Cytoplasmic Fate of Eukaryotic mRNA: Identification and Characterization of AU-Binding Proteins

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Conserved Structures and Diversity of Functions of RNA-Binding Proteins

1994 • 1,873 citations

Structural features in eukaryotic mRNAs that modulate the initiation of translation.

1991 • 1,849 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins

1985 • 1,253 citations

At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells

1987 • 1,189 citations

Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus

1979 • 1,178 citations

The Granulocyte-Macrophage Colony-Stimulating Factors

1985 • 1,007 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma

1983 • 732 citations

Expression of human immune interferon cDNA in E. coli and monkey cells

1982 • 703 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

1993 • 660 citations

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

1989 • 601 citations

c-fos protein can induce cellular transformation: A novel mechanism of activation of a cellular oncogene

1984 • 601 citations

A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm

1988 • 565 citations

HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and sex-lethal

1991 • 553 citations

The intracellular localization of messenger RNAs

1995 • 534 citations

Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1.

1993 • 533 citations

The Nonamer UUAUUUAUU Is the Key AU-Rich Sequence Motif That Mediates mRNA Degradation

1995 • 524 citations

Extreme instability of myc mRNA in normal and transformed human cells.

1984 • 522 citations

The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain

1988 • 522 citations

Identification of an AUUUA-Specific Messenger RNA Binding Protein

1989 • 515 citations

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

1994 • 511 citations

A nuclear localization domain in the hnRNP A1 protein.

1995 • 510 citations

An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro.

1991 • 484 citations

Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte—macrophage colony stimulating factor

1984 • 451 citations

Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.

1983 • 446 citations

Heterogeneous Nuclear Ribonucleoproteins: Role in RNA Splicing

1986 • 399 citations

RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos

1991 • 391 citations

A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells

1991 • 381 citations

Messenger RNA in HeLa cells: Kinetics of formation and decay

1973 • 377 citations

The role of mRNA and protein stability in gene expression

1989 • 370 citations

Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs.

1993 • 356 citations

Translational Blockade Imposed by Cytokine-Derived UA-Rich Sequences

1989 • 347 citations

AUUUA Is Not Sufficient To Promote Poly(A) Shortening and Degradation of an mRNA: the Functional Sequence within AU-Rich Elements May Be UUAUUUA(U/A)(U/A)

1994 • 331 citations

The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation.

1994 • 330 citations

Poly(A) shortening and degradation of the 3' A+U-rich sequences of human c-myc mRNA in a cell-free system.

1988 • 324 citations

Cis-Trans Models for Post-Transcriptional Gene Regulation

1989 • 322 citations

mRNA decay: Finding the right targets

1989 • 318 citations

In Vivo and In Vitro Arginine Methylation of RNA-Binding Proteins

1995 • 302 citations

Rapid Cytoplasmic Turnover of c-myc mRNA: Requirement of the 3′ Untranslated Sequences

1987 • 302 citations

The protein-coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors.

1991 • 297 citations

An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA.

1991 • 293 citations

Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening.

1994 • 290 citations

REGULATED mRNA STABILITY

1990 • 279 citations

mRNA Decay Mediated by Two Distinct AU-Rich Elements from c-fos and Granulocyte-Macrophage Colony-Stimulating Factor Transcripts: Different Deadenylation Kinetics and Uncoupling from Translation

1995 • 276 citations

An Early Hierarchic Role of U1 Small Nuclear Ribonucleoprotein in Spliceosome Assembly

1988 • 271 citations

A 32-kilodalton protein binds to AU-rich domains in the 3' untranslated regions of rapidly degraded mRNAs.

1991 • 268 citations

Selective Degradation of Early-Response-Gene mRNAs: Functional Analyses of Sequence Features of the AU-Rich Elements

1994 • 253 citations

Ribosome binding to reovirus mRNA in protein synthesis requires 5′ terminal 7-methylguanosine

1975 • 241 citations

Regulation of Cytokine Gene Expression

1988 • 234 citations

Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors

1985 • 227 citations

The adenosine-uridine binding factor recognizes the AU-rich elements of cytokine, lymphokine, and oncogene mRNAs.

