Enzymatic DNA Methylation

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

DNA Modification Mechanisms and Gene Activity During Development

1975 • 1,859 citations

Cellular differentiation, cytidine analogs and DNA methylation

1980 • 1,803 citations

The pathogenesis of cancer metastasis

1980 • 1,750 citations

Completion of mouse embryogenesis requires both the maternal and paternal genomes

1984 • 1,529 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Metastasis Results from Preexisting Variant Cells Within a Malignant Tumor

1977 • 1,422 citations

Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis

1984 • 1,402 citations

X inactivation, differentiation, and DNA methylation

1975 • 1,283 citations

Hereditary cancer, oncogenes, and antioncogenes.

1985 • 1,261 citations

Molecular basis of base substitution hotspots in Escherichia coli

1978 • 1,185 citations

DNA methylation and the frequency of CpG in animal DNA

1980 • 1,146 citations

DNA METHYLATION AND GENE ACTIVITY

1983 • 1,115 citations

Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine

1979 • 1,101 citations

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

1987 • 1,088 citations

The purine and pyrimidine composition of deoxypentose nucleic acids

1951 • 1,084 citations

The Inheritance of Epigenetic Defects

1987 • 1,058 citations

Amount and distribution of 5-methylcytosine in human DNA from different types of tissues or cells

1982 • 1,002 citations

DNA methylation and gene activity

1988 • 904 citations

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

1985 • 844 citations

The 5-methylcytosine content of DNA from human tumors

1983 • 835 citations

Enzymatic Synthesis of Deoxyribonucleic Acid

1961 • 758 citations

Sequence specificity of methylation in higher plant DNA

1981 • 719 citations

Reactivation of an Inactive Human X Chromosome: Evidence for X Inactivation by DNA Methylation

1981 • 711 citations

Differential activity of maternally and paternally derived chromosome regions in mice

1985 • 708 citations

THE QUANTITATIVE SEPARATION OF PURINES, PYRIMIDINES, AND NUCLEOSIDES BY PAPER CHROMATOGRAPHY

1948 • 707 citations

A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA

1985 • 668 citations

Evolution of tumours and the impact of molecular oncology

1985 • 666 citations

X‐CHROMOSOME INACTIVATION AND DEVELOPMENTAL PATTERNS IN MAMMALS

1972 • 657 citations

DNA Methylation Decreases in Aging But Not in Immortal Cells

1983 • 635 citations

DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues

1980 • 634 citations

Mechanisms of Tumor Progression

2010 • 608 citations

DNA methylation affects the formation of active chromatin

1986 • 588 citations

Restriction sites containing CpG show a higher frequency of polymorphism in human DNA

1984 • 586 citations

Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine.

1982 • 575 citations

Active chromatin

1982 • 549 citations

De novo methylation and expression of retroviral genomes during mouse embryogenesis

1982 • 524 citations

Genomic 5-methyldeoxycytidine decreases with age.

1987 • 504 citations

5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β⁺Thalassemia

1982 • 496 citations

Genomic imprinting determines methylation of parental alleles in transgenic mice

1987 • 480 citations

Parental legacy determines methylation and expression of an autosomal transgene: A molecular mechanism for parental imprinting

1987 • 478 citations

Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation

1981 • 475 citations

Enzymatic Synthesis of Deoxyribonucleic Acid

1962 • 466 citations

DNA methylation controls the inducibility of the mouse metallothionein-I gene in lymphoid cells

1981 • 464 citations

DNA methylation and the regulation of globin gene expression

1983 • 451 citations

Substrate and sequence specificity of a eukaryotic DNA methylase

1982 • 441 citations

Left-handed Z-DNA is induced by supercoiling in physiological ionic conditions

1982 • 439 citations

5-Methylcytosine, Gene Regulation, and Cancer

1983 • 425 citations

Degree of methylation of transgenes is dependent on gamete of origin

1987 • 407 citations

The somatic replication of DNA methylation

1981 • 368 citations

Temporal order of chromatin structural changes associated with activation of the major chicken vitellogenin gene

1983 • 366 citations

Specific DNA methylation sites in the vicinity of the chicken β-globin genes

1979 • 365 citations

Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation

1987 • 363 citations

DNA methylation: organ specific variations in the methylation pattern within and around ovalbumin and other chicken genes

1979 • 356 citations

α-globin-gene switching during the development of chicken embryos: Expression and chromosome structure

1981 • 353 citations

DNA methylation, biochemistry, and biological significance

1984 • 343 citations

Recognition sequence of the dam methylase of Escherichia coli K12 and mode of cleavage of Dpn I endonuclease.

