The hormonal control of protein turnover

Energy and protein requirements*

2019 • 2,613 citations

Protein turnover in mammalian tissues and in the whole body

1978 • 1,237 citations

Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man.

1987 • 519 citations

Muscle Protein Synthesis Measured by Stable Isotope Techniques in Man: The Effects of Feeding and Fasting

1982 • 446 citations

The diurnal response of muscle and liver protein synthesis in vivo in meal-fed rats

1973 • 426 citations

The relative importance of muscle protein synthesis and breakdown in the regulation of muscle mass

1976 • 346 citations

Acute metabolic effects and half-lives of intravenously administered insulinlike growth factors I and II in normal and hypophysectomized rats.

1986 • 306 citations

A positive relationship between protein synthetic rate and intracellular glutamine concentration in perfused rat skeletal muscle

1987 • 285 citations

Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Effect of branched-chain amino acids

1988 • 279 citations

Intracellular Protein Catabolism

1996 • 259 citations

Hormonal regulation of protein degradation and synthesis in skeletal muscle.

1980 • 254 citations

Increase in anterior tibialis muscle protein synthesis in healthy man during mixed amino acid infusion: studies of incorporation of [1−13C]leucine

1989 • 213 citations

The effects of endotoxaemia on protein metabolism in skeletal muscle and liver of fed and fasted rats

1986 • 203 citations

Studies on gastric digestion of protein and carbohydrate, gastric secretion and exocrine pancreatic secretion in the growing pig

1983 • 188 citations

Growth restoration of insulin-deficient diabetic rats by recombinant human insulin-like growth factor I

1986 • 187 citations

Comparison of in vivo effects of insulin-like growth factors I and II and of growth hormone in hypophysectomized rats

1985 • 180 citations

Insulin in the regulation of protein turnover in heart and skeletal muscle.

1974 • 158 citations

The nutritional role of indispensable amino acids and the metabolic basis for their requirements.

1988 • 158 citations

Phosphorylation inhibits guanine nucleotide exchange on eukaryotic initiation factor 2

1982 • 141 citations

Relationship of Serum Immunoreactive Somatomedin-C to Dietary Protein and Energy in Growing Rats

1982 • 126 citations

Insulin‐like growth factor binding protein secretion by muscle cells: Effect of cellular differentiation and proliferation

1988 • 119 citations

The role of insulin and thyroid hormones in the regulation of muscle growth and protein turnover in response to dietary protein in the rat

1988 • 117 citations

Supplemental essential amino acids augment the somatomedin-C/insulin-like growth factor I response to refeeding after fasting

1985 • 111 citations

Ovine Somatomedin, Multiplication-Stimulating Activity, and Insulin Promote Skeletal Muscle Satellite Cell Proliferationin Vitro*

1985 • 111 citations

Proceedings of the Nutrition Society

1985 • 107 citations

Protein metabolism in skeletal muscle: the effect of feeding and fasting on muscle RNA, free amino acids and plasma insulin concentrations

1974 • 102 citations

The nutritional regulation of muscle growth and protein turnover

1989 • 99 citations

Effects of starvation, diabetes and acute insulin treatment on the regulation of polypeptide-chain initiation in rat skeletal muscle

1984 • 86 citations

The role of insulin, corticosterone and other factors in the acute recovery of muscle protein synthesis on refeeding food-deprived rats

1983 • 84 citations

Triiodothyronine stimulates cartilage growth and maturation by different mechanisms

1987 • 69 citations

Rate of protein synthesis in skeletal muscle of normal man and patients with muscular dystrophy: A reassessment

1988 • 66 citations

Human Amino Acid and Protein Requirements: Current Dilemmas and Uncertainties

1989 • 63 citations

Influence of fasting on leucine and muscle protein metabolism across the human forearm determined using <scp>l</scp>-[1-13C,15N]leucine as the tracer

1987 • 61 citations

Thyroid hormone metabolism in primary cultured rat hepatocytes. Effects of glucose, glucagon, and insulin.

1981 • 57 citations

The need for indispensable amino acids: The concept of the anabolic drive

1989 • 55 citations

Muscle protein synthesis in the streptozotocin-diabetic rat. A possible role for corticosterone in the insensitivity to insulin infusion in vivo

1982 • 53 citations

The relative contribution of the nervous system, hormones, and metabolites to the total insulin response during a meal in the rat

1984 • 53 citations

Urine C-peptide and creatinine (Jaffe Method) excretion in healthy young adults on varied diets: sustained effects of varied carbohydrate, protein, and meat content

1986 • 51 citations

The mechanism of recovery of hepatic T4-5′-deiodinase during glucose-refeeding: Role of glucagon and insulin

1983 • 39 citations

Stimulatory effect of insulin-like growth factor-I on [3H]thymidine incorporation, DNA content and insulin biosynthesis and secretion of isolated pancreatic rat islets

1988 • 38 citations

Hypothesis: PGE, Carbohydrate Homeostasis, and Insulin Secretion: A Suggested Resolution of the Controversy

1983 • 34 citations

Nutrition and somatomedin. XIV. Altered levels of somatomedins and somatomedin inhibitors in rats with streptozotocin-induced diabetes

1985 • 26 citations

Metabolic Rate and Thyroid Status in Rats Fed Diets of Different Protein-Energy Value: The Importance of Free T3

1984 • 21 citations

Adrenergic modulation of insulin secretion in vivo dependent on thyroid states.

1978 • 20 citations

The effect of tri-iodothyronine administration on protein synthesis in the diabetic rat

1983 • 20 citations

Influence of Selected Amino Acid Deficiencies on Somatomedin, Growth and Glycosaminoglycan Metabolism in Weanling Rats

1985 • 19 citations

The influence of plasma concentrations of tri-iodothyronine on the acute increases in insulin and muscle protein synthesis in the refed fasted rat

1988 • 17 citations

The Endocrine Response to Dietary Protein: the Anabolic Drive on Growth

1989 • 15 citations

Hypothesis. PGE, carbohydrate homeostasis, and insulin secretion. A suggested resolution of the controversy

1983 • 15 citations

Muscle protein synthesis: regulation of a translational inhibitor

1984 • 12 citations

The role of metabolites of arachidonic acid in the physiology and pathophysiology of muscle protein metabolism

1987 • 10 citations

Effect of the Cyclo-Oxygenase Inhibitor Fenbufen on Muscle and Liver Protein Metabolism, Muscle Glutamine and Plasma Insulin in Endotoxaemic Rats

1989 • 9 citations

Amino acid control of hepatic protein degradation: novel requirement for alanine.

1985 • 5 citations

The role of prostaglandins in the hormonal control of protein turnover

1987 • 3 citations

Evidence for Presence of Proinsulin Immunoreactive Glycoprotein(s) in Fetal Bovine Pancreatic Extracts

1987 • 1 citations