Prostaglandin and thromboxane biosynthesis

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

1981 • 2,777 citations

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

1987 • 2,237 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina

1983 • 1,740 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Drugs which inhibit prostaglandin biosynthesis.

1974 • 1,325 citations

Flow Effects on Prostacyclin Production by Cultured Human Endothelial Cells

1985 • 1,237 citations

Aspirin, Sulfinpyrazone, or Both in Unstable Angina

1985 • 1,146 citations

Peroxidases in chemistry and biology

1990 • 1,039 citations

On the function and mechanism of action of peroxidases

1976 • 1,017 citations

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

1976 • 956 citations

The eicosanoids and their biochemical mechanisms of action

1989 • 882 citations

Molecular Mechanisms of Oxygen Activation

1974 • 879 citations

Isolation and properties of intermediates in prostaglandin biosynthesis

1973 • 796 citations

Triene prostaglandins: Prostacyclin and thromboxane biosynthesis and unique biological properties

1979 • 786 citations

The chemical structure of prostaglandin X (prostacyclin)

1976 • 729 citations

Production of diglyceride from phosphatidylinositol in activated human platelets.

1979 • 727 citations

Stimulation of Endothelial Cell Prostacyclin Production by Thrombin, Trypsin, and the Ionophore A 23187

1978 • 715 citations

Diglyceride lipase: a pathway for arachidonate release from human platelets.

1979 • 696 citations

Cloning and expression of cDNA for a human thromboxane A2 receptor

1991 • 680 citations

Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man.

1983 • 675 citations

Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

1976 • 668 citations

Structure and Properties of a Human Non-pancreatic Phospholipase A2

1989 • 668 citations

Prostaglandin endoperoxide synthase: regulation of enzyme expression

1991 • 642 citations

Detection and Isolation of an Endoperoxide Intermediate in Prostaglandin Biosynthesis

1973 • 640 citations

Transcriptional autoregulation of the proto-oncogene fos

1988 • 630 citations

Prostaglandin endoperoxide synthase: structure and catalysis

1991 • 607 citations

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.

1988 • 604 citations

Mechanism for irreversible self-deactivation of prostaglandin synthetase.

1976 • 600 citations

Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription.

1986 • 548 citations

Inflammation and the mechanism of action of anti‐inflammatory drugs

1987 • 523 citations

Preliminary Report: Findings from the Aspirin Component of the Ongoing Physicians' Health Study

1988 • 504 citations

Prostaglandin Endoperoxides. A New Concept Concerning the Mode of Action and Release of Prostaglandins

1974 • 495 citations

Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells.

1990 • 484 citations

Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis.

1980 • 481 citations

Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype.

1993 • 475 citations

Metabolism of [14C]arachidonic acid by human platelets

1976 • 453 citations

A calcium-dependent mechanism for associating a soluble arachidonoyl-hydrolyzing phospholipase A2 with membrane in the macrophage cell line RAW 264.7.

1990 • 447 citations

Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2

1991 • 447 citations

Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme.

1976 • 435 citations

Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).

1988 • 431 citations

The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases.

1990 • 429 citations

Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937.

1990 • 428 citations

Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.

1986 • 424 citations

Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands

1977 • 421 citations

The Ca2(+)-sensitive cytosolic phospholipase A2 is a 100-kDa protein in human monoblast U937 cells.

1991 • 413 citations

Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.

1977 • 409 citations

On the Mechanism of the Biosynthesis of Prostaglandins E1 and F1α

1967 • 403 citations

Regulation of fibroblast cyclooxygenase synthesis by interleukin-1.

1988 • 401 citations

Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats.

1987 • 386 citations

Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

1979 • 375 citations

Prostacyclin Synthesis Induced in Vascular Cells by Interleukin-1

1985 • 364 citations

Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular glands

1972 • 362 citations

Prostaglandin biosynthesis can be triggered by lipid peroxides

1979 • 357 citations

Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species

1978 • 339 citations

Lipid composition of subcellular particles of human blood platelets

1969 • 337 citations

Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme

1989 • 333 citations

Evolutionary relationships and implications for the regulation of phospholipase A2 from snake venom to human secreted forms

1990 • 328 citations

Identification of a phorbol ester-repressible v-src-inducible gene.

