Regulation of protein turnover in skeletal and cardiac muscle

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Insulin‐like growth factors I and II

1990 • 1,006 citations

Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle.

1984 • 987 citations

A rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of [3H]phenylalanine

1980 • 983 citations

A Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins

1989 • 932 citations

Insulin-like growth factors and their binding proteins

1990 • 929 citations

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

1988 • 877 citations

Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation

1989 • 749 citations

Stimulation of Muscle Protein Degradation and Prostaglandin E₂Release by Leukocytic Pyrogen (Interleukin-1)

1983 • 689 citations

Tumors secreting human TNF/cachectin induce cachexia in mice

1987 • 634 citations

Atrophy of the soleus muscle by hindlimb unweighting

1990 • 632 citations

Regulation of intracellular pH in eukaryotic cells

1988 • 618 citations

Effects of pH and free Mg2+ on the Keq of the creatine kinase reaction and other phosphate hydrolyses and phosphate transfer reactions.

1979 • 602 citations

Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man.

1987 • 519 citations

Effects of Growth Factors on Intracellular pH Regulation

1986 • 498 citations

Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating.

1985 • 485 citations

Muscle Proteolysis Induced by a Circulating Peptide in Patients with Sepsis or Trauma

1983 • 469 citations

INTRACELLULAR PROTEASES

1987 • 460 citations

Ubiquitin-mediated protein degradation.

1988 • 453 citations

Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle?

1982 • 445 citations

Oxygen radicals stimulate intracellular proteolysis and lipid peroxidation by independent mechanisms in erythrocytes.

1987 • 414 citations

EFFECT OF PARENTERAL GLUTAMINE PEPTIDE SUPPLEMENTS ON MUSCLE GLUTAMINE LOSS AND NITROGEN BALANCE AFTER MAJOR SURGERY

1989 • 395 citations

Ntau-methylhistidine (3-methylhistidine) and muscle protein turnover: an overview.

1978 • 392 citations

Initiation of protein synthesis in mammalian cells

1986 • 359 citations

Effect of insulin and plasma amino acid concentrations on leucine metabolism in man. Role of substrate availability on estimates of whole body protein synthesis.

1987 • 349 citations

Proteins damaged by oxygen radicals are rapidly degraded in extracts of red blood cells.

1987 • 336 citations

Stimulation of muscle growth by clenbuterol: lack of effect on muscle protein biosynthesis

1986 • 317 citations

Hormonal control of muscle growth

1987 • 314 citations

The regulation of the intracellular pH in cells from vertebrates

1988 • 311 citations

Protein Phosphorylation Controls Translation Rates

1989 • 303 citations

Activation of casein kinase II in response to insulin and to epidermal growth factor.

1987 • 299 citations

Alpha 1-adrenergic and muscarinic cholinergic stimulation of phosphoinositide hydrolysis in adult rat cardiomyocytes.

1985 • 298 citations

Multiple actions of β-adrenergic agonists on skeletal muscle and adipose tissue

1989 • 291 citations

Effect of glucocorticoid administration on the rate of muscle protein breakdown in vivo in rats, as measured by urinary excretion of Nτ-methylhistidine

1979 • 290 citations

Reaction rates of creatine kinase and ATP synthesis in the isolated rat heart. A 31P NMR magnetization transfer study.

1985 • 286 citations

A positive relationship between protein synthetic rate and intracellular glutamine concentration in perfused rat skeletal muscle

1987 • 285 citations

Effects of food deprivation on protein synthesis and degradation in rat skeletal muscles

1976 • 284 citations

Arachidonic acid, prostaglandin E2 and F2 alpha influence rates of protein turnover in skeletal and cardiac muscle.

1982 • 283 citations

Chronic effects of β2 agonists on body composition and protein synthesis in the rat

1984 • 280 citations

Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Effect of branched-chain amino acids

1988 • 279 citations

The effect of insulin infusion and food intake on muscle protein synthesis in postabsorptive rats

1983 • 270 citations

Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression.

1986 • 263 citations

MUSCLE PROTEIN TURNOVER AND THE WASTING DUE TO INJURY AND DISEASE

1985 • 258 citations

HORMONAL CONTROL OF METABOLISM IN TRAUMA AND SEPSIS

1986 • 249 citations

Measurement of the rate of protein synthesis and compartmentation of heart phenylalanine

1978 • 246 citations

The multicatalytic proteinase of mammalian cells

1989 • 242 citations

Peptide sequences that target proteins for enhanced degradation during serum withdrawal.

1988 • 238 citations

Time course of soleus muscle myosin expression during hindlimb suspension and recovery

1987 • 236 citations

Expression of cellular oncogenes in the myocardium during the developmental stage and pressure-overloaded hypertrophy of the rat heart.

