Interleukin-18

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

1998 • 2,047 citations

TRAF6 is a signal transducer for interleukin-1

1996 • 1,287 citations

Interleukin-18 Regulates Both Th1 and Th2 Responses

2001 • 1,284 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

1997 • 1,137 citations

MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex

1997 • 1,104 citations

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

2002 • 985 citations

Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice

1998 • 914 citations

Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System

1996 • 903 citations

CCR5⁺and CXCR3⁺T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions

1999 • 839 citations

IL-18: A TH1 -inducing, proinflammatory cytokine and new member of the IL-1 family

1999 • 806 citations

Interleukin-18 Binding Protein

1999 • 759 citations

A Family of Stress-Inducible GADD45-like Proteins Mediate Activation of the Stress-Responsive MTK1/MEKK4 MAPKKK

1998 • 740 citations

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

1997 • 726 citations

IL-12 Up-Regulates IL-18 Receptor Expression on T Cells, Th1 Cells, and B Cells: Synergism with IL-18 for IFN-γ Production

1998 • 636 citations

Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.

1996 • 635 citations

A proinflammatory role for IL-18 in rheumatoid arthritis

1999 • 629 citations

Interferon‐γ‐inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin‐12 for interferon‐γ production

1996 • 606 citations

Murine Macrophages Secrete Interferon γ upon Combined Stimulation with Interleukin (IL)-12 and IL-18: A Novel Pathway of Autocrine Macrophage Activation

1998 • 594 citations

IL-18, a Novel Immunoregulatory Cytokine, Is Up-Regulated in Crohn’s Disease: Expression and Localization in Intestinal Mucosal Cells

1999 • 576 citations

Expression of Interleukin (IL)-18 and Functional IL-18 Receptor on Human Vascular Endothelial Cells, Smooth Muscle Cells, and Macrophages

2002 • 489 citations

Role of T‐Cell Derived Cytokines in the Downregulation of Immune Responses in Parasitic and Retroviral Infection

1992 • 473 citations

Purification and Characterization of the Human Interleukin-18 Receptor

1997 • 471 citations

Impaired IL-18 processing protects caspase-1–deficient mice from ischemic acute renal failure

2001 • 460 citations

Interleukin-18: A Novel Cytokine That Augments Both Innate and Acquired Immunity

1998 • 458 citations

IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils

1999 • 435 citations

IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones.

1996 • 425 citations

IL-1β-converting enzyme (caspase-1) in intestinal inflammation

2001 • 408 citations

Bioactive IL-18 Expression Is Up-Regulated in Crohn’s Disease

1999 • 399 citations

IL-1-Independent Role of IL-17 in Synovial Inflammation and Joint Destruction During Collagen-Induced Arthritis

2001 • 396 citations

Caspase-1 Activation of IL-1β and IL-18 Are Essential for Shigella flexneri–Induced Inflammation

2000 • 388 citations

Interleukin-18 (Interferon-γ–inducing Factor) Is Produced by Osteoblasts and Acts Via Granulocyte/Macrophage Colony-stimulating Factor and Not Via Interferon-γ to Inhibit Osteoclast Formation

1997 • 381 citations

Acute Toxoplasmosis Leads to Lethal Overproduction of Th1 Cytokines

2001 • 380 citations

Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1β are differentially regulated in human blood mononuclear cells and mouse spleen cells

1999 • 368 citations

Selective Expression and Functions of Interleukin 18 Receptor on T Helper (Th) Type 1 but not Th2 Cells

1998 • 356 citations

IL-18 Is a Potent Coinducer of IL-13 in NK and T Cells: A New Potential Role for IL-18 in Modulating the Immune Response

1999 • 351 citations

IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6

2000 • 343 citations

Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18

2000 • 335 citations

Cloning of a Novel Receptor Subunit, AcPL, Required for Interleukin-18 Signaling

1998 • 326 citations

A Role for IL-18 in Neutrophil Activation

2001 • 293 citations

Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development

1998 • 289 citations

Neutrophil Proteinase 3-Mediated Induction of Bioactive IL-18 Secretion by Human Oral Epithelial Cells