1979 • 339 citations

Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment

1977 • 335 citations

5-azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: Evidence for regulatory genes controlling determination

1984 • 330 citations

Preferential expression of the maternally derived X chromosome in the mouse yolk sac

1977 • 328 citations

EFFECTS OF HIGH LEVELS OF DNA ADENINE METHYLATION ON METHYL-DIRECTED MISMATCH REPAIR IN ESCHERICHIA COLI

1983 • 294 citations

Methylation of CpG sequences in eukaryotic DNA

1981 • 289 citations

Use of restriction enzymes to study eukaryotic DNA methylation

1978 • 281 citations

DNA methylation at a CCGG sequence in the large intron of the rabbit β-globin gene: tissue-specific variations

1978 • 268 citations

5-Methylcytosine localised in mammalian constitutive heterochromatin

1974 • 267 citations

Inhibition of DNA methylation by chemical carcinogens in vitro

1983 • 252 citations

Biological function for 6-methyladenine residues in the DNA of Escherichia coli K12

1974 • 232 citations

Hemimethylation prevents DNA replication in E. coli

1987 • 227 citations

Cell lineage-specific undermethylation of mouse repetitive DNA

1984 • 225 citations

Selective Silencing of Eukaryotic DNA

1975 • 224 citations

Age related reactivation of an X-linked gene

1987 • 220 citations

Hypomethylation of DNA in pathological conditions of the human prostate.

1987 • 219 citations

Methylation of DNA in developing sea urchin embryos

1968 • 214 citations

The absence of detectable methylated bases in Drosophila melanogaster DNA

1982 • 211 citations

Variable patterns of total DNA and rDNA methylation in animals

1980 • 210 citations

Correlation between Hypomethylation of DNA and Expression of Globin Genes in Friend Erythroleukemia Cells

1977 • 209 citations

Independent mechanisms involved in suppression of the moloney leukemia virus genome during differentiation of murine teratocarcinoma cells

1983 • 205 citations

Induction of thymidine kinase in enzyme-deficient chinese hamster cells

1982 • 205 citations

Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation

1987 • 202 citations

A specific mismatch repair event protects mammalian cells from loss of 5-methylcytosine

1987 • 201 citations

Nucleotide Sequence Specificity of Restriction Endonucleases

1979 • 199 citations

Mitochondrial DNA in mortal and immortal human cells. Genome number, integrity, and methylation.

1983 • 197 citations

Methylated and unmethylated DNA compartments in the sea urchin genome

1979 • 195 citations

Eukaryotic DNA methylation

1983 • 192 citations

Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells

1981 • 190 citations

Delayed de novo methylation in teratocarcinoma suggests additional tissue-specific mechanisms for controlling gene expression

1983 • 187 citations

Molecular Biology of DNA Methylation

1985 • 186 citations

Effect of 5-azacytidine on differentiation and DNA methylation in human promyelocytic leukemia cells (HL-60).

1983 • 183 citations

Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal

1981 • 179 citations

The Isolation and Characterization of theEsherichia ColiDNA adenine methylase(dam)gene

1983 • 177 citations

Unusual methylation pattern of the α2(I) collagen gene

1982 • 177 citations

Comparative study of DNA methylation in three unicellular eucaryotes

1978 • 176 citations

Unmethlated domains in vertebrate DNA

1983 • 173 citations

5-Aza-2'-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias

1984 • 173 citations

Doublet frequency analysis of fractionated vertebrate nuclear DNA

1976 • 172 citations

Molecular biology of DNA methylation

1987 • 166 citations

Antigenic Tumor Cell Variants Obtained with Mutagens

1983 • 166 citations

Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet

1984 • 165 citations

Rapid incorporation of label from ribonucleoside disphosphates into DNA by a cell-free high molecular weight fraction from animal cell nuclei

1983 • 165 citations

Enzymatic Alteration of Nucleic Acid Structure

1964 • 161 citations

Ultraviolet radiation-induced metallothionein-I gene activation is associated with extensive DNA demethylation

1983 • 159 citations

Building for Earthquakes

2004 • 157 citations

Studies of X chromosome DNA methylation in normal human cells

1982 • 157 citations

Induction of morphological transformation in mouse C3H/10T1/2 clone 8 cells and chromosomal damage in hamster A(T1)C1-3 cells by cancer chemotherapeutic agents.

