The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine-induced demethylation

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Cellular differentiation, cytidine analogs and DNA methylation

1980 • 1,803 citations

In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain

1977 • 1,743 citations

DNA Methylation Decreases in Aging But Not in Immortal Cells

1983 • 635 citations

DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues

1980 • 634 citations

Characteristics of a Human Diploid Cell Designated MRC-5

1970 • 593 citations

Limited and unlimited growth of sv40-transformed cells from human diploid mrc-5 fibroblasts

1983 • 241 citations

Gene expression: DNA methylation — how important in gene control?

1984 • 178 citations

The Biochemistry of the Nucleic Acids

1992 • 133 citations

Antineoplastic and Immunosuppressive Agents.

1975 • 109 citations

Commitment to senescence: A model for the finite and infinite growth of diploid and transformed human fibroblasts in culture

1975 • 96 citations

Dna Methylation in Eukaryote

1982 • 88 citations

DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells.

1984 • 76 citations

Shortening of Life and Causes of Death in Mice Exposed to a Single Whole-Body Dose of Radiation

1961 • 37 citations

The Biochemistry of the Nucleic Acids

1977 • 34 citations

Reversion of bovine papillomavirus-induced transformation and immortalization by a xanthate compound

1985 • 28 citations

Methylation patterns in the gene for the alpha subunit of chorionic gonadotropin are inherited with variable fidelity in clonal lineages of human fibroblasts

1985 • 26 citations

DNA Hypomethylation: A New Theory of Aging

1985 • 10 citations

Cell proliferation: Paths to immortality and back

1984 • 6 citations