2001 • 286 citations

Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-γ and TNF-α production

2001 • 286 citations

Endotoxin-induced serum factor that stimulates gamma interferon production

1989 • 285 citations

Interferon-γ-Inducing Factor, a Novel Cytokine, Enhances Fas Ligand-Mediated Cytotoxicity of Murine T Helper 1 Cells

1996 • 277 citations

A NOVEL IL-18BP ELISA SHOWS ELEVATED SERUM IL-18BP IN SEPSIS AND EXTENSIVE DECREASE OF FREE IL-18

2001 • 272 citations

Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease

2001 • 267 citations

Cutting Edge: Generation of IL-18 Receptor-Deficient Mice: Evidence for IL-1 Receptor-Related Protein as an Essential IL-18 Binding Receptor

1999 • 267 citations

Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes.

1997 • 267 citations

Evidence of IL-18 as a Novel Angiogenic Mediator

2001 • 261 citations

Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage

2002 • 254 citations

Synergy of IL-12 and IL-18 for IFN-γ Gene Expression: IL-12-Induced STAT4 Contributes to IFN-γ Promoter Activation by Up-Regulating the Binding Activity of IL-18-Induced Activator Protein 1

2002 • 250 citations

Role of Interleukin-18 (IL-18) in Mycobacterial Infection in IL-18-Gene-Disrupted Mice

1999 • 249 citations

Cloning of a Novel Mitogen-activated Protein Kinase Kinase Kinase, MEKK4, That Selectively Regulates the c-Jun Amino Terminal Kinase Pathway

1997 • 242 citations

Synergistic Effects of IL-4 and IL-18 on IL-12-Dependent IFN-γ Production by Dendritic Cells

2000 • 238 citations

IL-18 Is Produced by Articular Chondrocytes and Induces Proinflammatory and Catabolic Responses

1999 • 238 citations

IL-18–stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production

2001 • 237 citations

Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily

2002 • 236 citations

Cutting Edge: IL-12 and IL-18 Differentially Regulate the Transcriptional Activity of the Human IFN-γ Promoter in Primary CD4+ T Lymphocytes

1998 • 235 citations

IL-18 Up-Regulates Perforin-Mediated NK Activity Without Increasing Perforin Messenger RNA Expression by Binding to Constitutively Expressed IL-18 Receptor

1999 • 234 citations

Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells

1997 • 229 citations

Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1β

2001 • 227 citations

IL-1Rrp Is a Novel Receptor-like Molecule Similar to the Type I Interleukin-1 Receptor and Its Homologues T1/ST2 and IL-1R AcP

1996 • 225 citations

Virus Infection Activates IL-1β and IL-18 Production in Human Macrophages by a Caspase-1-Dependent Pathway

1999 • 225 citations

Influenza A Virus-Induced IFN-α/β and IL-18 Synergistically Enhance IFN-γ Gene Expression in Human T Cells

1998 • 218 citations

Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor.

1998 • 216 citations

Reduced Incidence and Severity of Collagen-Induced Arthritis in Mice Lacking IL-18

2001 • 208 citations

Propionibacterium acnes treatment diminishes CD4+ NK1.1+ T cells but induces type I T cells in the liver by induction of IL-12 and IL-18 production from Kupffer cells.