1989 • 322 citations

Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid

1979 • 318 citations

Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate.

1983 • 312 citations

Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes

1978 • 306 citations

Prostaglandins and Related Factors

1963 • 290 citations

Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs.

1975 • 288 citations

Higher oxidation states of prostaglandin H synthase

1988 • 284 citations

Persantine Aspirin Trial in cerebral ischemia. Part II: Endpoint results. The American-Canadian Co-Operative Study group.

1985 • 284 citations

Oxygenation of Unsaturated Fatty Acids by the Vesicular Gland of Sheep

1967 • 279 citations

Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.

1977 • 279 citations

Angiotensin II Stimulation of Prostaglandin Production in Cultured Human Vascular Endothelium

1975 • 278 citations

Requirements for hydroperoxide by the cyclooxygenase and peroxidase activities of prostaglandin H synthase

1983 • 277 citations

Prostaglandin H Synthase and Xenobiotic Oxidation

1990 • 276 citations

Cytochrome P-450 metabolism of arachidonic acid: formation and biological actions of "epoxygenase"-derived eicosanoids.

1988 • 261 citations

Biochemical significance of porphyrin .pi. cation radicals

1974 • 257 citations

Higher oxidation states of prostaglandin H synthase

1988 • 254 citations

Evidence for two sources of arachidonic acid for oxidative metabolism by mouse peritoneal macrophages.

1982 • 247 citations

Thrombin-induced hydrolysis of phosphatidylinositol in human platelets.

1980 • 244 citations

Purification and characterization of rat brain prostaglandin D synthetase.

1985 • 239 citations

Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7

1988 • 236 citations

Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases.

1989 • 235 citations

Purification and characterization of canine myocardial cytosolic phospholipase A2. A calcium-independent phospholipase with absolute f1-2 regiospecificity for diradyl glycerophospholipids.

1990 • 234 citations

Evidence of protein kinase C involvement in phorbol diester-stimulated arachidonic acid release and prostaglandin synthesis.

1987 • 232 citations

Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis

1990 • 229 citations

Constraints on prostaglandin biosynthesis in tissues.

1987 • 222 citations

Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase.

1985 • 219 citations

Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence

1988 • 217 citations

Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities.

1987 • 217 citations

Prostaglandin endoperoxide E isomerase from bovine vesicular gland microsomes, a glutathione-requiring enzyme.

1977 • 212 citations

Prostaglandin endoperoxide synthase gene structure: Identification of the transcriptional start site and 5′-flanking regulatory sequences

1992 • 210 citations

FACTORS REGULATING THE BIOSYNTHESIS OF VARIOUS PROSTAGLANDINS

1971 • 203 citations

Identification and characterization of a hormonally regulated form of phospholipase A2 in rat renal mesangial cells.

1988 • 203 citations

Prostaglandin Biosynthesis and its Compartmentation in Vascular Smooth Muscle and Endothelial Cells

1986 • 195 citations

Isolation and characterization of thromboxane synthase from human platelets as a cytochrome P-450 enzyme.

1985 • 194 citations

Conversion of prostaglandin endoperoxides to C₁₇‐hydroxy acids catalyzed by human platelet thromboxane synthase

1977 • 188 citations

Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents.

1985 • 185 citations

Purification of a high-molecular-mass form of phospholipase A2 from rat kidney activated at physiological calcium concentrations

1990 • 174 citations

Subcellular localization of prostaglandin-forming cyclooxygenase in Swiss mouse 3T3 fibroblasts by electron microscopic immunocytochemistry.

1980 • 174 citations

Stimulation of prostaglandin E2 synthesis in cloned osteoblastic cells of mouse (MC3T3-E1) by epidermal growth factor.

