Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis.

1997 • 832 citations

Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor

1989 • 726 citations

Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

1991 • 429 citations

Thymidine phosphorylase is angiogenic and promotes tumor growth.

1995 • 394 citations

Clinicopathologic and Prognostic Significance of an Angiogenic Factor, Thymidine Phosphorylase, in Human Colorectal Carcinoma

1996 • 367 citations

Mechanisms of neovascularization. Vascular sprouting can occur without proliferation of endothelial cells.

1984 • 339 citations

Purification and properties of an endothelial cell growth factor from human platelets.

1987 • 330 citations

Different angiogenic pathways characterize superficial and invasive bladder cancer.

1995 • 293 citations

A far upstream estrogen response element of the ovalbumin gene contains several half-palindromic 5′-TGACC-3′ motifs acting synergistically

1992 • 290 citations

THE ENZYMATIC SYNTHESIS OF NUCLEOSIDES

1954 • 289 citations

Platelet-Derived Endothelial Cell Growth Factor in Human Colon Cancer Angiogenesis: Role of Infiltrating Cells

1996 • 245 citations

Protein histidine kinases and signal tranduction in prokaryotes and eukaryotes

1994 • 233 citations

Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity

1997 • 217 citations

Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer.

1993 • 209 citations

Modulation of Transcription Factor Sp1 by cAMP-dependent Protein Kinase

1997 • 209 citations

Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis

1998 • 207 citations

Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression

1997 • 202 citations

Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity

1992 • 198 citations

The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo.

1997 • 179 citations

Localization of two angiogenic growth factors (PDECGF and VEGF) in human placentae throughout gestation

1994 • 177 citations

Expression of platelet‐derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer

1995 • 164 citations

Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma

1996 • 159 citations

The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase is up-regulated in breast cancer epithelium and endothelium

1996 • 156 citations

Expression of the angiogenic factor thymidine phosphorylase/platelet-derived endothelial cell growth factor in primary bladder cancers.

1996 • 151 citations

Increased Expression of Vascular Permeability Factor (Vascular Endothelial Growth Factor) in Bullous Pemphigoid, Dermatitis Herpetiformis, and Erythema Multiforme

1995 • 148 citations

Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small-cell lung cancer

1997 • 140 citations

Association of ovarian Malignancy With Expression of Paltelet-Derived Endothelial Cell Growth Factor

1994 • 139 citations

Activation of 5'-deoxy-5-fluorouridine by thymidine phosphorylase in human tumors.

1983 • 133 citations

Kinetic studies of thymidine phosphorylase from mouse liver

1985 • 131 citations

Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase

1995 • 130 citations

Tamoxifen enhances cell death in implanted MCF7 breast cancer by inhibiting endothelium growth.

1994 • 121 citations

Expression of Thymidine Phosphorylase in Human Gastric Carcinoma

1996 • 104 citations

Catabolism of thymidine in human blood platelets purification and properties of thymidine phosphorylase

1981 • 100 citations

Thymidine transport in cultured mammalian cells. Kinetic analysis, temperature dependence and specificity of the transport system

1979 • 98 citations

Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution.

1990 • 90 citations

Substrate Specificity and Induction of Thymidine Phosphorylase in Escherichia coli

1964 • 83 citations

Identification and Comparative Analysis of Thymidine Phosphorylase in the Plasma of Healthy Subjects and Cancer Patients: Brief Communication 2

1977 • 81 citations

Glycogenolysis versus glucose transport in human granulocytes: differential activation in phagocytosis and chemotaxis

1982 • 76 citations

Combined analysis of vascular endothelial growth factor and platelet-derived endothelial cell growth factor expression in gastric carcinoma

1997 • 73 citations

Sensitivity of human KB cells expressing platelet-derived endothelial cell growth factor to pyrimidine antimetabolites.

1993 • 71 citations

Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factor.

1992 • 71 citations

Studies on the energy metabolism of pig red cells

1971 • 68 citations

The amino acid sequence of D-ribose-binding protein from Escherichia coli K12.

1983 • 65 citations

Anticancer strategies involving the vasculature: vascular targeting and the inhibition of angiogenesis.

1992 • 65 citations

Overexpression of the angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase in psoriatic epidermis

1997 • 63 citations

Organization and chromosomal localization of the human platelet-derived endothelial cell growth factor gene.

1991 • 59 citations

High-yield purification of platelet-derived endothelial cell growth factor: structural characterization and establishment of a specific antiserum

1989 • 53 citations

Aberrant production of gliostatin/platelet‐derived endothelial cell growth factor in rheumatoid synovium

1994 • 52 citations

The expression of thymidine phosphorylase and thrombomodulin in human colorectal carcinomas

1995 • 49 citations

A Novel Glial Growth Inhibitory Factor, Gliostatin, Derived from Neurofibroma

1992 • 49 citations

Enhancement of drug sensitivity and a bystander effect in PC-9 cells transfected with a platelet-derived endothelial cell growth factor thymidine phosphorylase cDNA

1997 • 48 citations

Regulation of angiogenesis

1997 • 46 citations

Localization of platelet-derived endothelial cell growth factor in human placenta and purification of an alternatively processed form.

