IL-18: A TH1 -inducing, proinflammatory cytokine and new member of the IL-1 family

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Chemokines — Chemotactic Cytokines That Mediate Inflammation

1998 • 3,660 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

1998 • 2,047 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

1994 • 1,695 citations

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

1997 • 1,651 citations

The Inverse Association Between Tuberculin Responses and Atopic Disorder

1997 • 1,305 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

TRAF6 is a signal transducer for interleukin-1

1996 • 1,287 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

1997 • 1,137 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

1996 • 985 citations

Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist

1998 • 956 citations

Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice

1998 • 914 citations

IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production.

1998 • 775 citations

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

1997 • 726 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

The human interferon $alpha;/$beta; receptor: Characterization and molecular cloning

1994 • 658 citations

IL-12 Up-Regulates IL-18 Receptor Expression on T Cells, Th1 Cells, and B Cells: Synergism with IL-18 for IFN-γ Production

1998 • 636 citations

Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.

1996 • 635 citations

Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex

1995 • 634 citations

Interleukin 1 signaling occurs exclusively via the type I receptor.

1993 • 609 citations

Murine Macrophages Secrete Interferon γ upon Combined Stimulation with Interleukin (IL)-12 and IL-18: A Novel Pathway of Autocrine Macrophage Activation

1998 • 594 citations

Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants

1998 • 573 citations

Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.

1990 • 557 citations

Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells.

1998 • 556 citations

IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12.

1997 • 528 citations

Purification and Characterization of the Human Interleukin-18 Receptor

1997 • 471 citations

Soluble cytokine receptors are present in normal human urine.

1989 • 441 citations

IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones.

1996 • 425 citations

Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis.

1998 • 419 citations

Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells

1997 • 385 citations

Interleukin-18 (Interferon-γ–inducing Factor) Is Produced by Osteoblasts and Acts Via Granulocyte/Macrophage Colony-stimulating Factor and Not Via Interferon-γ to Inhibit Osteoclast Formation

1997 • 381 citations

Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1β are differentially regulated in human blood mononuclear cells and mouse spleen cells

1999 • 368 citations

A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock

1995 • 344 citations

Cloning of a Novel Receptor Subunit, AcPL, Required for Interleukin-18 Signaling

1998 • 326 citations

The Interleukin-1 Receptor Accessory Protein (IL-1RAcP) Is Essential for IL-1-induced Activation of Interleukin-1 Receptor-associated Kinase (IRAK) and Stress-activated Protein Kinases (SAP Kinases)

1997 • 311 citations

IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes.

1998 • 306 citations

Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity.

1987 • 305 citations

Destruction of Rat Islet Cell Monolayers by Cytokines: Synergistic Interactions of Interferon-γ, Tumor Necrosis Factor, Lymphotoxin, and Interleukin 1

1988 • 296 citations

Interferon-γ-Inducing Factor, a Novel Cytokine, Enhances Fas Ligand-Mediated Cytotoxicity of Murine T Helper 1 Cells

1996 • 277 citations

Influenza A virus-induced IFN-alpha/beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells.

1998 • 272 citations

Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes.

1997 • 267 citations

IL-1 beta is required for IL-12 to induce production of IFN-gamma by NK cells. A role for IL-1 beta in the T cell-independent mechanism of resistance against intracellular pathogens.

1995 • 253 citations

IL-18 (IFN-gamma-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice.

1998 • 238 citations

Cutting Edge: IL-12 and IL-18 Differentially Regulate the Transcriptional Activity of the Human IFN-γ Promoter in Primary CD4+ T Lymphocytes

1998 • 235 citations

IFN-gamma-inducing factor/IL-18 administration mediates IFN-gamma- and IL-12-independent antitumor effects.

1998 • 229 citations

Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein

1997 • 227 citations

IL-1Rrp Is a Novel Receptor-like Molecule Similar to the Type I Interleukin-1 Receptor and Its Homologues T1/ST2 and IL-1R AcP

1996 • 225 citations

Influenza A Virus-Induced IFN-α/β and IL-18 Synergistically Enhance IFN-γ Gene Expression in Human T Cells

1998 • 218 citations

Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor.

1998 • 216 citations

IL-18 Augments Perforin-Dependent Cytotoxicity of Liver NK-T Cells

1998 • 203 citations

IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-gamma production.

1997 • 196 citations

IL-18 (IFN-γ-Inducing Factor) Regulates Early Cytokine Production in, and Promotes Resolution of, Bacterial Infection in Mice

1998 • 195 citations

Interleukin-18 Regulation of Interferon γ Production and Cell Proliferation as Shown in Interleukin-1β–Converting Enzyme (Caspase-1)-Deficient Mice

1998 • 194 citations

Interleukin-18 Activates NF-κB in Murine T Helper Type 1 Cells

1997 • 192 citations

IFN-γ-Inducing Factor/IL-18 Administration Mediates IFN-γ- and IL-12-Independent Antitumor Effects

1998 • 185 citations

Experimental autoimmune encephalomyelitis is exacerbated by IL-1 alpha and suppressed by soluble IL-1 receptor.

