Analysis of a Successful Immune Response against Hepatitis C Virus

An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis

1989 • 3,401 citations

Hepatitis C

1994 • 1,906 citations

Genetic organization and diversity of the hepatitis C virus.

1991 • 1,717 citations

Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of viral disease

1991 • 854 citations

Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection

1995 • 702 citations

Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.

1996 • 669 citations

Vaccination of chimpanzees against infection by thehepatitis C virus.

1994 • 572 citations

Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis.

1992 • 465 citations

Hepatitis C Infection in Patients with Primary Hypogammaglobulinemia after Treatment with Contaminated Immune Globulin

1994 • 380 citations

Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.

1995 • 344 citations

Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif.

1995 • 322 citations

The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C.

1997 • 316 citations

Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A,-B,-C null human cell line.

1989 • 305 citations

Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection.

1996 • 294 citations

Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C.

1993 • 247 citations

Expression of T Cell Antigen Receptor Heterodimers in a Lipid-Linked Form

1990 • 224 citations

Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses

1993 • 220 citations

Styles of dominance and their endocrine correlates among wild olive baboons (Papio anubis)

1989 • 199 citations

Hepatitis C

1996 • 156 citations

Influence of HLA haplotypes on the clinical courses of individuals infected with hepatitis C virus

1998 • 149 citations

Hypervariable region of hepatitis C virus envelope glycoprotein (E2/NS1) in an agammaglobulinemic patient

1994 • 143 citations

Analysis of Hepatitis C Virus-Inoculated Chimpanzees Reveals Unexpected Clinical Profiles

1998 • 143 citations

Hepatitis C Virus‐Specific Cytolytic T Lymphocyte and T Helper Cell Responses in Seronegative Persons

1997 • 142 citations

Comparison of Class I MHC Alleles in Humans and Apes

1990 • 137 citations

Evolution of Major Histocompatibility Complex Polymorphisms and T‐Cell Receptor Diversity in Primates

1995 • 130 citations

Hepatitis C virus-specific CTL responses in the liver of chimpanzees with acute and chronic hepatitis C.

1993 • 124 citations

Diagnosis of hepatitis C virus (HCV) infection using an immunodominant chimeric polyprotein to capture circulating antibodies: reevaluation of the role of HCV in liver disease.

1992 • 115 citations

Structural heterogeneity in HLA‐B70, a high‐frequency antigen of black populations *

1993 • 101 citations

Comparative features of hepatitis C virus infection in humans and chimpanzees

1997 • 84 citations

Clinical outcome of hypogammaglobulinaemic patients following outbreak of acute hepatitis C: 2 year follow up

1997 • 83 citations

Molecular biology of the hepatitis C virus

1994 • 77 citations

Detection of hepatitis C virus in paraffin-embedded liver biopsies of patients negative for viral RNA in serum

1999 • 73 citations

Epidemiology of hepatitis C

1996 • 73 citations

The Evolution of Major Histocompatibility Class I Genes in Primates

1995 • 63 citations

Detection of hepatitis C virus RNA: comparison of one-stage polymerase chain reaction (PCR) with nested-set PCR

1993 • 63 citations

Non‐A, Non‐B Hepatitis‐Related Hepatocellular Carcinoma in a Chimpanzee

1988 • 62 citations

Full-length nucleotide sequence of a Japanese hepatitis C virus isolate (HC-J1) with high homology to USA isolates

1992 • 49 citations

Induction in vitro of a primary human antiviral cytotoxic T cell response

1995 • 48 citations

Patr-A and B, the orthologues of HLA-A and B, present hepatitis C virus epitopes to CD8+ cytotoxic T cells from two chronically infected chimpanzees.

1996 • 41 citations

NATURAL RECOVERY FROM ACUTE HEPATITIS C VIRUS INFECTION BY AGAMMAGLOBULINEMIC TWIN CHILDREN

1997 • 40 citations

A major histocompatibility complex class I allele shared by two species of chimpanzee

1998 • 39 citations

Antibody response to E2/NS1 hepatitis C virus protein in patients with acute hepatitis C

1997 • 30 citations

The presentation of a hepatitis C viral peptide by distinct major histocompatibility complex class I allotypes from two chimpanzee species.

1996 • 19 citations

Use of recombinant HCV antigen in the serodiagnosis of hepatitis C virus infection: Significant improvement in HCV antibody detection as compared with the first generation HCV C100‐3 ELISA and the synthetic peptide EIA tests

1993 • 8 citations

Chimpanzees in Captivity: Humane Handling and Breeding Within the Confines Imposed by Medical Research and Testing: ???Position Paper for the Jane Goodall Institute Workshop on the Psychological Well‐Being of Captive Chimpanzees 1st to 3rd December, 1987

1989 • 6 citations