Hepatitis C Virus Infection

Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

1989 • 6,910 citations

Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection

2002 • 6,505 citations

Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial

2001 • 6,133 citations

Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C

1998 • 3,550 citations

An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis

1989 • 3,401 citations

Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line

1999 • 2,796 citations

Randomised trial of interferon α2b plus ribavirin for 48 weeks or for 24 weeks versus interferon α2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus

1998 • 2,374 citations

Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy

1998 • 2,112 citations

Binding of Hepatitis C Virus to CD81

1998 • 2,042 citations

Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection

2014 • 1,661 citations

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

2003 • 1,623 citations

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

2002 • 1,583 citations

Efficient Initiation of HCV RNA Replication in Cell Culture

2000 • 1,412 citations

Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region

1993 • 1,401 citations

Viruses and interferon: a fight for supremacy

2002 • 1,335 citations

Ledipasvir and Sofosbuvir for Previously Treated HCV Genotype 1 Infection

2014 • 1,289 citations

Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

2000 • 1,270 citations

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

2003 • 1,220 citations

Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection

2001 • 1,183 citations

Genomic analysis of the host response to hepatitis C virus infection

2002 • 1,171 citations

The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus

2002 • 1,152 citations

Infectious Hepatitis C Virus Pseudo-particles Containing Functional E1–E2 Envelope Protein Complexes

2003 • 1,093 citations

The Outcome of Acute Hepatitis C Predicted by the Evolution of the Viral Quasispecies

2000 • 892 citations

Genetic Heterogeneity of Hepatitis C Virus: Quasispecies and Genotypes

1995 • 855 citations

Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein

1997 • 824 citations

Analysis of a Successful Immune Response against Hepatitis C Virus

1999 • 823 citations

HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help

2003 • 811 citations

Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

2003 • 792 citations

Lack of Protective Immunity Against Reinfection with Hepatitis C Virus

1992 • 760 citations

Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C

2000 • 747 citations

Inhibition of the Interferon- Inducible Protein Kinase PKR by HCV E2 Protein

1999 • 741 citations

Recurrence of hepatitis C virus after loss of virus-specific CD4+ T-cell response in acute hepatitis C

1999 • 716 citations

Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection

1995 • 702 citations

Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.

1996 • 669 citations

The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses

1998 • 666 citations

Impaired Effector Function of Hepatitis C Virus-Specific CD8+ T Cells in Chronic Hepatitis C Virus Infection

2002 • 644 citations

Memory CD8+ T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection

2003 • 636 citations

Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease

2002 • 636 citations

Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties

2000 • 505 citations

Progressive differentiation and selection of the fittest in the immune response

2002 • 503 citations

Sustained Dysfunction of Antiviral CD8⁺T Lymphocytes after Infection with Hepatitis C Virus

2001 • 496 citations

Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization.

1994 • 496 citations

Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis.

1992 • 465 citations

Inhibition of Natural Killer Cells through Engagement of CD81 by the Major Hepatitis C Virus Envelope Protein

2001 • 458 citations

DNA Microarray Analysis of Chimpanzee Liver during Acute Resolving Hepatitis C Virus Infection

2001 • 442 citations

Binding of the Hepatitis C Virus Envelope Protein E2 to CD81 Inhibits Natural Killer Cell Functions

2001 • 439 citations

Protection against persistence of hepatitis C

2002 • 439 citations

Quantitative analysis of hepatitis C virus-specific CD8⁺T cells in peripheral blood and liver using peptide-MHC tetramers

1999 • 421 citations

The Outcome of Hepatitis C Virus Infection Is Predicted by Escape Mutations in Epitopes Targeted by Cytotoxic T Lymphocytes

2001 • 415 citations

Detection of type 2-like T-helper cells in hepatitis C virus infection: Implications for hepatitis C virus chronicity

1997 • 413 citations

Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection

2001 • 410 citations

Hepatitis C Virus Glycoproteins Interact with DC-SIGN and DC-SIGNR

2003 • 382 citations

The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection

2013 • 371 citations

Impaired Allostimulatory Capacity of Peripheral Blood Dendritic Cells Recovered from Hepatitis C Virus-Infected Individuals

1999 • 364 citations

DC-SIGN and L-SIGN Are High Affinity Binding Receptors for Hepatitis C Virus Glycoprotein E2

2003 • 363 citations

Association of Hepatitis C Virus–Specific CD8⁺T Cells with Viral Clearance in Acute Hepatitis C

2000 • 362 citations

Suppression of HCV-specific T cells without differential hierarchy demonstrated in persistent HCV infection

2003 • 357 citations

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes

1998 • 354 citations

CD81 Is Required for Hepatitis C Virus Glycoprotein-Mediated Viral Infection

2004 • 354 citations

Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.