1986 • 167 citations

REGIONAL DISTRIBUTION AND RATE OF PRODUCTION OF FREE FATTY ACIDS IN RAT BRAIN

1971 • 165 citations

Prostaglandin Endoperoxide Synthase in Rat Ovarian Follicles: Content, Cellular Distribution, and Evidence for Hormonal Induction Preceding Ovulation*

1987 • 164 citations

Novel prostaglandin derivative formed from arachidonic acid by rat stomach homogenates

1971 • 163 citations

X-ray absorption studies of intermediates in peroxidase activity

1984 • 162 citations

Spectral properties of the higher oxidation states of prostaglandin H synthase.

1985 • 159 citations

Acetylation of Prostaglandin Endoperoxide Synthetase with Acetylsalicylic Acid

1980 • 158 citations

Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog.

1988 • 156 citations

Human myeloperoxidase and thyroid peroxidase, two enzymes with separate and distinct physiological functions, are evolutionarily related members of the same gene family

1988 • 151 citations

Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung.

1985 • 150 citations

Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endothelium and smooth muscle of bovine aorta.

1983 • 148 citations

Identification and purification of sheep platelet phospholipase A2 isoforms. Activation by physiologic concentrations of calcium ion.

1986 • 147 citations

Reviews in biochemical toxicology

1984 • 147 citations

Differential activation of platelet phospholipases by thrombin and ionophore A23187.

1981 • 145 citations

Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.

1990 • 143 citations

Exaggerated human vascular cell prostaglandin biosynthesis mediated by monocytes: role of monokines and interleukin 1.

1985 • 142 citations

Hormone selective lipase activation in the isolated rabbit heart

1977 • 142 citations

A role for Gi in control of thrombin receptor-phospholipase C coupling in human platelets.

1988 • 138 citations

Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans.

1985 • 136 citations

Epidermal growth factor stimulation of prostaglandin E2 biosynthesis in amnion cells. Induction of prostaglandin H2 synthase.

1988 • 135 citations

Effects of non-steroidal anti-inflammatory drugs on fatty acid cyclooxygenase and prostaglandin hydroperoxidase activities.

1982 • 134 citations

Biochemical and immunological characterization of rat spleen prostaglandin D synthetase.

1987 • 133 citations

Stimulation of de novo synthesis of prostaglandin G/H synthase in human endothelial cells by phorbol ester.

1988 • 132 citations

Regulation of cyclic AMP metabolism in rabbit cortical collecting tubule cells by prostaglandins.

1988 • 132 citations

Inhibition of prostaglandin biosynthesis by eicosa-5,8,11,14-tetraynoic acid

1970 • 132 citations

Kinin-induced prostaglandin synthesis by renal papillary collecting tubule cells in culture

1981 • 130 citations

Regulation of Eicosanoid Production: Role of Phospholipases and Inhibitors

1987 • 129 citations

Characterization and properties of a phosphatidylinositol phosphodiesterase (phospholipase C) from platelet cytosol

1979 • 129 citations

Arachidonate release and phosphatidic acid turnover in stimulated human platelets.

1983 • 126 citations

Basal and stimulated rates of renal secretion and excretion of prostaglandins E2, Fα, and 13,14-dihydro-15-keto Fα in the dog

1978 • 125 citations

Purification of a phospholipase A2 from human monocytic leukemic U937 cells. Calcium-dependent activation and membrane association.

1990 • 125 citations

Regulation of Prostaglandin H Synthase mRNA Levels and Prostaglandin Biosynthesis by Platelet-derived Growth Factor

1989 • 124 citations

Brain free fatty acid levels in rats sacrificed by decapitation versus focused microwave irradiation

1975 • 123 citations

Bacterial lipopolysaccharide priming of P388D1 macrophage-like cells for enhanced arachidonic acid metabolism. Platelet-activating factor receptor activation and regulation of phospholipase A2.

1990 • 122 citations

Prostaglandin H synthase and hydroperoxides: Peroxidase reaction and inactivation kinetics

1986 • 120 citations

Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein.

1983 • 118 citations

Prostaglandin H synthase. Stoichiometry of heme cofactor.

1984 • 118 citations

On the haemoprotein character of prostaglandin endoperoxide synthetase

1979 • 118 citations

Triene prostaglandins: Prostacyclin and thromboxane biosynthesis and unique biological properties

1979 • 118 citations

Molecular cloning of human platelet thromboxane a synthase

1991 • 116 citations

Essential histidines of prostaglandin endoperoxide synthase. His-309 is involved in heme binding.