1977 • 155 citations

Methylation of milk-borne and genetically transmitted mouse mammary tumor virus proviral DNA

1980 • 155 citations

Methylation pattern of mouse mitochondrial DNA

1984 • 147 citations

[6N]METHYL ADENINE IN THE NUCLEAR DNA OF A EUCARYOTE, TETRAHYMENA PYRIFORMIS

1973 • 145 citations

Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes

1985 • 145 citations

5-Azacytidine-Induced Reactivation of a Herpes Simplex Thymidine Kinase Gene

1982 • 144 citations

The tumorigenicity of 5-azacytidine in the male Fischer rat

1984 • 143 citations

Methylation of reiterated sequences in mammalian DNAs Effects of the tissue type, age, malignancy and hormonal induction

1981 • 140 citations

Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virus-transformed hamster cells In vivo and in vitro methylation

1973 • 138 citations

Biochemistry and biology of DNA methylation

1986 • 134 citations

DNA methylation in thermophilic bacteria: N⁴-methylcytosine, 5-methylcytosine, and N⁵methyladenine

1985 • 133 citations

Properties of the satellite DNA associated with the chloroplasts of Euglena gracilis

1964 • 131 citations

DNA methylation and viral gene expression in adenovirus-transformed and-infected cells

1980 • 131 citations

Methylation patterns of repetitive DNA sequences in germ cells ofMus muscutus

1984 • 126 citations

Restriction of nonglucosylated T-even bacteriophage: Properties of permissive mutants of Escherichia coli B and K12

1967 • 125 citations

Undermethylation at the 5′ end of the albumin gene is necessary but not sufficient for albumin production by rat hepatoma cells in culture

1982 • 124 citations

Differences in the DNA of the inactive X chromosomes of fetal and extraembryonic tissues of mice

1983 • 123 citations

Molecular Cloning and Gene Regulation in Bacilli

1982 • 123 citations

Hydroxymethyluracil in Eukaryote DNA: A Natural Feature of the Pyrrophyta (Dinoflagellates)

1976 • 122 citations

Patchwork structure of a bovine satellite DNA

1979 • 122 citations

Hypomethylation of DNA in Human Cancer Cells: A Site-Specific Change in the <italic>c-myc</italic> Oncogene<xref ref-type="fn" rid="FN2">2</xref>

1984 • 120 citations

Expression and methylation of the mouse alpha-fetoprotein gene in embryonic, adult, and neoplastic tissues.

1982 • 119 citations

The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine-induced demethylation

1987 • 119 citations

Expression of the G6PD locus on the human X chromosome is associated with demethylation of three CpG islands within 100 kb of DNA.

1988 • 119 citations

Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA

1982 • 117 citations

Effects of 5-azacytidine and its 2′-deoxyderivative on cell differentiation and DNA methylation

1985 • 116 citations

Effect of 5-aza-2'-deoxycytidine against leukemic and hemopoietic tissues in AKR mice.

1968 • 114 citations

DNA methylase from HeLa cell nuclei

1975 • 114 citations

Differentiation of X chromosomes in early female mouse embryos

1974 • 112 citations

The kinetics of DNA methylation in cultures of a mouse adrenal cell line

1970 • 112 citations

Mouse nuclear satellite DNA: 5-methylcytosine content, pyrimidine isoplith distribution and electron microscopic appearance

1969 • 105 citations

Site specific demethylation in the promoter of human gamma-globin gene does not alleviate methylation mediated suppression.

1987 • 105 citations

Neoplastic Development 2

1975 • 104 citations

Strong effects of 5-azacytidine on the in vitro lifespan of human diploid fibroblasts

1986 • 104 citations

Altered methionine metabolism and transmethylation in cancer.

1985 • 104 citations

Mechanism of action of rat liver DNA methylase

1971 • 103 citations

Complex and simple sequences in human repeated DNAs

1978 • 102 citations

Synthesis of low molecular weight ribonucleic acid in tumour cells

1967 • 101 citations

Influence of parental chromosomes on spatial specificity in androgenetic ↔ parthenogenetic chimaeras in the mouse

1987 • 100 citations

DNA methylation affecting the expression of murine leukemia proviruses

1982 • 99 citations

DNA-methylase from regenerating rat liver: purification and characterisation

1978 • 99 citations

A protein from human placental nuclei binds preferentially to 5-methylcytosine-rich DNA

1984 • 98 citations

Coincident start sites for divergent transcripts at a randomly selected CpG-rich island of mouse.

1987 • 98 citations

Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infectious

1983 • 98 citations

Cytosine modification in DNA by BcnI methylase yields N⁴‐methylcytosine

1983 • 97 citations

Extent of DNA methylation in human tumor cells.

1983 • 97 citations

DNA methylase: purification from ascites cells and the effect of various DNA substrates on its activity.

