The role of the p53 and Rb-1 genes in cancer, development and apoptosis

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

p53 function and dysfunction

1992 • 1,918 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

The international incidence of childhood cancer

1988 • 984 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Antioncogenes and human cancer.

1993 • 772 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

1994 • 564 citations

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

1993 • 476 citations

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.

1993 • 471 citations

Vision and Visual Dysfunction

1992 • 463 citations

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

1992 • 381 citations

Cell cycle-specific association of E2F with the p130 E1A-binding protein.

1993 • 348 citations

Enhanced proliferative potential in culture of cells from p53-deficient mice.

1993 • 341 citations

The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.

1993 • 341 citations

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.

1990 • 327 citations

Negative regulation of human c-fos expression by thes retinoblastoma gene product

1990 • 298 citations

Apoptosis and cancer chemotherapy

2001 • 296 citations

Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene.

1994 • 295 citations

Genetic background alters the spectrum of tumors that develop in p53‐deficient mice

1993 • 284 citations

A Comprehensive Study of the Radiobiological Response of the Murine (BDF1) Small Intestine

1990 • 268 citations

p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation.

1994 • 264 citations

Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein.

1989 • 248 citations

Retinoblastoma in transgenic mice

1990 • 246 citations

Retinoma: Spontaneous regression of retinoblastoma or benign manifestation of the mutation?

1982 • 226 citations

Cell proliferation, DNA repair, and p53 function are not required for programmed death of prostatic glandular cells induced by androgen ablation.

1993 • 201 citations

International incidence of childhood cancer

1989 • 166 citations

Retinocytoma

1983 • 131 citations

The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.

1993 • 108 citations

Retinoblastoma protein and the cell cycle

1993 • 91 citations

Cell type and differentiation dependent heterogeneity in retinoblastoma protein expression in SCID mouse fetuses.

1992 • 76 citations

Embryonal Stem Cells: Introducing Planned Changes into the Animal Germline

1992 • 37 citations

Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells

1993 • 34 citations