1991 • 115 citations

Solubilization, purification, and characterization of a membrane-bound phospholipase A2 from the P388D1 macrophage-like cell line.

1988 • 114 citations

Interleukin 1 amplifies receptor-mediated activation of phospholipase A2 in 3T3 fibroblasts.

1988 • 110 citations

Bronchopulmonary and cardiovascular effects of prostaglandin D2 in the dog

1977 • 110 citations

In vivo suppression of prostaglandin biosynthesis by non-steroidal anti-inflammatory agents

1976 • 110 citations

Orientation of the active site and antigenic determinants of prostaglandin endoperoxide synthase in the endoplasmic reticulum.

1981 • 108 citations

Heme spin states and peroxide-induced radical species in prostaglandin H synthase.

1987 • 108 citations

Inhibition Studies on the Membrane-associated Phospholipase A2 in vitro and Prostaglandin E2 Production in vivo of the Macrophage-like P388D1 Cell

1989 • 107 citations

The activation of phosphatidylinositol-hydrolyzing phospholipase A2 during prostaglandin synthesis in transformed mouse BALB/3T3 cells.

1981 • 104 citations

An arachidonoyl (polyenoic)-specific phospholipase A2 activity regulates the synthesis of platelet-activating factor in granulocytic HL-60 cells.

1990 • 104 citations

Biochemical and immunological demonstration of prostaglandin D2, E2, and F2α formation from prostaglandin H2 by various rat glutathione S-transferase isozymes

1988 • 100 citations

Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase

1981 • 100 citations

Bimodal distribution of the prostaglandin I2 synthase antigen in smooth muscle cells.

1983 • 99 citations

Primary structure of human thromboxane synthase determined from the cDNA sequence.

1992 • 99 citations

Regulation of vascular prostaglandin synthesis by metabolites of arachidonic acid in perfused rabbit aorta.

1983 • 98 citations

Restoration of prostacyclin synthase in vascular smooth muscle cells after aspirin treatment: regulation by epidermal growth factor.

1985 • 98 citations

Histamine-stimulated and GTP-binding proteins-mediated phospholipase A2 activation in rabbit platelets.

1990 • 97 citations

Prostaglandin E receptors in bovine adrenal medulla are coupled to adenylate cyclase via Gi and to phosphoinositide metabolism in a pertussis toxin-insensitive manner

1989 • 97 citations

9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways.

1987 • 97 citations

Lipoxygenation activity of purified prostaglandin-forming cyclooxygenase

1978 • 95 citations

Immunochemical evidence for the involvement of prostaglandin H synthase in hydroperoxide-dependent oxidations by ram seminal vesicle microsomes.

1983 • 95 citations

Prostaglandin H synthase: spectroscopic studies of the interaction with hydroperoxides and with indomethacin

1990 • 95 citations

The LDL receptor pathway delivers arachidonic acid for eicosanoid formation in cells stimulated by platelet-derived growth factor

1990 • 94 citations

Solubilization and properties of Ca2+-dependent human platelet phospholipase A2

1986 • 94 citations

Rapid Induction of Prostaglandin Endoperoxide Synthase in Rat Preovulatory Follicles by Luteinizing Hormone and cAMP is Blocked by Inhibitors of Transcription and Translation

1989 • 92 citations

Association of a solubilized prostaglandin E2 receptor from renal medulla with a pertussis toxin-reactive guanine nucleotide regulatory protein.

1986 • 91 citations

Primary Structure of Rat Brain Prostaglandin D Synthetase Deduced from cDNA Sequence

1989 • 91 citations

Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets.

1988 • 90 citations

Immunochemical and kinetic evidence for two different prostaglandin H-prostaglandin E isomerases in sheep vesicular gland microsomes.

1987 • 90 citations

Leukotriene C promotes prostacyclin synthesis by human endothelial cells.

1983 • 89 citations

Kinetic analysis of the Ca2+-dependent, membrane-bound, macrophage phospholipase A2 and the effects of arachidonic acid.