1997 • 208 citations

Interleukin 18 Contributes to Host Resistance and Gamma Interferon Production in Mice Infected with VirulentSalmonella typhimurium

1999 • 206 citations

IL-1H, AN INTERLEUKIN 1-RELATED PROTEIN THAT BINDS IL-18 RECEPTOR/IL-1Rrp

2001 • 205 citations

IL-18 Augments Perforin-Dependent Cytotoxicity of Liver NK-T Cells

1998 • 203 citations

Involvement of Caspase-1 and Caspase-3 in the Production and Processing of Mature Human Interleukin 18 in Monocytic THP.1 Cells

1997 • 198 citations

Caspase-1 Regulates the Inflammatory Process Leading to Autoimmune Demyelination

1999 • 198 citations

IL-18 binding and inhibition of interferon γ induction by human poxvirus-encoded proteins

1999 • 197 citations

IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-gamma production.

1997 • 196 citations

Macrophage-derived IL-18–mediated intestinal inflammation in the murine model of Crohn's disease

2001 • 196 citations

Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis

2001 • 195 citations

IL-18 (IFN-γ-Inducing Factor) Regulates Early Cytokine Production in, and Promotes Resolution of, Bacterial Infection in Mice

1998 • 195 citations

Interleukin-18 Regulation of Interferon γ Production and Cell Proliferation as Shown in Interleukin-1β–Converting Enzyme (Caspase-1)-Deficient Mice

1998 • 194 citations

Interleukin-18 Activates NF-κB in Murine T Helper Type 1 Cells

1997 • 192 citations

Cutting Edge: Selective IL-18 Requirements for Induction of Compartmental IFN-γ Responses During Viral Infection

2000 • 185 citations

Interleukin (IL)‐18 induces Langerhans cell migration by a tumour necrosis factor‐α‐ and IL‐1β‐dependent mechanism

2001 • 180 citations

A Poxvirus Protein That Binds to and Inactivates IL-18, and Inhibits NK Cell Response

2000 • 175 citations

Altered Immune Responses and Susceptibility toLeishmania majorandStaphylococcus aureusInfection in IL-18-Deficient Mice

1999 • 173 citations

IL-18 Directs Autoreactive T Cells and Promotes Autodestruction in the Central Nervous System Via Induction of IFN-γ by NK Cells

2000 • 173 citations

Interleukin-18 Protects Mice against Acute Herpes Simplex Virus Type 1 Infection

1999 • 171 citations

In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells

2000 • 170 citations

A Novel Role for Interleukin-18 in Adhesion Molecule Induction through NFκB and Phosphatidylinositol (PI) 3-Kinase-dependent Signal Transduction Pathways

2001 • 167 citations

Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2.

1997 • 165 citations

Defective Interleukin (IL)-18–mediated Natural Killer and T Helper Cell Type 1 Responses in IL-1 Receptor–associated Kinase (IRAK)-deficient Mice

1999 • 164 citations

Regulation of IL-18 (IFN-gamma-inducing factor) gene expression.

1997 • 162 citations

Phosphorylation Events Modulate the Ability of Interferon Consensus Sequence Binding Protein to Interact with Interferon Regulatory Factors and to Bind DNA

1997 • 162 citations

Induction of Interferon-γ Inducing Factor in the Adrenal Cortex

1997 • 156 citations

IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background

2000 • 153 citations

Human Keratinocytes Constitutively Express Interleukin-18 and Secrete Biologically Active Interleukin-18 After Treatment with Pro-Inflammatory Mediators and Dinitrochlorobenzene

1999 • 153 citations

Murine Microglial Cells Produce and Respond to Interleukin‐18

1999 • 153 citations

Combined Effects of IL-12 and IL-18 on the Induction of Collagen-Induced Arthritis

2000 • 150 citations

Expression and Release of IL-18 Binding Protein in Response to IFN-γ

2001 • 141 citations

IL-18 Promotes Type 1 Cytokine Production from NK Cells and T Cells in Human Intracellular Infection

1999 • 141 citations

Interleukin-18 Activates the IRAK-TRAF6 Pathway in Mouse EL-4 Cells

1998 • 138 citations

Interleukin-18 as a novel diagnostic marker and indicator of disease severity in adult-onset Still's disease

2001 • 138 citations

Interferon-?-inducing activity of interleukin-18 in the joint with rheumatoid arthritis

