A comparison of two short intensive adjuvant chemotherapy regimens in operable osteosarcoma of limbs in children and young adults: the first study of the European Osteosarcoma Intergroup.

Clinical Trials: A Practical Approach.

1984 • 2,966 citations

The Effect of Adjuvant Chemotherapy on Relapse-Free Survival in Patients with Osteosarcoma of the Extremity

1986 • 1,164 citations

Preoperative chemotherapy for osteogenic sarcoma:Selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy

1982 • 1,079 citations

Chemotherapy for nonmetastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience.

1992 • 674 citations

Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial.

1987 • 528 citations

Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based on histological tumor response.

1988 • 461 citations

Primary osteogenic sarcoma: pathologic aspects in 20 patients after treatment with chemotherapy en bloc resection, and prosthetic bone replacement.

1977 • 386 citations

Neoadjuvant chemotherapy for osteogenic sarcoma: results of a Cooperative German/Austrian study.

1984 • 353 citations

Adjuvant chemotherapy of high-grade osteosarcoma of the extremity. Updated results of the Multi-Institutional Osteosarcoma Study.

1991 • 257 citations

Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for osteosarcoma of the extremities the istituto rizzoli experience in 127 patients treated preoperatively with intravenous methotrexate (high versus moderate doses) and intraarterial cisplatin

1990 • 236 citations

Methotrexate: clinical pharmacology, current status and therapeutic guidelines

1977 • 203 citations

Weekly high-dose methotrexate and doxorubicin for osteosarcoma: the Dana-Farber Cancer Institute/the Children's Hospital--study III.

1987 • 131 citations

Trends and variability in survival from osteosarcoma.

1978 • 108 citations

A controlled pilot study of high-dose methotrexate as postsurgical adjuvant treatment for primary osteosarcoma.

1984 • 105 citations

High-dose methotrexate in osteogenic sarcoma: a 5-year experience.

1978 • 90 citations

Osteosarcoma of the limbs.Report of the EORTC-SIOP 03 trial 20781 investigating the value of adjuvant treatment with chemotherapy and/or prophylactic lung irradiation

1988 • 88 citations

Chemotherapy for osteogenic sarcoma: an investigative method, not a recipe.

1982 • 62 citations

Age-related pharmacokinetics of high-dose methotrexate in patients with osteosarcoma.

1979 • 47 citations

Adjuvant adriamycin and cisplatin in newly diagnosed, nonmetastatic osteosarcoma of the extremity.

1986 • 33 citations

The dilemma of adjuvant chemotherapy for osteogenic sarcoma.

1980 • 29 citations

Adjuvant therapy for osteosarcoma: preoperative and postoperative treatment.

1978 • 27 citations

High-dose methotrexate in osteogenic sarcoma adjuvant chemotherapy and limb salvage results.

1981 • 18 citations

Neoadjuvant Chemotherapy for Osteosarcoma — Results of a Prospective Study

1988 • 16 citations

An analysis of spontaneous and chemotherapy‐associated changes in skeletal osteosarcomas

1988 • 15 citations