Cardiac-Specific Overexpression of Inducible Nitric Oxide Synthase Does Not Result in Severe Cardiac Dysfunction

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Methods of Enzymatic Analysis

1975 • 20,446 citations

Automatic Recording Apparatus for Use in Chromatography of Amino Acids

1958 • 9,612 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart

1996 • 993 citations

Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine.

1993 • 832 citations

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

1992 • 616 citations

New insights into the regulation of inducible nitric oxide synthesis

1994 • 582 citations

Expression of Inducible Nitric Oxide Synthase in Human Heart Failure

1996 • 496 citations

Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

1991 • 479 citations

Myoglobin: A scavenger of bioactive NO

2001 • 419 citations

Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme.

1993 • 391 citations

Negative feedback regulation of endothelial cell function by nitric oxide.

1993 • 371 citations

Nitric oxide synthase activities in human myocardium

1993 • 358 citations

Isolation and characterization of the mouse cardiac myosin heavy chain genes

1991 • 331 citations

Increased Inducible Nitric Oxide Synthase Expression Contributes to Myocardial Dysfunction and Higher Mortality After Myocardial Infarction in Mice

2001 • 291 citations

Coronary Hemodynamics in Endothelial NO Synthase Knockout Mice

1998 • 265 citations

Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters.

2000 • 228 citations

Coinduction of nitric oxide synthase and argininosuccinate synthetase in a murine macrophage cell line. Implications for regulation of nitric oxide production.

1994 • 216 citations

Cytokines and Insulin Induce Cationic Amino Acid Transporter (CAT) Expression in Cardiac Myocytes

1996 • 178 citations

Expression, activity and functional significance of inducible nitric oxide synthase in the failing human heart

1998 • 177 citations

Increased Sensitivity to Nitric Oxide Synthase Inhibition in Patients With Heart Failure

1998 • 167 citations

Endomyocardial Nitric Oxide Synthase and Left Ventricular Preload Reserve in Dilated Cardiomyopathy

1999 • 160 citations

Role of Endothelium-Derived Nitric Oxide in the Regulation of Cardiac Oxygen Metabolism

2000 • 160 citations

Mice Lacking Inducible Nitric Oxide Synthase Have Improved Left Ventricular Contractile Function and Reduced Apoptotic Cell Death Late After Myocardial Infarction

2001 • 159 citations

Induction of Nitric Oxide Synthase in the Human Cardiac Allograft Is Associated With Contractile Dysfunction of the Left Ventricle

1996 • 155 citations

Transgenic Mice Overexpressing Type 2 Nitric-oxide Synthase in Pancreatic β Cells Develop Insulin-dependent Diabetes without Insulitis

1998 • 145 citations

Subcellular localization and characterization of nitric oxide synthase(s) in endothelial cells: physiological implications

1994 • 133 citations

NO and cardiac diastolic function

1999 • 129 citations

Chronic <scp>l</scp> -Arginine Administration Attenuates Cardiac Hypertrophy in Spontaneously Hypertensive Rats

1996 • 118 citations

Nicotinamide-Adenine Dinucleotides (NAD, NADP, NADH, NADPH)

1974 • 113 citations

Nitric Oxide Modulates Mitochondrial Respiration in Failing Human Heart

1999 • 106 citations

Myocardial calcium-independent nitric oxide synthase activity is present in dilated cardiomyopathy, myocarditis, and postpartum cardiomyopathy but not in ischaemic or valvar heart disease.

1995 • 98 citations

Heterogeneous Basal Expression of Nitric Oxide Synthase and Superoxide Dismutase Isoforms in Mammalian Heart

1999 • 83 citations

Nitric oxide induced contractile dysfunction is related to a reduction in myocardial energy generation

1997 • 81 citations

Tumor Necrosis Factorα(TNFα) is Cardiodepressant in Pathophysiologically Relevant Concentrations Without Inducing Inducible Nitric Oxide-(NO)-Synthase (iNOS) or Triggering Serious Cytotoxicity

1997 • 74 citations

Discrimination between citrulline and arginine transport in activated murine macrophages: inefficient synthesis of NO from recycling of citrulline to arginine

1994 • 67 citations

L‐arginine infusion has no effect on systemic haemodynamics in normal volunteers, or systemic and pulmonary haemodynamics in patients with elevated pulmonary vascular resistance.

1993 • 64 citations

Isolation and characterization of argininosuccinate synthetase from human liver

1979 • 53 citations

TNF-α enhances cardiac myocyte NO production through MAP kinase-mediated NF-κB activation

1999 • 47 citations

Left Ventricular Contractile Effects of Inducible Nitric Oxide Synthase in the Human Allograft

1997 • 45 citations

Nitric oxide and the pathogenesis of heart muscle disease

1995 • 30 citations

In Vivo Definition of a Cardiac Specific Promoter and Its Potential Utility in Remodeling the Heart

1995 • 24 citations

Effects of cytokines and nitric oxide on myocardial E-C coupling

1998 • 21 citations

Inhibition of nitric oxide synthase activity in cerebral cortical synaptosomes by nitric oxide donors: Evidence for feedback autoregulation

1995 • 19 citations