2001 • 136 citations

IL-18 Activates STAT3 in the Natural Killer Cell Line 92, Augments Cytotoxic Activity, and Mediates IFN-γ Production by the Stress Kinase p38 and by the Extracellular Regulated Kinases p44erk-1and p42erk-21

2000 • 135 citations

Treatment of T Cell-Dependent Experimental Colitis in SCID Mice by Local Administration of an Adenovirus Expressing IL-18 Antisense mRNA

2002 • 128 citations

IL-18 Contributes to Host Resistance Against Infection withCryptococcus neoformansin Mice with Defective IL-12 Synthesis Through Induction of IFN-γ Production by NK Cells

2000 • 128 citations

Cloning and expression of interleukin‐18 binding protein

1999 • 122 citations

Elevation of plasma interleukin‐18 concentration is correlated with disease activity in systemic lupus erythematosus

2000 • 122 citations

Interleukin-18 induces production of proinflammatory cytokines in mice: no intermediate role for the cytokines of the tumor necrosis factor family and interleukin-1β

2000 • 120 citations

IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock

1999 • 120 citations

IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-gamma dependent manner

2000 • 118 citations

Purification of a factor which provides a costimulatory signal for gamma interferon production

1993 • 118 citations

Neutralizing Antibodies to IFN-γ-Inducing Factor Prevent Experimental Autoimmune Encephalomyelitis

1998 • 117 citations

Interleukin-18 (IL-18) Enhances Innate IL-12-Mediated Resistance toToxoplasma gondii

2000 • 115 citations

Interleukin 18 stimulates HIV type 1 in monocytic cells

1998 • 113 citations

Role of IL-18 in Acute Lung Inflammation

2001 • 105 citations

IL-18 Improves the Early Antimicrobial Host Response to Pneumococcal Pneumonia

2002 • 104 citations

Roles of IFN Consensus Sequence Binding Protein and PU.1 in Regulating IL-18 Gene Expression

1999 • 103 citations

Interleukin (Il)-18 Promotes the Development of Chronic Gastrointestinal Helminth Infection by Downregulating IL-13

2001 • 101 citations

IN VIVO ANTIVIRAL EFFECT OF INTERLEUKIN 18 IN A MOUSE MODEL OF VACCINIA VIRUS INFECTION

1999 • 99 citations

Regulation of Interleukin (Il)-18 Receptor α Chain Expression on Cd4+ T Cells during T Helper (Th)1/Th2 Differentiation

2001 • 97 citations

Down modulation of IL‐18 expression by human papillomavirus type 16 E6 oncogene via binding to IL‐18

2001 • 96 citations

Elevation of serum interleukin-18 levels and activation of kupffer cells in biliary atresia

2000 • 94 citations

Potentiality of Interleukin-18 as a Useful Reagent for Treatment and Prevention ofLeishmania majorInfection

2000 • 94 citations

Differential induction of interleukin-12, interleukin-18, and interleukin-1β converting enzyme mRNA in experimental autoimmune encephalomyelitis of the Lewis rat

1998 • 93 citations

An Essential Role for NF-κB in IL-18-Induced IFN-γ Expression in KG-1 Cells

1999 • 90 citations

Serum levels of the interferon-γ-inducing cytokine interleukin-18 are increased in individuals at high risk of developing Type I diabetes

2001 • 90 citations

Contribution of IL-18 to Th1 Response and Host Defense Against Infection by Mycobacterium tuberculosis: A Comparative Study with IL-12p40

2002 • 88 citations

IL-18-Binding Protein Expression by Endothelial Cells and Macrophages Is Up-Regulated During Active Crohn’s Disease

2002 • 88 citations

Cellular and molecular changes accompanying the progression from insulitis to diabetes

1999 • 85 citations

IL-18 Inhibits Diabetes Development in Nonobese Diabetic Mice by Counterregulation of Th1-Dependent Destructive Insulitis

