Therapeutic targets for hypoxia-elicited pathways.

Adhesion receptors of the immune system

1990 • 6,585 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

2017 • 4,665 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

Thalidomide is an inhibitor of angiogenesis.

1994 • 2,460 citations

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1998 • 2,427 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

Proteasome inhibitors: valuable new tools for cell biologists

1998 • 1,453 citations

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

1993 • 1,441 citations

Angiostatin induces and sustains dormancy of human primary tumors in mice

1996 • 1,193 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

1998 • 1,066 citations

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

1997 • 1,059 citations

TRANSCRIPTIONAL REGULATION BY CYCLIC AMP

1997 • 967 citations

A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation

1992 • 811 citations

Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway

1999 • 744 citations

Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.

1998 • 721 citations

Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions.

1995 • 694 citations

Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells

1997 • 673 citations

Adenosine, an endogenous anti-inflammatory agent

1994 • 635 citations

Selective pharmacological inhibition of distinct nitric oxide synthase isoforms

1996 • 576 citations

Pathophysiology of ischaemia reperfusion injury: Central role of the neutrophil

1991 • 520 citations

The Hypoxic Response: Huffing and HIFing

1997 • 482 citations

Lactacystin, Proteasome Function, and Cell Fate

1998 • 420 citations

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

1993 • 411 citations

Lipid mediator networks in cell signaling: update and impact of cytokines ¹

1996 • 401 citations

Oxygen Sensing, Hypoxia-Inducible Factor-1 and the Regulation of Mammalian Gene Expression

1998 • 362 citations

Hypoxic induction of interleukin-8 gene expression in human endothelial cells.

1994 • 346 citations

Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface.

1992 • 341 citations

Design of Lipoxin A4 Stable Analogs That Block Transmigration and Adhesion of Human Neutrophils

1995 • 326 citations

Regulated Delivery of Therapeutic Proteins After in Vivo Somatic Cell Gene Transfer

1999 • 308 citations

p53 Inhibits Hypoxia-inducible Factor-stimulated Transcription

1998 • 284 citations

Lipoxin biosynthesis and its impact in inflammatory and vascular events

1994 • 275 citations

Role of nitric oxide in tumour progression: lessons from human tumours.

1998 • 275 citations

Characterization of the Genomic Structure, Chromosomal Location and Promoter of Human Prostaglandin H Synthase-2 Gene

1994 • 272 citations

Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.

1997 • 264 citations

Mechanisms of cell death in hypoxia/reoxygenation injury

1998 • 250 citations

Adenovirus-mediated regulable target gene expression in vivo

1999 • 249 citations

Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues.

1998 • 231 citations

Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia

1998 • 230 citations

Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer

1998 • 228 citations

Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers.

1993 • 213 citations

Anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells

1992 • 204 citations

Hypoxia-induced increased permeability of endothelial monolayers occurs through lowering of cellular cAMP levels

1992 • 197 citations

Autocrine regulation of epithelial permeability by hypoxia: Role for polarized release of tumor necrosis factor α

1998 • 193 citations

CREB-binding Protein Is a Nuclear Integrator of Nuclear Factor-κB and p53 Signaling

1999 • 192 citations

Erythropoietin: a Model System for Studying Oxygen-Dependent Gene Regulation

1998 • 191 citations

The nitric oxide/cyclic GMP pathway in organ transplantation: critical role in successful lung preservation.

1994 • 190 citations

Aspirin-Triggered Lipoxins (15-epi-LX) Are Generated by the Human Lung Adenocarcinoma Cell Line (A549)–Neutrophil Interactions and Are Potent Inhibitors of Cell Proliferation

1996 • 189 citations

Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs.

1998 • 162 citations

Differential Regulation and Function of CD73, a Glycosyl-Phosphatidylinositol–linked 70-kD Adhesion Molecule, on Lymphocytes and Endothelial Cells

1997 • 157 citations

Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle. Implications for increased muscle lactate production in sepsis.

1996 • 153 citations

Tumor oxygenation: a matter of supply and demand.