1988 • 222 citations

Evidence that lysosomes are not involved in the degradation of myofibrillar proteins in rat skeletal muscle

1986 • 221 citations

Effect of Streptozotocin Diabetes and Insulin Treatment on the Rate of Protein Synthesis in Tissues of the Rat in Vivo

1974 • 220 citations

Increase in anterior tibialis muscle protein synthesis in healthy man during mixed amino acid infusion: studies of incorporation of [1−13C]leucine

1989 • 213 citations

Protein metabolism and beta-myosin heavy-chain mRNA in unweighted soleus muscle

1989 • 208 citations

CHARACTERISTICS OF A GLUTAMINE CARRIER IN SKELETAL MUSCLE HAVE IMPORTANT CONSEQUENCES FOR NITROGEN LOSS IN INJURY, INFECTION, AND CHRONIC DISEASE

1986 • 206 citations

Relationship between glutamine concentration and protein synthesis in rat skeletal muscle

1988 • 206 citations

The effects of endotoxaemia on protein metabolism in skeletal muscle and liver of fed and fasted rats

1986 • 203 citations

Time course of the effect of catabolic doses of corticosterone on protein turnover in rat skeletal muscle and liver

1983 • 200 citations

Interleukin 1 and tumor necrosis factor do not regulate protein balance in skeletal muscle

1987 • 200 citations

Endocrine regulation of protein breakdown in skeletal muscle

1988 • 199 citations

Calcium-Dependent Regulation of Protein Synthesis in Intact Mammalian Cells

1990 • 198 citations

Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. Evidence for distinct mechanisms in regulation of net amino acid deposition.

1987 • 197 citations

Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters.

1990 • 197 citations

3-Methylhistidine Excretion and the Urinary 3-Methylhistidine/Creatinine Ratio Are Poor Indicators of Skeletal Muscle Protein Breakdown

1983 • 196 citations

Biochemical Mechanisms of Cardiac Hypertrophy

1987 • 192 citations

Maintenance of normal length improves protein balance and energy status in isolated rat skeletal muscles

1986 • 189 citations

Effect of leucine and metabolites of branched chain amino acids on protein turnover in heart.

1979 • 188 citations

Effect of beta-hydroxybutyrate on whole-body leucine kinetics and fractional mixed skeletal muscle protein synthesis in humans.

1988 • 185 citations

Alpha 1-adrenergic stimulation of cardiac gene transcription in neonatal rat myocardial cells. Effects on myosin light chain-2 gene expression.

1988 • 185 citations

Differential acute and chronic response of protein kinase C in cultured neonatal rat heart myocytes to α1-adrenergic and phorbol ester stimulation

1988 • 185 citations

Stretch activated ion channels in ventricular myocytes

1988 • 184 citations

The stimulation of protein degradation in muscle by Ca2+ is mediated by prostaglandin E2 and does not require the calcium-activated protease.

1982 • 179 citations

Effects of thyroid hormone on cardiac size and myosin content of the heterotopically transplanted rat heart.

1986 • 177 citations

Protein synthesis in muscle measured in vivo in cachectic patients with cancer.

1984 • 174 citations

Effect of insulin on protein turnover in heart muscle.

1975 • 172 citations

Intracellular regulatory system involving calpain and calpastatin.

1989 • 170 citations

Cardiocyte Adaptation to Chronically Altered Load

1987 • 168 citations

Measurements of half-life of rat cardiac myosin heavy chain with leucyl-tRNA used as precursor pool.

1977 • 167 citations

Euglycemic hyperinsulinemia augments amino acid uptake by human leg tissues during hyperaminoacidemia

1990 • 160 citations

Calcium-dependent regulation of protein synthesis and degradation in muscle

1979 • 160 citations

Assessment of protein turnover by use of radioisotopic tracers.

1979 • 156 citations

Load responsiveness of protein synthesis in adult mammalian myocardium: role of cardiac deformation linked to sodium influx.

1989 • 153 citations

Failure of leucine to stimulate protein synthesis in vivo

1982 • 151 citations

Alanine and glutamine synthesis and release from skeletal muscle. IV. beta-Adrenergic inhibition of amino acid release.

1976 • 151 citations

Thyroid hormones control lysosomal enzyme activities in liver and skeletal muscle

1978 • 150 citations

Measurement of the Rate of Protein Synthesis in Muscle of Postabsorptive Young Men by Injection of a ‘Flooding Dose’ of [1-13C]leucine

1989 • 149 citations

Effects of glucocorticoids on muscle protein turnover in perfused rat hemicorpus

1980 • 148 citations

Inhibition of protein breakdown by glutamine in perfused rat skeletal muscle

1988 • 147 citations

Effect of exercise on synthesis and degradation of muscle protein

1980 • 145 citations

Myofibrillar protein turnover and urinary N-τ-methylhistidine output. Response to dietary supply of protein and energy

1975 • 141 citations

Sensitivity of myofibrillar proteins to glucocorticoid-induced muscle proteolysis

1987 • 140 citations

Skeletal muscle growth is stimulated by intermittent stretch-relaxation in tissue culture

1989 • 136 citations

Phorbol esters induce immediate-early genes and activate cardiac gene transcription in neonatal rat myocardial cells

1990 • 134 citations

3-Methylhistidine as a Measure of Skeletal Muscle Protein Breakdown in Human Subjects: The Case for Its Continued Use

1983 • 133 citations

Quantitative importance of non-skeletal-muscle sources of Nτ-methylhistidine in urine

1980 • 133 citations

Effects of branched‐chain amino acids on protein turnover

1989 • 132 citations

The multifactorial role of catecholamines in hypertensive cardiac hypertrophy

1982 • 131 citations

Activation of protein breakdown and prostaglandin E2 production in rat skeletal muscle in fever is signaled by a macrophage product distinct from interleukin 1 or other known monokines.

