Sarcoma

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Identification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's Sarcoma

1994 • 5,605 citations

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

1998 • 5,369 citations

Cancer Statistics, 2006

2006 • 5,351 citations

Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors

1998 • 4,380 citations

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

2002 • 4,254 citations

Platinum Compounds: a New Class of Potent Antitumour Agents

1969 • 3,785 citations

Diagnosis of gastrointestinal stromal tumors: A consensus approach

2002 • 3,361 citations

Two Hundred Gastrointestinal Stromal Tumors

2000 • 2,510 citations

Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial

2006 • 2,500 citations

Adipocyte differentiation from the inside out

2006 • 2,438 citations

Enzinger and Weiss's Soft Tissue Tumors

2001 • 2,340 citations

PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors

2003 • 2,224 citations

Kinase Mutations and Imatinib Response in Patients With Metastatic Gastrointestinal Stromal Tumor

2003 • 2,216 citations

Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal Stromal Tumor

2001 • 2,038 citations

Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995

1999 • 1,895 citations

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

1992 • 1,787 citations

Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial

2004 • 1,629 citations

Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity.

1998 • 1,465 citations

Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial

2002 • 1,445 citations

A cancer family syndrome in twenty-four kindreds.

1988 • 1,274 citations

Addition of Ifosfamide and Etoposide to Standard Chemotherapy for Ewing's Sarcoma and Primitive Neuroectodermal Tumor of Bone

2003 • 1,271 citations

Soft‐tissue sarcomas of adults; study of pathological prognostic variables and definition of a histopathological grading system

1984 • 1,215 citations

Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities.

1996 • 1,196 citations

Biology of Gastrointestinal Stromal Tumors

2004 • 1,190 citations

The Effect of Adjuvant Chemotherapy on Relapse-Free Survival in Patients with Osteosarcoma of the Extremity

1986 • 1,164 citations

Intergroup Rhabdomyosarcoma Study-IV: Results for Patients With Nonmetastatic Disease

2001 • 1,038 citations

Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data

1997 • 1,013 citations

Prognostic Factors in Ewing’s Tumor of Bone: Analysis of 975 Patients From the European Intergroup Cooperative Ewing’s Sarcoma Study Group

2000 • 1,006 citations

A SARCOMA OF THE FOWL TRANSMISSIBLE BY AN AGENT SEPARABLE FROM THE TUMOR CELLS

1911 • 995 citations

The Third Intergroup Rhabdomyosarcoma Study.

1995 • 994 citations

The intergroup rhabdomyosarcoma study-I.A final report

1988 • 899 citations

Detection of Kaposi sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma

1995 • 885 citations

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

1993 • 884 citations

Idiopathisches multiples Pigmentsarkom der Haut

1872 • 877 citations

Action of 2',2'-difluorodeoxycytidine on DNA synthesis.

1991 • 868 citations

Soft-Tissue Sarcomas in Adults

2005 • 859 citations

Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma.

1997 • 828 citations

Molecular Correlates of Imatinib Resistance in Gastrointestinal Stromal Tumors

2006 • 793 citations

Reduction of Doxorubicin Cardiotoxicity by Prolonged Continuous Intravenous Infusion

1982 • 768 citations

A phase I clinical, plasma, and cellular pharmacology study of gemcitabine.

1991 • 755 citations

Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma

1994 • 748 citations

The intergroup rhabdomyosarcoma study-II

1993 • 732 citations

PAX3-FKHR and PAX7-FKHR Gene Fusions Are Prognostic Indicators in Alveolar Rhabdomyosarcoma: A Report From the Children’s Oncology Group

2002 • 704 citations

Adjuvant Chemotherapy for Adult Soft Tissue Sarcomas of the Extremities and Girdles: Results of the Italian Randomized Cooperative Trial

2001 • 688 citations

Gemcitabine and Docetaxel in Patients With Unresectable Leiomyosarcoma: Results of a Phase II Trial

2002 • 670 citations

Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor

1997 • 655 citations

MIC2 is a specific marker for ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration

1991 • 652 citations

Regulation of Adipocyte Development

1994 • 631 citations

Prognosis of Gastrointestinal Smooth-Muscle (Stromal) Tumors

1999 • 629 citations

Pegylated-liposomal doxorubicin versus doxorubicin, bleomycin, and vincristine in the treatment of AIDS-related Kaposi's sarcoma: results of a randomized phase III clinical trial.

1998 • 625 citations

Common Musculoskeletal Tumors of Childhood and Adolescence

1999 • 621 citations

Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology and end results program, 1978–2001: An analysis of 26,758 cases

2006 • 613 citations

Soft tissue sarcomas of adults: state of the translational science.

2003 • 613 citations

Molecular characterisation of soft tissue tumours: a gene expression study

2002 • 581 citations

Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma.

1994 • 580 citations

Management of malignant gastrointestinal stromal tumours

2002 • 574 citations

Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: a long-term follow-up of the First Intergroup study.