1976 • 97 citations

Role of de novo DNA methylation in the glucocorticoid resistance of a T-lymphoid cell line

1983 • 95 citations

Quantitative determination of 5-methylcytosine in DNA by reverse-phase high-performance liquid chromatography

1983 • 95 citations

The DNA modification function of temperate phage Mu-1

1976 • 95 citations

The effect of site-specific methylation on restriction-modification enzymes

1987 • 95 citations

5-Azacytidine-induced re-expression of alleles on the inactive X chromosome in a hybrid mouse cell line

1982 • 94 citations

A Portable Signal Causing Faithful DNA Methylation de Novo in Neurospora crassa

1987 • 93 citations

DNA methylation can enhance or induce DNA curvature.

1987 • 92 citations

Formation of Z-DNA in negatively supercoiled plasmids is sensitive to small changes in salt concentration within the physiological range.

1983 • 92 citations

Undermethylation of structural gene sequences in extraembryonic lineages of the mouse

1986 • 91 citations

Presence of a DNA demethylating activity in the nucleus of murine erythroleukemic cells.

1982 • 88 citations

In contrast to other Xenopus genes the estrogen-inducible vitellogenin genes are expressed when totally methylated

1983 • 87 citations

On a possible epigenetic mechanism(s) of tumor cell heterogeneity

1983 • 87 citations

Methylation of DNA in mouse early embryos, teratocarcinoma cells an adult tissues of mouse and rabbit

1979 • 86 citations

Cell cycle-dependent regulation of eukaryotic DNA methylase level.

1985 • 86 citations

Deoxyribonucleic acid methylase of mammalian tissues

1968 • 85 citations

Sequence arrangement of a highly methylated satellite DNA of a plant, Scilla : A tandemly repeated inverted repeat

1981 • 85 citations

Selection of strongly immunogenic "tum-" variants from tumors at high frequency using 5-azacytidine.

1984 • 85 citations

5-Methylcytidylic Acid: Absence from Mitochondrial DNA of Frogs and HeLa Cells

1974 • 84 citations

Variable effects of DNA-synthesis inhibitors upon DNA methylation in mammalian cells

1986 • 83 citations

Detection of cytosine methylation in the maize alcohol dehydrogenase gene by genomic sequencing

1986 • 83 citations

Inhibition of DNA methylation by S-adenosylethionine with the production of methyl-deficient DNA in regenerating rat liver.

1977 • 82 citations

Specific methylation pattern at the 3′ end of the human housekeeping gene for glucose 6-phosphate dehydrogenase.

1984 • 82 citations

The Purification and Properties of Deoxyribonucleic Acid Methylase from Rat Spleen

1969 • 82 citations

Analysis of Calf‐Thymus Satellite DNA: Evidence for Specific Methylation of Cytosine in C‐G Sequences

1977 • 81 citations

Absence of cytosine methylation at C-C-G-G and G-C-G-C sites in the rDNA coding regions and intervening sequences of Drosophila and the rDNA of other higher insects

1979 • 80 citations

Ontogeny of X-chromosome inactivation in the female germ line

1975 • 79 citations

The unmethylated state of the promoter/leader and 5′-regions of integrated adenovirus genes correlates with gene expression.

1982 • 79 citations

An Analysis of the Bovine Genome by Density‐Gradient Centrifugation

1978 • 79 citations

Genetic effects of 5-azacytidine in Saccharomyces cerevisiae

1984 • 79 citations

Methylation of satellite sequences in mouse spermatogenic and somatic DNAs

1984 • 78 citations

Selective suppression of human papillomavirus transcription in non-tumorigenic cells by 5-azacytidine.

1988 • 77 citations

Studies on the in vivo methylation of DNA in Escherichia coli 15T−

1968 • 77 citations

DNA methylation of viruses infecting a eukaryoticChlorella-like green alga

1985 • 76 citations

Cancer genes: rare recombinants instead of activated oncogenes (a review).

1987 • 76 citations

Allele-specific methylation of the human c-Ha-ras-1 gene

1987 • 75 citations

Methylation of the T-DNA inAgrobacterium tumefaciensand In several crown gall tumors

1983 • 74 citations

S-adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line

1975 • 73 citations

Incorporation of a potent antileukemic agent, 5-aza-2'-deoxycytidine, into DNA of cells from leukemic mice.

1977 • 73 citations

Heavily methylated amplified DNA in transformants of Neurospora crassa

1984 • 71 citations

DNA hypermethylation in sodium butyrate-treated WI-38 fibroblasts.

1986 • 70 citations

Changes in methylation pattern of albumin and α-fetoprotein genes in developing rat liver and neoplasia

1983 • 70 citations

DNA restriction-modification enzymes of phage P1 and plasmid p15B

1983 • 69 citations

Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-azacytidine.