1988 • 129 citations

Regulation of myosin synthesis by thyroid hormone: relative change in the .alpha.- and .beta.-myosin heavy chain mRNA levels in rabbit heart

1984 • 128 citations

Skeletal muscle enlargement with weight-lifting exercise by rats

1988 • 123 citations

Phorbol esters stimulate phosphorylation of eukaryotic initiation factors 3, 4B, and 4F

1989 • 121 citations

Simultaneous cytoplasmic redistribution of ribosomal protein L32 mRNA and phosphorylation of eukaryotic initiation factor 4E after mitogenic stimulation of Swiss 3T3 cells.

1990 • 120 citations

Binding properties and biological potencies of insulin-like growth factors in L6 myoblasts

1986 • 120 citations

An isotopic method for measurement of muscle protein synthesis and degradation in vivo

1987 • 120 citations

The response of muscle protein synthesis to nutrient intake in postabsorptive rats: The role of insulin and amino acids

1986 • 120 citations

The effect of a growth promoting drug, clenbuterol, on fibre frequency and area in hind limb muscles from young male rats

1986 • 119 citations

The role of tumor necrosis factor (cachectin) in cachexia

1988 • 117 citations

The role of insulin and thyroid hormones in the regulation of muscle growth and protein turnover in response to dietary protein in the rat

1988 • 117 citations

The role of degradation in the acute control of protein balance in adult man: Failure of feeding to stimulate protein synthesis as assessed by L-[1-13C]leucine infusion

1989 • 117 citations

The effect of amino acid infusion on leg protein turnover assessed by L‐[¹⁵N]phenylalanine and L‐[1‐¹³C]leucine exchange

1990 • 117 citations

The effect of cortisone on protein breakdown and synthesis in rat skeletal muscle

1977 • 116 citations

The differing responses of four muscle types to dexamethasone treatment in the rat

1982 • 115 citations

The role of amino acids in the regulation of protein synthesis in perfused rat liver. I. Reduction in rates of synthesis resulting from amino acid deprivation and recovery during flow-through perfusion.

1982 • 115 citations

Stretch-induced prostaglandins and protein turnover in cultured skeletal muscle

1990 • 114 citations

The effects of surgical stress and short-term fasting on protein synthesis in vivo in diverse tissues of the mature rat

1988 • 112 citations

Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue.

1988 • 111 citations

Myofibrillar protein turnover. Synthesis rates of myofibrillar and sarcoplasmic protein fractions in different muscles and the changes observed during postnatal development and in response to feeding and starvation

1983 • 110 citations

Aortic perfusion pressure as a determinant of cardiac protein synthesis

1984 • 110 citations

Effects of diabetes on protein synthesis in fast- and slow-twitch rat skeletal muscle

1980 • 108 citations

Glucocorticoid action on protein synthesis and protein breakdown in isolated skeletal muscles

1982 • 107 citations

Effects of catecholamines on protein synthesis in cardiac myocytes and perfused hearts isolated from adult rats. Stimulation of translation is mediated through the α1-adrenoceptor

1990 • 107 citations

Contribution of rat liver and gastrointestinal tract to whole-body protein synthesis in the rat

1980 • 104 citations

Effect of recombinant human tumour necrosis factor α on protein synthesis in liver, skeletal muscle and skin of rats

1989 • 102 citations

Contraction modulates the capacity for protein synthesis during growth of neonatal heart cells in culture.

1989 • 102 citations

Faster protein and ribosome synthesis in thyroxine-induced hypertrophy of rat heart

1985 • 101 citations

Protein synthesis in isolated rabbit forelimb muscles. The possible role of metabolites of arachidonic acid in the response to intermittent stretching

1983 • 101 citations

Effects of noncarbohydrate substrates on protein synthesis in muscle

1974 • 101 citations

Regulation of protein synthesis and degradation in L8 myotubes. Effects of serum, insulin and insulin-like growth factors

1989 • 100 citations

Identification of a ribosomal protein S6 kinase regulated by transformation and growth-promoting stimuli.

1987 • 99 citations

Protein Synthesis and Amino Acid Transport in the Isolated Rabbit Right Ventricular Papillary Muscle: EFFECT OF ISOMETRIC TENSION DEVELOPMENT

1972 • 99 citations

Phosphorylation of the guanine nucleotide exchange factor from rabbit reticulocytes regulates its activity in polypeptide chain initiation.

1988 • 98 citations

Regulation of myofibrillar protein degradation in rat skeletal muscle during brief and prolonged starvation

1986 • 97 citations

Load regulation of the properties of adult feline cardiocytes. The role of substrate adhesion.

1986 • 97 citations

Effect of corticosterone treatment on muscle protein turnover in adrenalectomized rats and diabetic rats maintained on insulin

1982 • 97 citations

A morphological/biochemical study on the actions of corticosteroids on rat skeletal muscle

1986 • 94 citations

Protein and amino acid metabolism after injury

1989 • 94 citations

A hemodynamic load in vivo induces cardiac expression of the cellular oncogene, c-myc

1987 • 94 citations

Inhibitors of prostaglandin synthesis or cathepsin B prevent muscle wasting due to sepsis in the rat.

