Evidence of IL-18 as a Novel Angiogenic Mediator

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis

1992 • 2,130 citations

Etanercept Therapy in Rheumatoid Arthritis

1999 • 1,407 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

1987 • 1,210 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

1997 • 1,137 citations

Regulators of Angiogenesis

1991 • 959 citations

A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor.

1992 • 807 citations

IL-18: A TH1 -inducing, proinflammatory cytokine and new member of the IL-1 family

1999 • 806 citations

Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β

1989 • 785 citations

Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.

1996 • 635 citations

A proinflammatory role for IL-18 in rheumatoid arthritis

1999 • 629 citations

Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1

1995 • 599 citations

Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells.

1998 • 556 citations

The role of vascular endothelial growth factor in pathological angiogenesis

1995 • 419 citations

Interleukin-18 (Interferon-γ–inducing Factor) Is Produced by Osteoblasts and Acts Via Granulocyte/Macrophage Colony-stimulating Factor and Not Via Interferon-γ to Inhibit Osteoclast Formation

1997 • 381 citations

Overview of interleukin-18: more than an interferon-γ inducing factor

1998 • 371 citations

Macrophage-derived angiogenesis factors

1991 • 325 citations

Decreased angiogenesis and arthritic disease in rabbits treated with an αvβ3 antagonist

1999 • 306 citations

Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development

1998 • 289 citations

Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes.

1997 • 267 citations

IL-18 Is Produced by Articular Chondrocytes and Induces Proinflammatory and Catabolic Responses

1999 • 238 citations

Angiogenesis and rheumatoid arthritis: pathogenic and therapeutic implications.

1992 • 212 citations

Adhesion molecule expression in human synovial tissue

1993 • 211 citations

Interleukin‐18 acts as an angiogenesis and tumor suppressor

1999 • 208 citations

Reduced Incidence and Severity of Collagen-Induced Arthritis in Mice Lacking IL-18

2001 • 208 citations

Interleukin-18 Activates NF-κB in Murine T Helper Type 1 Cells

1997 • 192 citations

Tumor Angiogenesis: Iris Neovascularization at a Distance From Experimental Intraocular Tumors2

1973 • 162 citations

A proposal for the definition of terms related to locomotion of leucocytes and other cells.

1977 • 161 citations

Human Keratinocytes Constitutively Express Interleukin-18 and Secrete Biologically Active Interleukin-18 After Treatment with Pro-Inflammatory Mediators and Dinitrochlorobenzene

1999 • 153 citations

Combined Effects of IL-12 and IL-18 on the Induction of Collagen-Induced Arthritis

2000 • 150 citations

Disruption of estrogen receptor gene prevents 17 beta estradiol-induced angiogenesis in transgenic mice.

1996 • 124 citations

Interleukin-18/interferon-γ-inducing factor, a novel cytokine, up-regulates ICAM-1 (CD54) expression in KG-1 cells

1998 • 119 citations

Interleukin 18, a Cytokine Which Resembles IL-1 Structurally and IL-12 Functionally but Exerts Its Effect Independently of Both

1998 • 114 citations

Interleukin 18 stimulates HIV type 1 in monocytic cells

1998 • 113 citations

Interleukin 18 enhances Fas ligand expression and induces apoptosis in Fas-expressing human myelomonocytic KG-1 cells.

1997 • 111 citations

Expression of interleukin-12 in synovial tissue from patients with rheumatoid arthritis

1998 • 109 citations

The disc angiogenesis system.

1988 • 83 citations

Interleukin-18 Induces Rheumatoid Arthritis Synovial Fibroblast CXC Chemokine Production through NFκB Activation

2001 • 82 citations

Angiogenesis in rheumatoid arthritis: pathogenic and clinical significance.

1998 • 78 citations

Angiogenesis in arthritis: role in disease pathogenesis and as a potential therapeutic target.

1998 • 77 citations

Tetramethylbenzidine--a substitute for benzidine in hemoglobin analysis.

1979 • 76 citations

Quantitative determination of hemoglobin and cytochemical staining for peroxidase using 3,3′,5,5′-tetramethylbenzidine dihydrochloride, a safe substitute for benzidine

1979 • 72 citations

A Proposal for the Definition of Terms Related to Locomotion of Leukocytes and Other Cells

1978 • 66 citations

Protein kinase C regulates endothelial cell tube formation on basement membrane matrix, Matrigel

1992 • 62 citations

The immunopathogenesis of rheumatoid arthritis

1991 • 58 citations

Angiogenesis — Retrospect and outlook

1992 • 51 citations

Treatment with sulfasalazine or sulfapyridine, but not 5-aminosalicylic acid, inhibits basic fibroblast growth factor-induced endothelial cell chemotaxis

1999 • 48 citations

Chemokines in disease

1996 • 43 citations

Angiogenesis in Inflammatory Disease

1997 • 8 citations

Bcl-2 blocks peroxynitrite-induced apoptosis in HL-60 cells, an association with reactive oxygen species

1997 • 7 citations