Conditional Transgene Expression in the Heart

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

MyoD or Myf-5 is required for the formation of skeletal muscle

1993 • 1,663 citations

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

1993 • 1,314 citations

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development

1992 • 973 citations

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

1994 • 777 citations

Enhanced Myocardial Function in Transgenic Mice Overexpressing the β ₂ -Adrenergic Receptor

1994 • 745 citations

Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death

1992 • 700 citations

Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

1991 • 479 citations

The MyoD family of transcription factors and skeletal myogenesis

1995 • 441 citations

Modulation of firefly luciferase stability and impact on studies of gene regulation

1991 • 437 citations

Rescue of the En-1 Mutant Phenotype by Replacement of En-1 with En-2

1995 • 402 citations

Ventricular Expression of a MLC-2v-ras Fusion Gene Induces Cardiac Hypertrophy and Selective Diastolic Dysfunction in Transgenic Mice

1995 • 314 citations

Position effect variegation and chromatin proteins

1992 • 311 citations

Myogenin is required for late but not early aspects of myogenesis during mouse development.

1995 • 292 citations

Atrial Natriuretic Factor-SV40 T Antigen Transgenes Produce Tumors and Cardiac Arrhythmias in Mice

1988 • 275 citations

Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene.

1995 • 259 citations

Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart.

1991 • 228 citations

Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements.

1991 • 192 citations

Molecular and physiological alterations in murine ventricular dysfunction.

1994 • 160 citations

Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin

1996 • 157 citations

Alpha-skeletal actin is associated with increased contractility in the mouse heart.

1994 • 128 citations

Comparison of normal, hypodynamic, and hyperdynamic mouse hearts using isolated work-performing heart preparations

1993 • 117 citations

A chimeric mammalian transactivator based on the lac repressor that is regulated by temperature and isopropyl beta-D-thiogalactopyranoside.

1991 • 98 citations

Tetracycline-regulated cardiac gene expression in vivo.

1994 • 90 citations

Regulated expression of foreign genes in vivo after germline transfer.

1994 • 86 citations

Length dependence of Ca2+ sensitivity of tension in mouse cardiac myocytes expressing skeletal troponin C.

1995 • 77 citations

The mouse as a model for human cardiovascular disease and hyperlipidemia

1994 • 71 citations

Molecular Advances in Cardiovascular Biology

1993 • 71 citations

Regulation of Mouse Mammary Tumor Virus Gene Expression by Glucocorticoid Hormones

1983 • 67 citations

Murine pulmonary myocardium: Developmental analysis of cardiac gene expression

1994 • 53 citations

Transgenic Mice in Cardiovascular Research

1993 • 53 citations

Implementing Transgenic and Embryonic Stem Cell Technology to Study Gene Expression, Cell-Cell Interactions and Gene Function

1995 • 53 citations

Anin vivo analysis of transcriptional elements in the mouse α-myosin heavy chain gene promoter

1995 • 42 citations

Gene targeting. The precise manipulation of the mammalian genome.

1993 • 38 citations

Heart and lung disease in engineered mice

1995 • 36 citations

Cardiac muscle diseases in genetically engineered mice: evolution of molecular physiology

1995 • 33 citations

Targeting gene expression to specific cardiovascular cell types in transgenic mice.

1993 • 23 citations

Exploring Pathogenetic Mechanisms Using Transgenic Animals

1993 • 9 citations

Transgenic Mice as Models for Heritable Diseases

1992 • 7 citations

Genetic engineering of cardiac muscle cells: in vitro and in vivo.

1994 • 5 citations

Recent advances in the molecular biology of cardiac growth and hypertrophy: of mouse and man.

1992 • 1 citations