Cytokines in chronic inflammatory arthritis. V. Mutual antagonism between interferon-gamma and tumor necrosis factor-alpha on HLA-DR expression, proliferation, collagenase production, and granulocyte macrophage colony-stimulating factor production by rheumatoid arthritis synoviocytes.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.

1986 • 632 citations

Quantitative analysis of cytokine gene expression in rheumatoid arthritis.

1990 • 610 citations

Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum

1988 • 570 citations

Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells.

1976 • 555 citations

Prostaglandins modulate macrophage Ia expression

1982 • 545 citations

Isolation of an interleukin‐1‐like factor from human joint effusions

1983 • 450 citations

Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers.

1986 • 401 citations

Prostaglandin-stimulated bone resorption by rheumatoid synovia. A possible mechanism for bone destruction in rheumatoid arthritis.

1975 • 393 citations

Induction of the synthesis of tumor necrosis factor receptors by interferon-gamma.

1986 • 328 citations

Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids.

1989 • 320 citations

Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor.

1986 • 302 citations

Cytokines in chronic inflammatory arthritis. II. Granulocyte-macrophage colony-stimulating factor in rheumatoid synovial effusions.

1989 • 265 citations

Tumor necrosis factor enhances HLA-A,B,C and HLA-DR gene expression in human tumor cells.

1987 • 248 citations

Arthritogenic actions of recombinant IL-1 and tumour necrosis factor alpha in the rabbit: evidence for synergistic interactions between cytokines in vivo.

1989 • 241 citations

Synergistic stimulation of fibroblast prostaglandin production by recombinant interleukin 1 and tumor necrosis factor.

1987 • 233 citations

Identification of Three Major Synovial Lining Cell Populations by Monoclonal Antibodies Directed to Ia Antigens and Antigens Associated with Monocytes/Macrophages and Fibroblasts

1983 • 204 citations

Prostaglandin inhibition of T-cell proliferation is mediated at two levels

1981 • 202 citations

Effects of interferon-gamma and tumor necrosis factor-alpha on the expression of an Ia antigen on a murine macrophage cell line.

1986 • 199 citations

Prostaglandin production by rheumatoid synovial cells: stimulation by a factor from human mononuclear Cells.

1977 • 188 citations

Cytokines and the chronic inflammation of rheumatic disease. I. The presence of interleukin-1 in synovial fluids.

1984 • 186 citations

Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. ii. low levels of synovial fluid and synovial tissue interferon suggest that γgm‐interferon is not the primary macrophage activating factor

1987 • 177 citations

Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis.

1989 • 166 citations

Transforming growth factor-beta production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats. Studies on secretion by synovial fibroblast-like cells and immunohistologic localization.

1989 • 161 citations

Analysis of the defects responsible for the impaired regulation of Epstein-Barr virus-induced B cell proliferation by rheumatoid arthritis lymphocytes. I. Diminished gamma interferon production in response to autologous stimulation.

1983 • 146 citations

Influences of gamma interferon on synovial fibroblast-like cells. Ia induction and inhibition of collagen synthesis.

1985 • 134 citations

Up‐regulation of the Expression of Secretory Component and HLA Molecules in a Human Colonic Cell Line by Tumour Necrosis Factor‐α and Gamma Interferon

1988 • 120 citations

Pathology of Rheumatic Diseases

1975 • 120 citations

Immune interferon inhibits proliferation and induces 2'-5'-oligoadenylate synthetase gene expression in human vascular smooth muscle cells.

1989 • 117 citations

Interleukin‐1 lymphocyte chemotactic activity in rheumatoid arthritis synovial fluid

1986 • 115 citations

Effects of tumor necrosis factor on the interferon‐γ‐induced major histocompatibility complex class II antigen expression by human endothelial cells

1988 • 113 citations

Effects of human mononuclear cell factor on cultured rheumatoid synovial cells

1979 • 101 citations

Platelet-derived growth factor and IL-1 interactions in rheumatoid arthritis. Regulation of synoviocyte proliferation, prostaglandin production, and collagenase transcription.

1989 • 101 citations

Regulation of human lung fibroblast glycosaminoglycan production by recombinant interferons, tumor necrosis factor, and lymphotoxin.

1988 • 97 citations

Interferons And Their Actions

1987 • 91 citations

Increased proliferation of human synovial fibroblasts treated with recombinant immune interferon.

1985 • 79 citations

Results of a multicenter placebo-controlled double-blind randomized phase III clinical study of treatment of rheumatoid arthritis with recombinant interferon-gamma

1988 • 78 citations

Synergistic effect of tumor necrosis factor-α and interferon-γ on collagen synthesis of human skin fibroblasts in vitro

1989 • 77 citations

Electron microscopic study of HLA‐DR and monocyte/macrophage staining cells in the rheumatoid synovial membrane

1986 • 75 citations

COLLAGENASE PRODUCTION BY HUMAN SYNOVIAL TISSUES*

1975 • 67 citations

Stimulation of human synovial fibroblast DNA synthesis by recombinant human cytokines.

1988 • 64 citations

Intracellular collagen fibers at the pannus‐cartilage junction in rheumatoid arthritis

1977 • 63 citations

Down regulation of human monocyte differentiation antigens by interferon γ

1987 • 62 citations

Differential expression of Ia antigens by rheumatoid synovial lining cells.

1987 • 62 citations

Autocrine secretion of tumor necrosis factor under the influence of interferon-gamma amplifies HLA-DR gene induction in human monocytes.

1988 • 50 citations

Two neutralizing monoclonal antibodies against human granulocyte-macrophage colony-stimulating factor recognize the receptor binding domain of the molecule.

1990 • 49 citations

Stimulation of human synovial fibroblast DNA synthesis by platelet-derived growth factor and fibroblast growth factor. Differences to the activation by IL-1.

1989 • 46 citations

Prospective two-year followup of recombinant interferon-gamma in rheumatoid arthritis.

1990 • 45 citations

Growth Factors With Heparin Binding Affinity In Human Synovial Fluid

1987 • 39 citations

Effects of recombinant human tumor necrosis factor‐α on the surface phenotype and the growth of human malignant glioma cell lines

1988 • 37 citations

An assay of collagenase activity using enzyme-linked immunosorbent assay for mammalian collagenase

1987 • 32 citations

Ultrastructural characterisation of macrophages (type A cells) in the synovial lining

1988 • 31 citations

Inhibition of IFN-gamma-induced Ia antigen expression on synovial fibroblasts by IL-1.

1989 • 23 citations

Cooperative effect of tumor necrosis factor and gamma-interferon on chemotactic peptide receptor expression and stimulus-induced actin polymerization in HL-60 cells

1988 • 20 citations

Comparative and combined effects of transforming growth factors ? and ?, interleukin-1 and interferon-? on rheumatoid synovial cell proliferation, glycolysis and prostaglandin E production

1989 • 13 citations