1990 • 570 citations

Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type

1995 • 567 citations

Interstitial Cells of Cajal as Precursors of Gastrointestinal Stromal Tumors

1999 • 567 citations

Lymph Node Metastasis From Soft Tissue Sarcoma in Adults Analysis of Data From a Prospective Database of 1772 Sarcoma Patients

1993 • 565 citations

Pulmonary Metastases From Soft Tissue Sarcoma

1999 • 547 citations

Angiosarcoma of the face and scalp, prognosis and treatment

1987 • 542 citations

Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy

2006 • 538 citations

18FDG-Positron emission tomography for the early prediction of response in advanced soft tissue sarcoma treated with imatinib mesylate (Glivec®)

2003 • 528 citations

Angiosarcoma: A report of 67 patients and a review of the literature

1996 • 521 citations

Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: a randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group.

1995 • 519 citations

The grading of soft tissue sarcomas results of a clinicohistopathologic correlation in a series of 163 cases

1984 • 513 citations

Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor.

1994 • 509 citations

Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas.

1993 • 504 citations

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma

1999 • 501 citations

EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts

1993 • 491 citations

The Discovery and Development of Cisplatin

2006 • 476 citations

An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas.

1993 • 473 citations

Radiation-induced sarcoma of bone

1971 • 469 citations

Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma.

1995 • 467 citations

A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.

1995 • 466 citations

Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based on histological tumor response.

1988 • 461 citations

Grading of Soft Tissue Sarcomas: Review and Update

2006 • 459 citations

Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations

2002 • 457 citations

Cancer Incidence After Retinoblastoma

1997 • 455 citations

CT Evaluation of the Response of Gastrointestinal Stromal Tumors After Imatinib Mesylate Treatment: A Quantitative Analysis Correlated with FDG PET Findings

2004 • 453 citations

Prognostic Factors and Clinical Outcomes in Children and Adolescents With Metastatic Rhabdomyosarcoma—A Report From the Intergroup Rhabdomyosarcoma Study IV

2002 • 449 citations

Surgical Management of Advanced Gastrointestinal Stromal Tumors After Treatment With Targeted Systemic Therapy Using Kinase Inhibitors

2006 • 434 citations

Randomized phase III trial of liposomal daunorubicin versus doxorubicin, bleomycin, and vincristine in AIDS-related Kaposi's sarcoma.

1996 • 431 citations

Cancer: Principles and Practice of Oncology

1987 • 425 citations

Phase II Study of ET-743 in Advanced Soft Tissue Sarcomas: A European Organisation for the Research and Treatment of Cancer (EORTC) Soft Tissue and Bone Sarcoma Group Trial

2005 • 422 citations

RECIST revisited: A review of validation studies on tumour assessment

2006 • 418 citations

A genetic and clinical study of intestinal polyposis, a predisposing factor for carcinoma of the colon and rectum.

1951 • 406 citations

Gemcitabine: preclinical pharmacology and mechanisms of action.

1996 • 401 citations

Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine.

1990 • 393 citations

A TRANSMISSIBLE AVIAN NEOPLASM. (SARCOMA OF THE COMMON FOWL.)

1910 • 393 citations

Multimodal therapy for the management of nonpelvic, localized Ewing's sarcoma of bone: intergroup study IESS-II.

1990 • 388 citations

Paclitaxel in the treatment of patients with angiosarcoma of the scalp or face

1999 • 387 citations

Subtype Specific Prognostic Nomogram for Patients With Primary Liposarcoma of the Retroperitoneum, Extremity, or Trunk

2006 • 385 citations

A 14-Year Retrospective Review of Angiosarcoma

2005 • 385 citations

Randomised trial of two regimens of chemotherapy in operable osteosarcoma: a study of the European Osteosarcoma Intergroup

1997 • 378 citations

Rhabdomyosarcoma and Undifferentiated Sarcoma in the First Two Decades of Life: A Selective Review of Intergroup Rhabdomyosarcoma Study Group Experience and Rationale for Intergroup Rhabdomyosarcoma Study V

2001 • 375 citations

Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma.

1993 • 373 citations

The successful regression of large solid sarcoma 180 tumors by platinum compounds.

1970 • 372 citations

Doxorubicin Encapsulated in Liposomes Containing Surface‐Bound Polyethylene Glycol: Pharmacokinetics, Tumor Localization, and Safety in Patients with AIDS‐Related Kaposi's Sarcoma

1996 • 370 citations

Presurgical Chemotherapy Compared With Immediate Surgery and Adjuvant Chemotherapy for Nonmetastatic Osteosarcoma: Pediatric Oncology Group Study POG-8651

2003 • 368 citations

Pleomorphic Malignant Fibrous Histiocytoma

1992 • 367 citations

Randomised phase II trial of pegylated liposomal doxorubicin (DOXIL®/CAELYX®) versus doxorubicin in the treatment of advanced or metastatic soft tissue sarcoma

2001 • 357 citations

Molecular Biology of the Ewing’s Sarcoma/Primitive Neuroectodermal Tumor Family

2000 • 355 citations

Randomized comparative trial of pegylated liposomal doxorubicin versus bleomycin and vincristine in the treatment of AIDS-related Kaposi's sarcoma. International Pegylated Liposomal Doxorubicin Study Group.

1998 • 354 citations

Clinicopathologic Re-Evaluation of 100 Malignant Fibrous Histiocytomas: Prognostic Relevance of Subclassification

2001 • 343 citations

Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor)

1999 • 340 citations

High‐dose tamoxifen and sulindac as first‐line treatment for desmoid tumors

2004 • 339 citations

Gene Expression Profiling of Human Sarcomas: Insights into Sarcoma Biology

2005 • 338 citations

Recurrent chromosome aberrations in cancer

2000 • 337 citations

Correlation between clinicopathological features and karyotype in lipomatous tumors. A report of 178 cases from the Chromosomes and Morphology (CHAMP) Collaborative Study Group.

