Oxidative stress in the pathogenesis of preeclampsia.

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?

1994 • 3,002 citations

Lipid peroxidation: its mechanism, measurement, and significance

1993 • 2,324 citations

Free radicals, antioxidants, and human disease: where are we now?

1992 • 2,223 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Preeclampsia: An excessive maternal inflammatory response to pregnancy

1999 • 1,855 citations

Preeclampsia: An endothelial cell disorder

1989 • 1,848 citations

The role of oxidized lipoproteins in atherogenesis

1996 • 1,382 citations

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.

1995 • 1,316 citations

Cytokines and endothelial cell biology

1990 • 1,275 citations

A Study of Angiotensin II Pressor Response throughout Primigravid Pregnancy

1973 • 1,230 citations

Extensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry

1994 • 1,138 citations

A Prospective Study of Triglyceride Level, Low-Density Lipoprotein Particle Diameter, and Risk of Myocardial Infarction

1996 • 1,065 citations

Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis

1998 • 821 citations

Cytotoxicity and genotoxicity of lipid-oxidation products

1993 • 802 citations

Nitric oxide and pregnancy

1997 • 684 citations

Endothelial Dysfunction in Preeclampsia

1998 • 637 citations

Pathology of the placenta.

1978 • 635 citations

Invited Review Free Radicals in Disease Processes: A Compilation of Cause and Consequence

1993 • 581 citations

Heterogeneous causes constituting the single syndrome of preeclampsia: A hypothesis and its implications

1996 • 574 citations

Fetal umbilical artery flow velocity waveforms and placental resistance: clinical significance

1985 • 565 citations

Susceptibility of small, dense, low-density lipoproteins to oxidative modification in subjects with the atherogenic lipoprotein phenotype, pattern B

1993 • 556 citations

Evidence for In Vivo Peroxynitrite Production in Human Acute Lung Injury

1995 • 491 citations

What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?

1997 • 480 citations

Lipid peroxidation in pregnancy: New perspectives on preeclampsia

1989 • 458 citations

Prostaglandin and thromboxane biosynthesis

1991 • 444 citations

Fasting Insulin and Apolipoprotein B Levels and Low-Density Lipoprotein Particle Size as Risk Factors for Ischemic Heart Disease

1998 • 432 citations

The role of nitric oxide in the pathogenesis of preeclampsia

1994 • 392 citations

Hypertension in Pregnancy

1981 • 381 citations

The hyperlipidemia of pregnancy in normal and complicated pregnancies

1979 • 372 citations

The preterm prediction study: Risk factors for indicated preterm births

1998 • 358 citations

Ascorbic acid protects lipids in human plasma and low-density lipoprotein against oxidative damage

1991 • 317 citations

Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery.

1990 • 312 citations

Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in preeclampsia, are positively correlated, and decrease within 48 hours post partum

1996 • 308 citations

Genetic and familial predisposition to eclampsia and pre‐eclampsia in a defined population

1990 • 303 citations

Longitudinal study on lipoprotein profile, high density lipoprotein subclass, and postheparin lipases during gestation in women

1996 • 301 citations

Lipoprotein subfraction concentrations in preeclampsia: Pathogenic parallels to atherosclerosis

1997 • 291 citations

AN ULTRASTRUCTURAL STUDY OF UTERO‐PLACENTAL SPIRAL ARTERIES IN HYPERTENSIVE AND NORMOTENSIVE PREGNANCY AND FETAL GROWTH RETARDATION

1981 • 291 citations

Death rates from ischemic heart disease in women with a history of hypertension in pregnancy

1995 • 289 citations

[46] Methods to determine oxidation of low-density lipoproteins

1994 • 283 citations

Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats.

1997 • 270 citations

Serum lipoproteins, insulin, and urinary prostanoid metabolites in normal and hypertensive pregnant women

1995 • 260 citations

Maternal-Placental Interactions of Oxidative Stress and Antioxidants in Preeclampsia

1998 • 259 citations

Human neutrophils employ chlorine gas as an oxidant during phagocytosis.

1996 • 258 citations

Agonist-Induced Peroxynitrite Production from Endothelial Cells

1994 • 254 citations

Syndrome X: 6 years later.