1986 • 69 citations

Chemical composition of nucleosomes among domains of calf thymus chromatin differing in micrococcal nuclease accessibility and solubility properties.

1981 • 68 citations

Purification and properties of the P15 specific restriction endonuclease from Escherichia coli.

1977 • 68 citations

Demethylation of CpG sites in DNA of early rabbit trophoblast

1981 • 68 citations

In vivo methylation by Escherichia coli K-12 mec+ deoxyribonucleic acid-cytosine methylase protects against in vitro cleavage by the RII restriction endonuclease (R. Eco RII)

1976 • 68 citations

Variable 5-methylcytosine levels in human tumor cell lines and fresh pediatric tumor explants.

1983 • 68 citations

Latent Herpes Simplex Virus Type 1 DNA Is Not Extensively Methylated in vivo

1987 • 67 citations

Induction of differentiation and inhibition of DNA methylation in HL-60 myeloid leukemic cells by 5-AZA-2′-deoxycytidine

1985 • 67 citations

Sequence-specific DNA modification in Neisseria gonorrhoeae

1983 • 66 citations

Distribution of 5-methylcytosine in the DNA of somatic and germline cells from bovine tissues

1981 • 66 citations

Lipopolysaccharide-induced transcription of the kappa immunoglobulin locus occurs on both alleles and is independent of methylatlon status

1984 • 65 citations

Purification and Properties of a New Restriction Endonuclease from Haemophilus influenzae Rf

1978 • 65 citations

5-Methylcytosine in heterochromatic regions of chromosomes: chimpanzee and gorilla compared to the human

1975 • 65 citations

Developmental changes in the methylation of the rat albumin and alpha-fetoprotein genes.

1983 • 62 citations

Estimation of the amount of 5-methylcytosine in Drosophila melanogaster DNA by amplified ELISA and photoacoustic spectroscopy.

1984 • 61 citations

Hypomethylation of DNA in Raji cells after treatment with N-methyl-N-nitrosourea

1981 • 60 citations

The bacteriophage P1 restriction endonuclease

1974 • 60 citations

DNA methyltransferase induced by frog virus 3

1984 • 59 citations

DNA methylation. Inhibition of de novo and maintenance methylation in vitro by RNA and synthetic polynucleotides.

1984 • 59 citations

Effect of intravenous infusion of 5-aza-2'-deoxycytidine on survival time of mice with L1210 leukemia.

1978 • 59 citations

Induction of malignant transformation and mutagenesis in cell cultures by cancer chemotherapeutic agents

1977 • 58 citations

Modification of avian sarcoma proviral DNA sequences in nonpermissive XC cells but not in permissive chicken cells

1980 • 57 citations

Immunogenic (tum−) variants obtained by mutagenesis of mouse mastocytoma P815

1987 • 57 citations

DNA Methylation and Cellular Differentiation

1984 • 56 citations

Molecular cloning and gene regulation in bacilli

1982 • 53 citations

DNA Methylation

1984 • 53 citations

Is hypomethylation linked to activation of δ-crystallin genes during lens development?

1983 • 53 citations

Transcription in oocytes of highly methylated rDNA from Xenopus laevis sperm

1983 • 53 citations

Derepression with decreased expression of the G6PD locus on the inactive X chromosome in normal human cells

1982 • 52 citations

Purification of human DNA (cytosine-5-)-methyltransferase

1985 • 51 citations

Methylation of the chicken vilellogenin gene: influence of estradiol administration

1983 • 51 citations

Selective phosphorylation of human DNA methyltransferase by protein kinase C

1986 • 50 citations

Supercoiling-dependent sequence specificity of mammalian DNA methyitransferase

1987 • 50 citations

Mammalian DNA methyltransferases prefer poly(dI-dC) as substrate.

1986 • 50 citations

A human DNA-binding protein is methylation-specific and sequence-specific

1986 • 49 citations

Current Topics in Microbiology and Immunology

1983 • 49 citations

Gamma interferon and 5-azacytidine cause transcriptional elevation of class I major histocompatibility complex gene expression in K562 leukemia cells in the absence of differentiation.

1986 • 48 citations

Mechanism of action of rat liver DNA methylase

1971 • 47 citations

A Chicken Transferrin Gene in Transgenic Mice Escapes X-Chromosome Inactivation

1987 • 46 citations

Characteristics of mouse leukemic cells resistant to 5-azacytidine and 5-aza-2'-deoxycytidine.