1991 • 222 citations

Regulation of c-fosgene expression in hamster fibroblasts: initiation and elongation of transcription and mRNA degradation

1987 • 218 citations

Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences.

1993 • 208 citations

Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene.

1985 • 207 citations

The Mechanisms of mRNA Degradation in Eukaryotes

1999 • 204 citations

Detection and Characterization of a 3′ Untranslated Region Ribonucleoprotein Complex Associated with Human α-Globin mRNA Stability

1995 • 194 citations

AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A).

1994 • 189 citations

Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function

1994 • 184 citations

A redox switch and phosphorylation are involved in the post-translational up-regulation of the adenosine-uridine binding factor by phorbol ester and ionophore.

1991 • 184 citations

Rapid cytoplasmic turnover of c-myc mRNA: requirement of the 3' untranslated sequences.

1987 • 182 citations

Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex.

1992 • 181 citations

Determinants that contribute to cytoplasmic stability of human c-fos and beta-globin mRNAs are located at several sites in each mRNA.

1988 • 178 citations

Regulation of mRNA turnover in eukaryotic cells.

1991 • 171 citations

Cell cycle regulation of mouse H3 histone mRNA metabolism.

1984 • 165 citations

Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements.

1994 • 165 citations

Biosynthesis and stability of globin mRNA in cultured erythroleukemic friend cells

1976 • 163 citations

Regulation of interleukin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ions.

1990 • 163 citations

AU RNA-binding factors differ in their binding specificities and affinities.

1992 • 157 citations

The determinants of RNA-binding specificity of the heterogeneous nuclear ribonucleoprotein C proteins.

1994 • 155 citations

Aberrant c-myc RNAs of Burkitt's lymphoma cells have longer half-lives.

1985 • 152 citations

Multiple elements in the c-fos protein-coding region facilitate mRNA deadenylation and decay by a mechanism coupled to translation.

1994 • 147 citations

Erythroid cell-specific determinants of alpha-globin mRNA stability.

1994 • 145 citations

The iron-responsive element binding protein: a method for the affinity purification of a regulatory RNA-binding protein.

1989 • 144 citations

Dynamic Hsp83 RNA Localization during Drosophila Oogenesis and Embryogenesis

1993 • 142 citations

Position Is the Critical Determinant for Function of Iron-Responsive Elements as Translational Regulators

1992 • 138 citations

Selective Destabilization of Short-Lived mRNAs with the Granulocyte-Macrophage Colony-Stimulating Factor AU-Rich 3' Noncoding Region Is Mediated by a Cotranslational Mechanism

1993 • 131 citations

The half-life of c-myc mRNA in growing and serum-stimulated cells: influence of the coding and 3' untranslated regions and role of ribosome translocation.

1994 • 129 citations

AUH, a gene encoding an AU-specific RNA binding protein with intrinsic enoyl-CoA hydratase activity.

1995 • 126 citations

Cellular and molecular biology of lymphokines

1985 • 124 citations

Nucleolin and Heterogeneous Nuclear Ribonucleoprotein C Proteins Specifically Interact with the 3′-Untranslated Region of Amyloid Protein Precursor mRNA

1995 • 118 citations

Determination of Ocean Wave Spectra from Doppler Radio Return from the Sea Surface

1971 • 116 citations

Tumor necrosis factor alpha-induced glucose transporter (GLUT-1) mRNA stabilization in 3T3-L1 preadipocytes. Regulation by the adenosine-uridine binding factor.

1992 • 112 citations

Regulation of proto-oncogene mRNA stability

1992 • 111 citations

Regulation of messenger RNA turnover in eukaryotes

1987 • 111 citations

Functional hierarchy of AUUUA motifs in mediating rapid interleukin-3 mRNA decay.

