Signaling to Actin Dynamics

The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments

1998 • 1,388 citations

The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly

1999 • 1,332 citations

Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in Lamellipodia

1999 • 1,150 citations

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

1994 • 1,053 citations

Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

1998 • 933 citations

Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization

1996 • 873 citations

Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex

1999 • 771 citations

Analysis of the Actin–Myosin II System in Fish Epidermal Keratocytes: Mechanism of Cell Body Translocation

1997 • 700 citations

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

1998 • 696 citations

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.

1996 • 667 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

1998 • 656 citations

A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases

1995 • 625 citations

Actin polymerization is induced by Arp 2/3 protein complex at the surface of Listeria monocytogenes

1997 • 598 citations

The Human Arp2/3 Complex Is Composed of Evolutionarily Conserved Subunits and Is Localized to Cellular Regions of Dynamic Actin Filament Assembly

1997 • 504 citations

Interaction of Human Arp2/3 Complex and the Listeria monocytogenes ActA Protein in Actin Filament Nucleation

1998 • 500 citations

Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose.

1994 • 484 citations

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin

1995 • 437 citations

Mena Is Required for Neurulation and Commissure Formation

1999 • 415 citations

Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides.

1996 • 410 citations

Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott–Aldrich syndrome

1996 • 397 citations

WIP, a protein associated with Wiskott–Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

1997 • 376 citations

Role of Proteins of the Ena/VASP Family in Actin-based Motility of Listeria monocytogenes

1999 • 356 citations

The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function

1999 • 347 citations

SCAR, a WASP-related Protein, Isolated as a Suppressor of Receptor Defects in Late Dictyostelium Development

1998 • 268 citations

Gelsolin is a downstream effector of rac for fibroblast motility

1998 • 267 citations

The Wiskott–Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex

1999 • 263 citations

enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties.

1995 • 256 citations

Structure of the Enabled/VASP Homology 1 Domain–Peptide Complex

1999 • 241 citations

The essential role of profilin in the assembly of actin for microspike formation

1998 • 237 citations

Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein

1999 • 231 citations

Structure, Subunit Topology, and Actin-binding Activity of the Arp2/3 Complex from Acanthamoeba

1997 • 224 citations

Corequirement of Specific Phosphoinositides and Small GTP-binding Protein Cdc42 in Inducing Actin Assembly in Xenopus Egg Extracts

1998 • 219 citations

Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins

1997 • 212 citations

Relationship between Arp2/3 Complex and the Barbed Ends of Actin Filaments at the Leading Edge of Carcinoma Cells after Epidermal Growth Factor Stimulation

1999 • 199 citations

The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42

1998 • 188 citations

Visualization and Molecular Analysis of Actin Assembly in Living Cells

1998 • 175 citations

Capping protein levels influence actin assembly and cell motility in dictyostelium

1995 • 171 citations

Purification of a vasodilator‐regulated phosphoprotein from human platelets

1989 • 160 citations

Regulation of Actin Polymerization in Cell-free Systems by GTPγS and Cdc42

1997 • 160 citations

Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein.

1996 • 144 citations

Direct Binding of the Verprolin-Homology Domain in N-WASP to Actin Is Essential for Cytoskeletal Reorganization

1998 • 141 citations

The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes

1999 • 114 citations

How ADF/cofilin depolymerizes actin filaments

1998 • 108 citations

Regulation of CapZ, an actin capping protein of chicken muscle, by anionic phospholipids

1991 • 104 citations

Gelsolin and functionally similar actin-binding proteins are regulated by lysophosphatidic acid

1998 • 98 citations

Control of Actin Filament Length and Turnover by Actin Depolymerizing Factor (ADF/Cofilin) in the Presence of Capping Proteins and ARP2/3 Complex

1999 • 72 citations

Rho-family GTPases require the Arp2/3 complex to stimulate actin polymerizationin Acanthamoeba extracts

1999 • 71 citations

Capping Protein Terminates but Does Not Initiate Chemoattractant-induced Actin Assembly in Dictyostelium

1997 • 59 citations

Waltzing with WASP

1999 • 57 citations

F-Actin capping by cap3234 requires heterodimeric conformation and can be inhibited with PIP2

1991 • 51 citations

Cdc42 is required for membrane dependent actin polymerization in vitro

1998 • 44 citations

High concentrations of phosphatidylinositol-4,5-bisphosphate may promote actin filament growth by three potential mechanisms: Inhibiting capping by neutrophil lysates, severing actin filaments and removing capping protein-β2 from barbed ends1This work was supported by Cooper Faculty Grant SPF 2821-94.1

1997 • 23 citations