Molecular events in neutrophil transepithelial migration

Adhesion receptors of the immune system

1990 • 6,585 citations

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins

1989 • 2,045 citations

PECAM-1 is required for transendothelial migration of leukocytes.

1993 • 1,134 citations

Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice

1993 • 1,058 citations

Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo.

1991 • 977 citations

ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).

1990 • 898 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

THE ROLE OF ENDOTHELIAL CELLS IN INFLAMMATION

1990 • 808 citations

Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation

1991 • 796 citations

Structure and function of the leukocyte adhesion molecules CD11/CD18

1990 • 785 citations

Structure and Biology of Proteoglycans

1988 • 707 citations

Decreased Resistance to Bacterial Infection and Granulocyte Defects in IAP-Deficient Mice

1996 • 599 citations

Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils

1995 • 555 citations

Interleukin-8 (IL-8): The Major Neutrophil Chemotactic Factor in the Lung

1991 • 550 citations

The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.

1993 • 546 citations

Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils.

1993 • 460 citations

The dynamic regulation of integrin adhesiveness

1994 • 456 citations

Lung neutrophils in the adult respiratory distress syndrome. Clinical and pathophysiologic significance

1987 • 452 citations

The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule.

1991 • 446 citations

Integrin-associated Protein Is a Receptor for the C-terminal Domain of Thrombospondin

1996 • 401 citations

A novel divalent cation-binding site in the a domain of the ?2 integrin CR3 (CD11b/CD18) is essential for ligand binding

1993 • 383 citations

Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding.

1993 • 380 citations

Neutrophil migration across a cultured intestinal epithelium. Dependence on a CD11b/CD18-mediated event and enhanced efficiency in physiological direction.

1991 • 352 citations

Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions.

1996 • 334 citations

The structural and functional properties of thrombospondin

1986 • 333 citations

Interleukin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases

1993 • 315 citations

5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers.

1993 • 294 citations

Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin

1991 • 294 citations

Effects of polymorphonuclear leukocyte transmigration on the barrier function of cultured intestinal epithelial monolayers.

1987 • 289 citations

Expression of interleukin 8 and CD54 by human gastric epithelium after Helicobacter pylori infection in vitro

1995 • 288 citations

Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1).

1995 • 282 citations

Interleukin-8 and the neutrophil response to mucosal gram-negative infection.

1993 • 280 citations

The structural and functional properties of thrombospondin

1986 • 261 citations

A novel leukointegrin, αdβ2, binds preferentially to ICAM-3

1995 • 255 citations

Surface attachment of Salmonella typhimurium to intestinal epithelia imprints the subepithelial matrix with gradients chemotactic for neutrophils.

1995 • 237 citations

Intestinal epithelial restitution. Characterization of a cell culture model and mapping of cytoskeletal elements in migrating cells.

1992 • 224 citations

The A Adenosine Receptor Mediates cAMP Responses to Adenosine Receptor Agonists in Human Intestinal Epithelia

1995 • 223 citations

CD47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia.

1996 • 221 citations

Transendothelial migration of neutrophils involves integrin-associated protein (CD47).

1995 • 217 citations

The histopathologic spectrum of acute self-limited colitis (acute infectious -type colitis)

1982 • 201 citations

Deficiency of a surface membrane glycoprotein (Mo1) in man.

1984 • 192 citations

Transepithelial signaling to neutrophils by salmonellae: a novel virulence mechanism for gastroenteritis

1995 • 189 citations

Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans.

1990 • 184 citations

IL-4 directly modulates function of a model human intestinal epithelium.

1994 • 181 citations

Human leukocyte elastase is an endogenous ligand for the integrin CR3 (CD11b/CD18, Mac-1, alpha M beta 2) and modulates polymorphonuclear leukocyte adhesion.

1996 • 172 citations

The effect of elemental diet on intestinal permeability and inflammation in Crohn's disease

1991 • 170 citations

A 50-kDa integrin-associated protein is required for integrin-regulated calcium entry in endothelial cells.

1993 • 167 citations

Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion.

1993 • 163 citations

Expression and Polarization of Intercellular Adhesion Molecule-1 on Human Intestinal Epithelia: Consequences for CD11b/CD18-Mediated Interactions with Neutrophils

1996 • 159 citations

Electrolyte transport across colonic mucosa from patients with inflammatory bowel disease

1980 • 147 citations

Neutrophil migration across a cultured epithelial monolayer elicits a biphasic resistance response representing sequential effects on transcellular and paracellular pathways

1992 • 144 citations

An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains.

1992 • 142 citations

Integrin-associated protein immunoglobulin domain is necessary for efficient vitronectin bead binding.

1996 • 128 citations

Production of Peptides Inducing Chemotaxis and Lysosomal Enzyme Release in Human Neutrophils by Intestinal Bacteria in Vitro and in Vivo

1988 • 124 citations

Expression, function and regulation of the intercellular adhesion molecule‐1 (ICAM‐1) on human intestinal epithelial cell lines

1991 • 121 citations

A simple approach to measurement of electrical parameters of cultured epithelial monolayers: Use in assessing neutrophil-epithelial interactions

1992 • 111 citations

Function of the urokinase receptor (CD87) in neutrophil Chemotaxis

1995 • 98 citations

Epithelial exposure to hypoxia modulates neutrophil transepithelial migration.

1996 • 95 citations

Escherichia coli induces transuroepithelial neutrophil migration by an intercellular adhesion molecule-1-dependent mechanism

1995 • 91 citations

The selective and superoxide-independent disruption of intestinal epithelial tight junctions during leukocyte transmigration.

1988 • 91 citations

Endotoxin stimulates bronchial epithelial cells to release chemotactic factors for neutrophils. A potential mechanism for neutrophil recruitment, cytotoxicity, and inhibition of proliferation in bronchial inflammation.

1991 • 90 citations

Polymorphonuclear leukocyte migration through human amnion membrane

1981 • 83 citations

Intercellular Adhesion Molecule-1 Expression on the Alveolar Epithelium and Its Modification by Hyperoxia

1993 • 82 citations

In vitro model of intestinal crypt abscess. A novel neutrophil-derived secretagogue activity.

1991 • 79 citations

Unmasking of intestinal epithelial lateral membrane beta1 integrin consequent to transepithelial neutrophil migration in vitro facilitates inv-mediated invasion by Yersinia pseudotuberculosis

1997 • 69 citations

Epithelial permeability and the transepithelial migration of human neutrophils.

1983 • 68 citations

The effect of neutrophil migration and prolonged neutrophil contact on epithelial permeability.

1987 • 67 citations

Chapter 8 Chloride Channels in Epithelial Cells

1990 • 61 citations

Role of inflammation in respiratory tract infections

1995 • 57 citations

Receptors Involved in Carbohydrate Binding Modulate Intestinal Epithelial-Neutrophil Interactions

1995 • 55 citations

ICAM-1-independent, CD18-dependent adhesion between neutrophils and human airway epithelial cells exposed in vitro to ozone.

1994 • 40 citations

In vivo effects of transient neutrophil influx on nasal respiratory epithelial mucosubstances. Quantitative histochemistry.

1988 • 39 citations

Intestinal epithelial cytoskeleton selectively constrains lumen-to-tissue migration of neutrophils

1996 • 38 citations

Isolation of Leukocyte Response Integrin: A Novel RGD-Binding Protein Involved in Regulation of Phagocytic Function

1993 • 33 citations

Transepithelial chemotaxis of rat peritoneal exudate cells.

1983 • 29 citations

Tubulointerstitial inflammation, cast formation, and renal parenchymal damage in experimental pyelonephritis.

1983 • 19 citations