1999 • 84 citations

Increased Levels of Circulating Interleukin-18 in Patients with Advanced Tuberculosis

2000 • 84 citations

Human keratinocytes constitutively produce but do not process interleukin-18

2000 • 84 citations

Gene Expression Profile of Herpesvirus-Infected T Cells Obtained Using Immunomicroarrays: Induction of Proinflammatory Mechanisms

2001 • 84 citations

Genetically Resistant Mice Lacking IL-18 Gene Develop Th1 Response and Control CutaneousLeishmania majorInfection

2000 • 83 citations

Interleukin-18 Induces Rheumatoid Arthritis Synovial Fibroblast CXC Chemokine Production through NFκB Activation

2001 • 82 citations

Serum gamma‐interferon‐inducing factor (IL‐18) and IL‐10 levels in patients with acute hepatitis and fulminant hepatic failure

2002 • 82 citations

Interleukin 18 Restores Defective Th1 Immunity toCandida albicansin Caspase 1-Deficient Mice

2000 • 80 citations

Differential Roles of IL-18 in Allergic Airway Disease: Induction of Eotaxin by Resident Cell Populations Exacerbates Eosinophil Accumulation

2000 • 79 citations

IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-γ

2000 • 79 citations

Essential Role of Interleukin-12 (IL-12) and IL-18 for Gamma Interferon Production Induced by Listeriolysin O in Mouse Spleen Cells

2002 • 79 citations

IFN-γ Up-Regulates IL-18 Gene Expression Via IFN Consensus Sequence-Binding Protein and Activator Protein-1 Elements in Macrophages

2000 • 79 citations

Increased Levels of Interleukin-18 in Patients with Pulmonary Sarcoidosis

2000 • 76 citations

IL-18 deficiency selectively enhances allergen-induced eosinophilia in mice

2000 • 75 citations

Combined effects of IL-12 and IL-18 on the clinical course and local cytokine production in murine pulmonary infection withCryptococcus neoformans

1999 • 75 citations

Persistent Expression of Cytokines inÈthe Chronic Stage of CVB3-induced Myocarditis in NMRI Mice

2001 • 74 citations

Role of Interleukin-18 (IL-18) during Lethal Shock: Decreased Lipopolysaccharide Sensitivity but Normal Superantigen Reaction in IL-18-Deficient Mice

2000 • 74 citations

Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis

2002 • 74 citations

Production of Interleukin‐18 in Human Tuberculosis

2000 • 74 citations

IL-12-Independent Th1-Type Immune Responses to Respiratory Viral Infection: Requirement of IL-18 for IFN-γ Release in the Lung But Not for the Differentiation of Viral-Reactive Th1-Type Lymphocytes

2000 • 71 citations

Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice

2002 • 70 citations

Feline Leukemia Virus DNA Vaccine Efficacy Is Enhanced by Coadministration with Interleukin-12 (IL-12) and IL-18 Expression Vectors

2001 • 68 citations

Depressed Interleukin-12 (IL-12), but not IL-18, Production in Response to a 30- or 32-Kilodalton Mycobacterial Antigen in Patients with Active Pulmonary Tuberculosis

2000 • 67 citations

Peripheral levels of caspase-1 mRNA correlate with disease activity in patients with multiple sclerosis; a preliminary study

1999 • 67 citations

Comparative analysis of host responses related to immunosuppression between measles patients and vaccine recipients with live attenuated measles vaccines

2001 • 64 citations

Trypanosoma cruzi induces strong IL-12 and IL-18 gene expression in vivo: correlation with interferon-gamma (IFN-γ) production

1997 • 63 citations

The Possible Role of Interleukin (IL)-12 and Interferon-γ-Inducing Factor/IL-18 in Protection against ExperimentalMycobacterium lepraeInfection in Mice

1998 • 62 citations

IL-18 Gene Transfer by Adenovirus Prevents the Development of and Reverses Established Allergen-Induced Airway Hyperreactivity

2001 • 60 citations

Impaired Microglial Activation in the Brain of IL-18-Gene-Disrupted Mice after Neurovirulent Influenza A Virus Infection

2001 • 58 citations

Mature form of interleukin 18 is expressed in rheumatoid arthritis synovial tissue and contributes to interferon-gamma production by synovial T cells.

