Neutrophil Proteinase 3-Mediated Induction of Bioactive IL-18 Secretion by Human Oral Epithelial Cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

1997 • 1,137 citations

Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing.

1998 • 687 citations

Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.

1996 • 635 citations

IL-18, a Novel Immunoregulatory Cytokine, Is Up-Regulated in Crohn’s Disease: Expression and Localization in Intestinal Mucosal Cells

1999 • 576 citations

Generation of Biologically Active IL-1β by Matrix Metalloproteinases: A Novel Caspase-1-Independent Pathway of IL-1β Processing

1998 • 556 citations

Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells.

1998 • 556 citations

Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1).

1999 • 462 citations

Interleukin-18: A Novel Cytokine That Augments Both Innate and Acquired Immunity

1998 • 458 citations

Bacterial Lipopolysaccharide and IFN-γ Induce Toll-Like Receptor 2 and Toll-Like Receptor 4 Expression in Human Endothelial Cells: Role of NF-κB Activation

2001 • 445 citations

Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters.

1988 • 436 citations

IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils

1999 • 435 citations

IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones.

1996 • 425 citations

Bioactive IL-18 Expression Is Up-Regulated in Crohn’s Disease

1999 • 399 citations

Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme.

1990 • 397 citations

Interleukin-18 (Interferon-γ–inducing Factor) Is Produced by Osteoblasts and Acts Via Granulocyte/Macrophage Colony-stimulating Factor and Not Via Interferon-γ to Inhibit Osteoclast Formation

1997 • 381 citations

IL-18 Is a Potent Coinducer of IL-13 in NK and T Cells: A New Potential Role for IL-18 in Modulating the Immune Response

1999 • 351 citations

Converting enzyme-independent release of tumor necrosis factor α and IL-1β from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3

1999 • 346 citations

Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties

1991 • 303 citations

Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells

1989 • 293 citations

Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes.

1997 • 267 citations

Caspase-1-Independent, Fas/Fas Ligand–Mediated IL-18 Secretion from Macrophages Causes Acute Liver Injury in Mice

1999 • 245 citations

Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties.

1990 • 214 citations

Involvement of Caspase-1 and Caspase-3 in the Production and Processing of Mature Human Interleukin 18 in Monocytic THP.1 Cells

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Critical Roles of Toll-Like Receptors in Host Defense

2000 • 196 citations

Bioactive Proteinase 3 on the Cell Surface of Human Neutrophils: Quantification, Catalytic Activity, and Susceptibility to Inhibition

2000 • 193 citations

Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase.

1996 • 184 citations

Induction of Interferon-γ Inducing Factor in the Adrenal Cortex

1997 • 156 citations

Interleukin-18 (IL-18), although anti-allergic when administered with IL-12, stimulates IL-4 and histamine release by basophils

1999 • 151 citations

Preparation and properties of a standardized lipopolysaccharide from salmonella abortus equi (Novo-Pyrexal).

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Cytokine profile and ultrastructure of intraepithelial gamma delta T cells in chronically inflamed human gingiva suggest a cytotoxic effector function.

1994 • 132 citations

Heterogeneous Expression and Release of CD14 by Human Gingival Fibroblasts: Characterization and CD14-Mediated Interleukin-8 Secretion in Response to Lipopolysaccharide

1998 • 89 citations

Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro.

1996 • 86 citations

IFN-γ Up-Regulates IL-18 Gene Expression Via IFN Consensus Sequence-Binding Protein and Activator Protein-1 Elements in Macrophages

2000 • 79 citations

Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture

1996 • 62 citations

A Secreted Proform of Neutrophil Proteinase 3 Regulates the Proliferation of Granulopoietic Progenitor Cells

1999 • 59 citations

Proteinase 3, the target antigen of anticytoplasmic antibodies circulating in Wegener's granulomatosis. Immunolocalization in normal and pathologic tissues.

1991 • 55 citations

Proteinase 3 Interacts with a 111-kD Membrane Molecule of Human Umbilical Vein Endothelial Cells

2000 • 45 citations

Proteinase 3. A neutrophil proteinase with activity on platelets.

1994 • 43 citations

Differential Distribution of T Lymphocyte Subpopulations in the Bovine Mammary Gland During Lactation

1999 • 36 citations

Effect of Anti‐Neutrophil Cytoplasmic Antibodies on Proteinase 3‐Induced Apoptosis of Human Endothelial Cells

1998 • 36 citations

[3] Myeloblastin: Leukocyte proteinase 3

1994 • 23 citations

Immunohistologic and Morphometric Analysis of Cytotoxic T Lymphocytes in Gingivitis

1999 • 19 citations

A Comparative Analysis of the Antigenic, Structural, and Functional Properties of Three Different Preparations of Recombinant Human Interleukin-18

2000 • 11 citations

A Secreted Proform of Neutrophil Proteinase 3 Regulates the Proliferation of Granulopoietic Progenitor Cells

1999 • 7 citations