1991 • 183 citations

Primary demyelination in transgenic mice expressing interferon-γ

1997 • 180 citations

NF-κB Activation by Interleukin-1 (IL-1) Requires an IL-1 Receptor-associated Protein Kinase Activity

1995 • 172 citations

Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2.

1997 • 165 citations

Regulation of IL-18 (IFN-gamma-inducing factor) gene expression.

1997 • 162 citations

Interleukin-12 Is Required for Control of the Growth of Attenuated Aromatic-Compound-Dependent Salmonellae in BALB/c Mice: Role of Gamma Interferon and Macrophage Activation

1998 • 156 citations

Induction of Interferon-γ Inducing Factor in the Adrenal Cortex

1997 • 156 citations

Interleukin-18 Activates the IRAK-TRAF6 Pathway in Mouse EL-4 Cells

1998 • 138 citations

Hyperosmotic Stress as a Stimulant for Proinflammatory Cytokine Production

1997 • 137 citations

Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo.

1995 • 133 citations

Comparison of the effects of interleukin‐1α, interleukin‐lβ and interferon‐γ‐inducing factor on the production of interferon‐γ by natural killer

1997 • 130 citations

Characterization of anti-human interleukin-18 (IL-18)/interferon-γ-inducing factor (IGIF) monoclonal antibodies and their application in the measurement of human IL-18 by ELISA

1997 • 119 citations

Interleukin-18/interferon-γ-inducing factor, a novel cytokine, up-regulates ICAM-1 (CD54) expression in KG-1 cells

1998 • 119 citations

Interleukin 18 induces the sequential activation of natural killer cells and cytotoxic T lymphocytes to protect syngeneic mice from transplantation with Meth A sarcoma.

1997 • 116 citations

Interleukin 18 stimulates HIV type 1 in monocytic cells

1998 • 113 citations

Interleukins in the Control of Osteoclast Differentiation

1998 • 113 citations

Interleukin 18 enhances Fas ligand expression and induces apoptosis in Fas-expressing human myelomonocytic KG-1 cells.

1997 • 111 citations

The interleukin-1 receptor complex and interleukin-1 signal transduction.

1997 • 109 citations

Interleukin‐18 Enhances Lipopolysaccharide‐Induced Interferon‐γ Production in Human Whole Blood Cultures

1998 • 101 citations

The Human Interleukin 18 GeneIL18Maps to 11q22.2–q22.3, Closely Linked to the DRD2 Gene Locus and Distinct from Mapped IDDM Loci

1998 • 100 citations

Protection of neutropenic mice from lethal Candida albicans infection by recombinant interleukin 1

1988 • 100 citations

Role of p38 mitogen-activated protein kinase in HIV type 1 production in vitro

1998 • 100 citations

Interleukin-1 receptor antagonist suppresses experimental autoimmune encephalomyelitis (EAE) in rats by influencing the activation and proliferation of encephalitogenic cells

1998 • 83 citations

Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin, and interleukin 1

1988 • 79 citations

Examining a paradox in the pathogenesis of human pulmonary tuberculosis: Immune activation and suppression/anergy

1997 • 79 citations

Purification of soluble cytokine receptors from normal human urine by ligand-affinity and immunoaffinity chromatography

1990 • 70 citations

The Possible Role of Interleukin (IL)-12 and Interferon-γ-Inducing Factor/IL-18 in Protection against ExperimentalMycobacterium lepraeInfection in Mice

1998 • 62 citations

Phosphorylation of intracellular precursors of human IL-1.

1988 • 57 citations

Differential activity of interleukin 1α and interleukin 1β in the stimulation of the immune response in vivo

1990 • 55 citations

Systemic Production of Interferon-Gamma Inducing Factor (IGIF) Versus Local IFN-γ Expression Involved in the Development of Th1 Insulitis in NOD Mice

1997 • 53 citations

Interleukin-18 Induces Activation and Association of p56lck and MAPK in a Murine TH1 Clone

1997 • 53 citations

Coagulation of Whole Blood Stimulates Interleukin-1 Gene Expression

1995 • 41 citations

Inhibition ofin vitroimmunoglobulin production by IL-12 in murine chronic graft-vs. -host disease: synergism with IL-18

1998 • 33 citations

Antitumor effect of human pancreatic cancer cells transduced with cytokine genes which activate Th1 helper T cells.

1998 • 24 citations

Potential therapeutic use of antibodies directed towards HuIFN-gamma.

1997 • 9 citations

[Signal transduction of interleukin 12].

1997 • 1 citations