2001 • 53 citations

IL-18 modulates chronic fungal asthma in a murine model; putative involvement of Toll-like receptor-2

2001 • 52 citations

The Role of IL-18 in Blood-Stage Immunity Against Murine MalariaPlasmodium yoelii 265andPlasmodium berghei ANKA

2002 • 51 citations

IFN consenus sequence binding protein (ICSBP) is a conditional repressor of IFN inducible promoters

1994 • 51 citations

A Heritable Defect in IL-12 Signaling in B10.Q/J Mice. II. Effect on Acute Resistance to Toxoplasma gondii and Rescue by IL-18 Treatment

2001 • 49 citations

Chlamydia trachomatis Mouse Pneumonitis Lung Infection in IL-18 and IL-12 Knockout Mice: IL-12 Is Dominant over IL-18 for Protective Immunity

2000 • 44 citations

Interleukin‐18 Inhibits Human Immunodeficiency Virus Type 1 Production in Peripheral Blood Mononuclear Cells

2001 • 42 citations

Decreased Expression of Cytokines That Induce Type 1 Helper T Cell/Interferon-γ Responses in Genetically Susceptible Mice Infected withMycobacterium avium

1997 • 40 citations

Interleukin-18 enhances the production of interleukin-8 by eosinophils

2001 • 40 citations

Interleukin-18 modulates immune responses induced by HIV-1 Nef DNA prime/protein boost vaccine

2000 • 39 citations

Reduced Interleukin-18 Levels in BAL Specimens From Patients With Asthma Compared to Patients With Sarcoidosis and Healthy Control Subjects

2002 • 38 citations

Expression of interleukin‐18 and its monokine‐directed function in rheumatoid arthritis

2001 • 36 citations

Effect of Interleukin-18 on Viral Myocarditis: Enhancement of Interferon- γ and Natural Killer Cell Activity

2000 • 35 citations

Serum Interleukin-18 Concentrations in Patients With Inflammatory Bowel Disease

2002 • 32 citations

IFN-gamma and lipopolysaccharide induce DNA binding of transcription factor PU.1 in murine tissue macrophages.

1995 • 32 citations

Serum levels of interleukin-18 in patients with uncomplicated Plasmodium falciparum malaria.

2001 • 32 citations

Interleukin-18 and Crohn’s Disease

2001 • 32 citations

Human defenses against Cryptococcus neoformans: an update.

1998 • 30 citations

Interleukin-18 stimulates HIV-1 replication in a T-cell line.

2000 • 29 citations

Early IFN-γ production is related to the presence of interleukin (IL)-18 and the absence of IL-13 in experimental Trypanosoma cruzi infections

2001 • 28 citations

Expression of interleukin-18 receptor in fibroblast-like synoviocytes

2001 • 26 citations

Effects of post‐inhalation treatment with interleukin‐12 on airway hyper‐reactivity, eosinophilia and interleukin‐18 receptor expression in a mouse model of asthma

2002 • 25 citations

Mucosal Cytokine Therapy: Marked Antiviral and Antitumor Activity

1999 • 24 citations

Interleukin-18 expression induced by Epstein-Barr virus-infected cells

2001 • 17 citations

Interleukin-18 reduces expression of cardiac tumor necrosis factor-α and atrial natriuretic peptide in a murine model of viral myocarditis

2002 • 12 citations

Role of Interleukin-18 in Peripheral Blood Mononuclear Cells Infected with Human Herpes Virus Type 6

2001 • 7 citations