The Nck family of adapter proteins

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

SH3 domains: complexity in moderation

2001 • 778 citations

PAK Kinases Are Directly Coupled to the PIX Family of Nucleotide Exchange Factors

1998 • 745 citations

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

1998 • 696 citations

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.

1996 • 667 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

Wiskott-Aldrich Syndrome Protein-Deficient Mice Reveal a Role for WASP in T but Not B Cell Activation

1998 • 494 citations

Paxillin LD4 Motif Binds PAK and PIX through a Novel 95-kD Ankyrin Repeat, ARF–GAP Protein: A Role in Cytoskeletal Remodeling

1999 • 466 citations

SH2/SH3 signaling proteins

1994 • 457 citations

The Vascular Endothelial Growth Factor Receptor KDR Activates Multiple Signal Transduction Pathways in Porcine Aortic Endothelial Cells

1997 • 436 citations

Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling

1999 • 407 citations

Nck and Phosphatidylinositol 4,5-Bisphosphate Synergistically Activate Actin Polymerization through the N-WASP-Arp2/3 Pathway

2001 • 400 citations

Identification of a Mouse p21Cdc42/Rac Activated Kinase

1995 • 395 citations

PAK to the future

1999 • 391 citations

Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product.

1994 • 390 citations

p62 : A Constitutively Tyrosine-Phosphorylated, GAP-Associated Protein in Chronic Myelogenous Leukemia Progenitor Cells

1997 • 371 citations

Identification of the Abl- and rasGAP-Associated 62 kDa Protein as a Docking Protein, Dok

1997 • 350 citations

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

1993 • 319 citations

Trio Combines with Dock to Regulate Pak Activity during Photoreceptor Axon Pathfinding in Drosophila

2000 • 315 citations

Wiskott-Aldrich Syndrome Protein Physically Associates with Nck through Src Homology 3 Domains

1995 • 315 citations

Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites.

1994 • 313 citations

A Novel Regulator of p21-activated Kinases

1998 • 313 citations

Interaction of the Nck Adapter Protein with p21-activated Kinase (PAK1)

1996 • 309 citations

The LIM-Only Protein PINCH Directly Interacts with Integrin-Linked Kinase and Is Recruited to Integrin-Rich Sites in Spreading Cells

1999 • 300 citations

Fyn-Binding Protein (Fyb)/Slp-76–Associated Protein (Slap), Ena/Vasodilator-Stimulated Phosphoprotein (Vasp) Proteins and the Arp2/3 Complex Link T Cell Receptor (Tcr) Signaling to the Actin Cytoskeleton

2000 • 294 citations

Pak Functions Downstream of Dock to Regulate Photoreceptor Axon Guidance in Drosophila

1999 • 289 citations

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

1997 • 276 citations

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

1996 • 268 citations

Regulation of PAK Activation and the T Cell Cytoskeleton by the Linker Protein SLP-76

1998 • 268 citations

Signaling to Actin Dynamics

1999 • 260 citations

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck

1997 • 259 citations

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

1997 • 257 citations

Drosophila Photoreceptor Axon Guidance and Targeting Requires the Dreadlocks SH2/SH3 Adapter Protein

1996 • 248 citations

The Mechanism of PAK Activation

2001 • 243 citations

Differential Inhibition of Signaling Pathways by Dominant-Negative SH2/SH3 Adapter Proteins

1995 • 233 citations

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

1990 • 209 citations

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.

1993 • 207 citations

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.

1993 • 189 citations

Nck-2, a Novel Src Homology2/3-containing Adaptor Protein That Interacts with the LIM-only Protein PINCH and Components of Growth Factor Receptor Kinase-signaling Pathways

1998 • 188 citations

Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of Immunoreceptor Signaling

2000 • 186 citations

TNIK, a Novel Member of the Germinal Center Kinase Family That Activates the c-Jun N-terminal Kinase Pathway and Regulates the Cytoskeleton

1999 • 177 citations

Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation

2001 • 175 citations

The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors.

1992 • 174 citations

How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures

2000 • 174 citations

Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes.

