Identification of a New Biological Function for the Integrin α_vβ₃: Initiation of Fibronectin Matrix Assembly

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

FIBRONECTIN AND ITS RECEPTORS

1988 • 1,336 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function

1995 • 900 citations

Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

1990 • 746 citations

Embryonic mesodermal defects in α5 integrin-deficient mice

1993 • 694 citations

Integrin cytoplasmic domains mediate inside-out signal transduction

1994 • 682 citations

Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization.

1989 • 627 citations

The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression.

1995 • 627 citations

The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function.

1994 • 617 citations

Breaking the Integrin Hinge

1996 • 567 citations

Fibronectins

1990 • 523 citations

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.

1994 • 447 citations

A β ₃ Integrin Mutation Abolishes Ligand Binding and Alters Divalent Cation-Dependent Conformation

1990 • 418 citations

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

1991 • 367 citations

Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix

1995 • 349 citations

Interaction of the 70,000-mol-wt amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblasts.

1985 • 335 citations

Beta 1 integrin-dependent and -independent polymerization of fibronectin.

1996 • 292 citations

Binding of plasma fibronectin to cell layers of human skin fibroblasts.

1983 • 289 citations

Fibronectin's cell-adhesive domain and an amino-terminal matrix assembly domain participate in its assembly into fibroblast pericellular matrix.

1987 • 255 citations

Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin.

1993 • 240 citations

Inhibition of binding of fibronectin to matrix assembly sites by anti-integrin (alpha 5 beta 1) antibodies.

1990 • 231 citations

Selective Inhibition of Fibronectin-Mediated Cell Adhesion by Monoclonal Antibodies to a Cell-Surface Glycoprotein

1985 • 217 citations

Identification of the fibronectin sequences required for assembly of a fibrillar matrix.

1991 • 213 citations

Fibronectin's III-1 module contains a conformation-dependent binding site for the amino-terminal region of fibronectin.

1994 • 204 citations

The Conserved Membrane-proximal Region of an Integrin Cytoplasmic Domain Specifies Ligand Binding Affinity

1995 • 202 citations

Identification of a novel integrin binding site in fibronectin. Differential utilization by beta 3 integrins.

1994 • 198 citations

The alpha 5 beta 1 integrin fibronectin receptor, but not the alpha 5 cytoplasmic domain, functions in an early and essential step in fibronectin matrix assembly.

1993 • 160 citations

Assembly of extracellular matrix

1992 • 159 citations

The fibronectin receptor is organized by extracellular matrix fibronectin: implications for oncogenic transformation and for cell recognition of fibronectin matrices.

1989 • 150 citations

Fibronectin self-association is mediated by complementary sites within the amino-terminal one-third of the molecule.

1994 • 143 citations

Isolation and characterization of Chinese hamster ovary cell variants deficient in the expression of fibronectin receptor.

1989 • 135 citations

A novel role for the integrin-binding III-10 module in fibronectin matrix assembly.

1996 • 133 citations

Five type I modules of fibronectin form a functional unit that binds to fibroblasts and Staphylococcus aureus

1991 • 129 citations

Fibronectin's amino-terminal matrix assembly site is located within the 29-kDa amino-terminal domain containing five type I repeats.

1988 • 108 citations

the role of α4β1 integrin in cell motility and fibronectin matrix assembly

1995 • 83 citations

Integrins and Adhesive Receptors in Normal and Leukemic CD34+ Progenitor Cells: Potential Regulatory Checkpoints for Cellular Traffic

1994 • 68 citations

Dynamic regulation of integrins

1995 • 67 citations

Beta 3 integrin-mediated fibrin clot retraction by nucleated cells: differing behavior of alpha IIb beta 3 and alpha v beta 3

1995 • 65 citations

Beta 3 integrin-mediated fibrin clot retraction by nucleated cells: differing behavior of alpha IIb beta 3 and alpha v beta 3

1995 • 57 citations

Monoclonal antibodies to distinctive epitopes on the α and β subunits of the fibronectin receptor

1988 • 54 citations

Role of disulfide bonds in the attachment and function of large, external, transformation-sensitive glycoprotein at the cell surface

1978 • 52 citations

Distinct regions of human fibronectin are essential for fibril assembly in an in vivo developing system

1992 • 41 citations

Assembly of amino-terminal fibronectin dimers into the extracellular matrix.

1994 • 40 citations

Specific tissue invasion, localisation and matrix modification in hairy-cell leukemia.

1994 • 7 citations

Correction

1992 • 2 citations