1996 • 141 citations

Selection of novel analogs of thalidomide with enhanced tumor necrosis factor alpha inhibitory activity.

1996 • 140 citations

Vascular endothelial growth factor

1998 • 134 citations

Regulation of Erythropoietin Production: New Insights Into Molecular Mechanisms of Oxygen Homeostasis

1994 • 131 citations

The ubiquitin-mediated proteolytic pathway as a therapeutic area

1997 • 113 citations

Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes

1997 • 103 citations

Anti-tumor and anti-metastatic effects of human-vascular-endothelial-growth-factor-neutralizing antibody on human colon and gastric carcinoma xenotransplanted orthotopically into nude mice

1998 • 95 citations

Host Tissue Damage by Phagocytes

1997 • 95 citations

Epithelial exposure to hypoxia modulates neutrophil transepithelial migration.

1996 • 95 citations

Macrovascular and microvascular endothelium during long‐term hypoxia: Alterations in cell growth, monolayer permeability, and cell surface coagulant properties

1991 • 95 citations

Critical Role of cAMP Response Element Binding Protein Expression in Hypoxia-elicited Induction of Epithelial Tumor Necrosis Factor-α

1999 • 91 citations

Lipoxin B₄regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B₄analogs with increased biologic activity

1998 • 89 citations

Hypoxia response elements.

1997 • 81 citations

Restoration of the cAMP second messenger pathway enhances cardiac preservation for transplantation in a heterotopic rat model.

1993 • 81 citations

Molecular events in neutrophil transepithelial migration

1997 • 74 citations

Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells.

1996 • 68 citations

Regulated expression of a foreign gene targeted to the ischaemic myocardium

1997 • 60 citations

Novel preservation solution permits 24-hour preservation in rat and baboon cardiac transplant models.

1993 • 60 citations

Epithelial permeability induced by neutrophil transmigration is potentiated by hypoxia: Role of intracellular cAMP

1998 • 59 citations

The hypoxia-inducible factor-1 DNA recognition site is cAMP-responsive

1997 • 59 citations

Actions of Lipoxin A4 and Related Compounds in Smooth Muscle Preparations and on the Microcirculation in Vivo

1988 • 55 citations

Endothelial cell tolerance to hypoxia. Potential role of purine nucleotide phosphates.

1995 • 55 citations

Specific inhibition of iNOS decreases the intestinal mucosal peroxynitrite level and improves the barrier function after thermal injury

1998 • 54 citations

Preconditioning of Bovine Endothelial Cells

1996 • 51 citations

Tumor Vasculature Targeted Therapies

1998 • 46 citations

Hypoxia inhibits cyclic nucleotide-stimulated epithelial ion transport: role for nucleotide cyclases as oxygen sensors.

1998 • 46 citations

Modulation of Endothelial Function by Hypoxia: Perturbation of Barrier and Anticoagulant Function, and Induction of a Novel Factor X Activator

1990 • 41 citations

HIF-1, a Mediator of the Molecular Response to Hypoxia

1997 • 38 citations

Cardioprotection due to preconditioning correlates with increased ecto-5'-nucleotidase activity

1996 • 34 citations

Lipoxins Inhibit Microvascular Inflammatory Actions of Leukotriene B4

1991 • 33 citations

Vascular endothelial growth factor: gene therapy and therapeutic angiogenesis

1998 • 32 citations

Oxygen transport in tumors: characteristics and clinical implications.

1996 • 27 citations

Effect of hypoxia on adherence of granulocytes to endothelial cells in vitro

1994 • 24 citations

Activated endothelial cells elicit paracrine induction of epithelial chloride secretion. 6-Keto-PGF1alpha is an epithelial secretagogue.

1998 • 22 citations

Cyclic AMP-dependent pathway that mediates suppressive regulation of glycosaminoglycan production in cultured vascular endothelial cells

1996 • 10 citations

Gene therapy for vascular disease

1998 • 9 citations

Cardioprotection by ischemic preconditioning. Role of adenosine and glycogen.

1998 • 7 citations

Response of Purine Metabolism to Hypoxia and Ischemia

1998 • 5 citations