Induction of Nitric Oxide Synthase in the Human Cardiac Allograft Is Associated With Contractile Dysfunction of the Left Ventricle

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation.

1990 • 1,515 citations

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

1989 • 1,096 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Widespread tissue distribution, species distribution and changes in activity of Ca²⁺‐dependent and Ca²⁺‐independent nitric oxide synthases

1991 • 645 citations

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

1992 • 623 citations

Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator.

1991 • 529 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium.

1993 • 457 citations

Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?

1991 • 409 citations

Nitric oxide attenuates cardiac myocyte contraction

1993 • 405 citations

Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.

1994 • 403 citations

Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat

1990 • 399 citations

Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in humans. Assessment by bicoronary sodium nitroprusside infusion.

1994 • 378 citations

Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine.

1994 • 330 citations

Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia

1992 • 327 citations

Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.

1993 • 302 citations

Induction of myocardial nitric oxide synthase by cardiac allograft rejection.

1994 • 212 citations

Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line

1993 • 204 citations

EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft.

1992 • 195 citations

Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat.

1992 • 179 citations

Nitric oxide-mediated effects of interleukin-6 on [Ca2+]i and cell contraction in cultured chick ventricular myocytes.

1994 • 176 citations

The Role of Nitric Oxide in Endotoxic Shock: Effects of NG-Monomethyl-L-Arginine

1992 • 157 citations

Role of nitric oxide in antagonistic effects of transforming growth factor-beta and interleukin-1 beta on the beating rate of cultured cardiac myocytes.

1992 • 150 citations

Mechanisms of immune-mediated myocyte injury.

1994 • 141 citations

Reversible Cardiac Dysfunction Associated with Interferon Alfa Therapy in AIDS Patients with Kaposi's Sarcoma

1989 • 125 citations

Downregulation of c-myc expression by antisense oligonucleotides inhibits proliferation of human smooth muscle cells.

1993 • 117 citations

CYTOKINE GENE EXPRESSION IN REJECTING CARDIAC ALLOGRAFTS

1992 • 106 citations

Granzyme A and perforin as markers for rejection in cardiac transplantation

1991 • 81 citations

Myocardial Toxic Effects During Recombinant Interleukin-2 Therapy

1989 • 80 citations

LOCAL PRODUCTION OF CYTOKINES IN THE HUMAN CARDIAC ALLOGRAFT

1994 • 78 citations

Nitric oxide synthesis in the in vivo allograft response: a possible regulatory mechanism.

1991 • 71 citations

Influence of graft rejection on incidence of accelerated graft coronary artery disease: a new approach to analysis.

1993 • 58 citations

Vascular rejection in heart transplant recipients.

1993 • 56 citations

Influence of recipient atrial contraction on left ventricular filling dynamics of the transplanted heart assessed by Doppler echocardiography

1987 • 55 citations

Novel cardiac myofilament desensitizing factor released by endocardial and vascular endothelial cells.

1994 • 48 citations

Reliability and usefulness of immunofluorescence in heart transplantation.

1995 • 44 citations

Variability of Doppler Echocardiographic Indexes of Left Ventricular Filling in Transplant Recipients and in Normal Subjects

1990 • 25 citations

Acute reversible cardiogenic shock: Immune-mediated with mild histologic change

1986 • 16 citations