1968 • 45 citations

Host specificity of DNA produced by Escherichia coli

1970 • 45 citations

Alteration of Enzymatic Methylation of DNA Cytosines by Chemical Carcinogens: A Mechanism Involved in the Initiation of Carcinogenesis<xref ref-type="fn" rid="FN3">3</xref>

1983 • 45 citations

Human DNA (cytosme-5)methyftransferase selectively methylates duplex DNA containing mispairs

1987 • 45 citations

Methylation of type II and type I collagen genes in differentiated and dedifferentiated chondrocytes.

1985 • 44 citations

DNA synthesis, methylation and degradation during conjugation inTetrahymena thermophila

1985 • 44 citations

Direct role of the Escherichia coli Dam DNA methyltransferase in methylation-directed mismatch repair

1986 • 44 citations

Comparison of the methylation patterns of the two rat insulin genes.

1983 • 44 citations

Loss of type I procollagen gene expression in SV40-transformed human fibroblasts is accompanied by hypermethylation of these genes

1982 • 44 citations

Deoxyribonucleic Acid Methyltransferase from the Eukaryote, Chlamydomonas reinhardi

1980 • 43 citations

DNA methylation in wheat

1987 • 42 citations

Comparison of factor IX methylation on human active and inactive X chromosomes: implications for X inactivation and transcription of tissue-specific genes.

1986 • 42 citations

Proof of recombination between viral and cellular genomes in human KB cells productively infected by adenovirus type 12: structure of the junction site in a symmetric recombinant (SYREC)

1983 • 42 citations

Optimized genomic sequencing as a tool for the study of cytosine methylation in the regulatory region of the chicken vitellogenin II gene

1986 • 42 citations

Mechanism of inhibition of enzymic deoxyribonucleic acid methylation by 2-(acetylamino)fluorene bound to deoxyribonucleic acid

1981 • 41 citations

Transcription and site-specific hypomethylation of the delta-crystallin genes in the embryonic chicken lens.

1981 • 41 citations

DNA methylation affecting the transforming activity of the human Ha-ras oncogene.

1987 • 41 citations

Methylation of ribosomal RNA genes in the macronucleus ofTetrahymena thermophila

1983 • 41 citations

DNA methylation: sequences flanking C-G pairs modulate the specificity of the human DNA methylase

1985 • 40 citations

A study of the mechanism of selenite-induced hypomethylated DNA and differentiation of Friend erythroleukemic cells

1986 • 40 citations

Transcription and methylation of flax rDNA

1983 • 39 citations

5-Azacytidine potentiates initiation induced by carcinogens in rat liver

1985 • 39 citations

Differential methylation of the c-H-ras gene in normal mouse cells and during skin tumour progression.

1985 • 39 citations

Characterization of DNA methyltransferase from bovine thymus cells

1983 • 38 citations

The preparation of soluble DNA methylase from normal and regenerating rat liver.

1971 • 38 citations

Effect of modification by N-acetoxy-N-2-acetylaminofluorene on the level of DNA methylation

1979 • 38 citations

DNA methylase inhibition in vitro by N-methyl-N'-nitro-N-nitrosoguanidine.

1980 • 38 citations

Deoxyribonucleic Acid Methylase Activity in Rat Spleen

1968 • 38 citations

Human placental DNA methyltransferase: DNA substrate and DNA binding specificity

1984 • 37 citations

P1 plasmid replication requires methylated DNA.

1987 • 37 citations

Studies on the biological role of DNA methylation: V. The pattern ofE.coliDNA methylation

1982 • 37 citations

Inhibition of DNA methyltransferases in vitro by benzo[a]pyrene diol epoxide-modified substrates.

1984 • 36 citations

Structure, stability, methylation, expression and glucocorticoid induction of endogenous and transfected proviral genes of mouse mammary tumor virus in mouse fibroblasts

1981 • 35 citations

Methylated bases in the DNA of the ciliate Stylonychia mytilus.

1981 • 35 citations

DNase I sensitivity of the α2(I) collagen gene: correlation with its expression but not with its methylation pattern

1984 • 35 citations

Reduced levels of DNA 5-methylcytosine in metastatic variants of the human melanoma cell line MeWo.

1987 • 35 citations

Methylation of adenovirus genes in transformed cells and in vitro: influence on the regulation of gene expression?

1981 • 35 citations

Differential Implication of Deoxyribonucleic Acid Methylation in Rat Prolactin and Rat Growth Hormone Gene Expressions: A Comparison between Rat Pituitary Cell Strains*

1986 • 35 citations

The nucleotide composition and pyrimidine clusters in DNA from beef heart mitochondria

1974 • 34 citations

Partially deficient methylation of cytosine in DNA at CCTAGG sites stimulates genetic recombination of bacteriophage lambda

1982 • 33 citations

Induction of HL-60 cell differentiation by 3-deaza-(+/-)-aristeromycin, an inhibitor of S-adenosylhomocysteine hydrolase.

