An Essential Role for NF-κB in IL-18-Induced IFN-γ Expression in KG-1 Cells

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

1998 • 2,047 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

1997 • 726 citations

Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.

1996 • 635 citations

Interferon‐γ‐inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin‐12 for interferon‐γ production

1996 • 606 citations

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 • 552 citations

IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12.

1997 • 528 citations

Purification and Characterization of the Human Interleukin-18 Receptor

1997 • 471 citations

Interaction of NF-κB and NFAT with the Interferon-γ Promoter

1997 • 427 citations

IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones.

1996 • 425 citations

Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells

1997 • 385 citations

Interferon-γ-Inducing Factor, a Novel Cytokine, Enhances Fas Ligand-Mediated Cytotoxicity of Murine T Helper 1 Cells

1996 • 277 citations

Cutting Edge: IL-12 and IL-18 Differentially Regulate the Transcriptional Activity of the Human IFN-γ Promoter in Primary CD4+ T Lymphocytes

1998 • 235 citations

IL-1Rrp Is a Novel Receptor-like Molecule Similar to the Type I Interleukin-1 Receptor and Its Homologues T1/ST2 and IL-1R AcP

1996 • 225 citations

Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells.

1993 • 203 citations

The Proximal Regulatory Element of the Interferon-γ Promoter Mediates Selective Expression in T Cells

1996 • 200 citations

Interleukin-18 Activates NF-κB in Murine T Helper Type 1 Cells

1997 • 192 citations

IFN-γ-Inducing Factor/IL-18 Administration Mediates IFN-γ- and IL-12-Independent Antitumor Effects

1998 • 185 citations

The Nuclear Factor YY1 Suppresses the Human Gamma Interferon Promoter through Two Mechanisms: Inhibition of AP1 Binding and Activation of a Silencer Element

1996 • 171 citations

Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2.

1997 • 165 citations

Regulation of Interferon-γ Gene Expression

1996 • 160 citations

In vivo antitumor effects of murine interferon- γ -inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites

1997 • 154 citations

Both Amino- and Carboxyl-Terminal Sequences within IκBα Regulate Its Inducible Degradation

1996 • 153 citations

The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.

1994 • 140 citations

Interleukin-18 Activates the IRAK-TRAF6 Pathway in Mouse EL-4 Cells

1998 • 138 citations

The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element.

1992 • 134 citations

RelA Is a Potent Transcriptional Activator of the CD28 Response Element within the Interleukin 2 Promoter

1995 • 131 citations

Comparison of the effects of interleukin‐1α, interleukin‐lβ and interferon‐γ‐inducing factor on the production of interferon‐γ by natural killer

1997 • 130 citations

Negative Transcriptional Regulation of the Interferon-γ Promoter by Glucocorticoids and Dominant Negative Mutants of c-Jun

1995 • 130 citations

Interleukin 18, a Cytokine Which Resembles IL-1 Structurally and IL-12 Functionally but Exerts Its Effect Independently of Both

1998 • 114 citations

Differential Transcription Directed by Discrete Gamma Interferon Promoter Elements in Naive and Memory (Effector) CD4 T Cells and CD8 T Cells

1997 • 92 citations

Characterization of a Mutant Cell Line That Does Not Activate NF-κB in Response to Multiple Stimuli

1997 • 82 citations

IDENTIFICATION OF A CALCIUM-INDUCIBLE, CYCLOSPORINE-SENSITIVE ELEMENT IN THE IFN-?? PROMOTER THAT IS A POTENTIAL NFAT BINDING SITE1

1996 • 61 citations

A simple and sensitive bioassay for the detection of human interleukin-18/interferon-γ-inducing factor using human myelomonocytic KG-1 cells

1997 • 60 citations

Retinoic Acid-induced Transcriptional Modulation of the Human Interferon-γ Promoter

1996 • 58 citations