Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors.

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function

1995 • 900 citations

Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

1994 • 660 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization.

1989 • 627 citations

Integrin transmembrane signaling and cytoskeletal control

1995 • 616 citations

Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein.

1991 • 578 citations

Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information

1992 • 532 citations

Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex.

1995 • 503 citations

Regulation of signal transduction and signal diversity by receptor oligomerization

1994 • 485 citations

The Molecular Architecture of Focal Adhesions

1995 • 479 citations

Diversity in function and regulation of MAP kinase pathways

1994 • 469 citations

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.

1996 • 453 citations

Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling

1993 • 447 citations

Oligomerization of epidermal growth factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy. A stereochemical model for tyrosine kinase receptor activation.

1995 • 432 citations

Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation.

1995 • 415 citations

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases.

1995 • 410 citations

Sequential protein kinase reactions controlling cell growth and differentiation

1994 • 342 citations

Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown.

1993 • 335 citations

Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins

1996 • 305 citations

Regulation of fibronectin receptor distribution [published erratum appears in J Cell Biol 1992 Jul;118(2):491]

1992 • 295 citations

Tyrosine Phosphorylation of p130Cas and Cortactin Accompanies Integrin-mediated Cell Adhesion to Extracellular Matrix

1995 • 289 citations

Matrix/Integrin Interaction Activates the Mitogen-activated Protein Kinase, p44erk-1 and p42erk-2

1995 • 274 citations

Signal transduction through integrins: A central role for focal adhesion kinase?

1995 • 273 citations

Transmembrane molecular assemblies in cell-extracellular matrix interactions

1991 • 244 citations

Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium.

1993 • 242 citations

Signal transduction by cell adhesion receptors

1995 • 239 citations

Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1.

1996 • 227 citations

Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors.

1996 • 211 citations

Proteins associated with with cytoplasmic surface of adhesion molecules

1993 • 204 citations

Integrin alpha subunit ratios, cytoplasmic domains, and growth factor synergy regulate muscle proliferation and differentiation.

1996 • 195 citations

Control of Integrin Expression by Extracellular Matrix

1995 • 190 citations

Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals.

1993 • 179 citations

Integrin-dependent signal transduction

1996 • 148 citations

Integrin Signaling and Matrix Assembly

1996 • 144 citations

Molecular Interactions in the Submembrane Plaque of Cell-Cell and Cell-Matrix Adhesions

1995 • 125 citations

Signal transduction through chondrocyte integrin receptors induces matrix metalloproteinase synthesis and synergizes with interleukin‐1

1995 • 119 citations

The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes.

1994 • 117 citations

Mitogen-Activated Protein Kinase Activation Is Insufficient for Growth Factor Receptor-Mediated PC12 Cell Differentiation

1995 • 107 citations

Alpha v integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion

1994 • 105 citations

Regulation of rat mammary gene expression by extracellular matrix components

1987 • 104 citations

The epidermal growth factor receptor is associated with actin filaments

1992 • 101 citations

Adhesion is required for protein kinase C-dependent activation of the Na+/H+ antiporter by platelet-derived growth factor.

1992 • 87 citations

Signaling, mitogenesis and the cytoskeleton: Where the action is

1995 • 76 citations

Constitutive Phosphorylation of eps8 in Tumor Cell Lines: Relevance to Malignant Transformation

1995 • 75 citations

Integrin regulation of an inflammatory effector gene. Direct induction of the tissue factor promoter by engagement of beta 1 or alpha 4 integrin chains.

1995 • 70 citations

Beta 1 integrin-mediated interaction with extracellular matrix proteins regulates cytokine gene expression in synovial fluid cells of rheumatoid arthritis patients.

1993 • 55 citations

Characterization of the epidermal growth factor receptor associated with cytoskeletons of A431 cells

1989 • 48 citations

Evidence for the potentiation of epidermal growth factor receptor tyrosine kinase activity by association with the detergent-insoluble cellular cytoskeleton: analysis of intact and carboxy-terminally truncated receptors.

1993 • 38 citations

Cell shape and increased free cytosolic calcium [Ca2+]i induced by growth factors

1990 • 34 citations

Regulation of signal transduction

1995 • 24 citations

Adhesion and direct integrin engagement differentially regulate gene transcription, transcript stabilization and translation

1995 • 19 citations