1996 • 165 citations

Signaling by the Germinal Center Kinase Family of Protein Kinases

1999 • 156 citations

Nck Recruitment to Eph Receptor, EphB1/ELK, Couples Ligand Activation to c-Jun Kinase

1998 • 151 citations

The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R

1998 • 150 citations

Interaction between PAK and Nck: a Template for Nck Targets and Role of PAK Autophosphorylation

2000 • 149 citations

Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene

1994 • 148 citations

Isolation of a NCK-associated Kinase, PRK2, an SH3-binding Protein and Potential Effector of Rho Protein Signaling

1996 • 141 citations

The Wiskott-Aldrich Syndrome Protein-interacting Protein (WIP) Binds to the Adaptor Protein Nck

1998 • 139 citations

Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways.

1996 • 136 citations

Nck-Interacting Ste20 Kinase Couples Eph Receptors to c-Jun N-Terminal Kinase and Integrin Activation

2000 • 132 citations

The Tyrosine Kinase ACK1 Associates with Clathrin-coated Vesicles through a Binding Motif Shared by Arrestin and Other Adaptors

2001 • 126 citations

A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK

1998 • 124 citations

Tyrosine phosphorylation of p62Dok induced by cell adhesion and insulin: possible role in cell migration

1999 • 121 citations

Integrin-linked kinase and PINCH: partners in regulation of cell-extracellular matrix interaction and signal transduction

1999 • 115 citations

Identification of Vascular Endothelial Growth Factor Receptor-1 Tyrosine Phosphorylation Sites and Binding of SH2 Domain-containing Molecules

1998 • 112 citations

αPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase

1999 • 105 citations

A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT

2001 • 105 citations

Characterization of a Novel Member of the DOK Family That Binds and Modulates Abl Signaling

1999 • 102 citations

SH3 Binding Domains in the Dopamine D4 Receptor

1998 • 100 citations

Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes

1999 • 98 citations

Enhanced Phosphatidylinositol 3-Kinase Activity and High Phosphorylation State of Its Downstream Signalling Molecules Mediated by Ret with the MEN 2B Mutation

1999 • 96 citations

Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation

1999 • 96 citations

Binding of NCK to SOS and Activation of ras-Dependent Gene Expression

1995 • 94 citations

Phosphorylation of Nek in Response to a Variety of Receptors, Phorbol Myristate Acetate, and Cyclic AMP

1992 • 94 citations

Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK)

2001 • 91 citations

Nckβ Adapter Regulates Actin Polymerization in NIH 3T3 Fibroblasts in Response to Platelet-Derived Growth Factor bb

2000 • 89 citations

The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment.

1992 • 88 citations

Identification of Nck Family Genes, Chromosomal Localization, Expression, and Signaling Specificity

1998 • 86 citations

The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels.

1992 • 85 citations

A New LIM Protein Containing an Autoepitope Homologous to "Senescent Cell Antigen"

1994 • 85 citations

The Drosophila HEM-2/NAP1 homolog KETTE controls axonal pathfinding and cytoskeletal organization

2000 • 83 citations

Mechanism of activation of Pak1 kinase by membrane localization

1999 • 82 citations

A Single Point Mutation Switches the Specificity of Group III Src Homology (SH) 2 Domains to That of Group I SH2 Domains

1995 • 81 citations

Identification and Characterization of a New Family of Guanine Nucleotide Exchange Factors for the Ras-related GTPase Ral

2000 • 77 citations

The SH2/SH3 Adaptor Protein Dock Interacts with the Ste20-like Kinase Misshapen in Controlling Growth Cone Motility

1999 • 75 citations

A Novel Ligand for an SH3 Domain of the Adaptor Protein Nck Bears an SH2 Domain and Nuclear Signaling Motifs

1997 • 74 citations

The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck

1997 • 73 citations

Involvement of Hematopoietic Progenitor Kinase 1 in T Cell Receptor Signaling

2001 • 72 citations

p56dok-2 as a cytokine-inducible inhibitor of cell proliferation and signal transduction

2000 • 71 citations

The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins

1998 • 68 citations

Identification of Grb4/Nckβ, a Src Homology 2 and 3 Domain-containing Adapter Protein Having Similar Binding and Biological Properties to Nck

1999 • 67 citations

The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68

1997 • 67 citations

Vav binds to several SH2/SH3 containing proteins in activated lymphocytes.