1994 • 254 citations

Nitrotyrosine Residues in Placenta

1996 • 253 citations

Hypoxia Stimulates Cytokine Production by Villous Explants from the Human Placenta¹

1997 • 253 citations

Morphological Changes in the Utero-Placental Bed in Pregnancy Hypertension

1977 • 252 citations

Antioxidant Activities and mRNA Expression of Superoxide Dismutase, Catalase, and Glutathione Peroxidase in Normal and Preeclamptic Placentas

1996 • 241 citations

The Kidney in Toxemia of Pregnancy

1960 • 238 citations

Antioxidant systems in normal pregnancy and in pregnancy-induced hypertension

1991 • 237 citations

Preeclampsia and antioxidant nutrients: Decreased plasma levels of reduced ascorbic acid, α-tocopherol, and beta-carotene in women with preeclampsia

1994 • 235 citations

Evidence for Peroxynitrite Formation in the Vasculature of Women With Preeclampsia

1999 • 232 citations

The effect of placental syncytiotrophoblast microvillous membranes from normal and pre‐eclamptic women on the growth of endothelial cells in vitro

1993 • 232 citations

Noninvasive measures of oxidative stress status in humans

1991 • 230 citations

Influence of plasma lipid and LDL-subfraction profile on the interaction between low density lipoprotein with human arterial wall proteoglycans

1996 • 225 citations

Reduced umbilical and placental vascular prostacyclin in severe pre-eclampsia

1980 • 224 citations

The ultrastructure of acute atherosis in hypertensive pregnancy

1975 • 211 citations

High plasma cellular fibronectin levels correlate with biochemical and clinical features of preeclampsia but cannot be attributed to hypertension alone

1991 • 191 citations

Role of lipoprotein lipase activity on lipoprotein metabolism and the fate of circulating triglycerides in pregnancy

1988 • 190 citations

Hyperuricemia and xanthine oxidase in preeclampsia, revisited

1996 • 189 citations

Lipid Peroxidation in Pregnancy

1994 • 186 citations

Glomerular capillary endotheliosis in toxemia of pregnancy.

1959 • 185 citations

Peroxidative Reactions in Red Cell Biology

1982 • 185 citations

LIPID PEROXIDATION IN RELATION TO PROSTACYCLIN AND THROMBOXANE PHYSIOLOGY AND PATHOPHYSIOLOGY

1983 • 184 citations

Lipid Peroxidation In Biomembranes

2018 • 177 citations

Human placental syncytiotrophoblast microvillous membranes impair maternal vascular endothelial function

1997 • 170 citations

Findings on lipid peroxidation and antioxidant function in hypertensive complications of pregnancy

1993 • 169 citations

Common variation in the lipoprotein lipase gene: effects on plasma lipids and risk of atherosclerosis

1997 • 168 citations

Sera antioxidant activity in uncomplicated and preeclamptic pregnancies

1993 • 166 citations

Bradykinin-mediated relaxation of isolated maternal resistance arteries in normal pregnancy and preeclampsia

1996 • 164 citations

Deficient glutathione peroxidase activity in preeclampsia is associated with increased placental production of thromboxane and lipid peroxides

1993 • 164 citations

Urine but not plasma nitric oxide metabolites are decreased in women with preeclampsia

1996 • 157 citations

Circulating endothelial cell adhesion molecules as diagnostic markers for the early identification of pregnant women at risk for development of preeclampsia

1997 • 156 citations

Low Concentration of Oxidized Low-Density Lipoprotein and Lysophosphatidylcholine Upregulate Constitutive Nitric Oxide Synthase mRNA Expression in Bovine Aortic Endothelial Cells

1995 • 153 citations

Maternal levels of prostacyclin, thromboxane, vitamin E, and lipid peroxides throughout normal pregnancy

1991 • 151 citations

Small low-density lipoproteins and vascular cell adhesion molecule-1 are increased in association with hyperlipidemia in preeclampsia

1998 • 151 citations

Secretion of lipid peroxides by the human placenta

1993 • 151 citations

Accommodation of the human placenta to hypoxia

1966 • 144 citations

Preeclampsia selectively impairs endothelium-dependent relaxation and leads to oscillatory activity in small omental arteries.

1998 • 143 citations

Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsia

1999 • 142 citations

Trophoblast and placental villous core production of lipid peroxides, thromboxane, and prostacyclin in preeclampsia.