1994 • 109 citations

Translational repression in eukaryotes: partial purification and characterization of a repressor of ferritin mRNA translation.

1988 • 109 citations

Stability of globin mRNA in terminally differentiating murine erythroleukemia cells

1981 • 108 citations

Isolation of novel murine maternal mRNAs regulated by cytoplasmic polyadenylation.

1992 • 105 citations

Dynamic Hsp83 RNA localization during Drosophila oogenesis and embryogenesis.

1993 • 103 citations

Amyloid precursor protein mRNA stability is controlled by a 29-base element in the 3'-untranslated region.

1994 • 94 citations

Post-transcriptional regulation of groα, β, γ, and IL-8 mRNAs by IL-1β

1991 • 94 citations

Number and location of AUUUA motifs: role in regulating transiently expressed RNAs

1994 • 92 citations

Identification of sequences within the murine granulocyte-macrophage colony-stimulating factor mRNA 3'-untranslated region that mediate mRNA stabilization induced by mitogen treatment of EL-4 thymoma cells.

1991 • 87 citations

Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function.

1994 • 86 citations

A human RNase E-like activity that cleaves RNA sequences involved in mRNA stability control.

1995 • 84 citations

Tumor necrosis factor increases stability of interleukin-1 mRNA by activating protein kinase C.

1993 • 82 citations

Nuclease activity associated with mammalian mRNA in its native state: possible basis for selectivity in mRNA decay.

1990 • 81 citations

Differential mRNA stability to reticulocyte ribonucleases correlates with 3′ non‐coding (U)_nA sequences

1988 • 80 citations

Position is the critical determinant for function of iron-responsive elements as translational regulators.

1992 • 77 citations

Rapid Degradation of AU-Rich Element (ARE) mRNAs Is Activated by Ribosome Transit and Blocked by Secondary Structure at Any Position 5′ to the ARE

1995 • 76 citations

AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and the cytoplasm

1994 • 75 citations

Post-transcriptional regulation of granulocyte-macrophage colony-stimulating factor synthesis in murine T cells.

1990 • 74 citations

Viral small nuclear ribonucleoproteins bind a protein implicated in messenger RNA destabilization.

1992 • 72 citations

Regulation of mRNA stability and its relevance to disease.

1991 • 66 citations

Cytokine messenger RNA stability is enhanced in tumor cells

1991 • 65 citations

Modulation of granulocyte-macrophage colony-stimulating factor mRNA stability in vitro by the adenosine-uridine binding factor.

1994 • 64 citations

Cell Cycle-Regulated Phosphorylation of the Pre-mRNA-Binding (Heterogeneous Nuclear Ribonucleoprotein) C Protein

1993 • 63 citations

Protein synthesis inhibition stabilizes urokinase-type plasminogen activator mRNA. Studies in vivo and in cell-free decay reactions.

1991 • 62 citations

A viral long terminal repeat in the interleukin 2 gene of a cell line that constitutively produces interleukin 2.

1985 • 62 citations

Very short-lived and stable mRNAs from resting human lymphocytes.

1975 • 61 citations

Ca2+ ionophore A23187-dependent stabilization of granulocyte-macrophage colony-stimulating factor messenger RNA in murine thymoma EL-4 cells is mediated through two distinct regions in the 3'-untranslated region.

1993 • 60 citations

Selective destabilization of short-lived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich 3' noncoding region is mediated by a cotranslational mechanism.

1993 • 59 citations

The M(r) 35,000 beta-adrenergic receptor mRNA-binding protein induced by agonists requires both an AUUUA pentamer and U-rich domains for RNA recognition.