1990 • 44 citations

Glucose-induced transmigration of monocytes is linked to phosphorylation of PECAM-1 in cultured endothelial cells

1996 • 42 citations

5-Ethoxy-2'-deoxyuridine, a novel substrate for thymidine phosphorylase, potentiates the antitumor activity of 5-fluorouracil when used in combination with interferon, an inducer of thymidine phosphorylase expression.

1995 • 39 citations

Purification and properties of thymidine phosphorylase from Salmonella typhimurium

1975 • 39 citations

Angiogenesis: Models, Modulators, and Clinical Applications

2013 • 39 citations

Morphological and cytogenetic studies of angiosarcoma in Stewart-Treves syndrome

1991 • 38 citations

Photoaffinity labeling of the human erythrocyte glucose transporter with 8-azidoadenosine.

1986 • 35 citations

Tissue distribution of human gliostatin/platelet-derived endothelial cell growth factor (PD-ECGF) and its drug-induced expression

1996 • 34 citations

Regulation of the Expression of the Angiogenic Enzyme Platelet-Derived Endothelial Cell Growth Factor/ Thymidine Phosphorylase in Endometrial Isolates by Ovarian Steroids and Cytokines*

1997 • 33 citations

Transcription and activity of 5-fluorouracil converting enzymes in fluoropyrimidine resistance in colon cancer in vitro

1997 • 32 citations

Co-determination of the angiogenic factors thymidine phosphorylase and vascular endothelial growth factor in node-negative breast cancer: prognostic implications.

1997 • 30 citations

Covalent linkage between nucleotides and platelet-derived endothelial cell growth factor.

1991 • 30 citations

Differential expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human lung carcinoma cell lines

1993 • 30 citations

Studies on the energy metabolism of pig red cells

1971 • 29 citations

The role of blood platelets in nucleoside metabolism: assay, cellular location and significance of thymidine phosphorylase in human blood

1988 • 27 citations

Purification of thymidine phosphorylase from human amniochorion

1978 • 24 citations

A rapid and simple radiometric assay for thymidine phosphorylase of human peripheral blood cells

1981 • 23 citations

Identification and characterization of a ribose transport system in Leishmania donovani promastigotes

1987 • 23 citations

High concentrations of immunoreactive gliostatin/platelet-derived endothelial cell growth factor in synovial fluid and serum of rheumatoid arthritis

1993 • 23 citations

Purification of thymidine phosphorylase from Escherichia coli and its photoinactivation in the presence of thymine, thymidine, and some halogenated analogs.

1975 • 22 citations

Platelet-derived Endothelial Cell Growth Factor: Structure and function.

1991 • 19 citations

Angiogenesis in the endometrium.

1998 • 19 citations

L-Fucose, D-Mannose, L-Galactose, and Their BSA Conjugates Stimulate Macrophage Migration

1987 • 19 citations

Organization and Chromosomal Localization of the Human Platelet- Derived Endothelial Cell Growth Factor Gene

1991 • 15 citations

Evidence for participation of gliostatin/ Platelet-derived endothelial cell growth factor in gastric ulcer healing

1997 • 13 citations

Elevated Thymidine Phosphorylase Activity in Psoriatic Lesions Accounts for the Apparent Presence of an Epidermal “Growth Inhibitor,” But Is Not in Itself Growth Inhibitory

1991 • 12 citations

Structural properties of 3.0 kb and 3.2 kb transcripts encoding platelet-derived endothelial cell growth factor/thymidine phosphorylase in A431 cells

1994 • 12 citations

Specific simple sugars promote chemotaxis and chemokinesis of corneal endothelial cells

1993 • 12 citations

Platelet-derived endothelial cell growth factor/thymidine phosphorylase immunohistochemical expression in lymphoid tissue and lymphoid malignancies

1997 • 11 citations

Cytotoxic and biochemical effects of thymidine and 3-deazauridine on human tumor cells.

1984 • 10 citations

Pyrimidine and purine activities in non-Hodgkin's lymphoma. Correlation with histological status and survival

1984 • 8 citations

Thymidine phosphorylase expression in Kaposi sarcoma.

1996 • 7 citations

Crystallization and X-ray Diffraction Study of Recombinant Platelet-derived Endothelial Cell Growth Factor

1993 • 6 citations

Exofacial regions of the glucose transporter of human erythrocytes: detection with polyclonal antibodies

1988 • 5 citations

Regulation of endothelial growth factor expressions in breast cancer.

1996 • 4 citations

Acyclothymidine Alleviates Intestinal Toxicity of 5'-Deoxy-5-fluorouridine without Loss of Antitumor Activity in Mice.

1996 • 1 citations