Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Nitric oxide synthases in mammals

1994 • 2,762 citations

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

1994 • 2,216 citations

Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors

1998 • 1,475 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Inducible nitric oxide synthase: what difference does it make?

1997 • 964 citations

Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy

1995 • 954 citations

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

1994 • 840 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure

1999 • 791 citations

Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages

1997 • 680 citations

The role of neutrophils in myocardial ischemia–reperfusion injury

1999 • 642 citations

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

1992 • 623 citations

Expression of Inducible Nitric Oxide Synthase in Human Heart Failure

1996 • 496 citations

Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro.

1994 • 436 citations

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.

1994 • 409 citations

HISTOCHEMICAL METHODS FOR SEPARATE, CONSECUTIVE AND SIMULTANEOUS DEMONSTRATION OF ACETYLCHOLINESTERASE AND NOREPINEPHRINE IN CRYOSTAT SECTIONS

1967 • 400 citations

Nitric oxide synthase activities in human myocardium

1993 • 358 citations

Conduction Disturbances and Increased Atrial Vulnerability in Connexin40-Deficient Mice Analyzed by Transesophageal Stimulation

1999 • 301 citations

Inducible nitric oxide synthase gene expression in the brain during systemic inflammation

1996 • 287 citations

Role of nitric oxide in obesity-induced beta cell disease.

1997 • 287 citations

Induction of Nitric Oxide Synthase in the Human Cardiac Allograft Is Associated With Contractile Dysfunction of the Left Ventricle

1996 • 155 citations

Conditional Transgene Expression in the Heart

1996 • 155 citations

Decreased Myocardial nNOS, Increased iNOS and Abnormal ECGs in Mouse Models of Duchenne Muscular Dystrophy

1999 • 150 citations

Cardiac-Specific Overexpression of Inducible Nitric Oxide Synthase Does Not Result in Severe Cardiac Dysfunction

2002 • 142 citations

Complete heart block and sudden death in mice overexpressing calreticulin

2001 • 137 citations

A Novel Genetic Pathway for Sudden Cardiac Death via Defects in the Transition between Ventricular and Conduction System Cell Lineages

2000 • 133 citations

Superoxide dismutase reduces reperfusion arrhythmias but fails to salvage regional function or myocardium at risk in conscious dogs.

1989 • 129 citations

Nitric oxide and inflammatory bowel diseases

1998 • 126 citations

Effects of Nitric Oxide Synthase Inhibition on Basal Function and the Force-Frequency Relationship in the Normal and Failing Human Heart In Vivo

2001 • 106 citations

Attenuated Acute Cardiac Rejection in NOS2 −/− Recipients Correlates With Reduced Apoptosis

1999 • 96 citations

Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice

2001 • 95 citations

Verapamil ameliorates the clinical and pathological course of murine myocarditis.

1992 • 88 citations

Nitric Oxide in Cardiovascular Diseases

1995 • 65 citations

Targeting of Transgene Expression to the Vascular Endothelium of Mice by Homologous Recombination at the Thrombomodulin Locus

1996 • 52 citations

NOS2 Mediates Opposing Effects in Models of Acute and Chronic Cardiac Rejection

1998 • 52 citations

S-Methylisothiourea Inhibits Inducible Nitric Oxide Synthase and Improves Left Ventricular Performance after Acute Myocardial Infarction

1996 • 41 citations

Exacerbation of reperfusion arrhythmias by sudden oxidant stress.

1990 • 32 citations