Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium.

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice.

1996 • 602 citations

Chapter 9 The End of the (Cell) Line: Methods for the Study of Apoptosis in Vitro

1995 • 569 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

An immunochemical analysis of the human nuclear phosphoprotein p53

1992 • 533 citations

Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies.

1991 • 512 citations

Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression

1986 • 508 citations

Apoptosis in rheumatoid arthritis synovium.

1995 • 378 citations

The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.

1992 • 375 citations

Enhanced proliferative potential in culture of cells from p53-deficient mice.

1993 • 341 citations

Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids.

1989 • 320 citations

Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53.

1983 • 313 citations

Activating Mutations for Transformation by p53 Produce a Gene Product That Forms an hsc70-p53 Complex with an Altered Half-Life

1988 • 298 citations

Genetic basis for p53 overexpression in human breast cancer.

1991 • 287 citations

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

1992 • 274 citations

p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation.

1995 • 264 citations

Apoptosis and functional fas antigen in rheumatoid arthritis synoviocytes

1995 • 234 citations

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1984 • 225 citations

Induction of apoptosis in NK cells by monocyte-derived reactive oxygen metabolites.

1996 • 215 citations

Cytokines in chronic inflammatory arthritis. V. Mutual antagonism between interferon-gamma and tumor necrosis factor-alpha on HLA-DR expression, proliferation, collagenase production, and granulocyte macrophage colony-stimulating factor production by rheumatoid arthritis synoviocytes.

1990 • 214 citations

Dideoxy fingerprinting (ddF): A rapid and efficient screen for the presence of mutations

1992 • 212 citations

Alpha 4/beta 1 integrin (VLA-4) ligands in arthritis. Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes.

1992 • 202 citations

Local Proliferation of Fibroblast‐Like Synoviocytes Contributes to Synovial Hyperplasia

1994 • 201 citations

Abnormal expression of wild type p53 protein in normal cells of a cancer family patient

1992 • 199 citations

Endonuclease-induced DNA damage and cell death in oxidant injury to renal tubular epithelial cells.

1992 • 182 citations

Ultraviolet Light Induces Expression of p53 and p21 in Human Skin: Effect of Sunscreen and Constitutive p21 Expression in Skin Appendages

1995 • 154 citations

A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into scid mice

1994 • 152 citations

Characterization of human Gadd45, a p53-regulated protein.

1994 • 126 citations

Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53

1983 • 104 citations

P53 protein expression in lymphomas and reactive lymphoid tissue

1992 • 98 citations

The nature and origins of synovium: experimental approaches to the study of synoviocyte differentiation.

1994 • 86 citations

Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes.

1994 • 78 citations

Efficient screening of p53 mutations by denaturing gradient gel electrophoresis in colorectal tumors.

1993 • 71 citations

Association of p53 immunoreactivity with high Gleason tumor grade in prostatic adenocarcinoma

1994 • 66 citations

Demonstration of DNA damage/repair in individual cells using in situ end labelling: Association of p53 with sites of DNA damage

1995 • 63 citations

p53 Inhibits DNA Replication In Vitro in a DNA-Binding-Dependent Manner

1995 • 38 citations

Cytokine-induced modulation of tumor suppressor gene expression in ovarian cancer cells: Up-regulation of p53 gene expression and induction of apoptosis by tumor necrosis factor-α

1994 • 37 citations

Over-expression of p53 protein in neoplastic changes in ulcerative colitis: immunohistochemical study.

1995 • 31 citations

Immunohistochemical detection of p53 protein expression in HPV-induced condyloma acuminatum.

1995 • 7 citations