1993 • 59 citations

Rapid mRNA Degradation Mediated by the c-fos 3′ AU-Rich Element and That Mediated by the Granulocyte-Macrophage Colony-Stimulating Factor 3′ AU-Rich Element Occur through Similar Polysome-Associated Mechanisms

1995 • 57 citations

A novel transiently expressed, integral membrane protein linked to cell activation. Molecular cloning via the rapid degradation signal AUUUA.

1992 • 56 citations

Isolation and characterization of a novel, low abundance hnRNP protein: A0.

1995 • 55 citations

Long-Range RNA Interaction of Two Sequence Elements Required for Endonucleolytic Cleavage of Human Insulin-Like Growth Factor II mRNAs

1995 • 55 citations

Phorbol ester modulation of a novel cytoplasmic protein binding activity at the 3'-untranslated region of mammalian ribonucleotide reductase R2 mRNA and role in message stability.

1994 • 50 citations

Translational regulation of human beta interferon mRNA: association of the 3' AU-rich sequence with the poly(A) tail reduces translation efficiency in vitro.

1993 • 47 citations

mRNA STABILITY AND CELLULAR DIFFERENTIATION

1972 • 46 citations

5′ untranslated sequences modulate rapid mRNA degradation mediated by 3′ AU-rich element in v-/c-fosrecombinants

1992 • 44 citations

Cell cycle-regulated phosphorylation of the pre-mRNA-binding (heterogeneous nuclear ribonucleoprotein) C proteins.

1993 • 44 citations

Purification of an AU-Rich RNA Binding Protein from Sarcophaga peregrina (Flesh Fly) and Its Identification as a Thiolase1

1993 • 39 citations

Granulocyte-macrophage colony-stimulating factor mRNA stabilization enhances transgenic expression in normal cells and tissues

1995 • 37 citations

Degradation of unstable interleukin-1 alpha mRNA in a rabbit reticulocyte cell-free system. Localization of an instability determinant to a cluster of AUUUA motifs.

1994 • 37 citations

Sequence determinants of c-myc mRNA turn-over: influence of 3' and 5' non-coding regions.

1988 • 37 citations

Association of AUUUA-binding Protein with A + U-rich mRNA during nucleo-cytoplasmic transport

1992 • 33 citations

Autocrine transformation of hemopoietic cells resulting from cytokine message stabilization after intracisternal A particle transposition.

1993 • 32 citations

Suppressible and nonsuppressible autocrine mast cell tumors are distinguished by insertion of an endogenous retroviral element (IAP) into the interleukin 3 gene.

1993 • 31 citations

c-fos mRNA instability determinants present within both the coding and the 3' non coding region link the degradation of this mRNA to its translation.

1995 • 30 citations

Requirements for c-fos mRNA down regulation in growth stimulated murine cells.

1989 • 27 citations

Regulation of mammalian ribonucleotide reductase R1 mRNA stability is mediated by a ribonucleotide reductase R1 mRNA 3′-untranslated region cis-trans interaction through a protein kinase C-controlled pathway

1994 • 25 citations

Altered myc gene transcription and intron-induced stabilization of myc RNAs in two mouse plasmacytomas.

1989 • 24 citations

Cloning of a cDNA Encoding an RNA Binding Protein by Screening Expression Libraries Using a Northwestern Strategy

1993 • 19 citations

Post-transcriptional regulation of the p53 tumor suppressor gene during growth-induction of human peripheral blood mononuclear cells.

1995 • 13 citations

Small RNA expression from the oncogenic region of a highly oncogenic strain of herpesvirus saimiri

1994 • 13 citations

Protein kinase C modulates the amounts of IL-1 receptor mRNA in human lung fibroblasts.

1993 • 10 citations

Adenosine-Uridine Binding Factor Requires Metals for Binding to Granulocyte-Macrophage Colony-Stimulating Factor mRNA

1990 • 10 citations

Regulation of the turnover of mRNAs encoding cellular oncoproteins

1991 • 3 citations

Modification of mRNA-associated proteins during changes in growth conditions

1992 • 2 citations