THE DISCOVERY OF PROSTACYCLIN – – – A FRESH INSIGHT INTO ARACHIDONIC ACID METABOLISM

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Free Radical Mechanisms in Tissue Injury

1988 • 1,585 citations

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

1976 • 1,012 citations

Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation

1974 • 1,004 citations

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

1976 • 956 citations

Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs

1969 • 886 citations

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

1977 • 886 citations

Isolation and properties of intermediates in prostaglandin biosynthesis

1973 • 796 citations

The chemical structure of prostaglandin X (prostacyclin)

1976 • 729 citations

THE RELEASE OF PROSTAGLANDINS FROM LUNG AND OTHER TISSUES

1971 • 658 citations

Detection and Isolation of an Endoperoxide Intermediate in Prostaglandin Biosynthesis

1973 • 640 citations

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

1976 • 606 citations

The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones.

1966 • 573 citations

Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides

1976 • 533 citations

New Aspects of the Mode of Action of Nonsteroid Anti-Inflammatory Drugs

1974 • 427 citations

Prostacyclin (PGX) is the endogeneous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid

1977 • 412 citations

Prostaglandin Synthetase Inhibitors

1977 • 394 citations

Thromboxanes: Selective Biosynthesis and Distinct Biological Properties

1976 • 390 citations

The regeneration of aortic endothelium

1958 • 374 citations

Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig

1975 • 339 citations

Antisecretory, antiulcer, cytoprotective and diarrheogenic properties of prostaglandins.

1976 • 330 citations

: A selective inhibitor of thromboxane synthetase

1977 • 303 citations

Angiotensin II Stimulation of Prostaglandin Production in Cultured Human Vascular Endothelium

1975 • 278 citations

Comparative aspects of prostaglandin biosynthesis in animal tissues

1972 • 266 citations

Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig

1975 • 233 citations

On the Incorporation of Oxygen in the Conversion of 8,11,14-Eicosatrienoic Acid to Prostaglandin E₁

1965 • 231 citations

Platelet Aggregation induced by Arachidonic Acid is accompanied by Release of Potential Inflammatory Mediators distinct from PGE2 and PGF2

1973 • 227 citations

Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea‐pig lungs

1973 • 223 citations

Growth Rate in vivo of Platelet Thrombi, produced by Iontophoresis of ADP, as a Function of Mean Blood Flow Velocity

1970 • 219 citations

Formation of an Intermediate in Prostaglandin Biosynthesis and Its Association with the Platelet Release Reaction

1974 • 203 citations

Prostaglandin endoperoxides IV. Effects on smooth muscle

1975 • 193 citations

Release of novel prostaglandins and thromboxanes after immunological challenge of guinea pig lung

1976 • 192 citations

Prostaglandin Endoperoxides IX. Characterization of Rabbit Aorta Contracting Substance (RCS) from Guinea Pig Lung and Human Platelets

1975 • 179 citations

An endoperoxide aggregator (LASS), formed in platelets in response to thrombotic stimuli-purification, identification and unique biological significance

1974 • 178 citations

Prostaglandin endoperoxide and thromboxane generating systems and their selective inhibition

1976 • 176 citations

Novel prostaglandin derivative formed from arachidonic acid by rat stomach homogenates

1971 • 163 citations

Prostaglandin synthesis by bovine mesenteric arteries and veins.

1975 • 152 citations

Eine neue Methode zur Erzeugung von Thromben durch gezielte Überdehnung der Gefäßwand

1963 • 130 citations

Isolation, structure, and biosynthesis of 6-ketoprostaglandin F1.alpha. in the rat stomach

1976 • 124 citations

Release of Vasoactive Substances from Guinea-Pig Lungs by Slow-Reacting Substance C and Arachidonic Acid

1971 • 117 citations

Some biological effects of prostaglandin endoperoxide analogs

1976 • 117 citations

Polymorphonuclear leukocytes produce thromboxane A2-like activity during phagocytosis

1976 • 114 citations

The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti‐inflammatory drugs

1972 • 113 citations

Paradoxical endogenous synthesis of a coronary dilating substance from arachidonate

1976 • 110 citations

Metabolism of 8,11,14-eicosatrienoic acid in human platelets

1976 • 105 citations

Dihomo-γ-linolenate suppresses platelet aggregation when administered in vitro or in vivo

1974 • 102 citations

Formation and Action of Prostaglandin Endoperoxides in the Isolated Human Umbilical Artery

1976 • 84 citations

A new potential mediator of arterial thrombosis whose biosynthesis is inhibited by aspirin

1973 • 81 citations

The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins

1972 • 66 citations

Effects of prostaglandin synthesis inhibitors on angiotensin tachyphylaxis in the isolated coeliac and mesenteric arteries of the rabbit.

1974 • 58 citations

The effect of peroxidized arachidonic acid upon human platelet aggregation

1974 • 52 citations

Inhibition of basal and hormone-stimulated adenylate cyclase in adipocyte ghosts by the prostaglandin endoperoxide prostaglandin H2

1975 • 47 citations

N-0164 inhibits generation of thromboxane-A2-like activity from prostaglandin endoperoxides by human platelet microsomes

1976 • 45 citations

Prostaglandin feedback mechanism limits vasoconstrictor action of norepinephrine in perfused rabbit ear

1975 • 34 citations

INHIBITION BY NON‐STEROID ANTI‐INFLAMMATORY AGENTS OF RABBIT AORTA CONTRACTING ACTIVITY GENERATED IN BLOOD BY SLOW REACTING SUBSTANCE C

1974 • 34 citations

Metabolism and effect of prostaglandin H2 in adipose tissue

1976 • 17 citations

The Effect of Imidazole on Human Platelet Aggregation

1971 • 14 citations

Hypercoagulability and Thrombosis: Effect of Injected Thrombokinase and Adenosine Diphosphate on Established Microthrombi in Rabbits.

1964 • 8 citations

Comparative effects o ADP and thrombin in producing stasis thrombosis.

1967 • 6 citations

Comparative Effects of ADP and Thrombin in Producing Stasis Thrombosis

1967 • 4 citations