1986 • 32 citations

Relative levels of methylation in human growth hormone and chorionic somatomammotropin genes in expressing and non-expressing tissues

1982 • 31 citations

Regulation of viral and cellular oncogene expression by cytosine methylation

1983 • 31 citations

Effect of carcinogen ethionine on enzymatic methylation of DNA sequences with various degrees of repetitiveness

1979 • 30 citations

DNA methylation alters chromatin structure and regulates Thy-1 expression in EL-4 T cells.

1987 • 30 citations

Elevated transcriptional complexity and decrease in enzymatic DNA methylation in cells treated with L-ethionine.

1981 • 29 citations

Uudermethylation of interferon-γ gene in human T cell lines and normal T lymphocytes

1986 • 28 citations

The avian apoprotein II very low density lipoprotein gene. Methylation patterns of 5' and 3' flanking regions during development and following induction by estrogen.

1982 • 28 citations

Stage-specific DNA methylation in a fungal plant pathogen

1986 • 28 citations

Can partial methylation explain the complex fragment patterns observed when plant mitochondrial DNA is cleaved with restriction endonucleases?

1980 • 27 citations

Tissue specificity and organisation of CpG methylation in calf satellite DNA I

1982 • 26 citations

Embryotoxicity of 5-azacytidine in mice phase- and dose-specificity studies

1984 • 26 citations

Mouse DNA-cytosine-5-methyltransferase: sequence specificity of the methylation reaction and electron microscopy of enzyme-DNA complexes.

1985 • 25 citations

Modulatory effects of 5‐azacytidine, phorbol ester, and retinoic acid on the malignant phenotype of human lung cancer cells

1985 • 25 citations

Elevated level of enzymatic DNA methylation in cells treated with 1-beta-D-arabinofuranosylcytosine.

1982 • 25 citations

Developmental changes in DNA methylation around prostatic steroid-binding protein genes.

1983 • 25 citations

Methylation of the alpha-fetoprotein gene in productive and nonproductive rat hepatocellular carcinomas.

1984 • 23 citations

Pattern of undermethylation of the major satellite DNA of mouse sperm

1985 • 23 citations

DNA (cytosine) methylation in murine and human tumor cell lines treated with S-adenosylhomocysteine hydrolase inhibitors

1988 • 23 citations

Different levels of DNA modification at 5'CCGG in murine erythroleukemia cells and the tissues of normal mouse spleen

1982 • 23 citations

In vitro transformation of primary rat tracheal epithelial cells by 5-azacytidine.

1986 • 22 citations

Genotoxicity of 5-azacytidine in somatic cells of Drosophila

1985 • 22 citations

Sequence organisation in nuclear DNA from Physarum polycephalum: methylation of repetitive sequences

1981 • 22 citations

CpG deficiency, dinucleotide distributions and nucleosome positioning

1987 • 22 citations

Methylation of Marek's Disease Virus DNA in Chicken T-lymphoblastoid Cell Lines

1987 • 22 citations

Identification, purification, and characterization of Escherichia coli virus T1 DNA methyltransferase.

1987 • 22 citations

Base Composition of DNA from Chloroplasts and Nuclei of Phaseolus vulgaris

1969 • 22 citations

Evidence that Escherichia coli virus T1 induces a DNA methyltransferase

1984 • 21 citations

5-Azacytidine carcinogenesis in BALB/c mice

1987 • 21 citations

Inhibition of enzymatic dna methylation by n-methyl-n-nitro-n-nitrosoguanidine in human raji lymphoblast-like cells

1981 • 20 citations

Methylases of the Type II Restriction-Modification Systems

1984 • 20 citations

Inactivation of mammalian DNA methylase activities by N-methyl-N′-nitro-N-nitrosoguanidine

1975 • 19 citations

Aberrant de novo methylation of DNA after treatment of murine cells with N-acetoxy-N-2-acetylaminofluorene.

1983 • 19 citations

DNA-cytosine-5-methyltransferase from P815 mouse mastocytoma cells: “Maintenance” and “de novo” activities are carried out by the same enzyme molecule

1984 • 19 citations

Methylation and expression of rat kappa-casein gene in normal and neoplastic rat mammary gland.

