Multiple actions of β-adrenergic agonists on skeletal muscle and adipose tissue

Differentiation of Receptor Systems activated by Sympathomimetic Amines

1967 • 2,054 citations

Thermogenic mechanisms in brown fat.

1984 • 1,593 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

Relationships between calcium and cyclic nucleotides in cell activation.

1977 • 849 citations

Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs

1984 • 724 citations

cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

1987 • 687 citations

Cloning of the cDNA for the human beta 1-adrenergic receptor.

1987 • 577 citations

Brown‐Adipose‐Tissue Mitochondria: Photoaffinity Labelling of the Regulatory Site of Energy Dissipation

1978 • 400 citations

Excitation-Contraction Coupling

1976 • 355 citations

Stimulation of muscle growth by clenbuterol: lack of effect on muscle protein biosynthesis

1986 • 317 citations

Recent advances in animal nutrition

1987 • 304 citations

The relative significance of acetate and glucose as precursors for lipid synthesis in liver and adipose tissue from ruminants

1967 • 294 citations

Chronic effects of β2 agonists on body composition and protein synthesis in the rat

1984 • 280 citations

Actions of sympathomimetic amines and their antagonists on skeletal muscle.

1969 • 272 citations

Significance of Adipose Tissue and Liver as Sites of Fatty Acid Synthesis in the Pig and the Efficiency of Utilization of Various Substrates for Lipogenesis

1969 • 260 citations

Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man

1985 • 236 citations

Brown Adipose Tissue Metabolism and Thermogenesis

1985 • 221 citations

Lipid biosynthesis and transport in the domestic chick (Gallus domesticus)

1969 • 218 citations

Alanine and glutamine synthesis and release from skeletal muscle. I. Glycolysis and amino acid release.

1976 • 207 citations

Time course of the effect of catabolic doses of corticosterone on protein turnover in rat skeletal muscle and liver

1983 • 200 citations

Slow to fast alterations in skeletal muscle fibers caused by clenbuterol, a beta 2-receptor agonist

1988 • 195 citations

The stimulation of protein degradation in muscle by Ca2+ is mediated by prostaglandin E2 and does not require the calcium-activated protease.

1982 • 179 citations

A role for alpha-adrenergic receptors in abnormal insulin secretion in diabetes mellitus.

1976 • 178 citations

Cimaterol-Induced Muscle Hypertrophy and Altered Endocrine Status in Lambs

1987 • 177 citations

Myosin light‐chain kinase, a new enzyme from striated muscle

1974 • 170 citations

Calcium-dependent regulation of protein synthesis and degradation in muscle

1979 • 160 citations

The rat lipolytic β-adrenoceptor: Studies using novel β-adrenoceptor agonists

1984 • 158 citations

LIPOLYSIS IN CHICKEN ADIPOSE TISSUE IN VITRO

1969 • 153 citations

Effect of the β-Adrenergic Agonist Cimaterol (CL 263,780) on the Growth and Carcass Characteristics of Finishing Swine

1985 • 139 citations

Beta-adrenergic stimulation of brown adipocyte proliferation

1988 • 126 citations

The effect of a growth promoting drug, clenbuterol, on fibre frequency and area in hind limb muscles from young male rats

1986 • 119 citations

Decreased tyrosine kinase activity of insulin receptor isolated from rat adipocytes rendered insulin-resistant by catecholamine treatment in vitro

1986 • 119 citations

Lipogenesis in the Ruminant: in vivo Site of Fatty Acid Synthesis in Sheep

1972 • 118 citations

The action of ?-adrenergic blocking and stimulating agents on insulin secretion. Characterization of the type of ? receptor

1971 • 116 citations

The effect of the β-2-adrenergic agonist clenbuterol or implantation with oestradiol plus trenbolone acetate on protein metabolism in wether lambs

1987 • 115 citations

Effect of the Repartitioning Agent Cimaterol on Growth, Carcass and Skeletal Muscle Characteristics in Lambs

1987 • 113 citations

Effects of a β-agonist (clenbuterol) on growth, carcass composition, protein and energy metabolism of veal calves

1987 • 112 citations

Glucocorticoid action on protein synthesis and protein breakdown in isolated skeletal muscles

1982 • 107 citations

Phosphorylation of Purified Insulin Receptor by cAMP Kinase

1987 • 104 citations

Short term and long term effects of beta-adrenergic effectors and cyclic AMP on nitrendipine-sensitive voltage-dependent Ca2+ channels of skeletal muscle.

1985 • 98 citations

Heterogeneity of adenylate cyclase-coupled β-adrenergic receptors

1975 • 98 citations

The characterization and energetic potential of brown adipose tissue in man

1985 • 91 citations

Reduced Calcium-Dependent Proteinase Activity in Cimaterol-Induced Muscle Hypertrophy in Lambs

1988 • 87 citations

Changes in tissue blood flow and β-receptor density of skeletal muscle in rats treated with the β2-adrenoceptor agonist clenbuterol

1987 • 87 citations

An investigation of the β-adrenoceptor that mediates metabolic responses to the novel agonist BRL28410 in rat soleus muscle

1988 • 84 citations

Regulation of protein degradation in muscle by calcium. Evidence for enhanced nonlysosomal proteolysis associated with elevated cytosolic calcium.