1996 • 335 citations

Incidence of second primary tumours among childhood cancer survivors

1987 • 334 citations

Improvement in Histologic Response But Not Survival in Osteosarcoma Patients Treated With Intensified Chemotherapy: A Randomized Phase III Trial of the European Osteosarcoma Intergroup

2007 • 333 citations

Fibroxanthosarcoma of the soft tissues.A type of malignant fibrous histiocytoma

1972 • 329 citations

The Enigma of Desmoid Tumors

1999 • 322 citations

Diagnostic Relevance of Clonal Cytogenetic Aberrations in Malignant Soft-Tissue Tumors

1991 • 322 citations

Update on Kaposi's sarcoma and other HHV8 associated diseases. Part 1: epidemiology, environmental predispositions, clinical manifestations, and therapy

2002 • 322 citations

Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics.

2003 • 321 citations

Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors).

1997 • 320 citations

Local therapy in localized Ewing tumors: results of 1058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials

2002 • 318 citations

A comparison of two short intensive adjuvant chemotherapy regimens in operable osteosarcoma of limbs in children and young adults: the first study of the European Osteosarcoma Intergroup.

1992 • 315 citations

Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases.

2001 • 315 citations

Clinical and Molecular Studies of the Effect of Imatinib on Advanced Aggressive Fibromatosis (desmoid tumor)

2006 • 314 citations

cDNA microarrays detect activation of a myogenic transcription program by thePAX3-FKHRfusion oncogene

1999 • 313 citations

Comparison of PET, CT, and dual-modality PET/CT imaging for monitoring of imatinib (STI571) therapy in patients with gastrointestinal stromal tumors.

2004 • 310 citations

β-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds

2002 • 304 citations

Intensification of preoperative chemotherapy for osteogenic sarcoma: results of the Memorial Sloan-Kettering (T12) protocol.

1998 • 304 citations

Can APC mutation analysis contribute to therapeutic decisions in familial adenomatous polyposis? Experience from 680 FAP families

2001 • 299 citations

Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)

1992 • 299 citations

Prognosis in children with rhabdomyosarcoma: a report of the intergroup rhabdomyosarcoma studies I and II. Intergroup Rhabdomyosarcoma Committee.

1990 • 291 citations

OSTEOSARCOMA

1997 • 287 citations

Immunohistochemical analysis of Ewing's sarcoma cell surface antigen p30/32MIC2.

1991 • 286 citations

Radiotherapy for local control of osteosarcoma

2005 • 284 citations

[¹⁸F]Fluorodeoxyglucose Positron Emission Tomography Predicts Outcome for Ewing Sarcoma Family of Tumors

2005 • 282 citations

Response to mesna, doxorubicin, ifosfamide, and dacarbazine in 108 patients with metastatic or unresectable sarcoma and no prior chemotherapy.

1989 • 273 citations

Alveolar soft-part sarcoma: a review and update

2006 • 271 citations

Preoperative radiation, surgical margins, and local control of extremity sarcomas of soft tissues

1993 • 270 citations

Diffuse Endothelioma of Bone

1984 • 269 citations

Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors

1999 • 268 citations

Synovial sarcoma. Uniform response of metastases to high dose ifosfamide

1994 • 268 citations

Bone tumours in European children and adolescents, 1978–1997. Report from the Automated Childhood Cancer Information System project

2006 • 266 citations

Lymphangiosarcoma arising in chronic lymphedematous extremities

1972 • 265 citations

Function and Health Status Outcomes in a Randomized Trial Comparing Preoperative and Postoperative Radiotherapy in Extremity Soft Tissue Sarcoma

2002 • 264 citations

Metastatic osteosarcoma at diagnosis

2005 • 259 citations

Five-year survival after pulmonary metastasectomy for adult soft tissue sarcoma

1992 • 256 citations

High-dose ifosfamide in bone and soft tissue sarcomas: results of phase II and pilot studies--dose-response and schedule dependence.

1997 • 256 citations

Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans

2002 • 254 citations

Gene Expression of Osteoprotegerin Ligand, Osteoprotegerin, and Receptor Activator of NF-κB in Giant Cell Tumor of Bone

2000 • 251 citations

Saturation of 2?, 2?-difluorodeoxycytidine 5?-triphosphate accumulation by mononuclear cells during a phase I trial of gemcitabine

1991 • 250 citations

Pleomorphic Liposarcoma: Clinicopathologic, Immunohistochemical, and Follow-up Analysis of 63 Cases

2002 • 247 citations

Phase II Clinical Investigation of Gemcitabine in Advanced Soft Tissue Sarcomas and Window Evaluation of Dose Rate on Gemcitabine Triphosphate Accumulation

2001 • 245 citations

Low-dose chemotherapy with methotrexate and vinblastine for patients with advanced aggressive fibromatosis

2001 • 243 citations

Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase

2003 • 242 citations

Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors.

1990 • 242 citations

Ewing's tumors with primary lung metastases: survival analysis of 114 (European Intergroup) Cooperative Ewing's Sarcoma Studies patients.

