Transcription and activity of 5-fluorouracil converting enzymes in fluoropyrimidine resistance in colon cancer in vitro

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The precision of ultraviolet absorption measurements in the Schmidt-Thannhauser procedure for nucleic acid estimation

1962 • 1,066 citations

Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA

1984 • 973 citations

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.

1995 • 668 citations

Metabolism and mechanism of action of 5-fluorouracil

1990 • 431 citations

The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer.

1994 • 416 citations

Human thymidine kinase gene: molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells.

1984 • 205 citations

Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules.

1992 • 195 citations

Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil.

1994 • 191 citations

Phase II study of hepatic arterial floxuridine, leucovorin, and dexamethasone for unresectable liver metastases from colorectal carcinoma.

1994 • 177 citations

Nucleotide sequence of a functional cDNA for human thymidylate synthase

1985 • 141 citations

Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors.

1992 • 121 citations

Improving the anti-tumor activity of 5-fluorouracil by increasing its incorporation into RNA via metabolic modulation.

1980 • 119 citations

Thymidine Phosphorylase Mediates the Sensitivity of Human Colon Carcinoma Cells to 5-Fluorouracil

1995 • 106 citations

Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-fluorouracil.

1994 • 94 citations

Metabolism of 5-fluorouracil in sensitive and resistant Novikoff hepatoma cells.

1977 • 73 citations

Molecular cloning and nucleotide sequence for the complete coding region of human UMP synthase.

1988 • 69 citations

Reduced Activity of Anabolizing Enzymes in 5‐Fluorouracil‐resistant Human Stomach Cancer Cells

1996 • 68 citations

Decreased folylpolyglutamate synthetase expression: a novel mechanism of fluorouracil resistance.

1993 • 63 citations

Effect of 5-fluorouracil combination therapy on RNA processing in human colonic carcinoma cells

1990 • 47 citations

Mechanisms of resistance to fluoropyrimidines.

1992 • 39 citations

Sequence analysis of the large and small subunits of human ribonucleotide reductase

1992 • 38 citations

Effect of 5-fluoro- and 5-bromouracil substitution on the translation of human thymidylate synthase mRNA.

1994 • 34 citations

Thymidylate synthase as a determinant of 5-fluoro-2'-deoxyuridine response in human colonic tumor cell lines.

1988 • 33 citations

Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluorouracil metabolism between human adenocarcinomas and squamous cell carcinomas

1990 • 32 citations

Comparison of 5-fluorouracil metabolism in two human gastrointestinal tumor cell lines.

1984 • 29 citations

Enzymes of salvage and de novo pathways of synthesis of pyrimidine nucleotides in human colorectal adenocarcinomas

1982 • 24 citations

Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin.

1992 • 24 citations

Comparative levels of tissue enzymes concerned in the early metabolism of 5-fluorouracil in normal and malignant human colorectal tissue

1984 • 20 citations

Loss of murine tumor thymidine kinase activity in vivo following 5-fluorouracil (FUra) treatment by incorporation of FUra into RNA

1991 • 20 citations

Cellular pharmacology of 5-fluorouracil in a human colon adenocarcinoma cell line selected for thymidine kinase deficiency

1990 • 14 citations

The potential for clinical application of in vitro assays predicting 5-FU sensitivity in man.

1981 • 10 citations

Expression of recombinant platelet‐derived endothelial cell growth factor in the yeast Saccharomyces cerevisiae

1992 • 7 citations

Effects of 5-fluorouracil on human colon carcinoma and solid rat Walker 256 carcinosarcoma: evaluation as in vitro predictors of clinical response.

1978 • 5 citations

Prediction of Clinical Response to 5-Fluorouracil-Containing Chemotherapy: Preliminary Results of in Vitro Assay in Human Breast Cancer

1980 • 1 citations