1995 • 344 citations

Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus.

1997 • 333 citations

HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release.

1995 • 329 citations

Hepatitis C Virus Nonstructural 5A Protein Induces Interleukin-8, Leading to Partial Inhibition of the Interferon-Induced Antiviral Response

2001 • 323 citations

Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif.

1995 • 322 citations

Hepatitis C virus–specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C

2000 • 318 citations

The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C.

1997 • 316 citations

CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained

2000 • 313 citations

Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection

1997 • 306 citations

Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection

2001 • 306 citations

L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus

2003 • 296 citations

Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection.

1996 • 294 citations

Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV

1993 • 290 citations

Influence of MHC class II genotype on outcome of infection with hepatitis C virus

1999 • 288 citations

Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers

2003 • 279 citations

Synthesis of a novel hepatitis C virus protein by ribosomal frameshift

2001 • 278 citations

Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients

1996 • 265 citations

Hepatitis C Virus Core and Nonstructural Protein 3 Proteins Induce Pro- and Anti-inflammatory Cytokines and Inhibit Dendritic Cell Differentiation

2003 • 254 citations

Broad Specificity of Virus-Specific CD4⁺T-Helper-Cell Responses in Resolved Hepatitis C Virus Infection

2002 • 253 citations

Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C.

1993 • 247 citations

CD4 T Helper Type 1 and Regulatory T Cells Induced against the Same Epitopes on the Core Protein in Hepatitis C Virus–Infected Persons

2002 • 240 citations

Immunity in Hepatitis C Infection

1992 • 233 citations

Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection

2001 • 230 citations

Genes of the major histocompatibility complex class II influence the outcome of hepatitis C virus infection

1997 • 223 citations

Detection of functionally altered hepatitis C virus-specific CD4+ T cells in acute and chronic hepatitis C

2003 • 221 citations

Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules

1995 • 216 citations

Antiviral Effect and Virus-Host Interactions in Response to Alpha Interferon, Gamma Interferon, Poly(I)-Poly(C), Tumor Necrosis Factor Alpha, and Ribavirin in Hepatitis C Virus Subgenomic Replicons

2002 • 215 citations

Peginterferon alone or with ribavirin enhances HCV-specific CD4+ T-helper 1 responses in patients with chronic hepatitis C

2002 • 197 citations

Kinetics of CD4⁺and CD8⁺Memory T-Cell Responses during Hepatitis C Virus Rechallenge of Previously Recovered Chimpanzees

2003 • 192 citations

Comprehensive Analysis of CD8⁺-T-Cell Responses against Hepatitis C Virus Reveals Multiple Unpredicted Specificities

2002 • 188 citations

Previously Infected and Recovered Chimpanzees Exhibit Rapid Responses That Control Hepatitis C Virus Replication upon Rechallenge

2002 • 181 citations

Evidence of Viral Replication in Circulating Dendritic Cells during Hepatitis C Virus Infection

2003 • 177 citations

Regulation of PKR and IRF-1 during hepatitis C virus RNA replication

2002 • 176 citations

Early events in hepatitis C virus infection of chimpanzees.

1990 • 165 citations

Abnormal Priming of CD4⁺T Cells by Dendritic Cells Expressing Hepatitis C Virus Core and E1 Proteins

2002 • 164 citations

Binding of the hepatitis C virus envelope protein E2 to CD81 provides a co-stimulatory signal for human T cells

2001 • 155 citations

Cytotoxic T lymphocyte response and viral load in hepatitis C virus infection

1997 • 155 citations

Molecular Mimicry of Human Cytochrome P450 by Hepatitis C Virus at the Level of Cytotoxic T Cell Recognition

1999 • 154 citations

Detection of intrahepatic replication of hepatitis C virus RNA by in situ hybridization and comparison with histopathology.

1992 • 152 citations

Association of multispecific CD4+ response to hepatitis C and severity of recurrence after liver transplantation

1999 • 152 citations

Cellular immune responses against hepatitis C virus: the evidence base 2002

2002 • 147 citations

Hepatitis C Virus Structural Proteins Impair Dendritic Cell Maturation and Inhibit In Vivo Induction of Cellular Immune Responses

2003 • 142 citations

Association between MHC Class II Alleles and Clearance of Circulating Hepatitis C Virus

1998 • 139 citations

Novel CD4+ and CD8+ T-cell determinants within the NS3 protein in subjects with spontaneously resolved HCV infection

2003 • 131 citations

Directex vivo comparison of the breadth and specificity of the T cells in the liver and peripheral blood of patients with chronic HCV infection

2001 • 126 citations

Hepatitis C virus-specific CTL responses in the liver of chimpanzees with acute and chronic hepatitis C.

