Abnormal expression of wild type p53 protein in normal cells of a cancer family patient

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is

1975 • 4,443 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

1989 • 3,707 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

1990 • 607 citations

An immunochemical analysis of the human nuclear phosphoprotein p53

1992 • 533 citations

Primary structure polymorphism at amino acid residue 72 of human p53.

1987 • 466 citations

Overexpression and mutation of p53 in epithelial ovarian cancer.

1991 • 464 citations

Olfactory Recognition: A Simple Memory System

1990 • 349 citations

Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in Escherichia coli

1992 • 335 citations

Archival analysis of p53 genetic and protein alterations in Chinese esophageal cancer.

1991 • 185 citations

p53 germline mutations in Li-Fraumeni syndrome

1991 • 132 citations

No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families.

1992 • 53 citations

Detection of both mutant and wild-type p53 protein in normal skin fibroblasts and demonstration of a shared 'second hit' on p53 in diverse tumors from a cancer-prone family with Li-Fraumeni syndrome.

1992 • 48 citations

Elevated Levels of p53 Antigen in Cultured Skin Fibroblasts From Patients With Hereditary Adenocarcinoma of the Colon and Rectum and Its Relevance to Oncogenic Mechanisms<xref ref-type="fn" rid="FN2">2</xref>

1986 • 23 citations

Skin Fibroblasts from Humans Genetically Predisposed to Colon Cancer are Abnormally Sensitive to SV40

1984 • 13 citations

RAPID AND SENSITIVE DETECTION OF POINT MUTATION AND DNA POLYMORPHISMS USING THE POLYMERASE CHAINE REACTION

1989 • 7 citations