Altered patterns of RB expression define groups of soft tissue sarcoma patients with distinct biological and clinical behavior.

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

The RB and p53 pathways in cancer

2002 • 1,612 citations

A p16 ^INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

1995 • 1,147 citations

Soft Tissue Sarcomas

2004 • 831 citations

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control

2004 • 552 citations

Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

2000 • 504 citations

Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines.

1998 • 376 citations

Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions

1995 • 334 citations

Elevated and Absent pRb Expression is Associated With Bladder Cancer Progression and has Cooperative Effects With p53

1998 • 317 citations

Altered Expression of the Retinoblastoma Gene Product in Human Sarcomas

1990 • 221 citations

The retinoblastoma gene is involved in malignant progression of astrocytomas

1994 • 220 citations

Detection of DNA sequence polymorphisms by enzymatic amplification and direct genomic sequencing.

1989 • 166 citations

CDK4 gene amplification in osteosarcoma: Reciprocal relationship withINK4A gene alterations and mapping of 12q13 amplicons

1999 • 124 citations

Genetic evidence in melanoma and bladder cancers that p16 and p53 function in separate pathways of tumor suppression.

1995 • 118 citations

High Ki-67 proliferative index predicts disease specific survival in patients with high-risk soft tissue sarcomas

2001 • 97 citations

Hyperphosphorylation of pRb: a mechanism for RB tumour suppressor pathway inactivation in bladder cancer

2004 • 90 citations

Lack of nuclear RB protein staining in G0/middle G1 cells: correlation to changes in total RB protein level.

1991 • 88 citations

Expression of the retinoblastoma protein is regulated in normal human tissues.

1994 • 86 citations

Sarcomas of soft tissue and bone

1991 • 83 citations

DEVELOPMENT OF AN OPTIMAL PROTOCOL FOR ANTIGEN RETRIEVAL: A ‘TEST BATTERY’ APPROACH EXEMPLIFIED WITH REFERENCE TO THE STAINING OF RETINOBLASTOMA PROTEIN (pRB) IN FORMALIN-FIXED PARAFFIN SECTIONS

1996 • 83 citations

Alterations of INK4A and INK4B Genes in Adult Soft Tissue Sarcomas: Effect on Survival

1999 • 72 citations

Altered patterns of retinoblastoma gene product expression in adult soft-tissue sarcomas

1995 • 69 citations

Paradoxical increase in retinoblastoma protein in colorectal carcinomas may protect cells from apoptosis.

1999 • 67 citations

Evaluation of the proliferation marker MIB‐1 in the prognosis of cutaneous malignant melanoma

2002 • 65 citations

Clinical Categories of Neuroblastoma Are Associated with Different Patterns of Loss of Heterozygosity on Chromosome Arm 1p

2000 • 55 citations

Deletion of a splice donor site ablates expression of the following exon and produces an unphosphorylated RB protein unable to bind SV40 T antigen.

1990 • 52 citations

Phosphorylation of Retinoblastoma Protein Assayed in Individual HL-60 Cells during Their Proliferation and Differentiation

1998 • 32 citations

Prognostic role of cyclin D1 in retroperitoneal sarcomas

2001 • 12 citations