1998 • 239 citations

Combination chemotherapy in adult desmoid tumors

1993 • 232 citations

Intergroup Rhabdomyosarcoma Study: Update for Pathologists

1998 • 229 citations

Cytogenetic studies of adipose tissue tumors. II. Recurrent reciprocal translocation t(12;16)(q13;p11) in myxoid liposarcomas

1986 • 226 citations

Classification and Subtype Prediction of Adult Soft Tissue Sarcoma by Functional Genomics

2003 • 219 citations

Primary malignant fibrous histiocytoma of bone

1975 • 216 citations

Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis

2001 • 216 citations

Chromosomal aberrations in soft tissue tumors. Relevance to diagnosis, classification, and molecular mechanisms.

1994 • 216 citations

Lymphedema: An immunologically vulnerable site for development of neoplasms

2002 • 214 citations

Chemotherapy of sarcomas with a combination of adriamycin and dimethyl triazeno imidazole carboxamide

1972 • 213 citations

Prospective randomized evaluation of adjuvant chemotherapy in adults with soft tissue sarcomas of the extremities

1983 • 210 citations

Treatment of HIV-associated Kaposi's sarcoma with paclitaxel

1995 • 210 citations

Desmoid Tumors in Familial Polyposis Coli

1986 • 208 citations

Influence of Doxorubicin Dose Intensity on Response and Outcome for Patients With Osteogenic Sarcoma and Ewing's Sarcoma

1991 • 206 citations

Results from the IRS-IV randomized trial of hyperfractionated radiotherapy in children with rhabdomyosarcoma—a report from the IRSG 1 1For a complete list of the members of the Children’s Oncology Group Soft Tissue Sarcoma Committee (formerly Intergroup Rhabdomyosarcoma Group) representing the Children’s Oncology Group and the Quality Assurance Review Center, see the Appendix.

2001 • 204 citations

Angiosarcoma of the breast

2005 • 199 citations

Desmoid tumors in patients with familial adenomatous polyposis

1994 • 198 citations

Paclitaxel and pegylated‐liposomal doxorubicin are both active in angiosarcoma

2005 • 198 citations

Results of Two Consecutive Trials of Dose-Intensive Chemotherapy With Doxorubicin and Ifosfamide in Patients With Sarcomas

1998 • 197 citations

Sclerosing Epithelioid Fibrosarcoma

2001 • 197 citations

Expression of Osteoclast Differentiation Signals by Stromal Elements of Giant Cell Tumors

2000 • 194 citations

Response of extraabdominal desmoid tumors to therapy with imatinib mesylate

2002 • 193 citations

Temozolomide and intravenous irinotecan for treatment of advanced Ewing sarcoma

2005 • 192 citations

Ecteinascidin-743 (ET-743) for Chemotherapy-Naive Patients With Advanced Soft Tissue Sarcomas: Multicenter Phase II and Pharmacokinetic Study

2005 • 191 citations

Postoperative Nomogram for 12-Year Sarcoma-Specific Death

2002 • 191 citations

Phase II/III Trial of Etoposide and High-Dose Ifosfamide in Newly Diagnosed Metastatic Osteosarcoma: A Pediatric Oncology Group Trial

2002 • 188 citations

Prognostic factors in 227 patients with malignant fibrous histiocytoma

1992 • 187 citations

Cutaneous vascular proliferations. Part III. Malignant neoplasms, other cutaneous neoplasms with significant vascular component, and disorders erroneously considered as vascular neoplasms

1998 • 187 citations

Paclitaxel Is Safe and Effective in the Treatment of Advanced AIDS-Related Kaposi's Sarcoma

1999 • 185 citations

Successful Chemotherapeutic Modality of Doxorubicin Plus Dacarbazine for the Treatment of Desmoid Tumors in Association With Familial Adenomatous Polyposis

2005 • 182 citations

Complex composition and co‐amplification of SAS and MDM2 in ring and giant rod marker chromosomes in well‐differentiated liposarcoma

1994 • 180 citations

Rhabdomyosarcoma of the head and neck in children☆☆Presented at: American Academy of Oral and Maxillofacial Pathology, Annual Meeting Essay Section, Chicago, Illinois, May 2001.

2002 • 178 citations

Docetaxel and gemcitabine combination in 133 advanced soft‐tissue sarcomas: A retrospective analysis

2006 • 175 citations

Phase II trial with dose titration of paclitaxel for the therapy of human immunodeficiency virus-associated Kaposi's sarcoma.

1998 • 175 citations

Prognostic factors for patients with localized primary malignant fibrous histiocytoma: A multicenter study of 216 patients with multivariate analysis

1996 • 174 citations

Surgical management of intra-abdominal desmoid tumours

2000 • 174 citations

Efficacy of pegylated-liposomal doxorubicin in the treatment of AIDS-related Kaposi's sarcoma after failure of standard chemotherapy.

1997 • 170 citations

Multiple polyposis, gardner's syndrome and desmoid tumors

1958 • 169 citations

Phase III Comparison of Doxorubicin and Dacarbazine Given by Bolus Versus Infusion in Patients With Soft-Tissue Sarcomas: A Southwest Oncology Group Study

1991 • 167 citations

Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential

2007 • 167 citations

Changing disease patterns in patients with AIDS in a referral centre in the United Kingdom: the changing face of AIDS.