1984 • 93 citations

Protein degradation during endurance exercise and recovery

1987 • 91 citations

Thyroxine-Induced Cardiac Hypertrophy: Time Course of Development and Inhibition by Propranolol*

1988 • 89 citations

Protein metabolism in skeletal muscle, diaphragm, and heart of diabetic rats

1983 • 88 citations

Myocardial stretch stimulates phosphatidylinositol turnover.

1989 • 88 citations

Catabolism of intracellular protein: molecular aspects

1986 • 87 citations

Protein synthesis versus energy state in contracting muscles of perfused rat hindlimb

1984 • 87 citations

Effects of systemic inhibition of prostaglandin production on protein metabolism in tumor-bearing rats

1989 • 86 citations

Fiber-type composition of nine rat muscles. I. Changes during the first year of life

1989 • 86 citations

Effects of starvation, diabetes and acute insulin treatment on the regulation of polypeptide-chain initiation in rat skeletal muscle

1984 • 86 citations

The role of insulin, corticosterone and other factors in the acute recovery of muscle protein synthesis on refeeding food-deprived rats

1983 • 84 citations

Influence of nutrient intake on protein turnover

1989 • 84 citations

Proto-Oncogenes and Cardiac Hypertrophy

1989 • 84 citations

Regulation of protein metabolism by a physiological concentration of insulin in mouse soleus and extensor digitorum longus muscles. Effects of starvation and scald injury

1979 • 84 citations

Accelerated rates of ribosomal RNA synthesis during growth of contracting heart cells in culture

1989 • 84 citations

The effects of 6 hours of hypoxia on protein synthesis in rat tissues in vivo and in vitro

1985 • 84 citations

Hyperglucagonemia during insulin deficiency accelerates protein catabolism

1987 • 84 citations

Direct determination of leucine metabolism and protein breakdown in humans using L‐[1‐¹³C, ¹⁵N]‐leucine and the forearm model

1985 • 83 citations

Motion into mass: how does tension stimulate muscle growth?

1987 • 82 citations

Phenylephrine, vasopressin and angiotensin II as determinants of proto-oncogene and heat-shock protein gene expression in adult rat heart and aorta

1989 • 81 citations

The effect of β-agonists and antagonists on muscle growth and body composition of young rats (Rattus sp.)

1988 • 81 citations

Thyroid hormones and muscle protein turnover. The effect of thyroid-hormone deficiency and replacement in thryoidectomized and hypophysectomized rats

1981 • 81 citations

Effect of insulin on hind-limb and whole-body leucine and protein metabolism in fed and fasted lambs

1987 • 80 citations

The effect of glutamine on protein turnover in chick skeletal muscle in vitro

1990 • 80 citations

Aortic pressure as a determinant of cardiac protein degradation

1986 • 80 citations

Accelerated ribosome formation and growth in neonatal pig hearts

1990 • 80 citations

Control of protein degradation in muscle by prostaglandins, Ca2+, and leukocytic pyrogen (interleukin 1).

1984 • 78 citations

Cardiac protein synthesis and degradation during thyroxine-induced left ventricular hypertrophy

1986 • 78 citations

The measurement of protein synthesis in biological systems

1982 • 78 citations

Alpha 1-adrenergic stimulation of rat myocardial cells increases protein synthesis

1986 • 78 citations

The action of the β-agonist clenbuterol on protein metabolism in innervated and denervated phasic muscles

1989 • 77 citations

Control of peptide-chain initiation in rat skeletal muscle. Development of methods for preparation of native ribosomal subunits and analysis of the effect of insulin on formation of 40 S initiation complexes.

1985 • 76 citations

Stimulation of phosphatidylinositol metabolism in the isolated, perfused rat heart.

1987 • 76 citations

Contractile activity is required for the expression of neonatal myosin heavy chain in embryonic chick pectoral muscle cultures.

1986 • 75 citations

Inability to stimulate skeletal muscle or whole body protein synthesis in Type 1 (insulin-dependent) diabetic patients by insulin-plus-glucose during amino acid infusion: studies of incorporation and turnover of tracer L-[1-13C]leucine

1990 • 75 citations

Increased cyclic AMP content accelerates protein synthesis in rat heart.

1989 • 75 citations

Dose response of protein turnover in rat skeletal muscle to triiodothyronine treatment

1983 • 74 citations

Clenbuterol, a beta 2-agonist, retards atrophy in denervated muscles

1987 • 74 citations

Regulation of protein synthesis and degradation during in vitro cardiac work

1980 • 74 citations

3-Methylhistidine turnover in the whole body, and the contribution of skeletal muscle and intestine to urinary 3-methylhistidine excretion in the adult rat

1983 • 73 citations

The influence of changes in tension on protein synthesis and prostaglandin release in isolated rabbit muscles

1983 • 73 citations

Fiber-type composition of nine rat muscles. II. Relationship to protein turnover

1989 • 73 citations

Therapeutic Aspects of Branched-Chain Amino and Keto Acids

1984 • 73 citations

The association of NADPH with the guanine nucleotide exchange factor from rabbit reticulocytes: a role of pyridine dinucleotides in eukaryotic polypeptide chain initiation.