1994 • 65 citations

Molecular Cloning of p125Nap1, a Protein That Associates with an SH3 Domain of Nck

1996 • 64 citations

Tyrosine 1213 of Flt-1 Is a Major Binding Site of Nck and SHP-2

1998 • 64 citations

A Casein Kinase I Activity Is Constitutively Associated with Nck

1997 • 62 citations

Independent SH2-binding Sites Mediate Interaction of Dok-related Protein with RasGTPase-activating Protein and Nck

1999 • 60 citations

Interaction of Paxillin with p21-activated Kinase (PAK)

2001 • 59 citations

Molecular Cloning of a Novel Apoptosis-Related Gene, Human Nap1 (NCKAP1), and Its Possible Relation to Alzheimer Disease

2000 • 58 citations

R-Ras Contains a Proline-rich Site That Binds to SH3 Domains and Is Required for Integrin Activation by R-Ras

2000 • 56 citations

Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP.

1992 • 55 citations

Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac

1997 • 52 citations

SPIN90 (SH3 ProteinInteracting with Nck, 90 kDa), an Adaptor Protein That Is Developmentally Regulated during Cardiac Myocyte Differentiation

2001 • 52 citations

The Ste20 Kinase Misshapen Regulates Both Photoreceptor Axon Targeting and Dorsal Closure, Acting Downstream of Distinct Signals

2000 • 52 citations

Interaction of Insulin Receptor Substrate 3 with Insulin Receptor, Insulin Receptor-related Receptor, Insulin-like Growth Factor-1 Receptor, and Downstream Signaling Proteins

1999 • 47 citations

Activation of the Abl Tyrosine Kinase in Vivo by Src Homology 3 Domains from the Src Homology 2/Src Homology 3 Adaptor Nck

1999 • 47 citations

Identification and kinetic analysis of the interaction between Nck‐2 and DOCK180

2001 • 45 citations

A Novel Ligand for SH3 Domains

1995 • 43 citations

Requirement of multiple SH3 domains of Nck for ligand binding

1999 • 43 citations

Interactions between Src Homology (SH) 2/SH3 Adapter Proteins and the Guanylnucleotide Exchange Factor SOS Are Differentially Regulated by Insulin and Epidermal Growth Factor

1996 • 42 citations

Dominant-negative mutants of the SH2/SH3 adapters Nck and Grb2 inhibit MAP kinase activation and mesoderm-specific gene induction by eFGF in Xenopus

1998 • 41 citations

Characterization of Interactions of Nck with Sos and Dynamin

1999 • 41 citations

Cell Adhesion Regulates the Interaction between Nck and p21-activated Kinase

2001 • 37 citations

Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease

2001 • 35 citations

Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor

1997 • 33 citations

Inhibition of the Motility and Growth of B16F10 Mouse Melanoma Cells by Dominant Negative Mutants of Dok-1

2001 • 31 citations

MEK Kinase 2 Binds and Activates Protein Kinase C-related Kinase 2

2000 • 30 citations

Hepatocyte growth factor induces activation of Nck and phospholipase C-γ in lung carcinoma cells

1996 • 29 citations

Nck inhibits NGF and basic FGF induced PC12 cell differentiation via mitogen-activated protein kinase-independent pathway.

1996 • 29 citations

Chromosome Locations of Genes Encoding Human Signal Transduction Adapter Proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2)

1994 • 28 citations

Characterization of Grb4, an adapter protein interacting with Bcr-Abl

2000 • 27 citations

Localization of human ARF2 and NCK genes and 13 other <i>Not</i>l-linking clones to chromosome 3 by fluorescence in situ hybridization

1995 • 21 citations

Src homology 3 domain-dependent interaction of Nck-2 with insulin receptor substrate-1

2001 • 18 citations

Prediction and analysis of SH2 domain-phosphopeptide interactions

1995 • 14 citations

Src homology 3 domain-dependent interaction of Nck-2 with insulin receptor substrate-1

2001 • 13 citations