Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes

Adhesion receptors of the immune system

1990 • 6,585 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis

1978 • 1,954 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

Identification of an inducible endothelial-leukocyte adhesion molecule.

1987 • 1,639 citations

BIOCHEMISTRY OF ENDOTOXINS

1990 • 1,201 citations

Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.

1989 • 1,115 citations

Serial blood lactate levels can predict the development of multiple organ failure following septic shock

1996 • 834 citations

THE ROLE OF ENDOTHELIAL CELLS IN INFLAMMATION

1990 • 808 citations

Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation

1991 • 796 citations

Blood Lactate Levels Are Superior to Oxygen-Derived Variables in Predicting Outcome in Human Septic Shock

1991 • 717 citations

The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus

1990 • 709 citations

Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion.

1993 • 525 citations

Pathophysiology of ischaemia reperfusion injury: Central role of the neutrophil

1991 • 520 citations

The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway.

1996 • 440 citations

Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.

1994 • 394 citations

The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression

1995 • 354 citations

Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface.

1992 • 341 citations

Mechanism of basolateral membrane H+/OH-/HCO-3 transport in the rat proximal convoluted tubule. A sodium-coupled electrogenic process.

1985 • 266 citations

Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.

1997 • 264 citations

Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides.

1994 • 250 citations

Anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells

1992 • 204 citations

Vectorial targeting of apical and basolateral plasma membrane proteins in a human adenocarcinoma epithelial cell line.

1989 • 193 citations

Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1.

1993 • 192 citations

A Striking Similarity in the Organization of the E-Selectin and Bate Interferon gene Promoters

1994 • 187 citations

Regulation of human B-cell precursor adhesion to bone marrow stromal cells by cytokines that exert opposing effects on the expression of vascular cell adhesion molecule-1 (VCAM-1)

1993 • 155 citations

Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle. Implications for increased muscle lactate production in sepsis.

1996 • 153 citations

A striking similarity in the organization of the E-selectin and beta interferon gene promoters.

1994 • 117 citations

A Sustained Reduction in IκB-β May Contribute to Persistent NF-κB Activation in Human Endothelial Cells

1996 • 110 citations

Protein degradation and increased mRNAs encoding proteins of the ubiquitin-proteasome proteolytic pathway in BC3H1 myocytes require an interaction between glucocorticoids and acidification.

1996 • 92 citations

cAMP and tumor necrosis factor competitively regulate transcriptional activation through and nuclear factor binding to the cAMP-responsive element/activating transcription factor element of the endothelial leukocyte adhesion molecule-1 (E-selectin) promoter.

1994 • 79 citations

Isolation and primary culture of endothelial cells from human umbilical vessels

1978 • 74 citations

Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells.

1996 • 68 citations

Characterization of a hypoxia-responsive adhesion molecule for leukocytes on human endothelial cells.

1995 • 42 citations

Effect of hypoxia on adherence of granulocytes to endothelial cells in vitro

1994 • 24 citations

Hypoxic alterations in cellular signal transduction in shock and sepsis.

1996 • 22 citations

The Effect of Hypoxia on Endothelial Cell Function

1995 • 14 citations