1986 • 72 citations

Effect of higher aortic pressure on ribosome formation and cAMP content in rat heart

1989 • 71 citations

Effects of insulin in vitro on protein turnover in rat epitrochlearis muscle

1983 • 70 citations

Availability of amino acids supplied by constant intravenous infusion of synthetic dipeptides in healthy man

1989 • 69 citations

Alpha-actin and cytochrome c mRNAs in atrophied adult rat skeletal muscle

1988 • 69 citations

Inhibition and reversal of denervation-induced atrophy by the β-agonist growth promoter, clenbuterol

1986 • 68 citations

Beta-adrenergic agonists stimulate the synthesis of noncontractile but not contractile proteins in cultured myocytes isolated from adult rat heart.

1990 • 68 citations

Inhibition of protein degradation by anoxia and ischemia in perfused rat hearts.

1979 • 68 citations

Failure of Infused β-Hydroxybutyrate to Decrease Proteolysis in Man

1983 • 68 citations

The Use of Stable Isotopes for Diagnosis and Clinical Research

1982 • 68 citations

Effects of thyroxine on protein turnover in rat skeletal muscle.

1978 • 67 citations

N tau-methylhistidine release: contributions of rat skeletal muscle, GI tract, and skin

1982 • 67 citations

Comparison of different techniques for estimating rates of protein synthesis in vivo in healthy and bacteraemic rats

1985 • 64 citations

Cellular mechanisms involved in the action of insulin on protein synthesis

1988 • 62 citations

Effects of diabetes on protein turnover in cardiac muscle

1980 • 61 citations

Influence of fasting on leucine and muscle protein metabolism across the human forearm determined using <scp>l</scp>-[1-13C,15N]leucine as the tracer

1987 • 61 citations

Influence of calcium and other divalent cations on protein turnover in rat skeletal muscle

1986 • 60 citations

The effects of calcium on protein turnover in skeletal muscles of the rat

1982 • 60 citations

Clenbuterol prevents or inhibits loss of specific mRNAs in atrophying rat skeletal muscle

1988 • 59 citations

Effect of diabetes on guanine nucleotide exchange factor activity in skeletal muscle and heart

1988 • 59 citations

Protein synthesis measured in vivo in muscle and liver of cachectic tumor-bearing mice

1985 • 58 citations

Effect of isoproterenol on amino acid levels and protein turnover in skeletal muscle.

1977 • 57 citations

Rates of protein turnover in vivo and in vitro in ventricular muscle of hearts from fed and starved rats

1984 • 57 citations

Skeletal Muscle Proteolysis in Rats With Acute Streptozocin-Induced Diabetes

1989 • 57 citations

Experimental basis for use of peptides as substrates for parenteral nutrition: A review

1987 • 56 citations

Role of thyroid hormone in regulation of isomyosin composition, contractility, and size of heterotopically isotransplanted rat heart.

1987 • 56 citations

Effect of insulin and leucine on protein turnover in rat soleus muscle after burn injury.

1982 • 55 citations

Assessment of fractional rates of protein synthesis in cardiac muscle cultures after equilibrium labeling.

1981 • 55 citations

The need for indispensable amino acids: The concept of the anabolic drive

1989 • 55 citations

The possible involvement of prostaglandin F2α in the stimulation of muscle protein synthesis by insulin

1983 • 54 citations

Interactive effects of insulin and corticosterone on myofibrillar protein turnover in rats as determined by Nτ-methylhistidine excretion

1984 • 54 citations

Muscle protein synthesis in the streptozotocin-diabetic rat. A possible role for corticosterone in the insensitivity to insulin infusion in vivo

1982 • 53 citations

Influence of hyperinsulinaemia on intracellular amino acid levels and amino acid exchange across splanchnic and leg tissues in uraemia

1988 • 53 citations

In Vitro Work Load and Rat Heart Metabolism

1972 • 53 citations

Myofibrillar protein turnover. Synthesis of protein-bound 3-methylhistidine, actin, myosin heavy chain and aldolase in rat skeletal muscle in the fed and starved states

1983 • 52 citations

Effects of food deprivation and refeeding on total protein and actomyosin degradation

1984 • 52 citations

The effect of glucagon administration on protein synthesis in skeletal muscles, heart and liver in vivo

1985 • 51 citations

Effects of increasing extracellular pH on protein synthesis and protein degradation in the perfused working rat heart

1989 • 50 citations

Differential effects of acute changes in cell Ca2+ concentration on myofibrillar and non-myofibrillar protein breakdown in the rat extensor digitorum longus muscle in vitro. Assessment by production of tyrosine and Nτ-methylhistidine

1987 • 50 citations

Use of aromatic amino acids as monitors of protein turnover

1981 • 50 citations

Insulin rapidly induces the biosynthesis of elongation factor 2

1989 • 49 citations

EFFECTS OF INJURY, DISEASE, AND MALNUTRITION ON PROTEIN METABOLISM IN MAN

1984 • 49 citations

The effects of calcium ions, ionophore A23187 and inhibition of energy metabolism on protein degradation in the rat diaphragm and epitrochlearis muscles in vitro

1980 • 49 citations

The effect of indomethacin on the stimulation of protein synthesis by insulin in young post-absorptive rats

1985 • 49 citations

Morphological observations and rates of protein synthesis in rat muscles incubated in vitro

1985 • 48 citations

Biophysical studies of mechanoreceptors

1986 • 47 citations

Relationship of the reduction-oxidation state to protein degradation in skeletal and atrial muscle

1982 • 47 citations

The hormonal control of protein turnover

1990 • 47 citations

Inhibition of intracellular proteolysis in muscle cultures by multiplication-stimulating activity. Comparison of effects of multiplication-stimulating activity and insulin on proteolysis, protein synthesis, amino acid uptake, and sugar transport.