1985 • 83 citations

The regulation of glyceride synthesis in isolated white-fat cells. The effects of palmitate and lipolytic agents

1972 • 75 citations

Clenbuterol, a beta 2-agonist, retards atrophy in denervated muscles

1987 • 74 citations

Thermogenic and antiobesity activity of a novel β-adrenoceptor agonist (BRL 26830A) in mice and rats

1983 • 72 citations

Clenbuterol, a beta agonist, induces growth in innervated and denervated rat soleus muscle via apparently different mechanisms

1987 • 68 citations

Effects of isoprenaline on contractions of directly stimulated fast and slow skeletal muscles of the guinea‐pig

1973 • 68 citations

Cyclic AMP-Modulated Phosphorylation of Intermediate Filament Proteins in Cultured Avian Myogenic Cells

1982 • 65 citations

Protein synthesis, amino acid uptake, and pools during isoproterenol-induced hypertrophy of the rat heart and tibialis muscle

1981 • 60 citations

The effects of calcium on protein turnover in skeletal muscles of the rat

1982 • 60 citations

Metabolic Effects of Catecholamines in Sheep

1970 • 59 citations

Effect of continuous and intermittent clenbuterol feeding on rat growth rate and muscle

1989 • 57 citations

Effect of isoproterenol on amino acid levels and protein turnover in skeletal muscle.

1977 • 57 citations

Characterization of beta-adrenergic receptors of human skeletal muscle obtained by needle biopsy

1988 • 56 citations

Effects of Chronic β-Receptor Stimulation on Sympathetic Nervous System Activity, Energy Expenditure, and Thyroid Hormones*

1984 • 53 citations

Stereospecific stimulation of brown adipocyte respiration by catecholamines via beta 1-adrenoreceptors

1980 • 51 citations

SELECTIVITY OF β‐ADRENOCEPTOR AGONISTS AND ANTAGONISTS ON BRONCHIAL, SKELETAL, VASCULAR AND CARDIAC MUSCLE IN THE ANAESTHETIZED CAT

1976 • 51 citations

Effect of cyclic AMP-dependent protein kinase on insulin receptor tyrosine kinase activity

1987 • 45 citations

Differences between the effects of noradrenaline and the β-adrenoceptor agonist BRL 28410 in brown adipose tissue and hind limb of the anaesthetized rat

1986 • 44 citations

Relative contribution of the main tissues and organs to body fatty acid synthesis in the rat

1983 • 42 citations

Identification and subclassification of rat adipocyte β-adrenoceptors using

1983 • 38 citations

Clenbuterol-induced muscle growth: investigation of possible mediation by insulin

1987 • 38 citations

Analysis of the ?-receptor mediated effect on fast-contracting skeletal muscle in vitro

1977 • 36 citations

Analysis of the beta1 and beta2 adrenoceptor interactions of the partial agonist, clenbuterol (NAB365), in the rat jugular vein and atria

1982 • 31 citations

Functional and metabolic effects of terbutaline and propranolol in fast- and slow-contracting skeletal muscle in vitro

1980 • 31 citations

New muscle fiber production during compensatory hypertrophy

1980 • 31 citations

Propranolol apparently separates the physical and compositional characteristics of muscle growth induced by clenbuterol

1987 • 30 citations

Improved Glycemic Control in C57BI/KsJ (db/db) Mice After Treatment with the Thermogenic β-Adrenoceptor Agonist, BRL 26830

1985 • 30 citations

Hormonal effects on cyclic nucleotides and carbohydrate and lipid metabolism in isolated chicken hepatocytes

1982 • 30 citations

Side effects of clenbuterol as a repartitioning agent

1987 • 28 citations

DESENSITIZATION BY TERBUTALINE OF β‐ADRENOCEPTORS IN THE GUINEA‐PIG SOLEUS MUSCLE: BIOCHEMICAL ALTERATIONS ASSOCIATED WITH FUNCTIONAL CHANGES

1982 • 27 citations

Effects of BRL 26830, a novel β-adrenoceptor agonist, on glucose tolerance, insulin sensitivity and glucose turnover in zucker (fa/fa) rats

1985 • 26 citations

Partial Agonism and Functional Selectivity: A Study on β‐Adrenoceptor Mediated Effects in Tracheal, Cardiac and Skeletal Muscle

1986 • 23 citations

Beta-adrenoreceptors in rat brown adipose tissue: proportions of beta 1- and beta 2-subtypes

1985 • 22 citations

Effect of a thermogenic agent, BRL 26830A, on insulin receptors in obese mice

1988 • 21 citations

Effects of in vivo treatment with isoprenaline or prenalterol on beta-adrenoceptor mechanisms in the heart and soleus muscle of the cat

1984 • 20 citations

The muscle slice?A new preparation for the characterization of ?-adrenergic binding in fast- and slow-twitch skeletal muscle

1986 • 20 citations

Studies on the effects of acetylcholine, epinephrine, dibutyryl cyclic adenosine monophosphate, theophylline, and calcium on the synthesis of myoglobin in muscle cell cultures estimated by radioimmunoassay

1974 • 19 citations

Ca2+-ions as coupling agents in enzymatic differentiation and carbohydrate metabolism of cultured muscle cells

1978 • 17 citations

Inhibition of β-Adrenergic Responsiveness in Muscle Cell Cultures by Dexamethasone*

1981 • 16 citations

Regulation of myofibrillar accumulation in chick muscle cultures: evidence for the involvement of calcium and lysosomes in non-uniform turnover of contractile proteins.

1985 • 13 citations

Hormonal regulation of protein phosphorylation in isolated rat heart cells

1984 • 13 citations

Anabolic Effects of Catecholamines in Diaphragm Muscle from Hypophysectomized Rats*

1982 • 12 citations

Effect of Catecholamines on Insulin Secretion and Liver Glycogenolysis in the Rat

1978 • 8 citations

The receptors responsible for heat production in brown adipose tissue in the young rabbit

1986 • 8 citations