1988 • 89 citations

Two phospholipase pools for prostaglandin synthesis in macrophages

1981 • 89 citations

Alpha 1-adrenergic stimulation of arachidonic acid release and metabolism in a rat thyroid cell line. Mediation of cell replication by prostaglandin E2.

1986 • 89 citations

Receptor-stimulated phospholipase A2 activation is coupled to influx of external calcium and not to mobilization of intracellular calcium in C62B glioma cells

1989 • 87 citations

Progesterone induces expression of endometrial messenger RNA encoding for cyclooxygenase (sheep)

1990 • 86 citations

Characterization of prostaglandin production in tissue culture of rat renal medullary cells

1976 • 86 citations

New evidence with selective agonists and antagonists for the subclassification of PGE2-sensitive (EP) receptors.

1987 • 85 citations

Postnatal changes in the localization of prostaglandin D synthetase from neurons to oligodendrocytes in the rat brain.

1987 • 82 citations

Inositol and Phosphoinositides — Metabolism and Regulation

1986 • 82 citations

Regulation of Vasopressin Action by Prostaglandins

1982 • 81 citations

Inhibition of Thromboxane A Synthesis in U937 Cells by Glucocorticoids

1989 • 79 citations

Characterization of multiple forms of phosphoinositide-specific phospholipase C purified from human platelets

1986 • 78 citations

Specificity of phospholipases in methylcholanthrene-transformed mouse fibroblasts activated by bradykinin, thrombin, serum, and ionophore A23187.

1979 • 75 citations

Prostaglandin H synthase: Distinct binding sites for cyclooxygenase and peroxidase substrates

1988 • 74 citations

6 Cytochrome c Peroxidase

1976 • 73 citations

sn-1,2-Diacylglycerols and phorbol diesters stimulate thromboxane synthesis by de novo synthesis of prostaglandin H synthase in human promyelocytic leukemia cells.

1987 • 73 citations

Mechanism of oxygen transfer by prostaglandin hydroperoxidase.

1980 • 73 citations

Source of arachidonic acid for prostaglandin synthesis in Madin-Darby canine kidney cells.

1981 • 72 citations

Rapid inactivation of cyclooxygenase activity after stimulation of intact platelets

1979 • 72 citations

The Prostaglandin Forming Cyclooxygenase of Ovine Uterus: Relationship to Luteal Function

1979 • 72 citations

Influence of natural and recombinant interleukin 2 on endothelial cell arachidonate metabolism. Induction of de novo synthesis of prostaglandin H synthase.

1988 • 71 citations

The heme-binding properties of prostaglandin synthetase from sheep vesicular gland.

1981 • 71 citations

Partial purification of phosphoinositide phospholipase C from human platelet cytosol; characterization of its three forms

1986 • 70 citations

EPR study of ferric native prostaglandin H synthase and its ferrous NO derivative

1987 • 70 citations

Purification and characterization of cytochrome P-450-dependent arachidonic acid epoxygenase from human liver.

1988 • 69 citations

Determination of the structure of the carbohydrate chains of prostaglandin endoperoxide synthase from sheep

2008 • 69 citations

Immunoaffinity purification and characterization of thromboxane synthase from porcine lung.

1986 • 68 citations

Controlled tryptic digestion of prostaglandin H synthase. Characterization of protein fragments and enhanced rate of proteolysis of oxidatively inactivated enzyme.

1987 • 66 citations

A prostaglandin E receptor coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rabbit cortical collecting tubule cells.

1990 • 65 citations

Phospholipase activities of the P388D1 macrophage-like cell line

1985 • 65 citations

16 Enzymes in the Biosynthesis and Catabolism of the Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes and Hydroxy Fatty Acids

1983 • 64 citations

Evidence of GTP-binding protein regulation of phospholipase A2 activity in isolated human platelet membranes

1989 • 64 citations

Acetylenic inhibitors of sheep vesicular gland oxygenase

1973 • 63 citations

Prostaglandin-E2-9-ketoreductase in rabbit kidney

1975 • 62 citations

Topography of Prostaglandin H Synthase

1989 • 62 citations

Binding and inhibition studies on lipocortins using phosphatidylcholine vesicles and phospholipase A2 from snake venom, pancreas, and a macrophage-like cell line.