1991 • 166 citations

RANK (Receptor Activator of Nuclear Factor kappa B) and RANK Ligand Are Expressed in Giant Cell Tumors of Bone

2002 • 165 citations

Benefit of Intensified Therapy for Patients With Local or Regional Embryonal Rhabdomyosarcoma: Results From the Intergroup Rhabdomyosarcoma Study IV

2000 • 163 citations

Cohort Analysis of Patients With Localized, High-Risk, Extremity Soft Tissue Sarcoma Treated at Two Cancer Centers: Chemotherapy-Associated Outcomes

2004 • 162 citations

Low-dose chemotherapy of desmoid tumors

1989 • 162 citations

Desmoid fibromatosis is a clonal process

1996 • 161 citations

A phase II trial with rosiglitazone in liposarcoma patients

2003 • 161 citations

Phase II trial of gemcitabine as second-line chemotherapy of uterine leiomyosarcoma: a Gynecologic Oncology Group (GOG) Study

2004 • 161 citations

Involvement of the Pro-oncoprotein TLS (Translocated in Liposarcoma) in Nuclear Factor-κB p65-mediated Transcription as a Coactivator

2001 • 155 citations

Radiation therapy in the management of desmoid tumors

1998 • 155 citations

Human giant cell tumors of bone identification and characterization of cell types.

1987 • 154 citations

Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling

2004 • 153 citations

Reduced cardiotoxicity of doxorubicin by a 6-hour infusion regimen. A prospective randomized evaluation

1990 • 151 citations

Use of liposomal anthracyclines in Kaposi’s sarcoma

2004 • 150 citations

Improved outlook for Ewing's sarcoma with combination chemotherapy (vincristine, actinomycin D and cyclophosphamide) and radiation therapy

1976 • 147 citations

Effect of high-dose ifosfamide in advanced soft tissue sarcomas. A multicentre phase II study of the EORTC Soft Tissue and Bone Sarcoma Group

2000 • 147 citations

Preoperative radiation therapy for sarcoma of soft tissue

1981 • 146 citations

DISTINCT mdm2/p53 EXPRESSION PATTERNS IN LIPOSARCOMA SUBGROUPS: IMPLICATIONS FOR DIFFERENT PATHOGENETIC MECHANISMS

1997 • 146 citations

Local Control in Pelvic Ewing Sarcoma: Analysis From INT-0091—A Report From the Children's Oncology Group

2006 • 145 citations

Contribution of molecular genetic data to the classification of sarcomas

2000 • 144 citations

Combination chemotherapy using vinblastine and methotrexate for the treatment of progressive desmoid tumor in children.

1998 • 142 citations

Aggressive Fibromatosis (Desmoid Tumor) is A Monoclonal Disorder

1997 • 138 citations

Myogenic regulatory protein (MyoD1) expression in childhood solid tumors: diagnostic utility in rhabdomyosarcoma.

1990 • 138 citations

Malignant transformation in paget disease of bone

1992 • 137 citations

Efficacy and safety of liposomal anthracyclines in Phase I/II clinical trials

2004 • 137 citations

Model for the incidence of embryonal cancers: application to retinoblastoma.

1978 • 134 citations

Lipomatous tumours of soft tissues: an update

1995 • 133 citations

Impact of FDG PET for staging of Ewing sarcomas and primitive neuroectodermal tumours

2005 • 132 citations

Chromosomes in Ewing's sarcoma. II. Nonrandom additional changes, trisomy 8 and der(16)t(1;16)

1988 • 132 citations

Multifactorial Analysis of Long-term Follow-up (More Than 5 Years) of Primary Extremity Sarcoma

1999 • 131 citations

Spleen Cells Transmit Osteopetrosis in Mice

1975 • 129 citations

Clinical course of nonvisceral soft tissue leiomyosarcoma in 225 patients from the Scandinavian Sarcoma Group

2006 • 128 citations

Radiation-Associated Sarcoma

1989 • 128 citations

Occurrence of desmoids in patients with familial adenomatous polyposis of the colon

1987 • 127 citations

International variations in the incidence of childhood bone tumours

1993 • 127 citations

Molecular Profiling of Giant Cell Tumor of Bone and the Osteoclastic Localization of Ligand for Receptor Activator of Nuclear Factor κB

2005 • 126 citations

Malignant fibrous histiocytoma

1982 • 125 citations

Treatment of osteosarcoma at first recurrence after contemporary therapy

2005 • 125 citations

Gemcitabine in advanced adult soft-tissue sarcomas. A phase II study of the EORTC Soft Tissue and Bone Sarcoma Group

2002 • 120 citations

Differential gene expression in leiomyosarcoma

2003 • 118 citations

Radiation-induced sarcomas of the chest wall

1986 • 117 citations

Phase II Trial of Paclitaxel in Patients with Soft-Tissue Sarcoma

1998 • 115 citations

Immunomic analysis of human sarcoma

2003 • 113 citations

Adjuvant Epirubicin With or Without Ifosfamide for Adult Soft-Tissue Sarcoma

2002 • 112 citations

Phase II Trial Of Pegylated-liposomal Doxorubicin (Doxil™) In Sarcoma^*

2003 • 111 citations

The prognostic value of histologic subtypes in primary extremity liposarcoma

1989 • 111 citations

Correlation between Clinicopathological Features and Karyotype in Spindle Cell Sarcomas