1984 • 45 citations

Regional blood flow and skeletal muscle energy status in endotoxemic rats

1987 • 45 citations

INFLUENCE OF MUSCLE USE ON PROTEIN SYNTHESIS AND DEGRADATION

1982 • 45 citations

Protein synthesis in skeletal muscle of the perfused rat hemicorpus compared with rates in the intact animal

1983 • 44 citations

Effect of corticosterone and its route of administration on muscle protein breakdown, measured in vivo by urinary excretion of Nτ-methylhistidine in rats: Response to different levels of dietary protein and energy

1981 • 44 citations

Actin synthesis rate and mRNA level increase during early recovery of atrophied muscle

1987 • 43 citations

Insulin sensitivity and responsiveness of epitrochlearis and soleus muscles from fed and starved rats. Recognition of differential changes in insulin sensitivities of protein synthesis and glucose incorporation into glycogen

1985 • 43 citations

Increased K+ inhibits spontaneous contractions reduces myosin accumulation in cultured chick myotubes.

1982 • 43 citations

The effects of fasting or hypoxia on rates of protein synthesis in vivo in subcellular fractions of rat heart and gastrocnemius muscle

1989 • 43 citations

High molecular mass intracellular proteases

1989 • 43 citations

The effect of trauma and surgery on interorgan fluxes of amino acids in man

1987 • 42 citations

The in vivo study of cardiac and skeletal muscle protein turnover

1989 • 42 citations

The effect of pressure or flow stress on right ventricular protein synthesis in the face of constant and restricted coronary perfusion.

1975 • 41 citations

Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2 kinases via a human insulin receptor/v-ros hybrid.

1990 • 41 citations

Role of proto-oncogenes in myocardial hypertrophy

1988 • 41 citations

Protein synthesis in rat cardiac myocytes is stimulated at the level of translation by phorbol esters

1989 • 40 citations

Maintenance of protein synthesis in hearts of diabetic animals

1970 • 40 citations

The effect of the anabolic agent, clenbuterol, on overloaded rat skeletal muscle

1987 • 39 citations

Efficiency and capacity of protein synthesis are increased in pressure overload cardiac hypertrophy

1988 • 39 citations

Suppression of myocardial protein degradation in the rat during fasting. Effects of insulin, glucose, and leucine.

1980 • 38 citations

Effect of Indomethacin on Proteolysis in Septic Muscle

1985 • 38 citations

Insulin stimulation of growth in diabetic rats. Synthesis and degradation of ribosomes and total tissue protein in skeletal muscle and heart.

1986 • 38 citations

Cytochrome c protein-synthesis rates and mRNA contents during atrophy and recovery in skeletal muscle

1987 • 38 citations

Response of muscle protein turnover to insulin after acute exercise and training

1986 • 37 citations

Contraction regulates myosin synthesis and myosin content of cultured heart cells

1985 • 37 citations

Is regulation of proteolysis associated with redox-state changes in rat skeletal muscle?

1980 • 37 citations

Insulin promoted decrease in the phosphorylation of protein synthesis initiation factor eIF-2

1984 • 37 citations

Effect of sepsis on calcium uptake and content in skeletal muscle and regulation in vitro by calcium of total and myofibrillar protein breakdown in control and septic muscle: results from a preliminary study.

1989 • 36 citations

In vitro effects of catecholamines on protein synthesis in perfused rat heart*1

1976 • 36 citations

Faster ribosome synthesis induced by elevated aortic pressure in rat heart

1987 • 36 citations

Perspectives on molecular and cellular exercise physiology

1988 • 35 citations

α-Adrenergic receptors in rat skeletal muscle

1986 • 34 citations

Whole body protein synthesis: studies with different amino acids in the rat

1989 • 34 citations

Metabolic aspects of the development of experimental cardiac hypertrophy

1986 • 34 citations

Evidence that the hypertrophic action of clenbuterol on denervated rat muscle is not propranolol‐sensitive

1989 • 34 citations

Effects of glucose, pyruvate, lactate, and amino acids on muscle protein synthesis

1982 • 33 citations

Skeletal muscle protein synthesis and degradation in vitro: effects of temperature

1985 • 33 citations

Effects of temperature on protein turnover in isolated rat skeletal muscle

1984 • 33 citations

Modification of glucocorticoid-induced changes in myofibrillar protein turnover in rats by protein and energy deficiency as assessed by urinary excretion ofN^T-methylhistidine

1984 • 32 citations

Effect of parenteral nutrition on protein turnover in endotoxaemic rats

1989 • 32 citations

Determination of rates of protein synthesis, gain and degradation in intact hind-limb muscle of lambs

1986 • 31 citations

Elevation of plasma epinephrine concentrations inhibits proteolysis and leucine oxidation in man via beta-adrenergic mechanisms.

