The Role of αv Integrins during Angiogenesis

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Angiogenic Factors

1987 • 3,702 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis

1992 • 2,130 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures.

1988 • 1,209 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Randomised trial of coronary intervention with antibody against platelet IIb/IIIa iritegrin for reduction of clinical restenosis: results at six months

1994 • 852 citations

Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging

1998 • 851 citations

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.

1995 • 840 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression.

1990 • 771 citations

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors.

1996 • 769 citations

Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro

1989 • 746 citations

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

1992 • 743 citations

Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins

1998 • 649 citations

Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.

1987 • 571 citations

Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption

1993 • 537 citations

Susceptibility to Infection and Altered Hematopoiesis in Mice Deficient in Both P- and E-Selectins

1996 • 534 citations

Angiogenesis promoted by vascular endothelial growth factor: Regulation through α₁β₁and α₂β₁ integrins

1997 • 516 citations

The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro.

1995 • 508 citations

Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells.

1994 • 504 citations

Identification of an Inhibitor of Neovascularization from Cartilage

1990 • 481 citations

Tumor-promoting phorbol esters induce angiogenesis in vitro

1985 • 470 citations

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

1989 • 462 citations

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.

1994 • 447 citations

Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases.

1996 • 443 citations

Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells.

1991 • 420 citations

Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis

1988 • 410 citations

A Link Between Cyclin A Expression and Adhesion-Dependent Cell Cycle Progression

1993 • 399 citations

Integrin αvβ3 Requirement for Sustained Mitogen-activated Protein Kinase Activity during Angiogenesis

1998 • 397 citations

Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Effects of tumour necrosis factor α, interleukin 1 and phorbol ester

1993 • 388 citations

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis.

1996 • 385 citations

Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor–type integrins inhibits retinal neovascularization

1996 • 336 citations

Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown.

1993 • 335 citations

Affinity of integrins for damaged extracellular matrix: αvβ3 binds to denatured collagen type I through RGD sites

1992 • 326 citations

Angiogenesis inhibition: A review

1994 • 324 citations

Decreased angiogenesis and arthritic disease in rabbits treated with an αvβ3 antagonist

1999 • 306 citations

An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization

1995 • 304 citations

Mechanisms of Angiogenesis

1987 • 304 citations

Inhibition of angiogenesis by tissue inhibitor of metalloproteinase

1994 • 299 citations

Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death

1984 • 285 citations

Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin.

1995 • 247 citations

Extracellular matrix and cell shape: Potential control points for inhibition of angiogenesis

1991 • 247 citations

ArgGlyAsp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts*1

1991 • 246 citations

Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen

1992 • 239 citations

Interstitial Collagenase Is Required for Angiogenesis in Vitro

1994 • 231 citations

Integrin and Arg-Gly-Asp Dependence of Cell Adhesion to the Native and Unfolded Triple Helix of Collagen Type VI

1993 • 212 citations

Blood Vessel Fibronectin Increases in Conjunction with Endothelial Cell Proliferation and Capillary Ingrowth During Wound Healing

1982 • 211 citations

Induction of the Angiogenic Phenotype by Hox D3

1997 • 208 citations

Echistatin is a potent inhibitor of bone resorption in culture.

1990 • 201 citations

Differential expression of extracellular proteins is correlated with angiogenesis in vitro.

1991 • 199 citations

Cell adhesion induces expression of growth-associated genes in suspension-arrested fibroblasts.

1988 • 174 citations

Platelet vitronectin receptor expression differentiates Iraqi-Jewish from Arab patients with Glanzmann thrombasthenia in Israel

1991 • 173 citations

Basic FGF and TGF-β differentially modulate integrin expression of human microvascular endothelial cells

1992 • 163 citations

Molecular framework for angiogenesis: a complex web of interactions between extravasated plasma proteins and endothelial cell proteins induced by angiogenic cytokines.

1996 • 157 citations

Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases.

1994 • 154 citations

Signaling by integrins: implications for tumorigenesis.

1993 • 150 citations

Basic Fibroblast Growth Factor Increases Expression of the αvβ3 Integrin Complex on Human Microvascular Endothelial Cells

1994 • 140 citations

Review: The Integrin α_vβ₃: Angiogenesis and Apoptosis

1995 • 134 citations

A Single Immunoglobulin-like Domain of the Human Neural Cell Adhesion Molecule L1 Supports Adhesion by Multiple Vascular and Platelet Integrins

1997 • 128 citations

Approaches to studying cell adhesion molecules in angiogenesis

1995 • 127 citations

The microvascular extracellular matrix. Developmental changes during angiogenesis in the aortic ring-plasma clot model.

1987 • 118 citations

A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy.

1998 • 106 citations

An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization

1995 • 104 citations

Human microvascular endothelial cells express integrin‐related complexes that mediate adhesion to the extracellular matrix

1989 • 93 citations

Adhesion is required for protein kinase C-dependent activation of the Na+/H+ antiporter by platelet-derived growth factor.

1992 • 87 citations

Astrocytes modulate retinal vasculogenesis: effects on fibronectin expression

1994 • 87 citations

Immunolocalization of integrins in the human retina.

1994 • 83 citations

Inhibitors of basement membrane collagen synthesis prevent endothelial cell alignment in matrigel in vitro and angiogenesis in vivo.

1994 • 81 citations

Tumor Angiogenesis and Polyamines: α-Difluoromethylornithine, an Irreversible Inhibitor of Ornithine Decarboxylase, Inhibits B16 Melanoma-induced Angiogenesis in Ovo and the Proliferation of Vascular Endothelial Cells in Vitro

1990 • 80 citations

Confocal Microscopic Analysis of Integrin Expression on the Microvasculature and its Sprouts in the Neonatal Foreskin

1994 • 75 citations

Integrins: Structure, Function, and Biological Properties

1993 • 58 citations

A second case of variant of Glanzmann's thrombasthenia due to substitution of platelet GPIII (integrinβ₃) Arg214 by Trp

1993 • 27 citations

Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro.

1990 • 23 citations