1999 • 110 citations

Angiosarcoma of the Liver Following Vinyl Chloride Exposure

1974 • 108 citations

Bisphosphonates Induce Apoptosis of Stromal Tumor Cells in Giant Cell Tumor of Bone

2004 • 108 citations

Childhood soft tissue sarcomas incidence and survival in European children (1978–1997): Report from the Automated Childhood Cancer Information System project

2006 • 105 citations

Bisphosphonates May Reduce Recurrence in Giant Cell Tumor by Inducing Apoptosis

2004 • 103 citations

Adjuvant chemotherapy for localised resectable soft tissue sarcoma in adults

2000 • 103 citations

Prediction of high risk Ewing's sarcoma by gene expression profiling

2004 • 101 citations

Radiation-induced angiosarcoma

1987 • 101 citations

Congenital Osteopetrosis in Mice Cured by Parabiotic Union with Normal Siblings

1972 • 99 citations

MDM2 gene amplification correlates with ring chromosomes in soft tissue tumors

1994 • 99 citations

Phase II trial of gemcitabine in advanced sarcomas

2002 • 99 citations

Malignant fibrous histiocytoma of soft tissue. A population-based epidemiologic and prognostic study of 137 patients

1991 • 99 citations

A germline mutation at the extreme 3′ end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta‐catenin in the desmoid tumor

2000 • 96 citations

Molecular abnormalities in liposarcoma: role of MDM2 and CDK4-containing amplicons at 12q13-22

1998 • 95 citations

Desmoids in familial adenomatous polyposis are monoclonal proliferations

2000 • 93 citations

Chemotherapy, irradiation, and surgery for function‐preserving therapy of primary extremity soft tissue sarcomas

2002 • 90 citations

Molecular cytogenetic mapping of recurrent chromosomal breakpoints in tenosynovial giant cell tumors

2002 • 90 citations

Giant cell tumor of tendon sheath is a polyclonal cellular proliferation

1997 • 89 citations

Grading in soft tissue tumors: principles and problems

2001 • 88 citations

Doxorubicin: Effect of different schedules on toxicity and anti-tumor efficacy

1989 • 88 citations

Adjuvant chemotherapy in primary treatment of osteogenic sarcoma.A southwest oncology group study

1975 • 87 citations

Irinotecan for Pediatric Solid Tumors: The Memorial Sloan-Kettering Experience

2002 • 87 citations

Neoadjuvant Chemotherapy With Doxorubicin and Cisplatin in Malignant Fibrous Histiocytoma of Bone: A European Osteosarcoma Intergroup Study

1999 • 86 citations

Disease patterns and survival rate in children with metastatic soft-tissue sarcoma: A report from the intergroup rhabdomyosarcoma study (IRS)-I

1988 • 85 citations

DESMOID TUMORS: A REPORT OF THIRTY-ONE CASES

1923 • 85 citations

Therapy of Desmoid Tumors and Fibromatosis Using Vinorelbine

1999 • 82 citations

Analysis of SYT-SSX Fusion Transcripts and bcl-2 Expression and Phosphorylation Status in Synovial Sarcoma

2000 • 82 citations

Molecular classification of synovial sarcomas, leiomyosarcomas and malignant fibrous histiocytomas by gene expression profiling

2003 • 82 citations

Osteosarcoma of the trunk treated by multimodal therapy: Experience of the cooperative osteosarcoma study group (COSS)

1995 • 79 citations

Chromosome 17 abnormalities and TP53 mutations in adult soft tissue sarcomas.

1994 • 77 citations

A Gene Expression Signature Associated with Metastatic Outcome in Human Leiomyosarcomas

2004 • 77 citations

Human Translocation Liposarcoma-CCAAT/Enhancer Binding Protein (C/EBP) Homologous Protein (TLS-CHOP) Oncoprotein Prevents Adipocyte Differentiation by Directly Interfering with C/EBPβ Function

1998 • 75 citations

Phase II trial of gemcitabine in patients with advanced sarcomas (E1797)

2003 • 75 citations

Response to imatinib mesylate of a gastrointestinal stromal tumor with very low expression of KIT

2003 • 73 citations

Presurgical Window of Carboplatin and Surgery and Multidrug Chemotherapy for the Treatment of Newly Diagnosed Metastatic or Unresectable Osteosarcoma: Pediatric Oncology Group Trial

2001 • 72 citations

State-of-the Art Therapy for Gastrointestinal Stromal Tumors

2005 • 72 citations

Overrepresentation of 1q21–23 and 12q13–21 in lipoma-like liposarcomas but not in benign lipomas: A comparative genomic hybridization study

1997 • 70 citations

Gene expression in aggressive fibromatosis

2004 • 69 citations

Chemotherapy for desmoid tumors in association with familial adenomatous polyposis

1997 • 68 citations

Multiple chromosomal mechanisms generate an EWS/FLI1 or an EWS/ERG fusion gene in Ewing tumors

1997 • 67 citations

Role of High-Dose Chemotherapy With Hematopoietic Stem Cell Rescue in the Treatment of Metastatic or Recurrent Rhabdomyosarcoma