1985 • 18 citations

Preferential binding of DNA methyltransferase and increased de novo methylation of deoxyinosine containing DNA

1986 • 18 citations

Enzymatic methylation of replication-DNA intermediates in Ehrlich ascites tumor

1975 • 18 citations

Enzymatic methylation of DNA and poly(dG—dC) · poly(dG—dC) modified by 4‐acetoxyaminoquinoline‐1‐oxide, the ultimate carcinogen of 4‐nitroquinoline‐1‐oxide

1983 • 18 citations

DNA methylation levels in acute human leukemia

1988 • 17 citations

In vitro enzymatic methylation of DNA substituted by N‐2‐aminofluorene

1984 • 17 citations

The distribution of modified and non‐modified CG doublets in BHK‐21 cell DNA

1978 • 17 citations

Modification of the methylation pattern in the vicinity of the chicken globin genes in avian erythroblastosis virus transformed cells

1981 • 17 citations

Localization of DNA methyltransferase in the chromatin of Friend erythroleukemia cells

1981 • 16 citations

Synthesis and characterization of poly[d(G-aza5C)]. B-Z transition and inhibition of DNA methylase

1985 • 15 citations

Activation of a silent gene is accompanied by its demethylation

1985 • 14 citations

Methylation of a middle repetitive DNA sequence class during differentiation in Friend erythroleukemia cells

1984 • 14 citations

Periodate-oxidized adenosine induction of murine thymidine kinase: role of DNA methylation in the generation of tumor cell heterogeneity.

1986 • 14 citations

Effects of mutagens on the immunogenicity of tumor cells: comparison of cell surface changes induced by 5-azacytidine and N-methyl-N'-nitro-N-nitrosoguanidine.

1986 • 14 citations

Effects of DNA binding proteins on DNA methylation in vitro

1985 • 14 citations

Development of Escherichia coli virus T1: escape from host restriction

1979 • 13 citations

Methylation of the enhancer region of avian sarcoma virus long terminal repeat suppresses transcription

1987 • 13 citations

Methylation of the alphafetoprotein gene in cell populations isolated from rat livers during carcinogenesis

1985 • 13 citations

Mechanism of rat liver DNA methyltransferase interaction with anti-benzo[a]pyrenediol epoxide modified DNA templates

1984 • 13 citations

Tissue-specific DNase I-hypersensitive sites and hypomethylation in the chicken cardiac myosin light chain gene (L2-A).

1987 • 11 citations

5-Methylcytosine content of DNA during differentiation in mouse teratocarcinoma cells

1979 • 11 citations

Suppression of Tumorigenicity Mediated by 5-Azacytidine and Associated With Increased Chromosome Number&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1987 • 10 citations

Methylation and restriction endonuclease cleavage of linear Z-DNA in the presence of hexamminecobalt (III) ions

1986 • 10 citations

Effect of 5-azacytidine on malignant transformation of a mutant derived from the mouse BALB/c 3T3 cell line resistant to transformation by chemical carcinogens.

1987 • 10 citations

Heritable high frequency modulation of antigen expression in neoplastic cells exposed to 5-aza-2'-deoxycytidine or hydroxyurea: analysis and implications.

1988 • 10 citations

Nucleic acids methylation of synchronized BHK 21 HS 5 fibroblasts during the mitotic phase

1980 • 10 citations

Identification of Proliferatively Active Cells by Monoclonal Antibodies Against Dna-Cytosine-5 Methyltransferase

1985 • 8 citations

Senescence comes of age

1986 • 8 citations

Progress in clinical biochemistry and medicine

1987 • 7 citations

5-Methylcytosine content in different organs of the mouse and rat, several tumors and in mice embryos

1983 • 5 citations

Verteilung und enzymatische Hypermethylierung invers repetitiver DNA-Sequenzen in verschiedenen Mäuse-und menschlichen Zellen / Distribution and Enzymic Hypermethylation of Inverted DNA Repeats in Different Murine and Human Cells

1979 • 5 citations

DNA methylation and transcriptional controls of proviral DNA in avian sarcoma virus-transformed mammalian cells

1986 • 4 citations

Wirkung von Lithium- und Rhodanidionen auf den Nukleinsäure-Stoffwechsel von Tetrahymena pyriformis, normalen und neoplastischen Säugerzellen / Effect of Lithium and Thiocyanate Ions on the Metabolism of Nucleic Acids of Tetrahymena pyriformis, Normal and Neoplastic Mammalian Cells

1973 • 2 citations

Expression of endogenous murine leukemia virus in transplantable tumor cells and DNA methylation of the viral sequences.

1984 • 2 citations

5-Methylcytosin-Gehalt in Rattenerythroleukämie-Zellen nach Induktion mit Dimethylsulfoxid / 5-Methylcytosine Content in Erythroleucemic Cells of Rats after Induction with Dimethylsulfoxid

1982 • 2 citations