IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Real time quantitative PCR.

1996 • 6,155 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

A novel method for real time quantitative RT-PCR.

1996 • 2,093 citations

Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

1999 • 1,912 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

Regulation of Immunity to Parasites by T Cells and T Cell-Derived Cytokines

1992 • 843 citations

Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells

1997 • 823 citations

IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production.

1998 • 775 citations

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

1997 • 726 citations

IL-12 Up-Regulates IL-18 Receptor Expression on T Cells, Th1 Cells, and B Cells: Synergism with IL-18 for IFN-γ Production

1998 • 636 citations

T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function

1998 • 601 citations

QUANTIFICATION OF MURINE CYTOKINE mRNAs USING REAL TIME QUANTITATIVE REVERSE TRANSCRIPTASE PCR

1999 • 567 citations

Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.

1995 • 554 citations

IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12.

1997 • 528 citations

Selective Expression of a Stable Cell Surface Molecule on Type 2 but Not Type 1 Helper T Cells

1998 • 514 citations

IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils

1999 • 435 citations

Genetic Susceptibility to Leishmania : IL-12 Responsiveness in T _H 1 Cell Development

1996 • 367 citations

Selective Expression and Functions of Interleukin 18 Receptor on T Helper (Th) Type 1 but not Th2 Cells

1998 • 356 citations

IL-18 Is a Potent Coinducer of IL-13 in NK and T Cells: A New Potential Role for IL-18 in Modulating the Immune Response

1999 • 351 citations

Immunology of Leishmaniasis

1993 • 337 citations

Susceptibility to Leishmania major Infection in Interleukin-4-Deficient Mice

1996 • 292 citations

Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development

1998 • 289 citations

CD4+ T-cell subsets in autoimmunity

1997 • 249 citations

IFN-γ-Inducing Factor (IL-18) Increases Allergic Sensitization, Serum IgE, Th2 Cytokines, and Airway Eosinophilia in a Mouse Model of Allergic Asthma

2000 • 227 citations

Altered Immune Responses and Susceptibility toLeishmania majorandStaphylococcus aureusInfection in IL-18-Deficient Mice

1999 • 173 citations

Functional heterogeneity of CD4+ T cells in leishmaniasis

1989 • 171 citations

Interleukin-18 (IL-18), although anti-allergic when administered with IL-12, stimulates IL-4 and histamine release by basophils

1999 • 151 citations

Differential capacities of CD4+, CD8+, and CD4-CD8- T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18.

1998 • 124 citations

Development of CD8+ Effector T Cells Is Differentially Regulated by IL-18 and IL-12

1999 • 121 citations

Differential Capacities of CD4+, CD8+, and CD4−CD8− T Cell Subsets to Express IL-18 Receptor and Produce IFN-γ in Response to IL-18

1998 • 92 citations

IL-18 Inhibits Diabetes Development in Nonobese Diabetic Mice by Counterregulation of Th1-Dependent Destructive Insulitis

1999 • 84 citations

Genetically Resistant Mice Lacking IL-18 Gene Develop Th1 Response and Control CutaneousLeishmania majorInfection

2000 • 83 citations

Dealing from the Evolutionary Pawnshop

1999 • 81 citations

Protective Immune Responses Induced by Vaccination with an Expression Genomic Library ofLeishmania major

1999 • 59 citations

Soluble protein but not peptide administration diverts the immune response of a clonal CD4+ T cell population to the T helper 2 cell pathway.

1996 • 44 citations

Memory/effector T cells in TCR transgenic mice develop via recognition of enteric antigens by a second, endogenous TCR

1999 • 39 citations