cadherin expression in basal cell carcinoma

1994 • 66 citations