1990 • 61 citations

Evidence for coordinate, selective regulation of eicosanoid synthesis in platelet-derived growth factor-stimulated 3T3 fibroblasts and in HL-60 cells induced to differentiate into macrophages or neutrophils.

1988 • 57 citations

The influence of ambient peroxides on the conversion of 5,8,11,14,17-eicosapentaenoic acid to prostaglandins

1981 • 53 citations

Oxygen requirement for prostaglandin biosynthesis

1978 • 51 citations

NADP-linked 15-hydroxyprostaglandin dehydrogenase from human placenta: Partial purification and characterization of the enzyme and identification of an inhibitor in placental tissue of an inhibitor in placental tissue

1977 • 51 citations

Functional differentiation of cyclooxygenase and peroxidase activities of prostaglandin synthase by trypsin treatment. Possible location of a prosthetic heme binding site.

1988 • 49 citations

Isolation of an activator for prostaglandin hydroperoxidase from bovine vesicular gland cytosol and its identification as uric acid

1979 • 49 citations

Regulation of Prostaglandin Endoperoxide Synthase Gene Expression in Cultured Rat Mesangial Cells: Induction by Serum via a Protein Kinase-C-Dependent Mechanism

1991 • 48 citations

Conformational requirements at the prostaglandin cyclooxygenase receptor site: A template for designing non-steroidal anti-inflammatory drugs

1979 • 48 citations

Stimulation by GTP-binding proteins (Gi, Go) of partially purified phospholipase C activity from human platelet membranes

1987 • 47 citations

Altered arachidonic acid metabolism during differentiation of the human monoblastoid cell line U937

1990 • 47 citations

Substrate specificity of three prostaglandin dehydrogenases

1983 • 46 citations

Prostaglandin 9-ketoreductase/type II 15-hydroxyprostaglandin dehydrogenase is not a prostaglandin specific enzyme

1981 • 45 citations

Stable 9ß- or 11α-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor

1988 • 43 citations

Epidermal growth factor-stimulated prostaglandin E2 production in human amnion cells: specificity and nonesterified arachidonic acid dependency

1987 • 43 citations

Fatty acid cyclooxygenase activity stimulated by transforming growth factor-β in mouse osteoblastic cells (MC3T3-E1)

1989 • 43 citations

[13] Purification of PGH-PGE isomerase from sheep vesicular glands

1982 • 41 citations

Glucocorticoid-induced reduction of prostanoid synthesis in TPA-differentiated U937 cells is mainly due to a reduced cyclooxygenase activity

1990 • 41 citations

Stimulation of Human Amnion Prostaglandin E₂Production by Activators of Protein Kinase-C*

1988 • 40 citations

The inhibition of phospholipase A2 by manoalide and manoalide analogues

1987 • 39 citations

Cytochrome c Peroxidase

1970 • 38 citations

Inhibition by adenosine 3':5'-monophosphate of eicosanoid and platelet-activating factor biosynthesis in the mouse PT-18 mast cell.

1990 • 38 citations

Enzymatic Conversion of Prostaglandin H2 to Prostaglandin F2α by Aldehyde Reductase from Human Liver: Comparison to the Prostaglandin F Synthetase from Bovine Lung

1989 • 37 citations

Monoclonal antibodies to thromboxane synthase from porcine lung. Production and application to development of a tandem immunoradiometric assay.

1986 • 36 citations

Alkylaryl sulfides as Peroxidase Reducing Substrates for Prostaglandin H Synthase

1989 • 35 citations

Interrelationships among prostaglandins, vasopressin and cAMP in renal papillary collecting tubile cells in culture

1982 • 31 citations

EPR titration of ovine prostaglandin H synthase with hemin

1984 • 29 citations

Regulation of phosphatidylinositol breakdown and leukotriene synthesis by endogenous prostaglandins in resident mouse peritoneal macrophages.

