p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation.

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

p53 function and dysfunction

1992 • 1,918 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Induction of Differentiation in Human Promyelocytic Leukemia Cells by Tumor Promoters

1979 • 594 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Braking the cycle

1993 • 378 citations

The tumore suppressor p53

1993 • 336 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia.

1989 • 300 citations

Coordinate regulation of multiple histone mRNAs during the cell cycle in HeLa cells

1983 • 278 citations

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

1992 • 274 citations

Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

1993 • 271 citations

Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides.

1991 • 243 citations

Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells.

1993 • 196 citations

Levels of p53 protein increase with maturation in human hematopoietic cells.

1991 • 191 citations

Involvement of wild-type p53 in pre-B-cell differentiation in vitro.

1991 • 168 citations

Monoclonal antibodies that detect differentiation surface antigens on human myelomonocytic cells

1982 • 143 citations

Mutation of the p53 gene in human acute myelogenous leukemia

1991 • 128 citations

Expression of wild-type p53 in human A673 cells suppresses tumorigenicity but not growth rate.

1991 • 66 citations

Wild-type p53 gene expression induces granulocytic differentiation of HL-60 cells

1994 • 61 citations

An overview of membrane, cytosolic and nuclear proteins associated with the expression of resistance to multiple drugs in vitro

1992 • 58 citations

Constitutive cJun expression induces partial macrophage differentiation in U-937 cells.

1994 • 56 citations

Mitotic arrest and enhanced nuclear protein phosphorylation in human leukemia K562 cells by okadaic acid, a potent protein phosphatase inhibitor and tumor promoter

1991 • 55 citations

Thermal denaturation of DNA for immunochemical staining of incorporated bromodeoxyuridine (BrdUrd): Critical factors that affect the amount of fluorescence and the shape of BrdUrd/DNA histogram

1989 • 54 citations

Constitutive expression of p53 protein in enriched normal human marrow blast cell populations [see comments]

1992 • 53 citations

Expression of histone genes in a G1-specific temperature-sensitive mutant of the cell cycle

1984 • 53 citations

Cell cycle regulation and the p53 tumor suppressor protein.

1992 • 52 citations

The DNA-binding and transcription-activation abilities of p53 are necessary but not sufficient for its antiproliferation function.

1994 • 4 citations