1989 • 30 citations

The effect of sepsis in rats on skeletal muscle protein synthesis in vivo and in periphery and central core of incubated muscle preparations in vitro

1988 • 30 citations

Propranolol apparently separates the physical and compositional characteristics of muscle growth induced by clenbuterol

1987 • 30 citations

Adaptive responses of rats to prolonged treatment with epinephrine

1981 • 29 citations

Dual trophic effects of the alpha1-adrenergic receptor in cultured neonatal rat heart muscle cells

1986 • 29 citations

Ontogeny of insulin binding during chick skeletal myogenesis in vitro

1979 • 29 citations

Methods for studying protein synthesis and degradation in liver and skeletal muscle

1988 • 29 citations

Transcriptional regulation of decreased protein synthesis during skeletal muscle unloading

1989 • 29 citations

Prostaglandin E₂ and the regulation of protein degradation in skeletal muscle

1987 • 29 citations

The effect of insulin and intermittent mechanical stretching on rates of protein synthesis and degradation in isolated rabbit muscle

1985 • 28 citations

Role of contraction in the structure and growth of neonatal rat cardiocytes

1987 • 28 citations

Mechanisms of differential growth of heart ventricles in newborn pigs.

1989 • 28 citations

The effect of triiodothyronine on the cardiac mRNA

1982 • 27 citations

Different patterns of protein turnover in skeletal and gastrointestinal smooth muscle and the production of Nτ-methylhistidine during fasting in the rat

1986 • 27 citations

Contrasting response of protein degradation to starvation and insulin as measured by release of Nτ-methylhistidine or phenylalanine from the perfused rat heart

1986 • 27 citations

The effects of cutting or of stretching skeletal muscle in vitro on the rates of protein synthesis and degradation

1980 • 27 citations

Metabolism of inositol phosphates in α1-adrenoceptor-stimulated and homogenized cardiac myocytes of adult rats

1989 • 27 citations

Further Evidence that Accelerated Muscle Protein Breakdown During Sepsis Is Not Mediated by Prostaglandin E2

1988 • 26 citations

Biphasic changes in 3-methylhistidine excretion in humans after exercise

1985 • 26 citations

Protein metabolism in the tumour-bearing mouse. Rates of protein synthesis in host tissues and in an Ehrlich ascites tumour at different stages in tumour growth

1989 • 26 citations

Effect of intraventricular pressure on protein synthesis in arrested rat hearts

1986 • 26 citations

Total and myofibrillar protein degradation in isolated soleus muscles after exercise

1989 • 25 citations

Decreased myofibrillar proteolysis after refeeding requires dietary protein or amino acids

1987 • 25 citations

Incorporation of C¹⁴-amino acids into protein of isolated diaphragms: effect of epinephrine and norepinephrine

1960 • 25 citations

The effects of glucose, acetate, lactate and insulin on protein degradation in the perfused rat heart

1982 • 24 citations

Short-term effects of corticosterone treatment on muscle protein synthesis in relation to the response to feeding

1987 • 24 citations

Prostaglandin E2 and muscle proteolysis: effect of burn injury and cycloheximide

1986 • 23 citations

Elevated aortic pressure, calcium uptake, and protein synthesis in rat heart

1989 • 22 citations

Acute alterations in sodium flux in vitro lead to decreased myofibrillar protein breakdown in rat skeletal muscle

1987 • 22 citations

Myofibrillar Protein Breakdown in Skeletal Muscle is Diminished in Rats With Chronic Streptozocin-Induced Diabetes

1987 • 22 citations

Regulation of polypeptide-chain initiation in rat skeletal muscle Starvation does not alter the activity or phosphorylation state of initiation factor eIF-2

1988 • 22 citations

The effects of lactate, acetate, glucose, insulin, starvation and alloxan-diabetes on protein synthesis in perfused rat hearts

1986 • 22 citations

Metabolic Rate and Thyroid Status in Rats Fed Diets of Different Protein-Energy Value: The Importance of Free T3

1984 • 21 citations

Stimulation of left-atrial protein-synthesis rates by increased left-atrial filling pressures in the perfused working rat heart in vitro

1983 • 21 citations

Changes in protein turnover in hypertrophying plantaris muscles of rats: Effect of fenbufen — An inhibitor of prostaglandin synthesis

1987 • 21 citations

Regulation of Ca2+-dependent protein turnover in skeletal muscle by thyroxine

1986 • 21 citations

Wiggers Award lecture. Biochemical correlates of myocardial hypertrophy.

1985 • 21 citations

The effect of tri-iodothyronine administration on protein synthesis in the diabetic rat

1983 • 20 citations

The contribution of small gut to the 3-methylhistidine metabolism in the adult rat

1987 • 20 citations

Stimulation of protein synthesis by raised extracellular pH in cardiac myocytes and perfused hearts

1990 • 19 citations

Prostaglandin production in myotube cultures. Influence on protein turnover

1988 • 19 citations

A comparison of rates of protein turnover in rat diaphragm in vivo and in vitro

1986 • 19 citations

Daily running for 2 wk and mRNAs for cytochrome c and alpha-actin in rat skeletal muscle

1989 • 19 citations

Stimulation of protein synthesis, glucose uptake and lactate output by insulin and adenosine deaminase in the rat heart

1986 • 19 citations

The use of stable isotope tracers as metabolic probes of whole-body and limb metabolism

1984 • 18 citations

Protein synthesis in the early stages of cardiac hypertrophy

1983 • 17 citations

The effect of indomethacin on the response of protein synthesis to feeding in rats and man

1987 • 17 citations

The influence of plasma concentrations of tri-iodothyronine on the acute increases in insulin and muscle protein synthesis in the refed fasted rat

1988 • 17 citations

Altered protein kinetics in vivo after single-limb burn injury

1984 • 17 citations

Adrenergic and serotonergic regulation of skeletal muscle metabolism in rat. I. The effects of adrenergic and serotonergic antagonists on the regulation of muscle amino acid release, glycogenolysis, and cyclic nucleotide levels.