2001 • 66 citations

An analysis of primary site control and late effects according to local control modality in non‐metastatic Ewing sarcoma

2006 • 66 citations

The Interstitial Cells of Cajal and a Gastroenteric Pacemaker System

2002 • 66 citations

Altered pattern of metastasis following treatment of Ewing's sarcoma with radiotherapy and adjuvant chemotherapy

1971 • 66 citations

An immunohistological study of giant‐cell tumour of bone: Evidence for an osteoclast origin of the giant cells

1985 • 65 citations

How to Treat the Ewing's Family of Sarcomas in Adult Patients

2006 • 65 citations

Complete remission of a radio-resistant cutaneous angiosarcoma of the scalp by systemic treatment with liposomal doxorubicin

2002 • 63 citations

Chromosomal translocations and sarcomas

2002 • 61 citations

Aggressive metastasectomy for pulmonic sarcomatous metastases: A follow-up study

1993 • 61 citations

Trends in the incidence of soft tissue sarcomas in the United States from 1973 through 1987

1993 • 61 citations

Phase II study of continuous-infusion high-dose ifosfamide in advanced and/or metastatic pretreated soft tissue sarcomas

1997 • 60 citations

Desmoid Tumor Is a Clonal Cellular Proliferation: PCR Amplification of HUMARA for Analysis of Patterns of X-Chromosome Inactivation

1997 • 59 citations

Doxorubicin and cisplatin chemotherapy in high-grade spindle cell sarcomas of the bone, other than osteosarcoma or malignant fibrous histiocytoma: a European Osteosarcoma Intergroup Study

2004 • 59 citations

Gene expression in giant-celltumors

2004 • 58 citations

SYT-SSX fusion genes and prognosis in synovial sarcoma

2001 • 58 citations

High-risk ewing's sarcoma: end-intensification using autologous bone marrow transplantation

1988 • 56 citations

Technological Basis of Radiation Therapy: Practical Clinical Applications

1985 • 55 citations

Neoadjuvant chemotherapy in malignant fibrous histiocytoma of bone and in osteosarcoma located in the extremities: Analogies and differences between the two tumors

1997 • 55 citations

Bone metastases in osteosarcoma patients treated with neoadjuvant or adjuvant chemotherapy The Rizzoli experience in 52 patients

2006 • 55 citations

Cytogenetic and Immunohistochemical Profile of Myxoid Liposarcoma

1995 • 55 citations

The role of pulmonary metastasectomy in soft tissue sarcoma

2002 • 54 citations

Treatment with taxanes of refractory or life‐threatening Kaposi sarcoma not associated with human immunodeficiency virus infection

2006 • 54 citations

Gene expression of monocyte chemoattractant protein-1 in giant cell tumors of bone osteoclastoma: Possible involvement in CD68+ macrophage-like cell migration

1998 • 54 citations

Measurement and prediction of the short-term response of soft tissue sarcomas to chemotherapy

1993 • 53 citations

The ETS oncogene family in development, proliferation and neoplasia.

1994 • 53 citations

Pulmonary resection in children with metastatic osteogenic sarcoma

1978 • 52 citations

Transforming Growth Factor‐β1 Autocrine Stimulation Regulates Fibroblast Proliferation in Hereditary Gingival Fibromatosis

2001 • 51 citations

Possible Association Between Higher β-Catenin mRNA Expression and Mutated β-Catenin in Sporadic Desmoid Tumors: Real-Time Semiquantitative Assay by TaqMan Polymerase Chain Reaction

2002 • 50 citations

Induction of a secreted protein by the myxoid liposarcoma oncogene

1999 • 50 citations

Gene expression analysis of human soft tissue leiomyosarcomas

2003 • 49 citations

Cellular Origin of Gastrointestinal Stromal Tumors

2000 • 48 citations

Liposomal doxorubicin (Caelyx) in advanced pretreated soft tissue sarcomas: a phase II study of the Italian Sarcoma Group (ISG).

2000 • 48 citations

Human herpesvirus-8: detection of novel herpesvirus-like DNA sequences in Kaposi's sarcoma and other lesions

1995 • 47 citations

Imaging and Response in Soft Tissue Sarcomas

2005 • 47 citations

Angiosarcoma of the scalp: treatment with liposomal doxorubicin and radiotherapy

2001 • 47 citations

Familial adenomatous polyposis and other polyposis syndromes

1995 • 46 citations

GENETICS OF SOFT TISSUE TUMORS

2006 • 45 citations

Effect of Treatment on Health-Related Quality of Life in Acquired Immunodeficiency Syndrome (AIDS)-Related Kaposi's Sarcoma: A Randomized Trial of Pegylated-Liposomal Doxorubicin Versus Doxorubicin, Bleomycin, and Vincristine

2001 • 44 citations

Chromosomal translocations in sarcomas: prospects for therapy

2001 • 44 citations

Protocol for the Examination of Specimens From Patients (Children and Young Adults) With Rhabdomyosarcoma

2003 • 43 citations

Differential Gene Expression in Liposarcoma, Lipoma, and Adipose Tissue

2005 • 43 citations

Aggressive Fibromatosis

1992 • 43 citations

Biological significance of chromosomal imbalance aberrations in gastrointestinal stromal tumors

2004 • 43 citations

Fusion of theEWS Gene to a DNA segment from 9q22-31 in a human myxoid chondrosarcoma

1995 • 43 citations

Regulation of proliferation and platelet‐derived growth factor expression in palmar fibromatosis (Dupuytren contracture) by mechanical strain

1996 • 42 citations

Cancer incidence and specific occupational exposures in the Swedish leather tanning industry: a cohort based case-control study.

