DNA (cytosine) methylation in murine and human tumor cell lines treated with S-adenosylhomocysteine hydrolase inhibitors

The Metabolic Basis of Inherited Disease.

1983 • 2,885 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain

1977 • 1,743 citations

DNA METHYLATION AND GENE ACTIVITY

1983 • 1,115 citations

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

1985 • 844 citations

The 5-methylcytosine content of DNA from human tumors

1983 • 835 citations

Hypomethylation of ras oncogenes in primary human cancers

1983 • 507 citations

Incorporation of 3H-uridine and 3H-uracil into RNA

1974 • 485 citations

5-Methylcytosine, Gene Regulation, and Cancer

1983 • 425 citations

Apparent suicide inactivation of human lymphoblast S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine and adenine arabinoside. A basis for direct toxic effects of analogs of adenosine.

1979 • 277 citations

DNA Methylation and Cancer

2000 • 266 citations

Eukaryotic DNA methylation

1983 • 192 citations

Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2'-deoxycoformycin.

1984 • 168 citations

Biochemistry and biology of DNA methylation

1986 • 134 citations

Possible epigenetic mechanisms of tumor progression: Induction of high-frequency heritable but phenotypically unstable changes in the tumorigenic and metastatic properties of tumor cell populations by 5-azacytidine treatment

1984 • 125 citations

Hypomethylation of DNA in Human Cancer Cells: A Site-Specific Change in the <italic>c-myc</italic> Oncogene<xref ref-type="fn" rid="FN2">2</xref>

1984 • 120 citations

Induction of the metastatic phenotype in a mouse tumor model by 5-azacytidine, and characterization of an antigen associated with metastatic activity.

1984 • 110 citations

DNA Methylation and Cancer

1985 • 104 citations

Altered methionine metabolism and transmethylation in cancer.

1985 • 104 citations

Extent of DNA methylation in human tumor cells.

1983 • 97 citations

Dna Methylation in Eukaryote

1982 • 88 citations

Effects of adenosine dialdehyde on S-adenosylhomocysteine hydrolase and S-adenosylmethionine-dependent transmethylations in mouse L929 cells.

1984 • 87 citations

Resistance of an adenosine kinase-deficient human lymphoblastoid cell line to effects of deoxyadenosine on growth, S-adenosylhomocysteine hydrolase inactivation, and dATP accumulation.

1980 • 72 citations

Human leukemia K-562 cells: induction of erythroid differentiation by 5-azacytidine

1984 • 68 citations

Variable 5-methylcytosine levels in human tumor cell lines and fresh pediatric tumor explants.

1983 • 68 citations

The role of S-adenosylhomocysteine in the biological utilization of S-adenosylmethionine.

1985 • 65 citations

DNA methylation and methylase levels in normal and malignant mouse hepatic tissues

1981 • 60 citations

Effects of the S‐adenosylhomocysteine hydrolase inhibitors 3‐deazaadenosine and 3‐deazaaristeromycin on RNA methylation and synthesis

1986 • 47 citations

3-Deazaadenosine. S-adenosylhomocysteine hydrolase-independent mechanism of action in mouse lymphocytes.

1984 • 46 citations

5-Azacytidine, DNA Methylation, and Differentiation

1984 • 45 citations

Patterns of DNA methylation and gene expression in human tumor cell lines.

1986 • 43 citations

Reduced levels of DNA 5-methylcytosine in metastatic variants of the human melanoma cell line MeWo.

1987 • 35 citations

Effect of 5-azacytidine on DNA methylation and the malignant properties of B16 melanoma cells.

1985 • 35 citations

Induction of HL-60 cell differentiation by 3-deaza-(+/-)-aristeromycin, an inhibitor of S-adenosylhomocysteine hydrolase.

1986 • 32 citations

Disposition of homocysteine in rat hepatocytes and in nontransformed and malignant mouse embryo fibroblasts following exposure to inhibitors of S-adenosylhomocysteine catabolism.

1986 • 26 citations

Differentiation of myoblast cell lines and biological methylation: 3-deazaadenosine stimulates formation of multinucleated myofibers.

1984 • 17 citations

Inhibition of murine erythroleukemia cell differentiation by 3-deazaadenosine.

1985 • 16 citations

Periodate-oxidized adenosine induction of murine thymidine kinase: role of DNA methylation in the generation of tumor cell heterogeneity.

1986 • 14 citations

Characterization of In vitro immunoselected variants from a highly metastatic murine tumor for alterations in malignant behavior in vivo

1984 • 6 citations

On the possible contribution of DNA hypomethylation to the induction of high frequency and heritable drug-induced alterations in the malignant phenotype.

1986 • 3 citations