1990 • 28 citations

9 alpha,11 beta-prostaglandin F2 formation in various bovine tissues. Different isozymes of prostaglandin D2 11-ketoreductase, contribution of prostaglandin F synthetase and its cellular localization.

1990 • 27 citations

Immunoaffinity purification of human thromboxane synthase

1990 • 27 citations

Prostacyclin Synthase, a Cytochrome P450 Enzyme

1983 • 25 citations

Molecular basis for the inhibition of prostanoid biosynthesis by nonsteroidal anti-inflammatory agents.

1990 • 25 citations

The action of epidermal growth factor on human amnion prostaglandin E₂ output

1988 • 25 citations

Cooperation of Adipocytes and Endothelial Cells Required for Catecholamine Stimulation of PGI2 Production by Rat Adipose Tissue

1989 • 24 citations

Structure-function relationships in sheep, mouse, and human prostaglandin endoperoxide G/H synthases.

1990 • 23 citations

Mechanism of xenobiotic cooxygenation coupled to prostaglandin H2 biosynthesis.

1980 • 22 citations

[29] Receptors for PGI2 and PGD2 on human platelets

1982 • 21 citations

[1] Nomenclature

1990 • 21 citations

[14] Preparation and assay of prostacyclin synthase

1982 • 19 citations

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence

1988 • 18 citations

Prostaglandin H Synthase

1990 • 17 citations

Radioimmunoassay measurement of 2,3-dinor metabolites of prostacyclin and thromboxane in human urine.

1987 • 17 citations

The Biosynthesis and Actions of Prostaglandins in the Renal Collecting Tubule and Thick Ascending Limb

1989 • 17 citations

Regulation of prostanoids synthesis in human fibroblasts and human blood monocytes by interleukin-1, endotoxin, and glucocorticoids.

1990 • 16 citations

[12] Isolation of PGH-PGD isomerase from rat spleen

1982 • 14 citations

Effects of hydrodynamic forces on coronary production of prostacyclin and purines

1989 • 13 citations

Serum induction and superinduction of PGG/H synthase mRNA levels in 3T3 fibroblasts.

1991 • 13 citations

The purification and characterization of a prostacyclin dehydrogenase from rabbit kidney.

1982 • 12 citations

Synthesis of [5,6-3H]arachidonic acid and its use in development of a sensitive assay for prostacyclin synthetase

1980 • 11 citations

Properties of trout hemoglobins reconstituted with unnatural hemes

1978 • 11 citations

T-cell-derived arachidonic acid and eicosanoid synthesis by macrophages.

1983 • 10 citations

[19] Purification of PGD2 11-ketoreductase from rabbit liver

1982 • 9 citations

Cooperation of adipocytes and endothelial cells required for catecholamine stimulation of PGI2 production by rat adipose tissue

1989 • 9 citations

Evidence for two pools of prostaglandin H synthase in human endothelial cells.

1991 • 8 citations

Regulation of cyclooxygenase activity in human vascular tissue.

1987 • 8 citations

Enzymatic formation of prostaglandin F2α from prostaglandin H2 and D2 : Purification and properties of prostaglandin F synthetase from bovine lung

1985 • 8 citations

Mechanisms for Eicosanoid Precursor Uptake and Release by a Tissue Culture Cell Line

1985 • 7 citations

Incorporation of arachidonic acid into glycerophospholipids of a murine bone marrow derived mast cell.

1990 • 6 citations

Prostaglandin D2 and sleep.

1989 • 5 citations

Molecular characterization of the prostacyclin synthase.

1987 • 4 citations

Molecular mechanism of cyclooxygenase regulation in cloned mouse osteoblastic cell (MC3T3-E1).

1989 • 3 citations

Properties of trypsin-cleaved PGH synthase.

1991 • 2 citations

Inhibition of ovulation by the antiserum to cyclooxygenase and immunocytochemical study of cyclooxygenase in the ovarian follicles

1982 • 2 citations

Localization of Enzymes Responsible for Prostaglandin Formation

2017 • 2 citations

Deleted Work

1955 • 0 citations