1995 • 138 citations

Plasma Lipids and Vascular Dysfunction in Preeclampsia

1998 • 134 citations

Fasting Serum Free Fatty Acids and Triglycerides are Increased Before 20 Weeks of Gestation in Women who Later Develop Preeclampsia

1994 • 133 citations

Hypertension in pregnancy: Definitions, familial factor, and remote prognosis

1980 • 131 citations

Determinants of plasma vitamin E concentrations

1994 • 129 citations

Increased Ascorbate Radical Formation and Ascorbate Depletion in Plasma from Women With Preeclampsia: Implications for Oxidative Stress

1997 • 128 citations

Pregnancy-Related Hypertension

2009 • 127 citations

The Placental Bed

1996 • 123 citations

Linoleic acid and TNF-alpha cross-amplify oxidative injury and dysfunction of endothelial cells.

1996 • 119 citations

Dyslipidemia, Iron, and Oxidative Stress in Preeclampsia: Assessment of Maternal and Feto-Placental Interactions

1998 • 109 citations

Cardiovascular responses to circulating catecholamines in normal pregnancy and in pregnancy‐induced hypertension

1985 • 109 citations

A Reappraisal of Xanthine Dehydrogenase and Oxidase in Hypoxic Reperfusion Injury: the Role of NADH as an Electron Donor

1998 • 107 citations

Increased Nitrotyrosine in the Diabetic Placenta: Evidence for oxidative stress

1998 • 105 citations

Variation in lipid levels during pregnancy in women with different types of hypertension

1996 • 103 citations

NADH/NADPH Oxidase and Vascular Function

1997 • 97 citations

Metabolism of very-low-density lipoprotein triglyceride by human placental cells: The role of lipoprotein lipase

1992 • 94 citations

Insulin Resistance Syndrome in Preeclampsia

1998 • 92 citations

Elevation of Plasma Nitric Oxide End Products during Focal Cerebral Ischemia and Reperfusion in the Rat

1994 • 89 citations

Reactive oxygen metabolites cause massive, reversible proteinuria and glomerular sieving defect without apparent ultrastructural abnormality.

1991 • 88 citations

Changes in the levels of lipoperoxide and antioxidant factors in human placenta during gestation.

1990 • 87 citations

Plasma of Preeclamptic Women Stimulates and Then Inhibits Endothelial Prostacyclin

1996 • 83 citations

Hypertriglyceridemia and its Metabolic Consequences as a Risk Factor for Atherosclerotic Cardiovascular Disease in Non-Insulin-Dependent Diabetes Mellitus

1996 • 83 citations

Plasma Nitric Oxide Levels in Pregnant Patients with Preeclampsia and Essential Hypertension

1996 • 82 citations

Maternal and fetal modulators of lipid metabolism correlate with the development of preeclampsia

1997 • 79 citations

Nitric oxide production with preeclampsia

1999 • 78 citations

THE DISCOVERY OF PROSTACYCLIN – – – A FRESH INSIGHT INTO ARACHIDONIC ACID METABOLISM

1977 • 77 citations

Diagnostic Indocyanine Green Angiography in Preeclampsia

1996 • 76 citations

Analysis of Different Inheritance Patterns in Preeclampsia/Eclampsia Syndrome

1995 • 75 citations

Uteroplacental Blood Flow in Pregnancy Induced Hypertension

1984 • 69 citations

Immunocytochemical localization of neutrophil elastase in term placenta decidua and myometrium in pregnancy‐induced hypertension

1991 • 67 citations

Neutrophil activation is confined to the maternal circulation in pregnancy‐induced hypertension

1992 • 67 citations

Intravascular release of intact cellular fibronectin during oxidant-induced injury of the in vitro perfused rabbit lung.

1986 • 66 citations

NOS expression is increased in endothelial cells exposed to plasma from women with preeclampsia

1995 • 65 citations

Changes of lipid peroxidation and superoxide dismutase activity in the human placenta

1979 • 65 citations

Differential Localization of Superoxide Dismutase Isoforms in Placental Villous Tissue of Normotensive, Pre-eclamptic, and Intrauterine Growth-restricted Pregnancies

1997 • 64 citations

The role of the placenta in lipid metabolism and transport.

1989 • 64 citations

Dietary consumption and plasma concentrations of vitamin E in pregnancies complicated by preeclampsia

1996 • 64 citations

Role of iron and oxygen-derived free radicals in ischemia-reperfusion injury.

