Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential

Comparing the Areas under Two or More Correlated Receiver Operating Characteristic Curves: A Nonparametric Approach

1988 • 19,163 citations

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

1999 • 11,586 citations

TM4: A Free, Open-Source System for Microarray Data Management and Analysis

2003 • 4,724 citations

Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors

1998 • 4,380 citations

Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation

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Identifying biological themes within lists of genes with EASE

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Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities.

1996 • 1,196 citations

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

1996 • 1,183 citations

Oncogenic alterations of metabolism

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Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

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Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

1993 • 884 citations

Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor

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Soft tissue sarcomas of adults: state of the translational science.

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Molecular characterisation of soft tissue tumours: a gene expression study

2002 • 581 citations

Interstitial Cells of Cajal as Precursors of Gastrointestinal Stromal Tumors

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Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma

1999 • 501 citations

BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data

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Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma.

1995 • 467 citations

Mechanisms of sarcoma development

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The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease

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Gene Expression Profiling of Human Sarcomas: Insights into Sarcoma Biology

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Nomograms for Calculating the Number of Patients Needed for a Clinical Trial with Survival as an Endpoint

1982 • 338 citations

The value of FDG-PET in the detection, grading and response to therapy of soft tissue and bone sarcomas; a systematic review and meta-analysis

2003 • 288 citations

Identifying biological themes within lists of genes with EASE

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Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors

1999 • 268 citations

(F-18) fluorodeoxyglucose positron emission tomography as a predictor of pathologic grade and other prognostic variables in bone and soft tissue sarcoma.

2000 • 252 citations

Gene Expression Signatures Identify Rhabdomyosarcoma Subtypes and Detect a Novel t(2;2)(q35;p23) Translocation Fusing PAX3 to NCOA1

2004 • 240 citations

Hypoxia in human soft tissue sarcomas: Adverse impact on survival and no association with p53 mutations

2001 • 222 citations

Classification and Subtype Prediction of Adult Soft Tissue Sarcoma by Functional Genomics

2003 • 219 citations

Classification of Clear-Cell Sarcoma as a Subtype of Melanoma by Genomic Profiling

2003 • 195 citations

Gastrointestinal stromal tumors with KIT mutations exhibit a remarkably homogeneous gene expression profile.

2001 • 183 citations

Expression Profiling of Synovial Sarcoma by cDNA Microarrays

2002 • 183 citations

Genome-wide analysis of gene expression in synovial sarcomas using a cDNA microarray.

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Functional Domains of the SYT and SYT-SSX Synovial Sarcoma Translocation Proteins and Co-Localization with the SNF Protein BRM in the Nucleus

1999 • 153 citations

Analysis of Hypoxia-Related Gene Expression in Sarcomas and Effect of Hypoxia on RNA Interference of Vascular Endothelial Cell Growth Factor A

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The relationship between tumor oxygenation and cell proliferation in human soft tissue sarcomas

1996 • 147 citations

Gene Expression Patterns and Gene Copy Number Changes in Dermatofibrosarcoma Protuberans

2003 • 143 citations

Usefulness of Cytokeratin Subsets for Distinguishing Monophasic Synovial Sarcoma From Malignant Peripheral Nerve Sheath Tumor

1999 • 141 citations

Therapeutic potential of antibodies against FZD10, a cell-surface protein, for synovial sarcomas

2005 • 123 citations

Separate amplified regions encompassingCDK4 andMDM2 in human sarcomas

1996 • 120 citations

SYT Associates with Human SNF/SWI Complexes and the C-terminal Region of Its Fusion Partner SSX1 Targets Histones

2002 • 108 citations

Disruption of Fibroblast Growth Factor Signal Pathway Inhibits the Growth of Synovial Sarcomas: Potential Application of Signal Inhibitors to Molecular Target Therapy

2005 • 103 citations

Glut-1 expression and enhanced glucose metabolism are associated with tumour grade in bone and soft tissue sarcomas: a prospective evaluation by [18F]fluorodeoxyglucose positron emission tomography

2006 • 103 citations

Prediction of high risk Ewing's sarcoma by gene expression profiling

2004 • 101 citations

The value of MDM2 and CDK4 amplification levels using real-time polymerase chain reaction for the differential diagnosis of liposarcomas and their histologic mimickers

2006 • 97 citations

Prognostic information in soft tissue sarcoma using tumour size, vascular invasion and microscopic tumour necrosis—the SIN-system

2003 • 88 citations

Carbonic Anhydrase IX as a Marker for Poor Prognosis in Soft Tissue Sarcoma

2004 • 85 citations

Histopathologic Type: An Independent Prognostic Factor in Primary Soft Tissue Sarcoma of the Extremity?

2003 • 84 citations

Molecular classification of synovial sarcomas, leiomyosarcomas and malignant fibrous histiocytomas by gene expression profiling

2003 • 82 citations

Profiling and functional annotation of mRNA gene expression in pediatric rhabdomyosarcoma and Ewing's sarcoma

2004 • 77 citations

A Gene Expression Signature Associated with Metastatic Outcome in Human Leiomyosarcomas

2004 • 77 citations

Proteomic signatures corresponding to histological classification and grading of soft-tissue sarcomas

2006 • 71 citations

Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma

2005 • 63 citations

EF5 binding and clinical outcome in human soft tissue sarcomas

2006 • 59 citations

Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers

2003 • 56 citations

Gene expression analysis of human soft tissue leiomyosarcomas

2003 • 49 citations

Expression of hypoxia-inducible factor (HIF)-1α as a biomarker of outcome in soft-tissue sarcomas

2006 • 48 citations

Differential Gene Expression in Liposarcoma, Lipoma, and Adipose Tissue

2005 • 43 citations

Characterization of sarcomas by means of gene expression

2004 • 40 citations

The role of microarray technologies in the study of soft tissue tumours

2005 • 29 citations

Clinico-molecular study of dedifferentiation in well-differentiated liposarcoma

2004 • 26 citations

Molecular target therapy for synovial sarcoma

2005 • 11 citations

Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors

1999 • 10 citations

SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones.

2002 • 5 citations