1993 • 124 citations

Chronic viral hepatitis and the human genome

2000 • 118 citations

Influence of ethnicity in the outcome of hepatitis C virus infection and cellular immune response

2003 • 117 citations

CD30 induction and cytokine profiles in hepatitis C virus core-specific peripheral blood T lymphocytes.

1997 • 117 citations

Nonstructural Protein Precursor NS4A/B from Hepatitis C Virus Alters Function and Ultrastructure of Host Secretory Apparatus

2003 • 110 citations

Serum interleukin 4 and interleukin 10 levels in patients with chronic hepatitis C virus infection

1997 • 105 citations

Circulating Th1 and Th2 cytokines in patients with hepatitis C virus infection

1998 • 97 citations

Liver-Derived Hepatitis C Virus(HCV)-Specific CD4+ T Cells Recognize Multiple HCV Epitopes and Produce Interferon Gamma

2000 • 96 citations

Mutations in Immunodominant T Cell Epitopes Derived from the Nonstructural 3 Protein of Hepatitis C Virus Have the Potential for Generating Escape Variants That May Have Important Consequences for T Cell Recognition

1999 • 91 citations

Life, activation and death of intrahepatic lymphocytes in chronic hepatitis C

2000 • 91 citations

Hypervariable Region 1 Variants Act as TCR Antagonists for Hepatitis C Virus-Specific CD4+ T Cells

1999 • 87 citations

Decreased frequency of HCV core-specific peripheral blood mononuclear cells with type 1 cytokine secretion in chronic hepatitis C

1999 • 81 citations

Quantitative Analysis of Hepatitis C Virus in Peripheral Blood and Liver: Replication Detected Only in Liver

2001 • 75 citations

Effect of HLA class II genotype on T helper lymphocyte responses and viral control in hepatitis C virus infection

2001 • 73 citations

Intrahepatic and circulating HLA class II-restricted, hepatitis C virus-specific T cells: Functional characterization in patients with chronic hepatitis C

2002 • 72 citations

Liver Injury and Disease Pathogenesis in Chronic Hepatitis C

2013 • 71 citations

Impaired induction of cytotoxic T lymphocytes by antagonism of a weak agonist borne by a variant hepatitis C virus epitope

1997 • 66 citations

Conserved Hierarchy of Helper T Cell Responses in a Chimpanzee during Primary and Secondary Hepatitis C Virus Infections

2004 • 60 citations

Hepatitis C Virus: Immunosuppression by Complement Regulatory Pathway

2001 • 59 citations

Intrahepatic expression of hepatitis C virus antigens in chronic liver disease

1995 • 53 citations

Modulation of the peripheral T-Cell response by CD4 mutants of hepatitis C virus: transition from a Th1 to a Th2 response

2003 • 48 citations

Identification of antigenic escape variants in an immunodominant epitope of hepatitis C virus

1999 • 45 citations

Cell Surface Expression of Major Histocompatibility Complex Class I Molecules Is Reduced in Hepatitis C Virus Subgenomic Replicon-Expressing Cells

2003 • 45 citations

Characterization of HCV-specific Patr class II restricted CD4+ T cell responses in an acutely infected chimpanzee

2003 • 45 citations

Patr-A and B, the orthologues of HLA-A and B, present hepatitis C virus epitopes to CD8+ cytotoxic T cells from two chronically infected chimpanzees.

1996 • 41 citations

Hepatitis C Virus–Specific CD4⁺T Cell Response after Liver Transplantation Occurs Early, Is Multispecific, Compartmentalizes to the Liver, and Does Not Correlate with Recurrent Disease

2001 • 38 citations

Molecular and Immunological Significance of Chimpanzee Major Histocompatibility Complex Haplotypes for Hepatitis C Virus Immune Response and Vaccination Studies

2002 • 33 citations

Antiviral treatment of recurrent hepatitis C virus (HCV) infection after liver transplantation: association of a strong, multispecific, and long-lasting CD4+ T cell response with HCV-elimination

2003 • 33 citations

Expression of hepatitis C virus proteins does not interfere with major histocompatibility complex class I processing and presentation in vitro

2001 • 31 citations

Sequence Variation in the Gene Encoding the Nonstructural 3 Protein of Hepatitis C Virus: Evidence for Immune Selection

2002 • 30 citations

Inefficient Recognition of Autologous Viral Sequences by Intrahepatic Hepatitis C Virus-Specific Cytotoxic T Lymphocytes in Chronically Infected Subjects

1998 • 19 citations

Depletion of CD8+ T lymphocytes by murine monoclonal CD8 antibodies and restored specific T cell proliferation in vivo in a patient with chronic hepatitis C.

1997 • 17 citations