The role of blood platelets in nucleoside metabolism: assay, cellular location and significance of thymidine phosphorylase in human blood

Plasma and cerebrospinal fluid pharmacokinetics of 3′-azido-3′-deoxythymidine: A Novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases

1987 • 383 citations

Polypeptide Growth Factors: Roles In Normal And Abnormal Cell Growth

1987 • 339 citations

Haematologic manifestations of the human immune deficiency virus (HIV)

1987 • 335 citations

Permeation of Nucleosides, Nucleic Acid Bases, and Nucleotides in Animal Cells

1980 • 312 citations

THE ENZYMATIC SYNTHESIS OF NUCLEOSIDES

1954 • 289 citations

THE METABOLISM AND FATE OF TRITIATED THYMIDINE IN MAN *†

1960 • 233 citations

Identification and quantitation of nucleosides, bases and other UV-absorbing compounds in serum, using reversed-phase high-performance liquid chromatography

1979 • 192 citations

The pharmacology of the fluoropyrimidines.

1981 • 189 citations

Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets

1983 • 148 citations

Essential haematology

2004 • 143 citations

Identification and quantitation of nucleosides, bases and other UV-absorbing compounds in serum, using reversed-phase high-performance liquid chromatography

1979 • 140 citations

Thymidine concentrations in serum and urine of different animal species and man

1977 • 110 citations

Genetic and biochemical consequences of thymidylate stress

1982 • 101 citations

Catabolism of thymidine in human blood platelets purification and properties of thymidine phosphorylase

1981 • 100 citations

Adjustment of the osmolality of Percoll for the isopycnic separation of cells and cell organelles

1984 • 95 citations

The genetic consequences of nucleotide precursor pool imbalance in mammalian cells

1984 • 94 citations

Thymidine Catabolism by Normal and Leukemic Human Leukocytes*

1964 • 93 citations

5-Benzylacyclouridine and 5-benzyloxybenzylacyclouridine, potent inhibitors of uridine phosphorylase

1982 • 91 citations

The prevention of methotrexate toxicity by thymidine infusions in humans.

1977 • 91 citations

An overview of thymidine

1980 • 87 citations

A Review: Biological and Clinical Aspects of Pyrimidine Metabolism

1974 • 85 citations

Substrate Specificity and Induction of Thymidine Phosphorylase in Escherichia coli

1964 • 83 citations

From deoxynucleotides to DNA synthesis.

1978 • 82 citations

Identification and Comparative Analysis of Thymidine Phosphorylase in the Plasma of Healthy Subjects and Cancer Patients: Brief Communication 2

1977 • 81 citations

Nucleoside Phosphorylases

2006 • 80 citations

Role of thymidine in biochemical modulation: a review.

1987 • 79 citations

Genetic Consequences of Nucleotide Pool Imbalance

1986 • 65 citations

Prevention of doxorubicin myocardial toxicity in mice by reduced glutathione.

1986 • 63 citations

Deoxyribosyl Transfer

1964 • 55 citations

The enzymatic mechanisms for deoxythymidine synthesis in human leukocytes

1969 • 54 citations

Metabolic breakdown of [3H]thymidine and the inability to measure human lymphocyte proliferation by incorporation of radioactivity.

1986 • 52 citations

High-dose thymidine infusions in patients with leukemia and lymphoma.

1980 • 51 citations

Quantitative high-performance liquid chromatography of nucleosides and bases in human plasma

1980 • 49 citations

Cytoplasmic Uridine Phosphorylase of Rat Liver

1971 • 48 citations

A radioimmunoassay for measurement of serum thymidine

1973 • 48 citations

Pyrimidine metabolism in human leukocytes. I. Contribution of exogenous thymidine to DNA-thymine and its effect on thymine nucleotide synthesis in leukemic leukocytes.

1966 • 47 citations

High-performance liquid chromatographic profiling of nucleic acid components in physiological samples

1986 • 46 citations

Role of catabolism in pyrimidine utilization for nucleic acid synthesis in vivo.

1972 • 46 citations

The effect of bone cell stimulatory factors can be measured with thymidine incorporation only under specific conditions

1986 • 41 citations

Thymidine concentrations in human sera: Variations in patients with leukaemia and megaloblastic anaemia

1980 • 40 citations

What Ins Wrong With Fee Splitting?

1966 • 38 citations

Control of Nucleotide Pools in Mammalian Cells

2015 • 37 citations

Nucleotide Metabolism of Platelets

1985 • 36 citations

High‐dose intravenous and hepatic artery infusions of thymidine

1978 • 32 citations

Thymidine transport in phytohaemagglutinin-stimulated pig lymphocytes

1975 • 29 citations

Elevated Thymidine Phosphorylase Activity in the Plasma and Ascitic Fluids of Tumor-Bearing Animals

1978 • 28 citations

Altered excretion of modified nucleosides and beta-aminoisobutyric acid in subjects with acquired immunodeficiency syndrome or at risk for acquired immunodeficiency syndrome.

1986 • 25 citations

Molecular Mechanisms in Genetic Stability and Change: The Role of Deoxyribonucleotide Pool Balance

1985 • 25 citations

Radioimmunoassays of plasma thymidine, uridine, deoxyuridine, and cytidine/deoxycytidine

1981 • 22 citations

Catabolism of thymidine during the lymphocyte cell cycle

1977 • 20 citations

Isolation of a DNA polymerase alpha-associated regulatory protein from calf thymus.

1979 • 18 citations

Thymidine as a chemotherapeutic agent: sensitivity of normal human marrow, peripheral blood T cells, and acute nonlymphocytic leukemia

1980 • 17 citations

β-Aminoisobutyric acid as a marker of thymine catabolism in malignancy

1987 • 16 citations

Plasma and cerebrospinal fluid nucleosides and oxypurines in acute liver failure.

1987 • 15 citations

Depressed Phagocytic Function Exhibited by Polymorphonuclear Leucocytes from Chronically Iron Deficient Rabbits

1976 • 14 citations

The possible role of blood platelets in tumour growth and dissemination.

1986 • 13 citations

Catabolism of exogenously supplied thymidine to thymine and dihydrothymine by platelets in human peripheral blood.

1984 • 12 citations

Deoxyribosyl exchange reactions leading to the in vivo generation and regeneration of the antiviral agents (E)-5-(2-bromovinyl)-2′-deoxyuridine, 5-ethyl-2′-deoxyuridine and 5-(2-chloroethyl)-2′-deoxyuridine

1986 • 11 citations

Thymidylat-de novo-Synthese, salvage pathway und DNS-Synthese während der Differenzierung von Erythroblasten

1972 • 10 citations

Human Pyrimidine Metabolism

1966 • 8 citations

Detection of thymidine-phosphorylase in human blood platelets

1973 • 8 citations

Rapid and complete degradation of thymidine by human peripheral blood platelets: implications for genotoxicity assays

1986 • 6 citations

Nucleotide metabolism

2022 • 4 citations

Human pyrimidine metabolism

1966 • 3 citations

Venous thromboembolism and malignancy

1987 • 2 citations

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