1994 • 59 citations

Effect of hyperlipidemic serum on lipid peroxidation, synthesis of prostacyclin and thromboxane by cultured endothelial cells: Protective effect of antioxidants

1989 • 57 citations

Low-Density Lipoprotein Particle Size Decreases During Normal Pregnancy in Association With Triglyceride Increases

1998 • 57 citations

Low superoxide scavenging activity associated with enhanced superoxide generation by monocytes from male hypertriglyceridemia with and without diabetes

1991 • 55 citations

Retinal vasospasm associated with visual disturbance in preeclampsia: Color flow Doppler findings

1993 • 54 citations

Association of pre‐eclampsia with common coding sequence variations in the lipoprotein lipase gene

1999 • 53 citations

Distinct Factors in Plasma of Preeclamptic Women Increase Endothelial Nitric Oxide or Prostacyclin

1996 • 53 citations

Effect of exogenous fatty acids with greater than 22 carbon atoms (very long chain fatty acids) on superoxide production by human neutrophils.

1994 • 53 citations

Fatal eclamptic disease of pregnant rats fed anti-vitamin E stress diet.

1959 • 52 citations

Altered lipid composition, increased lipid peroxidation, and altered fluidity of the membrane as evidence of platelet damage in preeclampsia

1993 • 51 citations

Xanthine oxidase/dehydrogenase is present in human placenta

1996 • 50 citations

Pregnancy, outcome as related to hypertension, edema, and proteinuria.

1976 • 48 citations

Ail Instructive Case of Abdominal Pregnaney

1995 • 48 citations

Linkage of Low-Density Lipoprotein Size to the Lipoprotein Lipase Gene in Heterozygous Lipoprotein Lipase Deficiency

1999 • 47 citations

Erythrocyte Glutathione Balance and Membrane Stability During Preeclampsia

1998 • 44 citations

Vitamin C in health and disease

1982 • 43 citations

Endothelial Cell Dysfunction

2014 • 42 citations

Metabolism of modified LDL by cultured human placental cells

1995 • 40 citations

Placental Production of Lipid Peroxides, Thromboxane, And Prostacyclin in Preeclampsia

1996 • 39 citations

Introduction, History, Controversies, and Definitions

2014 • 39 citations

Oxidized low‐density lipoprotein induces the production of superoxide by neutrophils

1995 • 38 citations

Lipoprotein-induced prostacyclin production in endothelial cells and effects of lipoprotein modification

1996 • 37 citations

Linoleate oxidation products and cardiovascular lesions

1974 • 37 citations

Trophoblast function in normal and preeclamptic pregnancy

1996 • 36 citations

Renal structure and function in pregnant patients with acute hypertension

1964 • 36 citations

Lipid hydroperoxides potentiate mesenteric artery vasoconstrictor responses

1993 • 34 citations

Activation of human blood monocytes by oxidized polyunsaturated fatty acids: a possible mechanism for the generation of lipid peroxides in the circulation.

1991 • 32 citations

The isoprostanes: novel markers of lipid peroxidation and potential mediators of oxidant injury.

1995 • 30 citations

Autoantibodies against malondialdehyde-modified LDL are elevated in subjects with an LDL subclass pattern B

1995 • 29 citations

Low Density Lipoprotein Subfractions Increase Thromboxane Formation in Endothelial Cells

1993 • 28 citations

Neutrophil mediated damage to isolated myocytes after anoxia and reoxygenation

1994 • 27 citations

Mildly Oxidized LDL Evokes a Sustained Ca ²⁺ -Dependent Retraction of Vascular Smooth Muscle Cells

1996 • 26 citations

Immunohistochemical localization of lipoperoxidation products in normal human placenta

1997 • 26 citations

Genetic, Metabolic, and Dietary Influences on the Atherogenic Lipoprotein Phenotype

1997 • 24 citations

Hypertriglyceridemia Enhances Monocyte Binding to Endothelial Cells in NIDDM

1996 • 24 citations

Neutrophil activation in small for gestational age pregnancies

1991 • 23 citations

High altitude and hypertension during pregnancy

1995 • 23 citations

Normal Superoxide Dismutase (SOD) Gene in Pregnancy-Induced Hypertension: Is the Decreased Sod Activity a Secondary Phenomenon?

1994 • 22 citations

ASCORBIC ACID METABOLISM IN PREECLAMPSIA

1965 • 19 citations

Oxidized Low-Density Lipoprotein Stimulates Nitric Oxide Release by Rabbit Aortic Endothelial Cells

1995 • 16 citations

Xanthine oxidase activity in preeclamptic women is higher in invasive but not villous trophoblast

1996 • 4 citations