1996 • 42 citations

Molecular mechanisms of carcinogenesis by vinyl chloride.

2006 • 41 citations

Relative quantitation of p53 and MDM2 gene expression in leiomyosarcoma; real-time semi-quantitative reverse transcription-polymerase chain reaction

2001 • 40 citations

Characterization of sarcomas by means of gene expression

2004 • 40 citations

Ambulatory continuous infusion ifosfamide with oral etoposide in advanced sarcomas

1993 • 40 citations

New developments in gastrointestinal stromal tumor

2006 • 40 citations

The value of high-dose methotrexate-based neoadjuvant chemotherapy in malignant fibrous histiocytoma of bone.

1996 • 38 citations

Giant Cell Tumor of the Tendon Sheath

2012 • 37 citations

Characterization of molecular abnormalities in human fibroblastic neoplasms: a model for genotype-phenotype association in soft tissue tumors.

2001 • 37 citations

Treatment of mesenteric desmoid tumours with the anti-oestrogen ic agent toremifene

1999 • 37 citations

Gardner's syndrome complicated by mesenteric desmoid tumors.

1979 • 37 citations

Ifosfamide and Etoposide in the Treatment of Advanced Soft Tissue Sarcomas

1994 • 32 citations

Continuous venous infusion of doxorubicin in advanced sarcomas.

1987 • 32 citations

Ifosfamide and Actinomycin-D, Added in the Induction Phase to Vincristine, Cyclophosphamide and Doxorubicin, Improve Histologic Response and Prognosis in Patients with Non Metastatic Ewing's Sarcoma of the Extremity

1998 • 32 citations

Functional imaging techniques for evaluation of sarcomas

2005 • 30 citations

The role of microarray technologies in the study of soft tissue tumours

2005 • 29 citations

[Epidemiologic study of workers exposed to vinyl chloride in Porto Marghera: mortality update].

2003 • 28 citations

Control of aggressive fibromatosis by treatment with imatinib mesylate. A case report and review of the literature

2007 • 27 citations

Results of salvage surgery for metastatic sarcomas

1990 • 27 citations

Myofibroblasts of Palmar Fibromatosis co-express transforming growth factor-alpha and epidermal growth factor receptor

1997 • 25 citations

Phase II study of a combination of mitomycin, doxorubicin and cisplatin in advanced sarcomas

1985 • 24 citations

A novel type of EWS–CHOP fusion gene in myxoid liposarcoma

2006 • 24 citations

Molecular determination of the malignant potential of smooth muscle neoplasms

1997 • 23 citations

Mapping of the translocation breakpoints of primary pleomorphic adenomas and lipomas within a common region of chromosome 12

1996 • 20 citations

Acquired Immunodeficiency Syndrome-Related Kaposi's Sarcoma

1995 • 19 citations

Future directions for immunotherapeutic intervention against sarcomas

2006 • 19 citations

Improved relapse free survival in patients with poor prognosis Ewing's sarcoma after consolidation with hyperfractionated total body irradiation and fractionated high dose melphalan followed by high dose etoposide and hematopoietic rescue.

1991 • 19 citations

AIDS-related Kaposi's sarcoma: current treatment options, future trends.

2000 • 19 citations

A phase I study of ambulatory continuous infusion paclitaxel

1997 • 18 citations

Does histologic grade in soft tissue sarcoma influence response rate to systemic chemotherapy?

1991 • 18 citations

Prolonged schedule of temozolomide (Temodal) plus liposomal doxorubicin (Caelyx) in advanced solid cancers

2004 • 18 citations

Giant cell tumor of the uterus: case report and response to chemotherapy

2007 • 17 citations

Update on new diagnostic and therapeutic approaches for sarcomas.

2005 • 17 citations

Radiation-Induced Sarcoma following Treatment of Breast Cancer

1998 • 17 citations

Cutaneous angiosarcoma: a novel therapy with liposomal doxorubicin?

1996 • 15 citations

Complete Resolution of Angiosarcoma of the Scalp with Liposomal Daunorubicin and Radiotherapy

1999 • 15 citations

The effectiveness of chemotherapy in localized malignant fibrous histiocytoma (MFH) of bone: the Rizzoli Institute experience with 66 patients treated with surgery alone or surgery + adjuvant or neoadjuvant chemotherapy.

1988 • 15 citations

Postirradiation angiosarcoma

1997 • 14 citations

Regression of metastatic angiosarcoma of the skin after systemic treatment with liposome-encapsulated doxorubicin and interferon-alpha.

1999 • 13 citations

Altered patterns of RB expression define groups of soft tissue sarcoma patients with distinct biological and clinical behavior.

2006 • 12 citations

The management of retroperitoneal soft tissue sarcoma.

1999 • 11 citations

Malignant fibrous histiocytoma of bone

1997 • 7 citations

Role of gene expression arrays in sarcomas

2004 • 7 citations

Angiosarcoma.

1997 • 2 citations