1983 • 16 citations

Prostaglandin-dependent muscle wasting during infection in the broiler chick (Gallus domesticus) and the laboratory rat (Rattus norvegicus)

1989 • 16 citations

Effect of hyperoxic exposure on protein synthesis in the rat

1988 • 16 citations

Inhibition of protein synthesis by glucagon in different rat muscles and protein fractions in vivo and in the perfused rat hemicorpus

1988 • 16 citations

Protein synthesis and degradation in isolated muscle. Effect of ω3 and ω6 fatty acids

1987 • 16 citations

Effects of diabetes on cardiac lysosomes and protein degradation

1983 • 16 citations

Effects of insulin, amino acids and fasting on myofibrillar protein degradation in perfused hindquarters of rats.

1985 • 15 citations

Acute inhibition of rat heart protein synthesis in vitro during beta-adrenergic stimulation or hypoxia

1988 • 15 citations

Effects of pressure overload and insulin on protein turnover in the perfused rat heart. Prostaglandins are not involved although their synthesis is stimulated by insulin

1987 • 15 citations

Effect of corticosterone on myofibrillar protein turnover in diabetic rats as assessed by Nτ-methylhistidine excretion

1982 • 14 citations

The influence of restraint and infusion on rates of muscle protein synthesis in the rat. Effect of altered respiratory function

1988 • 14 citations

Increased cardiac contractility in high calcium perfusion and protein synthesis

1977 • 14 citations

Effect of malaria on rate of protein synthesis in individual tissues of rats

1985 • 14 citations

Effects of ischaemia, blood loss and reperfusion on rat muscle protein synthesis, metabolite concentrations and polyribosome profiles in vivo

1989 • 13 citations

Control of protein synthesis and ribosome formation in rat heart

1989 • 13 citations

Effects of noncarbohydrate substrates on protein synthesis in hearts from fed and fasted rats

1984 • 13 citations

Time dependent effect of indomethacin on the stimulation of protein synthesis in isolated rabbit muscle by insulin

1986 • 13 citations

The rate of protein degradation in isolated skeletal muscle does not correlate with reduction-oxidation status

1985 • 13 citations

Anabolic Effects of Catecholamines in Diaphragm Muscle from Hypophysectomized Rats*

1982 • 12 citations

Two phosphorylation sites on eIF‐2α

1990 • 12 citations

Metabolism of Nτ-methylhistidine by mice

1985 • 12 citations

Effects of insulin on cardiac lysosomes and protein degradation.

1984 • 11 citations

The cyclo-oxygenase inhibitors indomethacin and ibuprofen inhibit the insulin-induced stimulation of ribosomal RNA synthesis in L6 myoblasts

1989 • 10 citations

Simultaneous response of myocardial contractility and a major proteolytic process to β-adrenergic-receptor occupancy in the Langendorff isolated perfused rat heart

1985 • 10 citations

Distinction between major chloroquine-inhibitable and adrenergic-responsive pathways of protein degradation and their relation to tissue ATP content in the Langendorff isolated perfused rat heart

1988 • 9 citations

Effect of the Cyclo-Oxygenase Inhibitor Fenbufen on Muscle and Liver Protein Metabolism, Muscle Glutamine and Plasma Insulin in Endotoxaemic Rats

1989 • 9 citations

Effects of indomethacin and leupeptin on muscle cathepsin B activity and protein degradation during sepsis

1988 • 8 citations

Protein Turnover in Skeletal Muscle Tissue from Patients with Hyperparathyroidism and the Effect of Calcium in vitro

1986 • 7 citations

in‐vitro stimulation of the rat epitrochlearis muscle. I. Contractile activity per se affects myofibrillar protein degradation and amino acid metabolism

1989 • 7 citations

Effects of adrenaline and prior exercise on the release of alanine, glutamine and glutamate from incubated rat skeletal muscle

1989 • 6 citations

The Biochemical Actions of Phentolamine and Papaverine on Rat Perfused Skeletal Muscle

1988 • 6 citations

Biochemistry of Exercise

1988 • 6 citations

Factors controlling the disposition of primary nutrients

1988 • 5 citations

Catecholamines, glucagon, energy metabolism and protein degradation in rat heart.

1990 • 5 citations

Lysosomal changes during thyroxine-induced left ventricular hypertrophy in rabbits

1986 • 4 citations

Effect of redox potential on protein degradation in perfused rat heart

1985 • 4 citations

The effect of rejuvenation of aged erythrocytes on biochemical parameters in the perfused hind limb muscle preparation

1988 • 3 citations